Inactivation of hnRNP K by expanded intronic AUUCU repeat induces apoptosis via translocation of PKCδ to mitochondria in spinocerebellar ataxia 10

PLoS Genetics

Volumn 6, Issue 6, 2010, Pages 1-12

  White, Misti C ^a   Gao, Rui ^a   Xu, Weidong ^a   Mandal, Santi M ^a   Lim, Jung G ^a   Hazra, Tapas K ^a   Wakamiya, Maki ^a   Edwards, Sharon F ^a   Raskin, Salmo ^b   Teive, Hélio A G ^c   Zoghbi, Huda Y ^d   Sarkar, Partha S ^a   Ashizawa, Tetsuo ^a,e  

^a University of Texas Medical Branch School of Medicine   (United States)

^b PONTIFICAL CATHOLIC UNIVERSITY OF PARANÁ   (Brazil)

^c FEDERAL UNIVERSITY OF PARANÁ   (Brazil)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

^e UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATAXIN 10; CASPASE 3; CYSTEINE PROTEINASE; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN K; PROTEIN KINASE C DELTA; RNA; UNCLASSIFIED DRUG; ATXN10 PROTEIN, HUMAN; NERVE PROTEIN;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; INTRON; MITOCHONDRION; MOUSE; NONHUMAN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; RNA SPLICING; RNA TRANSCRIPTION; SPINOCEREBELLAR DEGENERATION; CELL LINE; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; NUCLEOTIDE REPEAT; PROTEIN BINDING;

MUS MUSCULUS;

APOPTOSIS; CELL LINE; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEIN K; HUMANS; INTRONS; MITOCHONDRIA; NERVE TISSUE PROTEINS; PROTEIN BINDING; PROTEIN KINASE C-DELTA; PROTEIN TRANSPORT; REPETITIVE SEQUENCES, NUCLEIC ACID; TRANSCRIPTION, GENETIC;

EID: 77954171034     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1000984     Document Type: Article

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