Aqueous extract of Glycyrrhiza inflata inhibits aggregation by upregulating PPARGC1A and NFE2L2-ARE pathways in cell models of spinocerebellar ataxia 3

Free Radical Biology and Medicine

Volumn 71, Issue , 2014, Pages 339-350

  Chen, Chiung Mei ^a   Weng, Yu Ting ^a   Chen, Wan Ling ^a   Lin, Te Hsien ^b   Chao, Chih Ying ^a   Lin, Chih Hsin ^a   Chen, I Cheng ^a   Lee, Li Ching ^b   Lin, Hsuan Yuan ^c   Wu, Yih Ru ^a   Chen, Yi Chun ^a   Chang, Kuo Hsuan ^a   Tang, Hsiang Yu ^a   Cheng, Mei Ling ^a   Lee Chen, Guey Jen ^b   Lin, Jung Yaw ^b,c  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b NATIONAL TAIWAN NORMAL UNIVERSITY   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Ammonium glycyrrhizinate; ATXN3; Free radicals; Glycyrrhiza inflata; Licochalcone A; Mitochondrial biogenesis; NFE2L2; Oxidative stress; PPARGC1A; Spinocerebellar ataxia

Indexed keywords

AMMONIUM GLYCYRRHIZIC ACID; ATAXIN 3; CYTOCHROME C; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE TRANSFERASE P1; GLYCYRRHIZA EXTRACT; GLYCYRRHIZA INFLATA EXTRACT; GLYCYRRHIZIC ACID DERIVATIVE; HEME OXYGENASE 1; LICOCHALCONE A; MANGANESE SUPEROXIDE DISMUTASE; NUCLEAR FACTOR; NUCLEAR FACTOR ERYTHROID DERIVED 2 LIKE 2; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PLANT EXTRACT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); UNCLASSIFIED DRUG; CHALCONE DERIVATIVE; GLYCYRRHIZIC ACID; GSTP1 PROTEIN, HUMAN; HMOX1 PROTEIN, HUMAN; NFE2L2 PROTEIN, HUMAN; NQO1 PROTEIN, HUMAN; PEPTIDE; POLYGLUTAMINE; PPARGC1A PROTEIN, HUMAN; PROTEIN AGGREGATE; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NRF2; WATER;

ANTIOXIDANT ACTIVITY; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; BIOGENESIS; CONTROLLED STUDY; ENZYME INHIBITION; GENE EXPRESSION; GLYCYRRHIZA INFLATA; HUMAN; HUMAN CELL; MEDICINAL PLANT; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN EXPRESSION; SPINOCEREBELLAR DEGENERATION; UPREGULATION; AGONISTS; ANTAGONISTS AND INHIBITORS; BIOLOGICAL MODEL; CHEMISTRY; GENE EXPRESSION REGULATION; GENETICS; GLYCYRRHIZA; HEK293 CELL LINE; ISOLATION AND PURIFICATION; MACHADO JOSEPH DISEASE; METABOLISM; NERVE CELL; PATHOLOGY; PLANT ROOT; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANTIOXIDANT RESPONSE ELEMENTS; CELL LINE, TUMOR; CHALCONES; GENE EXPRESSION REGULATION; GLUTATHIONE S-TRANSFERASE PI; GLYCYRRHIZA; GLYCYRRHIZIC ACID; HEK293 CELLS; HEME OXYGENASE-1; HUMANS; MACHADO-JOSEPH DISEASE; MODELS, BIOLOGICAL; NAD(P)H DEHYDROGENASE (QUINONE); NEURONS; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PEPTIDES; PLANT EXTRACTS; PLANT ROOTS; PROTEIN AGGREGATES; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTORS; WATER;

EID: 84898936024     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2014.03.023     Document Type: Article

References (54)

