Proteome response to ochratoxin A-induced apoptotic cell death in mouse hippocampal HT22 cells

NeuroToxicology

Volumn 30, Issue 4, 2009, Pages 666-676

  Yoon, Somy ^a   Cong, Wei Tao ^a   Bang, Yeojin ^a   Lee, Sang No ^a   Yoon, Chul Su ^a   Kwack, Seung Jun ^b   Kang, Tae Seok ^b   Lee, Kwang Youl ^a   Choi, Jung Kap ^a   Choi, Hyun Jin ^a  

^a Chonnam National University   (South Korea)

^b Korea Food and Drug Administration   (South Korea)

Author keywords

Cytotoxicity; HT22 cell; Mycotoxin; Ochratoxin A; Proteome response

Indexed keywords

CASPASE 3; INITIATION FACTOR 1; INITIATION FACTOR 1D; LACTATE DEHYDROGENASE; NUCLEOPHOSMIN; OCHRATOXIN; ORNITHINE OXOACID AMINOTRANSFERASE; PEROXIREDOXIN 6; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROHIBITIN; PROTEIN P53; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; HIPPOCAMPUS; HUMAN; HUMAN CELL; MOUSE; NERVE CELL NECROSIS; NERVE DEGENERATION; NEUROBLASTOMA CELL; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; UPREGULATION;

ANALYSIS OF VARIANCE; ANIMALS; APOPTOSIS; CALCIUM CHANNEL BLOCKERS; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; GENE EXPRESSION REGULATION; HIPPOCAMPUS; HUMANS; L-LACTATE DEHYDROGENASE; MICE; MITOCHONDRIA; NEUROBLASTOMA; OCHRATOXINS; PROTEOME; REACTIVE OXYGEN SPECIES; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TETRAZOLIUM SALTS; THIAZOLES;

ANIMALIA; EUKARYOTA; PENICILLIUM VERRUCOSUM;

EID: 67651004504     PISSN: 0161813X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuro.2009.04.013     Document Type: Article

References (53)

