메뉴 건너뛰기




Volumn 44, Issue 5, 2011, Pages 298-305

Mitochondrial superoxide anion (O2•-) inducible "mev-1" animal models for aging research

Author keywords

Aging; Apoptosis; Mitochondria; Oxidative stress; Tumorigenesis

Indexed keywords

REACTIVE OXYGEN METABOLITE; SUCCINATE DEHYDROGENASE; SUPEROXIDE;

EID: 79958718704     PISSN: 19766696     EISSN: 1976670X     Source Type: Journal    
DOI: 10.5483/BMBRep.2011.44.5.298     Document Type: Short Survey
Times cited : (32)

References (69)
  • 1
    • 0017810263 scopus 로고
    • Do mitochondria produce oxygen radicals in vivo?
    • Nohl, H. and Hegner, D. (1978) Do mitochondria produce oxygen radicals in vivo? Eur. J. Biochem. 82, 563-567.
    • (1978) Eur. J. Biochem. , vol.82 , pp. 563-567
    • Nohl, H.1    Hegner, D.2
  • 2
    • 0033525773 scopus 로고    scopus 로고
    • Mitochondrial diseases in man and mouse
    • Wallace, D. C. (1999) Mitochondrial diseases in man and mouse. Science 283, 1482-1488.
    • (1999) Science , vol.283 , pp. 1482-1488
    • Wallace, D.C.1
  • 3
    • 0034700807 scopus 로고    scopus 로고
    • Mitochondrial respiratory chain disorders: I. mitochondrial DNA defects
    • Leonard, J. V. and Schapira, A. H. (2000) Mitochondrial respiratory chain disorders: I. mitochondrial DNA defects. Lancet 355, 299-304.
    • (2000) Lancet , vol.355 , pp. 299-304
    • Leonard, J.V.1    Schapira, A.H.2
  • 5
    • 0142150051 scopus 로고    scopus 로고
    • Mitochondrial formation of reactive oxygen species
    • Turrens, J. F. (2003) Mitochondrial formation of reactive oxygen species. J. Physiol. 552, 335-344.
    • (2003) J. Physiol. , vol.552 , pp. 335-344
    • Turrens, J.F.1
  • 6
    • 0018776894 scopus 로고
    • Hydroperoxide metabolism in mammalian organs
    • Chance, B., Sies, H. and Boveris, A. (1979) Hydroperoxide metabolism in mammalian organs. Physiol. Rev. 59, 527-605.
    • (1979) Physiol. Rev. , vol.59 , pp. 527-605
    • Chance, B.1    Sies, H.2    Boveris, A.3
  • 7
    • 4444297565 scopus 로고    scopus 로고
    • Mitochondria: are they the seat of senescence?
    • Fridovich, I. (2004) Mitochondria: are they the seat of senescence? Aging Cell 3, 13-16.
    • (2004) Aging Cell , vol.3 , pp. 13-16
    • Fridovich, I.1
  • 8
    • 0030969868 scopus 로고    scopus 로고
    • Superoxide production by the mitochondrial respiratory chain
    • Turrens, J. F. (1997) Superoxide production by the mitochondrial respiratory chain. Biosci. Rep. 17, 3-8.
    • (1997) Biosci. Rep. , vol.17 , pp. 3-8
    • Turrens, J.F.1
  • 9
    • 0032504657 scopus 로고    scopus 로고
    • Role of mitochondria in oxidative stress and ageing
    • Lenaz, G. (1998) Role of mitochondria in oxidative stress and ageing. Biochim. Biophys. Acta. Bioenerg. 1366, 53-67.
    • (1998) Biochim. Biophys. Acta. Bioenerg. , vol.1366 , pp. 53-67
    • Lenaz, G.1
  • 10
    • 0034626735 scopus 로고    scopus 로고
    • Oxidants, oxidative stress and the biology of ageing
    • Finkel, T. and Holbrook, N. J. (2000) Oxidants, oxidative stress and the biology of ageing. Nature 408, 239-247.
    • (2000) Nature , vol.408 , pp. 239-247
    • Finkel, T.1    Holbrook, N.J.2
  • 11
    • 0034306267 scopus 로고    scopus 로고
    • Mitochondria, oxygen free radicals, disease and ageing
    • Raha, S. and Robinson, B. H. (2000) Mitochondria, oxygen free radicals, disease and ageing. Trends Biochem. Sci. 25, 502-508.
