메뉴 건너뛰기




Volumn , Issue , 2015, Pages 101-139

Natural Products as Pharmaceuticals and Sources for Lead Structures

Author keywords

Cancer; Genomics; Infectious Disease; Metabolomics; Natural Products

Indexed keywords


EID: 84939839223     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-417205-0.00005-5     Document Type: Chapter
Times cited : (23)

References (301)
  • 1
    • 0141828545 scopus 로고    scopus 로고
    • The beginnings of drug therapy: ancient mesopotamian medicine
    • Borchardt J.K. The beginnings of drug therapy: ancient mesopotamian medicine. Drug News Perspect 2002, 15:187-192.
    • (2002) Drug News Perspect , vol.15 , pp. 187-192
    • Borchardt, J.K.1
  • 4
    • 0032741242 scopus 로고    scopus 로고
    • Ancient-modern concordance in ayurvedic plants: some examples
    • Dev S. Ancient-modern concordance in ayurvedic plants: some examples. Environ Health Perspect 1999, 107:783-789.
    • (1999) Environ Health Perspect , vol.107 , pp. 783-789
    • Dev, S.1
  • 5
    • 0003773376 scopus 로고
    • University of Michigan Museum of Anthropology, Ann Arbor, MI
    • Moerman D.E. Medicinal plants of Native America 1986, University of Michigan Museum of Anthropology, Ann Arbor, MI.
    • (1986) Medicinal plants of Native America
    • Moerman, D.E.1
  • 7
    • 0025655003 scopus 로고
    • The role of ethnopharmacology in drug development
    • Wiley, Chichester, D.J. Chadwick, J. Marsh
    • Farnsworth N.R. The role of ethnopharmacology in drug development. Bioactive compounds from plants 1990, 2-21. Wiley, Chichester. D.J. Chadwick, J. Marsh (Eds.).
    • (1990) Bioactive compounds from plants , pp. 2-21
    • Farnsworth, N.R.1
  • 8
    • 84858308226 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the 30 years from 1981 to 2010
    • Newman D.J., Cragg G.M. Natural products as sources of new drugs over the 30 years from 1981 to 2010. J Nat Prod 2012, 75:311-335.
    • (2012) J Nat Prod , vol.75 , pp. 311-335
    • Newman, D.J.1    Cragg, G.M.2
  • 9
    • 0034082239 scopus 로고    scopus 로고
    • The influence of natural products upon drug discovery
    • Newman D.J., Cragg G.M., Snader K.M. The influence of natural products upon drug discovery. Nat Prod Rep 2000, 17:215-234.
    • (2000) Nat Prod Rep , vol.17 , pp. 215-234
    • Newman, D.J.1    Cragg, G.M.2    Snader, K.M.3
  • 10
    • 84939779427 scopus 로고    scopus 로고
    • Summary of novel new drugs
    • Available from
    • US Food and Drug Administration. Summary of novel new drugs. Available from: 2013. http://www.fda.gov/downloads/drugs/developmentapprovalprocess/druginnovation/ucm381803.pdf.
    • (2013)
  • 11
    • 0142228822 scopus 로고    scopus 로고
    • Rediscovering natural products
    • Rouhi M. Rediscovering natural products. Chem Eng News 2003, 81:77-91.
    • (2003) Chem Eng News , vol.81 , pp. 77-91
    • Rouhi, M.1
  • 12
    • 33745743541 scopus 로고    scopus 로고
    • Improving efficiency
    • Borman S. Improving efficiency. Chem Eng News 2006, 84:56-78.
    • (2006) Chem Eng News , vol.84 , pp. 56-78
    • Borman, S.1
  • 13
    • 67650436176 scopus 로고    scopus 로고
    • Drug discovery and natural products: end of an era or an endless frontier?
    • Li J.W., Vederas J.C. Drug discovery and natural products: end of an era or an endless frontier?. Science 2009, 325:161-165.
    • (2009) Science , vol.325 , pp. 161-165
    • Li, J.W.1    Vederas, J.C.2
  • 14
    • 84906778667 scopus 로고    scopus 로고
    • Advancing the drug discovery and development process
    • Nicolaou K.C. Advancing the drug discovery and development process. Angew Chem Int Ed 2014, 53:9128-9140.
    • (2014) Angew Chem Int Ed , vol.53 , pp. 9128-9140
    • Nicolaou, K.C.1
  • 15
    • 0000398117 scopus 로고
    • Secondary metabolism: fact and fiction
    • Haslam E. Secondary metabolism: fact and fiction. Nat Prod Rep 1986, 3:217-249.
    • (1986) Nat Prod Rep , vol.3 , pp. 217-249
    • Haslam, E.1
  • 16
    • 0024947834 scopus 로고
    • Why are secondary metabolites (natural products) biosynthesized?
    • Williams D.H., Stone M.J., Hauck P.R., Rahman S.K. Why are secondary metabolites (natural products) biosynthesized?. J Nat Prod 1989, 52:1189-1208.
    • (1989) J Nat Prod , vol.52 , pp. 1189-1208
    • Williams, D.H.1    Stone, M.J.2    Hauck, P.R.3    Rahman, S.K.4
  • 17
    • 0025669051 scopus 로고
    • Role of secondary metabolites in chemical defence mechanisms in plants
    • Wiley, Chichester, D.J. Chadwick, J. Marsh
    • Harborne J.B. Role of secondary metabolites in chemical defence mechanisms in plants. Bioactive compounds from plants 1990, 126-139. Wiley, Chichester. D.J. Chadwick, J. Marsh (Eds.).
    • (1990) Bioactive compounds from plants , pp. 126-139
    • Harborne, J.B.1
  • 19
    • 52949118506 scopus 로고    scopus 로고
    • Conus venoms: a rich source of peptide-based therapeutics
    • Han T.S., Teichert R.W., Olivera B.M., Bulaj G. Conus venoms: a rich source of peptide-based therapeutics. Curr Pharm Des 2008, 14:2462-2479.
    • (2008) Curr Pharm Des , vol.14 , pp. 2462-2479
    • Han, T.S.1    Teichert, R.W.2    Olivera, B.M.3    Bulaj, G.4
  • 21
    • 33750611879 scopus 로고    scopus 로고
    • Ziconotide: a new nonopioid intrathecal analgesic for the treatment of chronic pain
    • Wallace M.S. Ziconotide: a new nonopioid intrathecal analgesic for the treatment of chronic pain. Expert Rev Neurother 2006, 6:1423-1428.
    • (2006) Expert Rev Neurother , vol.6 , pp. 1423-1428
    • Wallace, M.S.1
  • 22
  • 23
    • 0041470136 scopus 로고    scopus 로고
    • Allelopathy and exotic plant invasion: from molecules and genes to species interactions
    • Bais H.P., Vepachedu R., Gilroy S., Callaway R.M., Vivanco J.M. Allelopathy and exotic plant invasion: from molecules and genes to species interactions. Science 2003, 301:1377-1380.
    • (2003) Science , vol.301 , pp. 1377-1380
    • Bais, H.P.1    Vepachedu, R.2    Gilroy, S.3    Callaway, R.M.4    Vivanco, J.M.5
  • 25
    • 33750595114 scopus 로고    scopus 로고
    • Bacterial conversations
    • Everts S. Bacterial conversations. Chem Eng News 2006, 84:17-26.
    • (2006) Chem Eng News , vol.84 , pp. 17-26
    • Everts, S.1
  • 26
    • 15744378878 scopus 로고    scopus 로고
    • The use of quorum-sensing blockers as therapeutic agents for the control of biofilm-associated infections
    • Rice S.A., McDougald D., Kumar N., Kjelleberg S. The use of quorum-sensing blockers as therapeutic agents for the control of biofilm-associated infections. Curr Opin Investig Drugs 2005, 6:178-184.
    • (2005) Curr Opin Investig Drugs , vol.6 , pp. 178-184
    • Rice, S.A.1    McDougald, D.2    Kumar, N.3    Kjelleberg, S.4
  • 27
    • 77949918387 scopus 로고    scopus 로고
    • Jamming bacterial communication: new approaches for the treatment of infectious diseases
    • Njoroge J., Sperandio V. Jamming bacterial communication: new approaches for the treatment of infectious diseases. EMBO Mol Med 2009, 1:201-210.