1. Alm H., Scholz B., Fischer C., Kultima K., Viberg H., Eriksson P., et al. Proteomic evaluation of neonatal exposure to 2,2,4,4,5-pentabromodiphenyl ether. Environ Health Perspect 114 (2006) 254-259
2. Arbillaga L., Azqueta A., Ezpeleta O., and López de Cerain A. Oxidative DNA damage induced by ochratoxin A in the HK-2 human kidney cell line: evidence of the relationship with cytotoxicity. Mutagenesis 22 (2007) 35-42
3. Arora R., Frölén H., and Fellner-Feldegg H. Inhibition of ochratoxin A teratogenesis by zearalenone and diethylstilboestrol. Food Chem Toxicol 21 (1983) 779-783
4. Belmadani A., Tramu G., Betbeder A., Steyn P., and Creppy E. Regional selectivity to ochratoxin A, distribution and cytotoxicity in rat brain. Arch Toxicol 72 (1998) 656-662
5. Boyd-Kimball D., Sultana R., Poon H., Lynn B., Casamenti F., Pepeu G., et al. Proteomic identification of proteins specifically oxidized by intracerebral injection of amyloid beta-peptide (1-42) into rat brain: implications for Alzheimer's disease. Neuroscience 132 (2005) 313-324
6. Bradford M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72 (1976) 248-254
7. Chin M., Qian W., Wang H., Petyuk V., Bloom J., Sforza D., et al. Mitochondrial dysfunction, oxidative stress, and apoptosis revealed by proteomic and transcriptomic analyses of the striata in two mouse models of Parkinson's disease. J Proteome Res 7 (2008) 666-677
8. Chipuk J., Fisher J., Dillon C., Kriwacki R., Kuwana T., and Green D. Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins. Proc Natl Acad Sci USA 105 (2008) 20327-20332
9. Chipuk J., and Green D. Dissecting p53-dependent apoptosis. Cell Death Differ 13 (2006) 994-1002
10. Choi J., Chae H., Hwang S., Choi H., Jin L., and Yoo G. Fast visible dye staining of proteins in one- and two-dimensional sodium dodecyl sulfate-polyacrylamide gels compatible with matrix assisted laser desorption/ionization-mass spectrometry. Electrophoresis 25 (2004) 1136-1141
11. Creppy E., Størmer F., Röschenthaler R., and Dirheimer G. Effects of two metabolites of ochratoxin A, (4R)-4-hydroxyochratoxin A and ochratoxin alpha, on immune response in mice. Infect Immun 39 (1983) 1015-1018
12. Delibas N., Altuntas I., Yonden Z., and Ozcelik N. Ochratoxin A reduces NMDA receptor subunits 2A and 2B concentrations in rat hippocampus: partial protective effect of melatonin. Hum Exp Toxicol 22 (2003) 335-339
13. Dörrenhaus A., Flieger A., Golka K., Schulze H., Albrecht M., Degen G., et al. Induction of unscheduled DNA synthesis in primary human urothelial cells by the mycotoxin ochratoxin A. Toxicol Sci 53 (2000) 271-277
14. Fink-Gremmels J. Ochratoxin A in food: recent developments and significance. Food Addit Contam 22 Suppl. 1 (2005) 1-5
15. Gareis M., and Wolff J. Relevance of mycotoxin contaminated feed for farm animals and carryover of mycotoxins to food of animal origin. Mycoses 43 Suppl. 1 (2000) 79-83
16. Gautier J., Holzhaeuser D., Markovic J., Gremaud E., Schilter B., and Turesky R. Oxidative damage and stress response from ochratoxin a exposure in rats. Free Radic Biol Med 30 (2001) 1089-1098
17. Gekle M., Schwerdt G., Freudinger R., Mildenberger S., Wilflingseder D., Pollack V., et al. Ochratoxin A induces JNK activation and apoptosis in MDCK-C7 cells at nanomolar concentrations. J Pharmacol Exp Ther 293 (2000) 837-844
18. Halawani D., and Latterich M. p97: The cell's molecular purgatory?. Mol Cell 22 (2006) 713-717
19. Hong J., Park K., Han S., Park K., Kim H., Oh S., et al. Effects of ochratoxin A on cytotoxicity and cell differentiation in cultured rat embryonic cells. J Toxicol Environ Health A 61 (2000) 609-621
20. Kamp H., Eisenbrand G., Janzowski C., Kiossev J., Latendresse J., Schlatter J., et al. Ochratoxin A induces oxidative DNA damage in liver and kidney after oral dosing to rats. Mol Nutr Food Res 49 (2005) 1160-1167
21. Kamp H., Eisenbrand G., Schlatter J., Würth K., and Janzowski C. Ochratoxin A: induction of (oxidative) DNA damage, cytotoxicity and apoptosis in mammalian cell lines and primary cells. Toxicology 206 (2005) 413-425
22. Katiyar S., Roy A., and Baliga M. Silymarin induces apoptosis primarily through a p53-dependent pathway involving Bcl-2/Bax, cytochrome c release, and caspase activation. Mol Cancer Ther 4 (2005) 207-216
23. Kerr L., Birse-Archbold J., Short D., McGregor A., Heron I., Macdonald D., et al. Nucleophosmin is a novel Bax chaperone that regulates apoptotic cell death. Oncogene 26 (2007) 2554-2562
24. Kim H., Rho H., Park J., Park B., Kim J., and Lee M. Assay of ornithine aminotransferase with ninhydrin. Anal Biochem 223 (1994) 205-207
25. Kisby G., Standley M., Park T., Olivas A., Fei S., Jacob T., et al. Proteomic analysis of the genotoxicant methylazoxymethanol (MAM)-induced changes in the developing cerebellum. J Proteome Res 5 (2006) 2656-2665
26. Klarić M., Rumora L., Ljubanović D., and Pepeljnjak S. Cytotoxicity and apoptosis induced by fumonisin B(1), beauvericin and ochratoxin A in porcine kidney PK15 cells: effects of individual and combined treatment. Arch Toxicol 82 (2008) 247-255