    • (2000) Trends Biochem. Sci. , vol.25 , pp. 502-508
    • Raha, S.1    Robinson, B.H.2
  • 12
    • 0142195820 scopus 로고    scopus 로고
    • Superoxide anion generation by the cytochrome bc1 complex
    • Sun, J. and Trumpower, B. L. (2003) Superoxide anion generation by the cytochrome bc1 complex. Arch. Biochem. Biophys. 419, 198-206.
    • (2003) Arch. Biochem. Biophys. , vol.419 , pp. 198-206
    • Sun, J.1    Trumpower, B.L.2
  • 13
    • 0037160091 scopus 로고    scopus 로고
    • Topology of superoxide production from different sites in the mitochondrial electron transport chain
    • St-Pierre, J., Buckingham, J. A., Roebuck, S. J. and Brand, M. D. (2002) Topology of superoxide production from different sites in the mitochondrial lectron transport chain. J. Biol. Chem. 277, 44784-44790.
    • (2002) J. Biol. Chem. , vol.277 , pp. 44784-44790
    • St-Pierre, J.1    Buckingham, J.A.2    Roebuck, S.J.3    Brand, M.D.4
  • 15
    • 0035834789 scopus 로고    scopus 로고
    • A defect in the cytochrome b large subunit in complex II causes both superoxide anion overproduction and abnormal energy metabolism in Caenorhabditis elegans
    • Senoo-Matsuda, N., Yasuda, K., Tsuda, M., Ohkubo, T., Yoshimura, S., Nakazawa, H., Hartman, P. S. and Ishii, N. (2001) A defect in the cytochrome b large subunit in complex II causes both superoxide anion overproduction and abnormal energy metabolism in Caenorhabditis elegans. J. Biol. Chem. 276, 41553-1558.
    • (2001) J. Biol. Chem. , vol.276 , pp. 41553-41558
    • Senoo-Matsuda, N.1    Yasuda, K.2    Tsuda, M.3    Ohkubo, T.4    Yoshimura, S.5    Nakazawa, H.6    Hartman, P.S.7    Ishii, N.8
  • 16
    • 11244279161 scopus 로고    scopus 로고
    • A mutation in the SDHC gene of complex II increases oxidative stress, resulting in apoptosis and tumorigenesis
    • Ishii, T., Yasuda, K., Akatsuka, A., Hino, O., Hartman, P. S. and Ishii, N. (2005) A mutation in the SDHC gene of complex II increases oxidative stress, resulting in apoptosis and tumorigenesis. Cancer Res. 65, 203-209.
    • (2005) Cancer Res , vol.65 , pp. 203-209
    • Ishii, T.1    Yasuda, K.2    Akatsuka, A.3    Hino, O.4    Hartman, P.S.5    Ishii, N.6
  • 17
    • 76049086567 scopus 로고    scopus 로고
    • Contribution of the FAD and quinone binding sites to the production of reactive oxygen species from Ascaris suum mitochondrial complex II
    • Paranagama, M. P., Sakamoto, K., Amino, H., Awano, M., Miyoshi, H. and Kita, K. (2010) Contribution of the FAD and quinone binding sites to the production of reactive oxygen species from Ascaris suum mitochondrial complex II. Mitochondrion 10, 158-165.
    • (2010) Mitochondrion , vol.10 , pp. 158-165
    • Paranagama, M.P.1    Sakamoto, K.2    Amino, H.3    Awano, M.4    Miyoshi, H.5    Kita, K.6
  • 18
    • 28544446058 scopus 로고    scopus 로고
    • Mitochondrial tumour suppressors: a genetic and biochemical update
    • Gottlieb, E. and Tomlinson, I. P. (2005) Mitochondrial tumour suppressors: a genetic and biochemical update. Nat. Rev. Cancer 5, 857-866.
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 857-866
    • Gottlieb, E.1    Tomlinson, I.P.2
  • 19
    • 34948890043 scopus 로고    scopus 로고
    • Mitochondrial uncoupling proteinswhat is their physiological role? Free Radic
    • Echtay, K. S. (2007) Mitochondrial uncoupling proteinswhat is their physiological role? Free Radic. Biol. Med. 43, 1351-1371.