    • (2009) EMBO Mol Med , vol.1 , pp. 201-210
    • Njoroge, J.1    Sperandio, V.2
  • 28
    • 77953633873 scopus 로고    scopus 로고
    • Paradigm shift in discovering next-generation anti-infective agents: targeting quorum sensing, c-di-GMP signaling and biofilm formation in bacteria with small molecules
    • Sintim H.O., Smith J.A., Wang J., Nakayama S., Yan L. Paradigm shift in discovering next-generation anti-infective agents: targeting quorum sensing, c-di-GMP signaling and biofilm formation in bacteria with small molecules. Future Med Chem 2010, 6:1005-1035.
    • (2010) Future Med Chem , vol.6 , pp. 1005-1035
    • Sintim, H.O.1    Smith, J.A.2    Wang, J.3    Nakayama, S.4    Yan, L.5
  • 29
    • 79959914661 scopus 로고    scopus 로고
    • Developing next generation antimicrobials by intercepting AI-2 mediated quorum sensing
    • Roy V., Adams B.L., Bentley W.E. Developing next generation antimicrobials by intercepting AI-2 mediated quorum sensing. Enzyme Microb Technol 2011, 49:113-123.
    • (2011) Enzyme Microb Technol , vol.49 , pp. 113-123
    • Roy, V.1    Adams, B.L.2    Bentley, W.E.3
  • 30
    • 84875596671 scopus 로고    scopus 로고
    • Bacterial quorum sensing inhibitors: attractive alternatives for control of infectious pathogens showing multiple drug resistance
    • Bhardwaj A.K., Vinothkumar K., Rajpara N. Bacterial quorum sensing inhibitors: attractive alternatives for control of infectious pathogens showing multiple drug resistance. Recent Pat Antiinfect Drug Discov 2013, 8:68-83.
    • (2013) Recent Pat Antiinfect Drug Discov , vol.8 , pp. 68-83
    • Bhardwaj, A.K.1    Vinothkumar, K.2    Rajpara, N.3
  • 31
    • 84896908713 scopus 로고    scopus 로고
    • Novel approaches for the design and discovery of quorum-sensing inhibitors
    • Scutera S., Zucca M., Savoia D. Novel approaches for the design and discovery of quorum-sensing inhibitors. Expert Opin Drug Discov 2014, 9:353-366.
    • (2014) Expert Opin Drug Discov , vol.9 , pp. 353-366
    • Scutera, S.1    Zucca, M.2    Savoia, D.3
  • 32
    • 84903587822 scopus 로고    scopus 로고
    • Polyhydroxyanthraquinones as quorum sensing inhiitors from the guttates of Penicillium restrictum and their analysis by desorption electrospray ionization mass spectrometry
    • Figueroa M., Jarmusch A.K., Raja H.A., El-Elimat T., Kavanaugh J.S., Horswill A.R., et al. Polyhydroxyanthraquinones as quorum sensing inhiitors from the guttates of Penicillium restrictum and their analysis by desorption electrospray ionization mass spectrometry. J Nat Prod 2014, 77:1351-1358.
    • (2014) J Nat Prod , vol.77 , pp. 1351-1358
    • Figueroa, M.1    Jarmusch, A.K.2    Raja, H.A.3    El-Elimat, T.4    Kavanaugh, J.S.5    Horswill, A.R.6
  • 33
    • 84949117251 scopus 로고    scopus 로고
    • Controlling bacterial behavoir with indole-containing natural products and derivatives
    • Melander R.J., Minvielle M.J., Melander C. Controlling bacterial behavoir with indole-containing natural products and derivatives. Tetrahedron 2014, 70:6363-6372.
    • (2014) Tetrahedron , vol.70 , pp. 6363-6372
    • Melander, R.J.1    Minvielle, M.J.2    Melander, C.3
  • 34
    • 84949117655 scopus 로고    scopus 로고
    • Draining the moat: disrupting bacterial biofilms with natural products
    • Fletcher M.H., Jennings M.C., Wuest W.M. Draining the moat: disrupting bacterial biofilms with natural products. Tetrahedron 2014, 70:6373-6383.
    • (2014) Tetrahedron , vol.70 , pp. 6373-6383
    • Fletcher, M.H.1    Jennings, M.C.2    Wuest, W.M.3
  • 35
    • 0242582505 scopus 로고    scopus 로고
    • Le cycle de division cellulaire et sa regulation [The cycle of cellular division and its regulation]
    • [in French]
    • Meijer L. Le cycle de division cellulaire et sa regulation [The cycle of cellular division and its regulation]. Oncologie 2003, 5:311-326. [in French].
    • (2003) Oncologie , vol.5 , pp. 311-326
    • Meijer, L.1
  • 36
    • 33746872563 scopus 로고    scopus 로고
    • Using high-throughput screening data to discriminate compounds with single-target effects from those with side effects
    • Klekota J., Brauner E., Roth F.P., Schreiber S.L. Using high-throughput screening data to discriminate compounds with single-target effects from those with side effects. J Chem Inf Model 2006, 46:1549-1562.
    • (2006) J Chem Inf Model , vol.46 , pp. 1549-1562
    • Klekota, J.1    Brauner, E.2    Roth, F.P.3    Schreiber, S.L.4
  • 37
    • 4344698841 scopus 로고    scopus 로고
    • Technological advances in high-throughput screening
    • Liu B., Li S., Hu J. Technological advances in high-throughput screening. Am J Pharmacogenomics 2004, 4:263-276.
    • (2004) Am J Pharmacogenomics , vol.4 , pp. 263-276
    • Liu, B.1    Li, S.2    Hu, J.3
  • 38
    • 3943067061 scopus 로고    scopus 로고
    • Drug discovery
    • Mullin R. Drug discovery. Chem Eng News 2004, 82:23-32.
    • (2004) Chem Eng News , vol.82 , pp. 23-32
    • Mullin, R.1
  • 39
    • 33744994317 scopus 로고    scopus 로고
    • Platensimycin is a selective FabF inhibitor with potent antibiotic properties
    • Wang J., Soisson S.M., Young K., Shoop W., Kodali S., Galgoci A., et al. Platensimycin is a selective FabF inhibitor with potent antibiotic properties. Nature 2006, 441:358-361.
    • (2006) Nature , vol.441 , pp. 358-361
    • Wang, J.1    Soisson, S.M.2    Young, K.3    Shoop, W.4    Kodali, S.5    Galgoci, A.6
  • 40
    • 84926474432 scopus 로고    scopus 로고
    • Platensimycin and platencin
    • Wiley-VCH Verlag, Switzerland, S. Hanessian (Ed.)
    • Ghosh A.K., Xi K. Platensimycin and platencin. Natural products in medicinal chemistry 2014, 271-300. Wiley-VCH Verlag, Switzerland. S. Hanessian (Ed.).
    • (2014) Natural products in medicinal chemistry , pp. 271-300
    • Ghosh, A.K.1    Xi, K.2
  • 41
    • 84872827945 scopus 로고    scopus 로고
    • The impact of the United Nations convention on biological diversity on natural products research
    • Cragg G.M., Katz F., Newman D.J., Rosenthal J. The impact of the United Nations convention on biological diversity on natural products research. Nat Prod Rep 2012, 29:1407-1423.
    • (2012) Nat Prod Rep , vol.29 , pp. 1407-1423
    • Cragg, G.M.1    Katz, F.2    Newman, D.J.3    Rosenthal, J.4
  • 42
    • 0037856664 scopus 로고    scopus 로고
    • Benefit-sharing case study. The access and benefit-sharing policies of the United States National Cancer Institute: a comparative account of the discovery and development of the drugs calanolide and topotecan
    • The Royal Botanic Gardens, Kew, UK
    • ten Kate K., Wells A. Benefit-sharing case study. The access and benefit-sharing policies of the United States National Cancer Institute: a comparative account of the discovery and development of the drugs calanolide and topotecan. Submission to the executive secretary of the convention on biological diversity 1998, The Royal Botanic Gardens, Kew, UK.