1. J.E. Gestwicki, and D. Garza Protein quality control in neurodegenerative disease Prog. Mol. Biol. Transl. Sci 107 2012 327 453
2. S. Hands, C. Sinadinos, and A. Wyttenbach Polyglutamine gene function and dysfunction in the ageing brain Biochim. Biophys. Acta 1779 2008 507 521
3. U. Rüb, L. Schöls, H. Paulson, G. Auburger, P. Kermer, J.C. Jen, K. Seidel, H.W. Korf, and T. Deller Clinical features, neurogenetics and neuropathology of the polyglutamine spinocerebellar ataxias type 1, 2, 3, 6 and 7 Prog. Neurobiol. 104 2013 38 66
4. A.G. Valera, M. Díaz-Hernández, F. Hernández, Z. Ortega, and J.J. Lucas The ubiquitin-proteasome system in Huntington's disease Neuroscientist 11 2005 583 594 (Pubitemid 41611870)
5. J.H. Cha Transcriptional signatures in Huntington's disease Prog. Neurobiol. 83 2007 228 248
6. E.C. Stack, W.R. Matson, and R.J. Ferrante Evidence of oxidant damage in Huntington's disease: translational strategies using antioxidants Ann. N. Y. Acad. Sci. 1147 2008 79 92
7. L.S. Havel, S. Li, and X.J. Li Nuclear accumulation of polyglutamine disease proteins and neuropathology Mol. Brain 2 2009 21
8. M. Damiano, L. Galvan, N. Deglon, and E. Brouillet Mitochondria in Huntington's disease Biochim. Biophys. Acta 1802 2010 52 61
9. J. Lin, P.H. Wu, P.T. Tarr, K.S. Lindenberg, J. St-Pierre, C.Y. Zhang, V.K. Mootha, S. Jäger, C.R. Vianna, R.M. Reznick, L. Cui, M. Manieri, M.X. Donovan, Z. Wu, M.P. Cooper, M.C. Fan, L.M. Rohas, A.M. Zavacki, S. Cinti, G.I. Shulman, B.B. Lowell, D. Krainc, and B.M. Spiegelman Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1α null mice Cell 119 2004 121 135 (Pubitemid 39349325)
10. L. Cui, H. Jeong, F. Borovecki, C.N. Parkhurst, N. Tanese, and D. Krainc Transcriptional repression of PGC-1α by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration Cell 127 2006 59 69 (Pubitemid 44466642)
11. P. Weydt, V.V. Pineda, A.E. Torrence, R.T. Libby, T.F. Satterfield, E.R. Lazarowski, M.L. Gilbert, G.J. Morton, T.K. Bammler, A.D. Strand, L. Cui, R.P. Beyer, C.N. Easley, A.C. Smith, D. Krainc, S. Luquet, I.R. Sweet, M.W. Schwartz, and A.R. La Spada Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1α in Huntington's disease neurodegeneration Cell Metab. 4 2006 349 362 (Pubitemid 44645069)
12. T. Hathorn, A. Snyder-Keller, and A. Messer Nicotinamide improves motor deficits and upregulates PGC-1α and BDNF gene expression in a mouse model of Huntington's disease Neurobiol. Dis. 41 2011 43 50
13. T. Tsunemi, T.D. Ashe, B.E. Morrison, K.R. Soriano, J. Au, R.A. Roque, E.R. Lazarowski, V.A. Damian, E. Masliah, and A.R. La Spada PGC-1α rescues Huntington's disease proteotoxicity by preventing oxidative stress and promoting TFEB function Sci. Transl. Med. 4 2012 142ra97
14. J. Ryu, S. Cho, and B.C. Park Lee, do H. Oxidative stress-enhanced SUMOylation and aggregation of ataxin-1: implication of JNK pathway Biochem. Biophys. Res. Commun. 393 2010 280 285
15. M. Guevara-García, L. Gil-del Valle, L. Velásquez- Pérez, and J.C. García-Rodríguez Oxidative stress as a cofactor in spinocerebellar ataxia type 2 Redox Rep. 17 2012 84 89
16. Y.C. Yu, C.L. Kuo, W.L. Cheng, C.S. Liu, and M. Hsieh Decreased antioxidant enzyme activity and increased mitochondrial DNA damage in cellular models of Machado-Joseph disease J. Neurosci. Res. 87 2009 1884 1891
17. A. Ajayi, X. Yu, S. Lindberg, U. Langel, and A.L. Strom Expanded ataxin-7 causes toxicity by inducing ROS production from NADPH oxidase complexes in a stable inducible spinocerebellar ataxia type 7 (SCA7) model BMC Neurosci. 13 2012 86
18. S. Hands, M.U. Sajjad, M.J. Newton, and A. Wyttenbach in vitro and in vivo aggregation of a fragment of huntingtin protein directly causes free radical production J. Biol. Chem. 286 2011 44512 44520