    • (2007) Biol. Med. , vol.43 , pp. 1351-1371
    • Echtay, K.S.1
  • 23
    • 0023235226 scopus 로고
    • Reduced oxygen species, mutation, induction and cancer initiation
    • Vuillaume, M. (1987) Reduced oxygen species, mutation, induction and cancer initiation. Mutat. Res. 186, 43-72.
    • (1987) Mutat. Res. , vol.186 , pp. 43-72
    • Vuillaume, M.1
  • 25
    • 0037411282 scopus 로고    scopus 로고
    • 4-Hydroxy-2-nonenal: a product and mediator of oxidative stress
    • Uchida K. (2003) 4-Hydroxy-2-nonenal: a product and mediator of oxidative stress. Prog. Lipid Res. 42, 318-343.
    • (2003) Prog. Lipid Res. , vol.42 , pp. 318-343
    • Uchida, K.1
  • 27
    • 27544484846 scopus 로고    scopus 로고
    • Are mitochondria critical in the pathogenesis of Alzheimer's disease?
    • Reddy, P. H. and Beal, M. F. (2005) Are mitochondria critical in the pathogenesis of Alzheimer's disease? Brain Res. Rev. 49, 618-632.
    • (2005) Brain Res. Rev , vol.49 , pp. 618-632
    • Reddy, P.H.1    Beal, M.F.2
  • 28
    • 33645879820 scopus 로고    scopus 로고
    • Oxidative damage and age-related functional declines
    • Martin, I. and Grotewiel, M. S. (2006) Oxidative damage and age-related functional declines. Mech. Ageing Dev. 127, 411-423.
    • (2006) Mech. Ageing Dev. , vol.127 , pp. 411-423
    • Martin, I.1    Grotewiel, M.S.2
  • 29
    • 32444433202 scopus 로고    scopus 로고
    • Free radicals, metals and antioxidants in oxidative stress-induced cancer
    • Valko, M., Rhodes, C. J., Moncol, J., Izakovic, M. and Mazur, M. (2006) Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem. iol. Interact. 160, 1-40.
    • (2006) Chem. Biol. Interact. , vol.160 , pp. 1-40
    • Valko, M.1    Rhodes, C.J.2    Moncol, J.3    Izakovic, M.4    Mazur, M.5
  • 31
    • 0017295767 scopus 로고
    • Characterization of the mitochondria of the free-living nematode Caenorhabditis elegans
    • Murfitt, R. R., Vogel, K. and Sanadi, D. R. (1976) Characterization of the mitochondria of the free-living nematode, Caenorhabditis elegans. Comp. Biochem. Physiol. B. 53, 423-430.
    • (1976) Comp. Biochem. Physiol. B. , vol.53 , pp. 423-430
    • Murfitt, R.R.1    Vogel, K.2    Sanadi, D.R.3
  • 34
    • 34748922899 scopus 로고    scopus 로고
    • A mev-1-like dominant-negative SdhC increases oxidative stress and reduces lifespan in Drosophila
    • Tsuda, M., Sugiura, T., Ishii, T., Ishii, N. and Aigaki, T.,(2007) A mev-1-like dominant-negative SdhC increases oxidative stress and reduces lifespan in rosophila. Biochem. Biophys. Res. Commun. 363, 342-346.
    • (2007) Biochem. Biophys. Res. Commun. , vol.363 , pp. 342-346
    • Tsuda, M.1    Sugiura, T.2    Ishii, T.3    Ishii, N.4    Aigaki, T.5
  • 36
    • 0027467912 scopus 로고
    • Oxygen-dependent perturbation of life span and aging rate in the nematode
    • Honda, S., Ishii, N., Suzuki, K. and Matsuo, M. (1993) Oxygen-dependent perturbation of life span and aging rate in the nematode. J. Gerontl. Ser. A Biol. ci. 48, B57-B61.
    • (1993) J. Gerontl. Ser. A Biol. Sci. , vol.48
    • Honda, S.1    Ishii, N.2    Suzuki, K.3    Matsuo, M.4
  • 37
    • 85047289687 scopus 로고
    • Rate and magnitude of age pigment accumulation in the human myocardium
    • Strehler, B. L., Mark, D. D., Mildvan, A. S. and Gee, M. V. (1959) Rate and magnitude of age pigment accumulation in the human myocardium. J. Gerontl. 4, 257-264.