    • (1998) Submission to the executive secretary of the convention on biological diversity
    • ten Kate, K.1    Wells, A.2
  • 43
    • 0033288221 scopus 로고    scopus 로고
    • Drug discovery, economic development, and conservation: the international cooperative biodiversity groups
    • Rosenthal J.P. Drug discovery, economic development, and conservation: the international cooperative biodiversity groups. Pharm Biol 1999, 37:5.
    • (1999) Pharm Biol , vol.37 , pp. 5
    • Rosenthal, J.P.1
  • 45
    • 0025580836 scopus 로고
    • Ethnobotany and the identification of therapeutic agents from the rainforest
    • Wiley, Chichester, D.J. Chadwick, J. Marsh
    • Balick M.J. Ethnobotany and the identification of therapeutic agents from the rainforest. Bioactive compounds from plants 1990, 22-39. Wiley, Chichester. D.J. Chadwick, J. Marsh (Eds.).
    • (1990) Bioactive compounds from plants , pp. 22-39
    • Balick, M.J.1
  • 46
    • 0025618230 scopus 로고
    • Ethnopharmacology and the search for new drugs
    • Wiley, Chichester, D.J. Chadwick, J. Marsh
    • Cox P.A. Ethnopharmacology and the search for new drugs. Bioactive compounds from plants 1990, 40-55. Wiley, Chichester. D.J. Chadwick, J. Marsh (Eds.).
    • (1990) Bioactive compounds from plants , pp. 40-55
    • Cox, P.A.1
  • 47
    • 0024251002 scopus 로고
    • Conservation, ethnobotany, and the search for new jungle medicines: pharmacognosy comes of age...again
    • Plotkin M.J. Conservation, ethnobotany, and the search for new jungle medicines: pharmacognosy comes of age...again. Pharmacotherapy 1988, 8:257-262.
    • (1988) Pharmacotherapy , vol.8 , pp. 257-262
    • Plotkin, M.J.1
  • 48
    • 0002456443 scopus 로고
    • Plant-derived natural products in drug discovery and development: an overview
    • Amer Chem Soc, Washington, DC, A.D. Kinghorn, M.F. Balandrin
    • Balandrin M.F., Kinghorn A.D., Farnsworth N.R. Plant-derived natural products in drug discovery and development: an overview. Human medicinal agents from plants 1993, 2-12. Amer Chem Soc, Washington, DC. A.D. Kinghorn, M.F. Balandrin (Eds.).
    • (1993) Human medicinal agents from plants , pp. 2-12
    • Balandrin, M.F.1    Kinghorn, A.D.2    Farnsworth, N.R.3
  • 50
    • 12444308313 scopus 로고    scopus 로고
    • Elicitation, a new window into plant chemodiversity and phytochemical drug discovery
    • Poulev A., O'Neal J.M., Logendra S., Pouleva R.B., Timeva V., Garvey A.S., et al. Elicitation, a new window into plant chemodiversity and phytochemical drug discovery. J Med Chem 2003, 2542-2547.
    • (2003) J Med Chem , pp. 2542-2547
    • Poulev, A.1    O'Neal, J.M.2    Logendra, S.3    Pouleva, R.B.4    Timeva, V.5    Garvey, A.S.6
  • 51
    • 33750728402 scopus 로고    scopus 로고
    • Directed biosynthesis of alkaloid analogs in the medicinal plant Catharanthus roseus
    • McCoy E., O'Connor S.E. Directed biosynthesis of alkaloid analogs in the medicinal plant Catharanthus roseus. J Am Chem Soc 2006, 128:14276-14277.
    • (2006) J Am Chem Soc , vol.128 , pp. 14276-14277
    • McCoy, E.1    O'Connor, S.E.2
  • 52
    • 4344650390 scopus 로고    scopus 로고
    • Marine natural products and related compounds in clinical and advanced preclinical trials
    • Newman D.J., Cragg G.M. Marine natural products and related compounds in clinical and advanced preclinical trials. J Nat Prod 2004, 67:1216-1238.
    • (2004) J Nat Prod , vol.67 , pp. 1216-1238
    • Newman, D.J.1    Cragg, G.M.2
  • 53
    • 33745045183 scopus 로고    scopus 로고
    • New drugs from marine microbes: the tide is turning
    • Newman D.J., Hill R.T. New drugs from marine microbes: the tide is turning. J Ind Microbiol Biotechnol 2006, 33:539-544.
    • (2006) J Ind Microbiol Biotechnol , vol.33 , pp. 539-544
    • Newman, D.J.1    Hill, R.T.2
  • 54
    • 53649106195 scopus 로고    scopus 로고
    • Next-generation DNA sequencing
    • Shendure J., Ji H. Next-generation DNA sequencing. Nat Biotech 2008, 26:1135-1145.
    • (2008) Nat Biotech , vol.26 , pp. 1135-1145
    • Shendure, J.1    Ji, H.2
  • 55
    • 84892365780 scopus 로고    scopus 로고
    • The complete genome sequence of a Neanderthal from the Altai Mountains
    • Prüfer K., Racimo F., Patterson N., Jay F., Sankararaman S., Sawyer S., et al. The complete genome sequence of a Neanderthal from the Altai Mountains. Nature 2014, 505:43-49.
    • (2014) Nature , vol.505 , pp. 43-49
    • Prüfer, K.1    Racimo, F.2    Patterson, N.3    Jay, F.4    Sankararaman, S.5    Sawyer, S.6
  • 56
    • 72949101201 scopus 로고    scopus 로고
    • A phylogeny-driven genomic encyclopaedia of Bacteria and Archaea
    • Wu D., Hugenholtz P., Mavromatis K., Pukall R., Dalin E., Ivanova N.N., et al. A phylogeny-driven genomic encyclopaedia of Bacteria and Archaea. Nature 2009, 462:1056-1060.
    • (2009) Nature , vol.462 , pp. 1056-1060
    • Wu, D.1    Hugenholtz, P.2    Mavromatis, K.3    Pukall, R.4    Dalin, E.5    Ivanova, N.N.6
  • 59
    • 44349169524 scopus 로고    scopus 로고
    • Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350
    • Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H., et al. Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350. J Bact 2008, 190:4050-4060.
    • (2008) J Bact , vol.190 , pp. 4050-4060
    • Ohnishi, Y.1    Ishikawa, J.2    Hara, H.3    Suzuki, H.4    Ikenoya, M.5    Ikeda, H.6
  • 60
    • 63849314526 scopus 로고    scopus 로고
    • A survey of nonribosomal peptide synthetase (NRPS) genes in Aspergillus nidulans
    • von Döhren H. A survey of nonribosomal peptide synthetase (NRPS) genes in Aspergillus nidulans. Fungal Genet Biol 2009, 46:S45-S52.
    • (2009) Fungal Genet Biol , vol.46 , pp. S45-S52
    • von Döhren, H.1
  • 61
    • 84863229860 scopus 로고    scopus 로고
    • Advances in Aspergillus secondary metabolite research in the post-genomic era
    • Sanchez J.F., Somoza A.D., Keller N.P., Wang C.C.C. Advances in Aspergillus secondary metabolite research in the post-genomic era. Nat Prod Rep 2012, 29:351-371.
    • (2012) Nat Prod Rep , vol.29 , pp. 351-371
    • Sanchez, J.F.1    Somoza, A.D.2    Keller, N.P.3    Wang, C.C.C.4
  • 62
    • 84881103723 scopus 로고    scopus 로고
    • Insights to fungal biology through LaeA sleuthing
    • Jain S., Keller N. Insights to fungal biology through LaeA sleuthing. Fungal Biol Rev 2013, 27:51-59.
    • (2013) Fungal Biol Rev , vol.27 , pp. 51-59
    • Jain, S.1    Keller, N.2
  • 63
    • 84907156522 scopus 로고    scopus 로고
    • Spatial and temporal control of fungal natural product synthesis
    • Lim F.Y., Keller N.P. Spatial and temporal control of fungal natural product synthesis. Nat Prod Rep 2014, 31:1277-1286.