19. A. Bertoni, P. Giuliano, M. Galgani, D. Rotoli, L. Ulianich, A. Adornetto, M.R. Santillo, A. Porcellini, and V.E. Avvedimento Early and late events induced by polyQ-expanded proteins: identification of a common pathogenic property of polyQ-expanded proteins J. Biol. Chem. 286 2011 4727 4741
20. S.J. Kim, T.S. Kim, S. Hong, H. Rhim, I.Y. Kim, and S. Kang Oxidative stimuli affect polyglutamine aggregation and cell death in human mutant ataxin-1-expressing cells Neurosci. Lett. 348 2003 21 24 (Pubitemid 37271927)
21. A. Johri, and M.F. Beal Antioxidants in Huntington's disease Biochim. Biophys. Acta 1822 2012 664 674
22. S.K. Niture, J.W. Kaspar, J. Shen, and A.K. Jaiswal Nrf2 signaling and cell survival Toxicol. Appl. Pharmacol. 244 2010 37 42
23. P.C. Chen, M.R. Vargas, A.K. Pani, R.J. Smeyne, D.A. Johnson, Y.W. Kan, and J.A. Johnson Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: critical role for the astrocyte Proc. Natl. Acad. Sci. USA 106 2009 2933 2938
24. Y.N. Jin, Y.V. Yu, S. Gundemir, C. Jo, M. Cui, K. Tieu, and G.V. Johnson Impaired mitochondrial dynamics and Nrf2 signaling contribute to compromised responses to oxidative stress in striatal cells expressing full-length mutant huntingtin PLoS One 8 2013 e57932
25. V. Calabrese, C. Cornelius, A.T. Dinkova-Kostova, E.J. Calabrese, and M.P. Mattson Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders Antioxid. Redox Signaling 13 2010 1763 1811
26. V. Calabrese, C. Cornelius, S. Cuzzocrea, I. Iavicoli, E. Rizzarelli, and E.J. Calabrese Hormesis cellular stress response and vitagenes as critical determinants in aging and longevity Mol. Aspects Med. 32 2011 279 304
27. V. Calabrese, C. Cornelius, A.T. Dinkova-Kostova, I. Iavicoli, R. Di Paola, A. Koverech, S. Cuzzocrea, E. Rizzarelli, and E.J. Calabrese Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity Biochim. Biophys. Acta 1822 2012 753 783
28. S. Baldelli, K. Aquilano, and M.R. Ciriolo Punctum on two different transcription factors regulated by PGC-1α: nuclear factor erythroid-derived 2-like 2 and nuclear respiratory factor 2 Biochim. Biophys. Acta 1830 2013 4137 4146
29. M.N. Asl, and H. Hosseinzadeh Review of pharmacological effects of Glycyrrhiza sp. and its bioactive compounds Phytother. Res. 22 2008 709 724 (Pubitemid 351955567)
30. K.H. Chang, W.L. Chen, L.C. Lee, C.H. Lin, P.J. Kung, T.H. Lin, Y.C. Wu, Y.R. Wu, Y.C. Chen, G.J. Lee-Chen, and C.M. Chen Aqueous extract of Paeonia lactiflora and paeoniflorin as aggregation reducers targeting chaperones in cell models of spinocerebellar ataxia 3 Evid. Based Complement. Alternat. Med 2013 2013 471659
31. Q.E. Wang, F.S. Lee, and X. Wang Isolation and purification of inflacoumarin A and licochalcone A from licorice by high-speed counter-current chromatography J. Chromatogr. A 1048 2004 51 57 (Pubitemid 39158819)
32. X. Yuan, H.L. Koh, and W.K. Chui A high performance liquid chromatography method for the simultaneous determination of arctiin, chlorogenic acid and glycyrrhizin in a Chinese proprietary medicine J. Pharm. Biomed. Anal. 39 2005 697 704 (Pubitemid 41196085)
33. Y.C. Wang, and Y.S. Yang Simultaneous quantification of flavonoids and triterpenoids in licorice using HPLC J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 850 2007 392 399
34. H. Li, B.T. Chen, L. Liu, and Q. Liu Simultaneous determination of six compounds in licorice and related Chinese herbal preparations Chromatographia 69 2009 229 235
35. R.N. Ghosh, R. DeBiasio, C.C. Hudson, E.R. Ramer, C.L. Cowan, and R.H. Oakley Quantitative cell-based high-content screening for vasopressin receptor agonists using transfluor technology J. Biomol. Screen. 10 2005 476 484 (Pubitemid 41233226)
36. I. Irrcher, V. Ljubicic, A.F. Kirwan, and D.A. Hood AMP-activated protein kinase-regulated activation of the PGC-1α promoter in skeletal muscle cells PLoS One 3 2008 e3614