    • (1959) J. Gerontl. , vol.14 , pp. 257-264
    • Strehler, B.L.1    Mark, D.D.2    Mildvan, A.S.3    Gee, M.V.4
  • 38
    • 0016143131 scopus 로고
    • Accumulation of lipofuscin in the myocardium of senile guinia pigs; dissolution and removal of lipofuscin following dimethylaminoethyl p-chloroohenoxyacetate administration. An electron microscopy study
    • Spoerri, P. E., Glass, P. and El Ghazzawi, E. (1974) Accumulation of lipofuscin in the myocardium of senile guinia pigs; dissolution and removal of lipofuscin following dimethylaminoethyl p-chloroohenoxyacetate administration. An electron microscopy study. Mech. Ageing Dev. 3, 311-321.
    • (1974) Mech. Ageing Dev. , vol.3 , pp. 311-321
    • Spoerri, P.E.1    Glass, P.2    El Ghazzawi, E.3
  • 39
    • 0025911829 scopus 로고
    • Metal-catalyzed oxidation of proteins
    • Stadman, E. R. and Oliver, C. N. (1991) Metal-catalyzed oxidation of proteins. J. Biol. Chem. 266, 2005-2008.
    • (1991) J. Biol. Chem. , vol.266 , pp. 2005-2008
    • Stadman, E.R.1    Oliver, C.N.2
  • 40
    • 0026795635 scopus 로고
    • Protein oxidation and aging
    • Stadman, E. R. (1992) Protein oxidation and aging. Science 257, 1220-1224.
    • (1992) Science , vol.257 , pp. 1220-1224
    • Stadman, E.R.1
  • 41
    • 0028228780 scopus 로고
    • Rapid accumulation of fluorescent material with aging in an oxygen-sensitive mutant mev-1 of Caenorhabditis elegans
    • Hosokawa, H., Ishii, N., Ishida, H., Ichimori, K., Nakazawa, H. and Suzuki, K. (1994) Rapid accumulation of fluorescent material with aging in an oxygen-sensitive mutant mev-1 of Caenorhabditis elegans. Mech. Ageing Dev. 74, 161-170.
    • (1994) Mech. Ageing Dev. , vol.74 , pp. 161-170
    • Hosokawa, H.1    Ishii, N.2    Ishida, H.3    Ichimori, K.4    Nakazawa, H.5    Suzuki, K.6
  • 42
    • 0031904566 scopus 로고    scopus 로고
    • Effects of oxygen on protein carbonyl and aging in Caenorhabditis elegans mutants with long (age-1) and short (mev-1) life spans
    • Adachi, H., Fujiwara, Y. and Ishii, N. (1998) Effects of oxygen on protein carbonyl and aging in Caenorhabditis elegans mutants with long (age-1) and short (mev-1) life spans. J. Gerontol. Ser. A Biol. Sci. Med. Sci. 53, B240-B244.
    • (1998) J. Gerontol. Ser. A Biol. Sci. Med. Sci. , vol.53
    • Adachi, H.1    Fujiwara, Y.2    Ishii, N.3
  • 43
    • 0037820623 scopus 로고    scopus 로고
    • A complex II defect affects mitochondrial structure, leading to ced-3- and ced-4-dependent apoptosis and aging
    • Senoo-Matsuda, N., Hartman, P. S., Akatsuka, A., Yoshimura, S. and Ishii, N. (2003) A complex II defect affects mitochondrial structure, leading to ced-3- and ced-4-dependent apoptosis and aging. J. Biol. Chem. 278, 22031-22036.
    • (2003) J. Biol. Chem. , vol.278 , pp. 22031-22036
    • Senoo-Matsuda, N.1    Hartman, P.S.2    Akatsuka, A.3    Yoshimura, S.4    Ishii, N.5
  • 44
    • 0034994933 scopus 로고    scopus 로고
    • Mitochondrial mutations differentially affect aging, mutability and anesthetic sensitivity in Caenorhabditis elegans
    • Hartman, P. S, Ishii, N., Kayser, E. B., Morgan, P. G. and Sedensky, M. M. (2001) Mitochondrial mutations differentially affect aging, mutability and anesthetic sensitivity in Caenorhabditis elegans. Mech. Ageing Dev. 122, 1187-1201.