    • (2014) Nat Prod Rep , vol.31 , pp. 1277-1286
    • Lim, F.Y.1    Keller, N.P.2
  • 65
    • 73949102298 scopus 로고    scopus 로고
    • Epigenome manipulation as a pathway to new natural product scaffolds and their congeners
    • Cichewicz R.H. Epigenome manipulation as a pathway to new natural product scaffolds and their congeners. Nat Prod Rep 2010, 27:11-22.
    • (2010) Nat Prod Rep , vol.27 , pp. 11-22
    • Cichewicz, R.H.1
  • 66
    • 79960720332 scopus 로고    scopus 로고
    • Induced production of N-formyl alkaloids from Aspergillus fumigatus by co-culture with Streptomyces peucetius
    • Zuck K.M., Shipley S., Newman D.J. Induced production of N-formyl alkaloids from Aspergillus fumigatus by co-culture with Streptomyces peucetius. J Nat Prod 2011, 74:1653-1657.
    • (2011) J Nat Prod , vol.74 , pp. 1653-1657
    • Zuck, K.M.1    Shipley, S.2    Newman, D.J.3
  • 67
    • 0032192790 scopus 로고    scopus 로고
    • Molecular biological access to the chemistry of unknown soil microbes: a new frontier for natural products
    • Handelsman J., Rondon M.R., Brady S.F., Clardy J., Goodman R.M. Molecular biological access to the chemistry of unknown soil microbes: a new frontier for natural products. Chem Biol 1998, 5:R245-R249.
    • (1998) Chem Biol , vol.5 , pp. R245-R249
    • Handelsman, J.1    Rondon, M.R.2    Brady, S.F.3    Clardy, J.4    Goodman, R.M.5
  • 68
    • 84886926372 scopus 로고    scopus 로고
    • Bioprospecting microbial metagenome for natural products
    • Nováková J., Farkašovský M. Bioprospecting microbial metagenome for natural products. Biologia 2013, 68:1079-1086.
    • (2013) Biologia , vol.68 , pp. 1079-1086
    • Nováková, J.1    Farkašovský, M.2
  • 69
    • 0032092924 scopus 로고    scopus 로고
    • Extremophiles
    • Persidis A. Extremophiles. Nat Biotechnol 1998, 16:593-594.
    • (1998) Nat Biotechnol , vol.16 , pp. 593-594
    • Persidis, A.1
  • 70
    • 0035283618 scopus 로고    scopus 로고
    • The biotechnological potential of piezophiles
    • Abe F., Horikoshi K. The biotechnological potential of piezophiles. Trends Biotechnol 2001, 19:102-108.
    • (2001) Trends Biotechnol , vol.19 , pp. 102-108
    • Abe, F.1    Horikoshi, K.2
  • 72
    • 33744506935 scopus 로고    scopus 로고
    • Microbes live near undersea CO2 lake
    • Amato A. Microbes live near undersea CO2 lake. Chem Eng News 2006, 84:14.
    • (2006) Chem Eng News , vol.84 , pp. 14
    • Amato, A.1
  • 73
    • 33846659466 scopus 로고    scopus 로고
    • New Zealand plays to its strengths
    • Short P.L. New Zealand plays to its strengths. Chem Eng News 2007, 85:20-21.
    • (2007) Chem Eng News , vol.85 , pp. 20-21
    • Short, P.L.1
  • 75
    • 0141741231 scopus 로고    scopus 로고
    • The microbiology of acidic mine waters
    • Johnson D.B., Hallberg K.B. The microbiology of acidic mine waters. Res Microbiol 2003, 154:466-473.
    • (2003) Res Microbiol , vol.154 , pp. 466-473
    • Johnson, D.B.1    Hallberg, K.B.2
  • 76
    • 4344570619 scopus 로고    scopus 로고
    • Novel sesquiterpenoid matrix metalloproteinase-3 inhibitors from an acid mine waste extremophile
    • Stierle A.A., Stierle D.B., Kemp K. Novel sesquiterpenoid matrix metalloproteinase-3 inhibitors from an acid mine waste extremophile. J Nat Prod 2004, 67:1392-1395.
    • (2004) J Nat Prod , vol.67 , pp. 1392-1395
    • Stierle, A.A.1    Stierle, D.B.2    Kemp, K.3
  • 77
    • 1642568806 scopus 로고    scopus 로고
    • Berkeleydione and berkeleytrione, new bioactive metabolites from an acid mine organism
    • Stierle D.B., Stierle A.A., Hobbs D., Stokken J., Clardy J. Berkeleydione and berkeleytrione, new bioactive metabolites from an acid mine organism. Org Lett 2004, 6:1049-1052.
    • (2004) Org Lett , vol.6 , pp. 1049-1052
    • Stierle, D.B.1    Stierle, A.A.2    Hobbs, D.3    Stokken, J.4    Clardy, J.5
  • 78
    • 84875480096 scopus 로고    scopus 로고
    • Bioprospecting in the Berkeley pit: the use of signal transduction enzyme inhibition assays to isolate bioactive secondary metabolites from the extremophilic fungi of an acid mine waste lake
    • Stierle A.A., Stierle D.B. Bioprospecting in the Berkeley pit: the use of signal transduction enzyme inhibition assays to isolate bioactive secondary metabolites from the extremophilic fungi of an acid mine waste lake. Stud Nat Prod Chem 2013, 39:1-45.
    • (2013) Stud Nat Prod Chem , vol.39 , pp. 1-45
    • Stierle, A.A.1    Stierle, D.B.2
  • 79
    • 84904351408 scopus 로고    scopus 로고
    • (-)-Berkelic acid: lessons learned from our investigations on a scalable total synthesis
    • Arto T., Mendoza A., Fañanás F.J., Rodríguez F. (-)-Berkelic acid: lessons learned from our investigations on a scalable total synthesis. Strategies Tactics Org Synth 2014, 10:33-50.
    • (2014) Strategies Tactics Org Synth , vol.10 , pp. 33-50
    • Arto, T.1    Mendoza, A.2    Fañanás, F.J.3    Rodríguez, F.4
  • 80
    • 84899571774 scopus 로고    scopus 로고
    • Spiromastixones A-O, antibacterial chlorodepsidones from a deep-sea-derived Spiromastix sp. fungus
    • Niu S., Liu D., Hu X., Proksch P., Shao H., Lin W. Spiromastixones A-O, antibacterial chlorodepsidones from a deep-sea-derived Spiromastix sp. fungus. J Nat Prod 2014, 77:1021-1030.
    • (2014) J Nat Prod , vol.77 , pp. 1021-1030
    • Niu, S.1    Liu, D.2    Hu, X.3    Proksch, P.4    Shao, H.5    Lin, W.6
  • 82
    • 84865017288 scopus 로고    scopus 로고
    • Isolation, biological activity, synthesis, and medicinal chemistry of the pederin/mycalamide family of natural products
    • Mosey R.A., Floreancig P.E. Isolation, biological activity, synthesis, and medicinal chemistry of the pederin/mycalamide family of natural products. Nat Prod Rep 2012, 29:980-995.
    • (2012) Nat Prod Rep , vol.29 , pp. 980-995
    • Mosey, R.A.1    Floreancig, P.E.2
  • 83
    • 84904163765 scopus 로고    scopus 로고
    • Recent advances in deep-sea natural products
    • Skropeta D., Wei L. Recent advances in deep-sea natural products. Nat Prod Rep 2014, 31:999-1025.
    • (2014) Nat Prod Rep , vol.31 , pp. 999-1025
    • Skropeta, D.1    Wei, L.2
  • 84
    • 0348109344 scopus 로고    scopus 로고
    • Bioprospecting for microbial endophytes and their natural products
    • Strobel G., Daisy B. Bioprospecting for microbial endophytes and their natural products. Microbiol Mol Biol Rev 2003, 67:491-502.
