Aggregation of ALS-linked FUS mutant sequesters RNA binding proteins and impairs RNA granules formation

Biochemical and Biophysical Research Communications

Volumn 452, Issue 3, 2014, Pages 600-607

  Takanashi, Keisuke ^a   Yamaguchi, Atsushi ^a  

^a CHIBA UNIVERSITY   (Japan)

Author keywords

ALS; FUS TLS; hnRNP A B; SMN1

Indexed keywords

DETERGENT; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A1; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A2; MESSENGER RNA; POLYADENYLIC ACID; RNA; RNA BINDING PROTEIN; SURVIVAL MOTOR NEURON PROTEIN 1; UNCLASSIFIED DRUG; HNRNP A1; HNRNP A2; PROTEIN AGGREGATE; SMN1 PROTEIN, HUMAN;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL GRANULE; CELL STRESS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; EMBRYO; FLUORESCENCE IN SITU HYBRIDIZATION; FUS GENE; GENE; GENE OVEREXPRESSION; HEK293 CELL LINE; HUMAN; HUMAN CELL; MUTANT; PROTEIN AGGREGATION; PROTEIN ASSEMBLY; REDUCTION; RNA GRANULE; TRANSIENT TRANSFECTION; WILD TYPE; CELL LINE; CELL NUCLEUS; CHEMISTRY; GENE EXPRESSION; GENETICS; METABOLISM; MUTATION; NERVE CELL; PATHOLOGY; PROTEIN TERTIARY STRUCTURE; PROTEINOSIS;

CELL LINE; CELL NUCLEUS; CYTOPLASM; CYTOPLASMIC GRANULES; GENE EXPRESSION; HEK293 CELLS; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEIN GROUP A-B; HUMANS; MUTATION; NEURONS; PROTEIN AGGREGATES; PROTEIN AGGREGATION, PATHOLOGICAL; PROTEIN STRUCTURE, TERTIARY; RNA, MESSENGER; RNA-BINDING PROTEIN FUS; SURVIVAL OF MOTOR NEURON 1 PROTEIN;

EID: 84907533335     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.08.115     Document Type: Article

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