27. Knott A., Perkins G., Schwarzenbacher R., and Bossy-Wetzel E. Mitochondrial fragmentation in neurodegeneration. Nat Rev Neurosci 9 (2008) 505-518
28. Krogh P. Role of ochratoxin in disease causation. Food Chem Toxicol 30 (1992) 213-224
29. Kuiper-Goodman T., and Scott P. Risk assessment of the mycotoxin ochratoxin A. Biomed Environ Sci 2 (1989) 179-248
30. Lei T., He Q., Cai Z., Zhou Y., Wang Y., Si L., et al. Proteomic analysis of chromium cytotoxicity in cultured rat lung epithelial cells. Proteomics 8 (2008) 2420-2429
31. Lim J., Kim K., Kim S., Hwang O., and Choi H. Bromocriptine activates NQO1 via Nrf2-PI3K/Akt signaling: novel cytoprotective mechanism against oxidative damage. Pharmacol Res 57 (2008) 325-331
32. Ling Y., Liebes L., Zou Y., and Perez-Soler R. Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic response to Bortezomib, a novel proteasome inhibitor, in human H460 non-small cell lung cancer cells. J Biol Chem 278 (2003) 33714-33723
33. Mancuso C., Scapagini G., Currò D., Giuffrida Stella A., De Marco C., Butterfield D., et al. Mitochondrial dysfunction, free radical generation and cellular stress response in neurodegenerative disorders. Front Biosci 12 (2007) 1107-1123
34. McCurrach M., Connor T., Knudson C., Korsmeyer S., and Lowe S. Bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis. Proc Natl Acad Sci USA 94 (1997) 2345-2349
35. Mobio T., Baudrimont I., Sanni A., Shier T., Saboureau D., Dano S., et al. Prevention by vitamin E of DNA fragmentation and apoptosis induced by fumonisin B1 in C6 glioma cells. Arch Toxicol 74 (2000) 112-119
36. Mobio T., Tavan E., Baudrimont I., Anane R., Carratú M., Sanni A., et al. Comparative study of the toxic effects of fumonisin B1 in rat C6 glioma cells and p53-null mouse embryo fibroblasts. Toxicology 183 (2003) 65-75
37. Noguchi M., Takata T., Kimura Y., Manno A., Murakami K., Koike M., et al. ATPase activity of p97/valosin-containing protein is regulated by oxidative modification of the evolutionally conserved cysteine 522 residue in Walker A motif. J Biol Chem 280 (2005) 41332-41341
38. Pfohl-Leszkowicz A., Chakor K., Creppy E., and Dirheimer G. DNA adduct formation in mice treated with ochratoxin A. IARC Sci Publ. (1991) 245-253
39. Power J., Asad S., Chataway T., Chegini F., Manavis J., Temlett J., et al. Peroxiredoxin 6 in human brain: molecular forms, cellular distribution and association with Alzheimer's disease pathology. Acta Neuropathol 115 (2008) 611-622
40. Reed J. Regulation of apoptosis by bcl-2 family proteins and its role in cancer and chemoresistance. Curr Opin Oncol 7 (1995) 541-546
41. Russell W., Park Z., and Russell D. Proteolysis in mixed organic-aqueous solvent systems: applications for peptide mass mapping using mass spectrometry. Anal Chem 73 (2001) 2682-2685
42. Sato A., Miyazaki E., Satake A., Hiramoto A., Hiraoka O., Miyake T., et al. Proteome and transcriptome analysis of cell death induced by 5-fluoro-2′-deoxyuridine. Nucl Acids Symp Ser (Oxf) (2007) 433-434
43. Sava V., Reunova O., Velasquez A., Harbison R., and Sánchez-Ramos J. Acute neurotoxic effects of the fungal metabolite ochratoxin-A. Neurotoxicology 27 (2006) 82-92
44. Sava V., Velasquez A., Song S., and Sanchez-Ramos J. Adult hippocampal neural stem/progenitor cells in vitro are vulnerable to the mycotoxin ochratoxin-A. Toxicol Sci 98 (2007) 187-197
45. Schaaf G., Nijmeijer S., Maas R., Roestenberg P., de Groene E., and Fink-Gremmels J. The role of oxidative stress in the ochratoxin A-mediated toxicity in proximal tubular cells. Biochim Biophys Acta 1588 (2002) 149-158
46. Shin S., Lee S., Boo J., Kim M., Yoon Y., Kim S., et al. Profiling proteins related to amyloid deposited brain of Tg2576 mice. Proteomics 4 (2004) 3359-3368
47. Siddiq A., Aminova L., and Ratan R. Prolyl 4-hydroxylase activity-responsive transcription factors: from hydroxylation to gene expression and neuroprotection. Front Biosci 13 (2008) 2875-2887
48. Siddiq A., Ayoub I., Chavez J., Aminova L., Shah S., LaManna J., et al. Hypoxia-inducible factor prolyl 4-hydroxylase inhibition. A target for neuroprotection in the central nervous system. J Biol Chem 280 (2005) 41732-41743
49. Sonich-Mullin C., Fielder R., Wiltse J., Baetcke K., Dempsey J., Fenner-Crisp P., et al. IPCS conceptual framework for evaluating a mode of action for chemical carcinogenesis. Regul Toxicol Pharmacol 34 (2001) 146-152
50. Souza M., Tomé A., and Rao V. Inhibition by the bioflavonoid ternatin of aflatoxin B1-induced lipid peroxidation in rat liver. J Pharm Pharmacol 51 (1999) 125-129
51. Tibbetts R., Brumbaugh K., Williams J., Sarkaria J., Cliby W., Shieh S., et al. A role for ATR in the DNA damage-induced phosphorylation of p53. Genes Dev 13 (1999) 152-157
52. Unger T., Sionov R., Moallem E., Yee C., Howley P., Oren M., et al. Mutations in serines 15 and 20 of human p53 impair its apoptotic activity. Oncogene 18 (1999) 3205-3212
53. Wangikar P., Dwivedi P., Sharma A., and Sinha N. Effect in rats of simultaneous prenatal exposure to ochratoxin A and aflatoxin B1. II. Histopathological features of teratological anomalies induced in fetuses. Birth Defects Res B Dev Reprod Toxicol 71 (2004) 352-358