    • (2003) Microbiol Mol Biol Rev , vol.67 , pp. 491-502
    • Strobel, G.1    Daisy, B.2
  • 85
    • 1442310075 scopus 로고    scopus 로고
    • Natural products from endophytic microorganisms
    • Strobel G., Daisy B., Castillo U., Harper J. Natural products from endophytic microorganisms. J Nat Prod 2004, 67:257-268.
    • (2004) J Nat Prod , vol.67 , pp. 257-268
    • Strobel, G.1    Daisy, B.2    Castillo, U.3    Harper, J.4
  • 86
    • 0027270462 scopus 로고
    • Taxol and taxane production by Taxomyces andreanae, an endophytic fungus of Pacific yew
    • Stierle A., Strobel G., Stierle D. Taxol and taxane production by Taxomyces andreanae, an endophytic fungus of Pacific yew. Science 1993, 260:214-216.
    • (1993) Science , vol.260 , pp. 214-216
    • Stierle, A.1    Strobel, G.2    Stierle, D.3
  • 87
    • 0031843384 scopus 로고    scopus 로고
    • Stimulation of taxol production in liquid cultures of Pestalotiopsis microspora
    • Li J.-Y., Sidhu R.S., Bollon A., Strobel G.A. Stimulation of taxol production in liquid cultures of Pestalotiopsis microspora. Mycolog Res 1998, 102:461-464.
    • (1998) Mycolog Res , vol.102 , pp. 461-464
    • Li, J.-Y.1    Sidhu, R.S.2    Bollon, A.3    Strobel, G.A.4
  • 88
    • 33748774962 scopus 로고    scopus 로고
    • Endophyte fungal Isolates from Podophyllum peltatum produce podophyllotoxin
    • Eyberger A.L., Dondapati R., Porter J.R. Endophyte fungal Isolates from Podophyllum peltatum produce podophyllotoxin. J Nat Prod 2006, 69:1121-1124.
    • (2006) J Nat Prod , vol.69 , pp. 1121-1124
    • Eyberger, A.L.1    Dondapati, R.2    Porter, J.R.3
  • 89
    • 33645337654 scopus 로고    scopus 로고
    • The endophytic fungus Trametes hirsuta as a novel alternative source of podophyllotoxin and related tetralin lignans
    • Puri S.C., Nazir A., Chawla R., Arora R., Riyaz-ul-Hasan S., Amna T., et al. The endophytic fungus Trametes hirsuta as a novel alternative source of podophyllotoxin and related tetralin lignans. J Biotech 2006, 122:494-510.
    • (2006) J Biotech , vol.122 , pp. 494-510
    • Puri, S.C.1    Nazir, A.2    Chawla, R.3    Arora, R.4    Riyaz-ul-Hasan, S.5    Amna, T.6
  • 90
    • 33745021906 scopus 로고    scopus 로고
    • Bioreactor studies on the endophytic fungus Entrophosphora infrequens for the production of an anticancer alkaloid camptothecin
    • Amna T., Puri S.C., Verma V., Sharma J.P., Khajuria R.K., Musarrat J., et al. Bioreactor studies on the endophytic fungus Entrophosphora infrequens for the production of an anticancer alkaloid camptothecin. Can J Microbiol 2006, 52:189-196.
    • (2006) Can J Microbiol , vol.52 , pp. 189-196
    • Amna, T.1    Puri, S.C.2    Verma, V.3    Sharma, J.P.4    Khajuria, R.K.5    Musarrat, J.6
  • 91
    • 30544436426 scopus 로고    scopus 로고
    • An endophytic fungus from Nothapodytes foetida that produces camptothecin
    • Puri S.C., Verma V., Amna T., Qazi G.N., Spiteller M. An endophytic fungus from Nothapodytes foetida that produces camptothecin. J Nat Prod 2005, 68:1717-1719.
    • (2005) J Nat Prod , vol.68 , pp. 1717-1719
    • Puri, S.C.1    Verma, V.2    Amna, T.3    Qazi, G.N.4    Spiteller, M.5
  • 92
    • 23044433917 scopus 로고    scopus 로고
    • Isolation of a fungus producing vinblastine
    • Guo B., Li H., Zhang L. Isolation of a fungus producing vinblastine. J Yunnan Univ 1998, 20:214-215.
    • (1998) J Yunnan Univ , vol.20 , pp. 214-215
    • Guo, B.1    Li, H.2    Zhang, L.3
  • 93
    • 23044479976 scopus 로고    scopus 로고
    • Preliminary study on the isolation of endophytic fungus of Catharanthus roseus and its fermentation to produce products of therapeutic value
    • Zhang L.Q., Guo B., Li H., Zeng S., Shao H., Gu S., et al. Preliminary study on the isolation of endophytic fungus of Catharanthus roseus and its fermentation to produce products of therapeutic value. Zhong Cao Yao (Chinese Tradit Herb Drugs) 2000, 31:805-807.
    • (2000) Zhong Cao Yao (Chinese Tradit Herb Drugs) , vol.31 , pp. 805-807
    • Zhang, L.Q.1    Guo, B.2    Li, H.3    Zeng, S.4    Shao, H.5    Gu, S.6
  • 94
    • 34247161266 scopus 로고    scopus 로고
    • Preliminary study of a vincristine-producing endophytic fungus isolated from leaves of Catharanthus roseus
    • Yang X., Zhang L., Guo B., Guo S. Preliminary study of a vincristine-producing endophytic fungus isolated from leaves of Catharanthus roseus. Zhong Cao Yao (Chinese Tradit Herb Drugs) 2004, 35:79-81.
    • (2004) Zhong Cao Yao (Chinese Tradit Herb Drugs) , vol.35 , pp. 79-81
    • Yang, X.1    Zhang, L.2    Guo, B.3    Guo, S.4
  • 95
    • 84862010656 scopus 로고    scopus 로고
    • Endophytic fungi: novel sources of anticancer lead molecules
    • Chandra S. Endophytic fungi: novel sources of anticancer lead molecules. App Microbiol Biotechnol 2012, 95:47-59.
    • (2012) App Microbiol Biotechnol , vol.95 , pp. 47-59
    • Chandra, S.1
  • 96
    • 84864417872 scopus 로고    scopus 로고
    • Chemical ecology of endophytic fungi: origins of secondary metabolites
    • Kusari S., Hertweck C., Spiteller M. Chemical ecology of endophytic fungi: origins of secondary metabolites. Chem Biol 2012, 19:792-798.
    • (2012) Chem Biol , vol.19 , pp. 792-798
    • Kusari, S.1    Hertweck, C.2    Spiteller, M.3
  • 97
    • 84886836071 scopus 로고    scopus 로고
    • Production of the alkaloid swainsonine by a fungal endophyte in the host Swainsona canescens
    • Grum D.S., Cook D., Baucom D., Mott I.W., Gardner D.R., Creamer R., et al. Production of the alkaloid swainsonine by a fungal endophyte in the host Swainsona canescens. J Nat Prod 2013, 76:1984-1988.
    • (2013) J Nat Prod , vol.76 , pp. 1984-1988
    • Grum, D.S.1    Cook, D.2    Baucom, D.3    Mott, I.W.4    Gardner, D.R.5    Creamer, R.6
  • 98
    • 84905227287 scopus 로고    scopus 로고
    • Swainsonine-containing plants and their relationship to endophytic fungi
    • Cook D., Gardner D.R., Pfister J.A. Swainsonine-containing plants and their relationship to endophytic fungi. J Agric Food Chem 2014, 62:7326-7334.
    • (2014) J Agric Food Chem , vol.62 , pp. 7326-7334
    • Cook, D.1    Gardner, D.R.2    Pfister, J.A.3
  • 99
    • 56049123651 scopus 로고    scopus 로고
    • In vivo and in vitro trans-acylation by bryP, the putative bryostatin pathway acyltransferase derived from an uncultured marine symbiont
    • Lopanik N.B., Shields J.A., Buchholz T.J., Rath C.M., Hothersall J., Haygood M.G., et al. In vivo and in vitro trans-acylation by bryP, the putative bryostatin pathway acyltransferase derived from an uncultured marine symbiont. Chem Biol 2008, 15:1175-1186.