37. N. Li, J.H. Liu, J. Zhang, and B.Y. Yu Comparative evaluation of cytotoxicity and antioxidative activity of 20 flavonoids J. Agric. Food Chem. 56 2008 3876 3883 (Pubitemid 351860197)
38. R.D. Shytle, P.C. Bickford, K. Rezai-zadeh, L. Hou, J. Zeng, J. Tan, P.R. Sanberg, C.D. Sanberg, B. Roschek Jr, R.C. Fink, and R.S. Alberte Optimized turmeric extracts have potent anti-amyloidogenic effects Curr. Alzheimer Res. 6 2009 564 571
39. M. Mielcarek, C.L. Benn, S.A. Franklin, D.L. Smith, B. Woodman, P.A. Marks, and G.P. Bates SAHA decreases HDAC 2 and 4 levels in vivo and improves molecular phenotypes in the R6/2 mouse model of Huntington's disease PLoS One 6 2011 e27746
40. M. Zuk, A. Kulma, L. Dymińska, K. Szołtysek, A. Prescha, J. Hanuza, and J. Szopa Flavonoid engineering of flax potentiates its biotechnological application BMC Biotechnol. 11 2011 10
41. T.G. van Rossum, A.G. Vulto, W.C. Hop, and S.W. Schalm Glycyrrhizin-induced reduction of ALT in European patients with chronic hepatitis C Am. J. Gastroenterol. 96 2001 2432 2437 (Pubitemid 32769207)
42. J.K. Kim, S.M. Oh, H.S. Kwon, Y.S. Oh, S.S. Lim, and H.K. Shin Anti-inflammatory effect of roasted licorice extracts on lipopolysaccharide- induced inflammatory responses in murine macrophages Biochem. Biophys. Res. Commun. 345 2006 1215 1223 (Pubitemid 44218790)
43. H.S. Kwon, J.H. Park, D.H. Kim, Y.H. Kim, J.H. Park, H.K. Shin, and J.K. Kim Licochalcone A isolated from licorice suppresses lipopolysaccharide- stimulated inflammatory reactions in RAW264.7 cells and endotoxin shock in mice J. Mol. Med. 86 2008 1287 1295
44. J. Furusawa, M. Funakoshi-Tago, T. Mashino, K. Tago, H. Inoue, Y. Sonoda, and T. Kasahara Glycyrrhiza inflata-derived chalcones, licochalcone A, licochalcone B and licochalcone D, inhibit phosphorylation of NF-κB p65 in LPS signaling pathway Int. Immunopharmacol. 9 2009 499 507
45. M. Funakoshi-Tago, S. Tanabe, K. Tago, H. Itoh, T. Mashino, Y. Sonoda, and T. Kasahara Licochalcone A potently inhibits tumor necrosis factor α-induced nuclear factor-κB activation through the direct inhibition of IκB kinase complex activation Mol. Pharmacol. 76 2009 745 753
46. J.R. Shi, L.G. Mao, R.A. Jiang, Y. Qian, H.F. Tang, and J.Q. Chen Monoammonium glycyrrhizinate inhibited the inflammation of LPS-induced acute lung injury in mice Int. Immunopharmacol. 10 2010 1235 1241
47. 1-42-induced neuroinflammation and regulates MAPK and NF-κB pathways in vitro and in vivo CNS Neurosci. Ther. 19 2013 117 124
48. Y.J. Choi, S.S. Lim, J.Y. Jung, J.S. Choi, J.K. Kim, S.J. Han, and Y.H. Kang Blockade of nitroxidative stress by roasted licorice extracts in high glucose-exposed endothelial cells J. Cardiovasc. Pharmacol. 52 2008 344 354
49. H.M. Oh, S. Lee, Y.N. Park, E.J. Choi, J.Y. Choi, J.A. Kim, J.H. Kweon, W.C. Han, S.C. Choi, J.K. Han, J.K. Son, S.H. Lee, and C.D. Jun Ammonium glycyrrhizinate protects gastric epithelial cells from hydrogen peroxide-induced cell death Exp. Biol. Med. 234 2009 263 277
50. S.W. Kim, Y. Jin, J.H. Shin, I.D. Kim, H.K. Lee, S. Park, P.L. Han, and J.K. Lee Glycyrrhizic acid affords robust neuroprotection in the postischemic brain via anti-inflammatory effect by inhibiting HMGB1 phosphorylation and secretion Neurobiol. Dis. 46 2012 147 156
51. 1-42-induced neurotoxicity PLoS One 7 2012 e35823
52. S.B. Yim, S.E. Park, and C.S. Lee Protective effect of glycyrrhizin on 1-methyl-4-phenylpyridinium-induced mitochondrial damage and cell death in differentiated PC12 cells J. Pharmacol. Exp. Ther. 321 2007 816 822
53. Y.J. Kim, and C.S. Lee Glycyrrhizin attenuates MPTP neurotoxicity in mouse and MPP-induced cell death in PC12 cells Korean J. Physiol. Pharmacol 12 2008 65 71 (Pubitemid 351736661)
54. D.E. Kim, Y.C. Youn, Y.K. Kim, K.M. Hong, and C.S. Lee Glycyrrhizin prevents 7-ketocholesterol toxicity against differentiated PC12 cells by suppressing mitochondrial membrane permeability change Neurochem. Res. 34 2009 1433 1442