    • (2001) Mech. Ageing Dev. , vol.122 , pp. 1187-1201
    • Hartman, P.S.1    Ishii, N.2    Kayser, E.B.3    Morgan, P.G.4    Sedensky, M.M.5
  • 46
    • 0043269302 scopus 로고    scopus 로고
    • Function and structure of complex II of the respiratory chain
    • Cecchini, G. (2003) Function and structure of complex II of the respiratory chain. Annu. Rev. Biochem. 72, 77-109.
    • (2003) Annu. Rev. Biochem. , vol.72 , pp. 77-109
    • Cecchini, G.1
  • 47
    • 21244503033 scopus 로고    scopus 로고
    • Crystal structure of mitochondrial respiratory membrane protein complex II
    • Sun, F., Huo, X., Zhai, Y. A., Wang, A., Xu, J., Su, D., Bartlam, M. and Rao, Z. (2005) Crystal structure of mitochondrial respiratory membrane protein omplex II. Cell 121, 1043-1057.
    • (2005) Cell , vol.121 , pp. 1043-1057
    • Sun, F.1    Huo, X.2    Zhai, Y.A.3    Wang, A.4    Xu, J.5    Su, D.6    Bartlam, M.7    Rao, Z.8
  • 49
    • 0033983147 scopus 로고    scopus 로고
    • Progress in understanding structure-function relationships in respiratory chain complex II
    • Ackrell, B. A. (2000) Progress in understanding structure-function relationships in respiratory chain complex II. FEBS Lett. 466, 1-5.
    • (2000) FEBS Lett , vol.466 , pp. 1-5
    • Ackrell, B.A.1
  • 50
    • 0036805853 scopus 로고    scopus 로고
    • Cytopathies involving mitochondrial complex II
    • Ackrell, B. A. (2002) Cytopathies involving mitochondrial complex II. Mol. Aspects. Med. 23, 369-384.
    • (2002) Mol. Aspects. Med. , vol.23 , pp. 369-384
    • Ackrell, B.A.1
  • 52
    • 0033767445 scopus 로고    scopus 로고
    • Mutations in SDHC cause autosomal dominant paraganglioma, type 3
    • Niemann, S. and Müller U. (2000) Mutations in SDHC cause autosomal dominant paraganglioma, type 3. Nat. Genet. 26, 268-270.
    • (2000) Nat. Genet. , vol.26 , pp. 268-270
    • Niemann, S.1    Müller, U.2
  • 53
  • 54
    • 0035213138 scopus 로고    scopus 로고
    • The R22X mutation of the SDHD gene in hereditary paraganglioma abolishes the enzymatic activity of complex II in the mitochondrial respiratory chain and activates the hypoxia pathway
    • Gimenez-Roqueplo, A. P., Favier, J., Rustin, P., Mourad, J. J., Plouin, P. F., Corvol, P., Rötig, A. and Jeunemaitre, X. (2001) The R22X mutation of the SDHD gene in hereditary paraganglioma abolishes the enzymatic activity of complex II in the mitochondrial respiratory chain and activates the hypoxia pathway. Am. . Hum. Genet. 69, 1186-1197.
    • (2001) Am. J. Hum. Genet , vol.69 , pp. 1186-1197
    • Gimenez-Roqueplo, A.P.1    Favier, J.2    Rustin, P.3    Mourad, J.J.4    Plouin, P.F.5    Corvol, P.6    Rötig, A.7    Jeunemaitre, X.8
  • 57
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza, G. L. (2003) Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer 3, 721-732.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 58
    • 0035834582 scopus 로고    scopus 로고
    • Correlation of functional and ultrastructural abnormalities of mitochondria in mouse heart carrying a pathogenic mutant mtDNA with a 4696-bp deletion
    • Nakada, K., Inoue, K., Chen, C. S., Nonaka, I., Goto, Y., Ogura, A. and Hayashi, J. I. (2001) Correlation of functional and ultrastructural abnormalities of mitochondria in mouse heart carrying a pathogenic mutant mtDNA with a 4696-bp deletion. Biochem. Biophys. Res. Commun. 288, 901-907.