    • (2008) Chem Biol , vol.15 , pp. 1175-1186
    • Lopanik, N.B.1    Shields, J.A.2    Buchholz, T.J.3    Rath, C.M.4    Hothersall, J.5    Haygood, M.G.6
  • 100
    • 58149516774 scopus 로고    scopus 로고
    • Nematicidal endophytic bacteria obtained from plants
    • Zheng L., Li G., Wang X., Pan W., Li L., Hua L., et al. Nematicidal endophytic bacteria obtained from plants. Ann Microbiol 2008, 58:569-572.
    • (2008) Ann Microbiol , vol.58 , pp. 569-572
    • Zheng, L.1    Li, G.2    Wang, X.3    Pan, W.4    Li, L.5    Hua, L.6
  • 101
  • 102
    • 38749111864 scopus 로고    scopus 로고
    • A novel ansamycin, naphthomycin K from Streptomyces sp
    • Lu C., Shen Y. A novel ansamycin, naphthomycin K from Streptomyces sp. J Antibiot 2007, 60:649-653.
    • (2007) J Antibiot , vol.60 , pp. 649-653
    • Lu, C.1    Shen, Y.2
  • 104
    • 0015520389 scopus 로고
    • Tumor inhibitors. LXXIII. Maytansine, a novel antileukemic ansa macrolide from Maytenus ovatus
    • Kupchan S.M., Komoda Y., Court W.A., Thomas G.J., Smith R.M., Karim A., et al. Tumor inhibitors. LXXIII. Maytansine, a novel antileukemic ansa macrolide from Maytenus ovatus. J Am Chem Soc 1972, 94:1354-1356.
    • (1972) J Am Chem Soc , vol.94 , pp. 1354-1356
    • Kupchan, S.M.1    Komoda, Y.2    Court, W.A.3    Thomas, G.J.4    Smith, R.M.5    Karim, A.6
  • 105
    • 0017707833 scopus 로고
    • Ansamitocin, a group of novel maytansinoid antibiotics with antitumour properties from Nocardia
    • Higashide E., Asai M., Ootsu K., Tanida S., Kozai Y., Hasegawa T., et al. Ansamitocin, a group of novel maytansinoid antibiotics with antitumour properties from Nocardia. Nature 1977, 270:721-722.
    • (1977) Nature , vol.270 , pp. 721-722
    • Higashide, E.1    Asai, M.2    Ootsu, K.3    Tanida, S.4    Kozai, Y.5    Hasegawa, T.6
  • 106
    • 84878940717 scopus 로고    scopus 로고
    • A study of the bacterial community in the root system of the maytansine containing plant Putterlickia verrucosa
    • Wings S., Müller H., Berg G., Lamshöft M., Leistner E. A study of the bacterial community in the root system of the maytansine containing plant Putterlickia verrucosa. Phytochemistry 2013, 91:158-164.
    • (2013) Phytochemistry , vol.91 , pp. 158-164
    • Wings, S.1    Müller, H.2    Berg, G.3    Lamshöft, M.4    Leistner, E.5
  • 107
    • 33845879084 scopus 로고    scopus 로고
    • Interactions among endophytic bacteria and fungi; effects and potential
    • Bandara W.M.M.S., Seneviratne G., Kulasooriya S.A. Interactions among endophytic bacteria and fungi; effects and potential. J Biosci 2006, 31:645-650.
    • (2006) J Biosci , vol.31 , pp. 645-650
    • Bandara, W.M.M.S.1    Seneviratne, G.2    Kulasooriya, S.A.3
  • 108
    • 80052154073 scopus 로고    scopus 로고
    • Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylation
    • Nützmann H.-W., Reyes-Dominguez Y., Scherlach K., Schroeckh V., Horn F., et al. Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylation. Proc Nat Acad Sci U S A 2011, 108:14282-14287.
    • (2011) Proc Nat Acad Sci U S A , vol.108 , pp. 14282-14287
    • Nützmann, H.-W.1    Reyes-Dominguez, Y.2    Scherlach, K.3    Schroeckh, V.4    Horn, F.5
  • 109
    • 27144465524 scopus 로고    scopus 로고
    • Pathogenic fungus harbours endosymbiotic bacteria for toxin production
    • Partida-Martinez L.P., Hertweck C. Pathogenic fungus harbours endosymbiotic bacteria for toxin production. Nature 2005, 437:884-888.
    • (2005) Nature , vol.437 , pp. 884-888
    • Partida-Martinez, L.P.1    Hertweck, C.2
  • 110
    • 34247396611 scopus 로고    scopus 로고
    • Endosymbiont-dependent host reproduction maintains bacterial-fungal mutualism
    • Partida-Martinez L.P., Monajembashi S., Greulich K.-O., Hertweck C. Endosymbiont-dependent host reproduction maintains bacterial-fungal mutualism. Curr Biol 2007, 17:773-777.
    • (2007) Curr Biol , vol.17 , pp. 773-777
    • Partida-Martinez, L.P.1    Monajembashi, S.2    Greulich, K.-O.3    Hertweck, C.4
  • 114
    • 0037455147 scopus 로고    scopus 로고
    • Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus Salinospora
    • Feling R.H., Buchanan G.O., Mincer T.J., Kauffman C.A., Jensen P.R., Fenical W. Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus Salinospora. Angew Chem Int Ed 2003, 42:355-357.
    • (2003) Angew Chem Int Ed , vol.42 , pp. 355-357
    • Feling, R.H.1    Buchanan, G.O.2    Mincer, T.J.3    Kauffman, C.A.4    Jensen, P.R.5    Fenical, W.6
  • 115
    • 34447302758 scopus 로고    scopus 로고
    • Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica
    • Udwary D.W., Zeigler L., Asolkar R.N., Singan V., Lapidus A., Fenical W., et al. Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica. Proc Natl Acad Sci U S A 2007, 104:10376-10381.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 10376-10381
    • Udwary, D.W.1    Zeigler, L.2    Asolkar, R.N.3    Singan, V.4    Lapidus, A.5    Fenical, W.6
  • 116
    • 79251509548 scopus 로고    scopus 로고
    • A sea of biosynthesis: marine natural products meet the molecular age
    • Lane A.L., Moore B.S. A sea of biosynthesis: marine natural products meet the molecular age. Nat Prod Rep 2011, 28:411-428.
    • (2011) Nat Prod Rep , vol.28 , pp. 411-428
    • Lane, A.L.1    Moore, B.S.2
  • 117
    • 77950455094 scopus 로고    scopus 로고
    • Engineering fluorometabolite production: fluorinase expression in Salinispora tropica yields fluorosalinosporamide
    • Eustáquio A.S., O'Hagan D., Moore B.S. Engineering fluorometabolite production: fluorinase expression in Salinispora tropica yields fluorosalinosporamide. J Nat Prod 2010, 73:378-382.
    • (2010) J Nat Prod , vol.73 , pp. 378-382
    • Eustáquio, A.S.1    O'Hagan, D.2    Moore, B.S.3
  • 118
    • 82355190330 scopus 로고    scopus 로고
    • Bacterial production of the tunicate-derived antitumor cyclic depsipeptide didemnin B
    • Tsukimoto M., Nagaoka M., Shishido Y., Fujimoto J., Nishisaka F., Matsumoto S., et al. Bacterial production of the tunicate-derived antitumor cyclic depsipeptide didemnin B. J Nat Prod 2011, 74:2329-2331.
    • (2011) J Nat Prod , vol.74 , pp. 2329-2331
    • Tsukimoto, M.1    Nagaoka, M.2    Shishido, Y.3    Fujimoto, J.4    Nishisaka, F.5    Matsumoto, S.6
  • 119
    • 0242669908 scopus 로고    scopus 로고
    • Tistrella mobilis gen. nov., sp. nov., a novel polyhydroxyalkanoate-producing bacterium belonging to alpha-Proteobacteria
    • Shi B.H., Arunpairojana V., Palakawong S., Yokota A. Tistrella mobilis gen. nov., sp. nov., a novel polyhydroxyalkanoate-producing bacterium belonging to alpha-Proteobacteria. J Gen Appl Microbiol 2002, 48:335-343.
