Global gene expression profiling of somatic motor neuron populations with different vulnerability identify molecules and pathways of degeneration and protection

Brain

Volumn 133, Issue 8, 2010, Pages 2313-2330

  Hedlund, Eva ^a,b   Karlsson, Martin ^a   Osborn, Teresia ^a   Ludwig, Wesley ^a   Isacson, Ole ^a  

^a MCLEAN HOSPITAL   (United States)

^b LUDWIG INSTITUTE FOR CANCER RESEARCH   (Sweden)

Author keywords

Cervical spinal cord; Cranial nerves; Hierarchical clustering; IGF II; Microarray; Motor neuron; SOD1G93A rat

Indexed keywords

CALCIUM; COPPER ZINC SUPEROXIDE DISMUTASE; EARLY GROWTH RESPONSE FACTOR 1; GLUTAMIC ACID; GUANINE DEAMINASE; GUANYLATE CYCLASE; MUTANT PROTEIN; PERIPHERIN; PLACENTAL GROWTH FACTOR; SOMATOMEDIN B; CARRIER PROTEIN; GDA PROTEIN, RAT; SUPEROXIDE DISMUTASE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASTROCYTE; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; CELL ISOLATION; CELL NUCLEUS; CELL POPULATION; CELL SUBPOPULATION; CERVICAL SPINAL CORD; CONTROLLED STUDY; DISEASE COURSE; DISEASE MODEL; DISEASE PREDISPOSITION; ENDOPLASMIC RETICULUM; FEMALE; GENE CONTROL; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; GROWTH; HYPOGLOSSAL NERVE; KENNEDY DISEASE; LASER CAPTURE MICRODISSECTION; MICROGLIA; MITOCHONDRION; MOTONEURON; MOUSE; NERVE DEGENERATION; NEUROPROTECTION; NEUROTOXICITY; NITROGEN METABOLISM; NONHUMAN; NUCLEOTIDE SEQUENCE; OCULOMOTOR NERVE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; REGULATORY MECHANISM; RNA PROCESSING; SPINAL MUSCULAR ATROPHY; TROCHLEAR NERVE; UBIQUITINATION; UNINDEXED SEQUENCE; ANIMAL; CELL CULTURE; CELL SURVIVAL; CRANIAL NERVE; GENE EXPRESSION PROFILING; GENETICS; METABOLISM; MOTOR NEURON DISEASE; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; SPINAL CORD; SPRAGUE DAWLEY RAT; TRANSGENIC RAT;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CARRIER PROTEINS; CELL SURVIVAL; CELLS, CULTURED; CRANIAL NERVES; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION PROFILING; GUANINE DEAMINASE; INSULIN-LIKE GROWTH FACTOR II; MOTOR NEURON DISEASE; MOTOR NEURONS; NERVE DEGENERATION; RATS; RATS, SPRAGUE-DAWLEY; RATS, TRANSGENIC; SIGNAL TRANSDUCTION; SPINAL CORD; SUPEROXIDE DISMUTASE;

EID: 77957091257     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awq167     Document Type: Article

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