    • (2001) Biochem. Biophys. Res. Commun. , vol.288 , pp. 901-907
    • Nakada, K.1    Inoue, K.2    Chen, C.S.3    Nonaka, I.4    Goto, Y.5    Ogura, A.6    Hayashi, J.I.7
  • 59
    • 0036890323 scopus 로고    scopus 로고
    • Complex II inactivation is lethal in the nematode Caenorhabditis elegans
    • Ichimiya, H., Huet, R. G., Hartman, P., Amino, H., Kita, K. and Ishii, N. (2002) Complex II inactivation is lethal in the nematode Caenorhabditis elegans. itochondrion 2, 191-198.
    • (2002) Mitochondrion , vol.2 , pp. 191-198
    • Ichimiya, H.1    Huet, R.G.2    Hartman, P.3    Amino, H.4    Kita, K.5    Ishii, N.6
  • 60
    • 77952312782 scopus 로고    scopus 로고
    • Cell growth of the mouse SDHC mutant cells was suppressed by apoptosis throughout mitochondrial pathway
    • Miyazawa, M., Ishii, T., Kirinashizawa, M., Yasuda, K., Hino, O., Hartman, P. S. and Ishii, N. (2008) Cell growth of the mouse SDHC mutant cells was suppressed by apoptosis throughout mitochondrial pathway. BioScience Trends 2, 22-30.
    • (2008) BioScience Trends , vol.2 , pp. 22-30
    • Miyazawa, M.1    Ishii, T.2    Kirinashizawa, M.3    Yasuda, K.4    Hino, O.5    Hartman, P.S.6    Ishii, N.7
  • 62
    • 0026720075 scopus 로고
    • Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
    • Gossen, M. and Bujard, H. (1992) Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. U.S.A. 9, 5547-5551.
    • (1992) Proc. Natl. Acad. Sci. U. S. A. , vol.89 , pp. 5547-5551
    • Gossen, M.1    Bujard, H.2
  • 63
  • 64
    • 0032600013 scopus 로고    scopus 로고
    • A tetracycline controlled activation/repression system with increased potential for gene transfer into mammalian cells
    • Freundlieb, S., Schirra-Muller, C. and Bujard, H. (1999) A tetracycline controlled activation/repression system with increased potential for gene transfer into ammalian cells. J. Gene Med. 1, 4-12.
    • (1999) J. Gene Med. , vol.1 , pp. 4-12
    • Freundlieb, S.1    Schirra-Muller, C.2    Bujard, H.3
  • 66
    • 0018749490 scopus 로고
    • Role of superoxide dismutase in cancer: a review
    • Oberley, L. W. and Buettner, G. R. (1979) Role of superoxide dismutase in cancer: a review. Cancer Res. 39, 1141-1149.
    • (1979) Cancer Res , vol.39 , pp. 1141-1149
    • Oberley, L.W.1    Buettner, G.R.2
  • 67
    • 0019230916 scopus 로고
    • Cell differentiation, aging and cancer: the possible roles of superoxide and superoxide dismutases
    • Oberley, L. W., Oberley, T. D. and Buettner, G. R. (1980) Cell differentiation, aging and cancer: the possible roles of superoxide and superoxide dismutases. ed. Hypotheses 6, 249-268.
    • (1980) Med. Hypotheses , vol.6 , pp. 249-268
    • Oberley, L.W.1    Oberley, T.D.2    Buettner, G.R.3
  • 68
    • 0024270397 scopus 로고
    • Role of antioxidant enzymes in cell immortalization and transformation
    • Oberley, L. W. and Oberley, T. D. (1988) Role of antioxidant enzymes in cell immortalization and transformation. Mol. Cell. Biochem. 84, 147-153.
    • (1988) Mol. Cell. Biochem. , vol.84 , pp. 147-153
    • Oberley, L.W.1    Oberley, T.D.2
  • 69
    • 77955301066 scopus 로고    scopus 로고
    • The NADH-fumarate reductase system, a novel mitochondrial energy metabolism, is a new target for anticancer therapy in tumor microenvironments
    • Tomitsuka, E., Kita, K. and Esumi H. (2010) The NADH-fumarate reductase system, a novel mitochondrial energy metabolism, is a new target for anticancer therapy in tumor microenvironments. Ann. NY Acad. Sci. 1201, 44-49.
    • (2010) Ann. NY Acad. Sci , vol.1201 , pp. 44-49
    • Tomitsuka, E.1    Kita, K.2    Esumi, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.