    • (2002) J Gen Appl Microbiol , vol.48 , pp. 335-343
    • Shi, B.H.1    Arunpairojana, V.2    Palakawong, S.3    Yokota, A.4
  • 121
    • 84861409243 scopus 로고    scopus 로고
    • Bacterial biosynthesis and maturation of the didemnin anti-cancer agents
    • Xu Y., Kersten R.D., Nam S.-J., Lu L., Al-Suwailem A.M., Zheng H., et al. Bacterial biosynthesis and maturation of the didemnin anti-cancer agents. J Am Chem Soc 2012, 134:8625-8632.
    • (2012) J Am Chem Soc , vol.134 , pp. 8625-8632
    • Xu, Y.1    Kersten, R.D.2    Nam, S.-J.3    Lu, L.4    Al-Suwailem, A.M.5    Zheng, H.6
  • 122
    • 84872436756 scopus 로고    scopus 로고
    • Microbial life under extreme energy limitation
    • Hoehler T.M., Jorgensen B.B. Microbial life under extreme energy limitation. Nat Rev Microbiol 2013, 11:83-93.
    • (2013) Nat Rev Microbiol , vol.11 , pp. 83-93
    • Hoehler, T.M.1    Jorgensen, B.B.2
  • 123
    • 4444264936 scopus 로고    scopus 로고
    • Metabolites from symbiotic bacteria
    • Piel J. Metabolites from symbiotic bacteria. Nat Prod Rep 2004, 21:519-538.
    • (2004) Nat Prod Rep , vol.21 , pp. 519-538
    • Piel, J.1
  • 124
    • 10744231115 scopus 로고    scopus 로고
    • Evidence for a symbiosis island involved in horizontal acquisition of pederin biosynthetic capabilities by the bacterial symbiont of Paederus fuscipes beetles
    • Piel J., Hofer I., Hui D. Evidence for a symbiosis island involved in horizontal acquisition of pederin biosynthetic capabilities by the bacterial symbiont of Paederus fuscipes beetles. J Bacteriol 2004, 186:1280-1286.
    • (2004) J Bacteriol , vol.186 , pp. 1280-1286
    • Piel, J.1    Hofer, I.2    Hui, D.3
  • 125
    • 17444392475 scopus 로고    scopus 로고
    • Exploring the chemistry of uncultivated bacterial symbionts: antitumor polyketides of the pederin family
    • Piel J., Butzke D., Fusetani N., Hui D., Platzer M., Wen G., et al. Exploring the chemistry of uncultivated bacterial symbionts: antitumor polyketides of the pederin family. J Nat Prod 2005, 68:472-479.
    • (2005) J Nat Prod , vol.68 , pp. 472-479
    • Piel, J.1    Butzke, D.2    Fusetani, N.3    Hui, D.4    Platzer, M.5    Wen, G.6
  • 126
    • 84886297369 scopus 로고    scopus 로고
    • Microbial natural products: molecular blueprints for antitumor drugs
    • Giddings L.-A., Newman D.J. Microbial natural products: molecular blueprints for antitumor drugs. J Ind Microbiol Biotechnol 2013, 40:1181-1210.
    • (2013) J Ind Microbiol Biotechnol , vol.40 , pp. 1181-1210
    • Giddings, L.-A.1    Newman, D.J.2
  • 127
    • 80055020580 scopus 로고    scopus 로고
    • Highlights of marine invertebrate-derived biosynthetic products: their biomedical potential and possible production by microbial associants
    • Radjasa O.K., Vaske Y.M., Navarro G., Vervoort H.C., Tenney K., Linington R.G., et al. Highlights of marine invertebrate-derived biosynthetic products: their biomedical potential and possible production by microbial associants. Bioorg Med Chem 2011, 19:6658-6674.
    • (2011) Bioorg Med Chem , vol.19 , pp. 6658-6674
    • Radjasa, O.K.1    Vaske, Y.M.2    Navarro, G.3    Vervoort, H.C.4    Tenney, K.5    Linington, R.G.6
  • 128
    • 84897412085 scopus 로고    scopus 로고
    • Scrutinizing the scaffolds of marine biosynthetics from different source organisms: gram-negative cultured bacterial products enter center stage
    • Still P.C., Johnson T.A., Theodore C.M., Loveridge S.T., Crews P. Scrutinizing the scaffolds of marine biosynthetics from different source organisms: gram-negative cultured bacterial products enter center stage. J Nat Prod 2014, 77:690-702.
    • (2014) J Nat Prod , vol.77 , pp. 690-702
    • Still, P.C.1    Johnson, T.A.2    Theodore, C.M.3    Loveridge, S.T.4    Crews, P.5
  • 129
    • 84893542053 scopus 로고    scopus 로고
    • An environmental bacterial taxon with a large and distinct metabolic repertoire
    • Wilson M.C., Mori T., Rückert C., Uria A.R., Helf M.J., Takada K., et al. An environmental bacterial taxon with a large and distinct metabolic repertoire. Nature 2014, 506:58-62.
    • (2014) Nature , vol.506 , pp. 58-62
    • Wilson, M.C.1    Mori, T.2    Rückert, C.3    Uria, A.R.4    Helf, M.J.5    Takada, K.6
  • 130
    • 84904641324 scopus 로고    scopus 로고
    • Calyculin biogenesis from a pyrophosphate protoxin produced by a sponge symbiont
    • Wakimoto T., Egami Y., Nakashima Y., Mori T., Awakawa T., Ito T., et al. Calyculin biogenesis from a pyrophosphate protoxin produced by a sponge symbiont. Nat Chem Biol 2014, 10:648-655.
    • (2014) Nat Chem Biol , vol.10 , pp. 648-655
    • Wakimoto, T.1    Egami, Y.2    Nakashima, Y.3    Mori, T.4    Awakawa, T.5    Ito, T.6
  • 131
    • 84903553792 scopus 로고    scopus 로고
    • Emerging strategies and integrated systems microbiology technologies for biodiscovery of marine bioactive compounds
    • Rocha-Martin J., Harrington C., Dobson A.D.W., O'Gara F. Emerging strategies and integrated systems microbiology technologies for biodiscovery of marine bioactive compounds. Mar Drugs 2014, 12:3516-3559.
    • (2014) Mar Drugs , vol.12 , pp. 3516-3559
    • Rocha-Martin, J.1    Harrington, C.2    Dobson, A.D.W.3    O'Gara, F.4
  • 132
    • 69849084988 scopus 로고    scopus 로고
    • Combinatorial biosynthesis of anticancer natural molecules
    • Taylor & Francis, Boca Raton, FL, G.M. Cragg, D.G.I. Kingston, D.J. Newman
    • Thomas M.G., Bixby K.A., Shen B. Combinatorial biosynthesis of anticancer natural molecules. Anticancer agents from natural products 2005, 519-552. Taylor & Francis, Boca Raton, FL. G.M. Cragg, D.G.I. Kingston, D.J. Newman (Eds.).
    • (2005) Anticancer agents from natural products , pp. 519-552
    • Thomas, M.G.1    Bixby, K.A.2    Shen, B.3
  • 133
    • 84876947577 scopus 로고    scopus 로고
    • Combinatorial biosynthesis of anticancer natural products
    • Taylor & Francis, Boca Raton, FL, 2nd ed.
    • Van Lanen S.G., Shen B. Combinatorial biosynthesis of anticancer natural products. Anticancer agents from natural products 2012, 2012:671-698. Taylor & Francis, Boca Raton, FL. 2nd ed.
    • (2012) Anticancer agents from natural products , vol.2012 , pp. 671-698
    • Van Lanen, S.G.1    Shen, B.2
  • 134
    • 84895072793 scopus 로고    scopus 로고
    • Microbial genome mining for accelerated natural products discovery: is a renaissance in the making?
    • Bachmann B.O., Van Lanen S.G., Baltz R.H. Microbial genome mining for accelerated natural products discovery: is a renaissance in the making?. J Ind Microbiol Biotechnol 2014, 41:175-184.
    • (2014) J Ind Microbiol Biotechnol , vol.41 , pp. 175-184
    • Bachmann, B.O.1    Van Lanen, S.G.2    Baltz, R.H.3
  • 135
    • 84905754600 scopus 로고    scopus 로고
    • Access to high value natural and unnatural products through hyphenating chemical synthesis and biosynthesis
    • Mahoney K.P.P., Smith D.R.M., Bogosyan E.J.A., Goss R.J.M. Access to high value natural and unnatural products through hyphenating chemical synthesis and biosynthesis. Synthesis 2014, 46:2122-2132.
    • (2014) Synthesis , vol.46 , pp. 2122-2132
    • Mahoney, K.P.P.1    Smith, D.R.M.2    Bogosyan, E.J.A.3    Goss, R.J.M.4
  • 136
    • 77954960773 scopus 로고    scopus 로고
    • High throughput extraction of plant, marine and fungal specimens for preservation of biologically active molecules
    • McCloud T.G. High throughput extraction of plant, marine and fungal specimens for preservation of biologically active molecules. Molecules 2010, 15:4526-4563.
    • (2010) Molecules , vol.15 , pp. 4526-4563
    • McCloud, T.G.1
  • 138
    • 0027317760 scopus 로고
    • A chemical-screening strategy for the dereplication and prioritization of HIV-inhibitory aqueous natural-products extracts
    • Cardellina J.H., Munro M.H.G., Fuller R.W., Manfredi K.P., McKee T.C., Tischler M., et al. A chemical-screening strategy for the dereplication and prioritization of HIV-inhibitory aqueous natural-products extracts. J Nat Prod 1993, 56:1123-1129.
    • (1993) J Nat Prod , vol.56 , pp. 1123-1129
    • Cardellina, J.H.1    Munro, M.H.G.2    Fuller, R.W.3    Manfredi, K.P.4    McKee, T.C.5    Tischler, M.6
  • 139
    • 0028906786 scopus 로고
    • Some practical considerations and applications of the National Cancer Institute in vitro anticancer drug discovery screen
    • Boyd M.R., Paull K.D. Some practical considerations and applications of the National Cancer Institute in vitro anticancer drug discovery screen. Drug Dev Res 1995, 34:91-109.
    • (1995) Drug Dev Res , vol.34 , pp. 91-109
    • Boyd, M.R.1    Paull, K.D.2
  • 140
    • 84939835152 scopus 로고    scopus 로고
    • Developmental Theraputics Program. 2014. http://dtp.nci.nih.gov/.
    • (2014)
  • 142
    • 84905566407 scopus 로고    scopus 로고
    • Ultra high throughput screening of natural product extracts to identify pro-apoptotic inhibitors of Bcl-2 family proteins
    • Hassig C.A., Zeng F.-Y., Kung P., Kiankarimi M., Kim S., Diaz P.W., et al. Ultra high throughput screening of natural product extracts to identify pro-apoptotic inhibitors of Bcl-2 family proteins. J Biomol Screening 2014, 19:1201-1211.
    • (2014) J Biomol Screening , vol.19 , pp. 1201-1211
    • Hassig, C.A.1    Zeng, F.-Y.2    Kung, P.3    Kiankarimi, M.4    Kim, S.5    Diaz, P.W.6
  • 143
    • 84905496728 scopus 로고    scopus 로고
    • Phenotypic screening in cancer drug discovery - past, present and future
    • Moffat J.G., Rudolph J., Bailey D. Phenotypic screening in cancer drug discovery - past, present and future. Nat Rev Drug Discov 2014, 13:588-602.
    • (2014) Nat Rev Drug Discov , vol.13 , pp. 588-602
    • Moffat, J.G.1    Rudolph, J.2    Bailey, D.3
  • 144
    • 84905495729 scopus 로고    scopus 로고
    • The discovery of first-in-class drugs: origins and evolution
    • Eder J., Sedrani R., Wiesmann C. The discovery of first-in-class drugs: origins and evolution. Nat Rev Drug Discov 2014, 13:577-587.
    • (2014) Nat Rev Drug Discov , vol.13 , pp. 577-587
    • Eder, J.1    Sedrani, R.2    Wiesmann, C.3
  • 145
    • 79959929769 scopus 로고    scopus 로고
    • How were new medicines discovered?
    • Swinney D.C., Anthony J. How were new medicines discovered?. Nat Rev Drug Discov 2011, 10:507-519.
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 507-519
    • Swinney, D.C.1    Anthony, J.2
  • 146
    • 84897973939 scopus 로고    scopus 로고
    • Mapping the cellular response to small molecules using chemogenomic fitness signatures
    • Lee A.Y., St Onge R.P., Proctor M.J., Wallace I.M., Nile A.H., Spagnuolo P.A., et al. Mapping the cellular response to small molecules using chemogenomic fitness signatures. Science 2014, 344:208-211.
    • (2014) Science , vol.344 , pp. 208-211
    • Lee, A.Y.1    St Onge, R.P.2    Proctor, M.J.3    Wallace, I.M.4    Nile, A.H.5    Spagnuolo, P.A.6
  • 149
    • 0031047560 scopus 로고    scopus 로고
    • Rapid detection and subsequent isolation of bioactive constituents of crude plant extracts
    • Hostettmann K., Wolfender J.-L., Rodriguez S. Rapid detection and subsequent isolation of bioactive constituents of crude plant extracts. Planta Med 1997, 63:2-10.
    • (1997) Planta Med , vol.63 , pp. 2-10
    • Hostettmann, K.1    Wolfender, J.-L.2    Rodriguez, S.3
  • 150
    • 4344699379 scopus 로고    scopus 로고
    • An N.M.R. method towards the routine chiral determination of natural products
    • Jaki B., Franzblau S., Pauli G.F. An N.M.R. method towards the routine chiral determination of natural products. Phytochem Anal 2004, 15:213-219.
    • (2004) Phytochem Anal , vol.15 , pp. 213-219
    • Jaki, B.1    Franzblau, S.2    Pauli, G.F.3
  • 151
    • 23744504882 scopus 로고    scopus 로고
    • Exploring uncharted terrain in Nature's structure space using capillary NMR spectroscopy: 13 steroids from 50 fireflies
    • Gronquist M., Meinwald J., Eisner T., Schroeder F.C. Exploring uncharted terrain in Nature's structure space using capillary NMR spectroscopy: 13 steroids from 50 fireflies. J Am Chem Soc 2005, 127:10810-10811.
    • (2005) J Am Chem Soc , vol.127 , pp. 10810-10811
    • Gronquist, M.1    Meinwald, J.2    Eisner, T.3    Schroeder, F.C.4
  • 152
    • 23644460869 scopus 로고    scopus 로고
    • Phytochemistry in the microgram domain - a LC-NMR perspective
    • Wolfender J.L., Queiroz E.F., Hostettmann K. Phytochemistry in the microgram domain - a LC-NMR perspective. Mag Res Chem 2005, 43:697-709.
    • (2005) Mag Res Chem , vol.43 , pp. 697-709
    • Wolfender, J.L.1    Queiroz, E.F.2    Hostettmann, K.3
  • 153
    • 33846964551 scopus 로고    scopus 로고
    • Molecular formula analysis by an MS/MS/MS technique to expedite dereplication of natural products
    • Konishi Y., Kiyota T., Draghici C., Gao J.M., Yeboah F., Acoca S., et al. Molecular formula analysis by an MS/MS/MS technique to expedite dereplication of natural products. Anal Chem 2007, 79:1187-1197.
    • (2007) Anal Chem , vol.79 , pp. 1187-1197
    • Konishi, Y.1    Kiyota, T.2    Draghici, C.3    Gao, J.M.4    Yeboah, F.5    Acoca, S.6
  • 155
    • 65549153498 scopus 로고    scopus 로고
    • Modern approaches in the search for new lead antiparasitic compounds from higher plants
    • Queiroz E.F., Wolfender J.L., Hostettmann K. Modern approaches in the search for new lead antiparasitic compounds from higher plants. Curr Drug Targ 2009, 10:202-211.
    • (2009) Curr Drug Targ , vol.10 , pp. 202-211
    • Queiroz, E.F.1    Wolfender, J.L.2    Hostettmann, K.3
  • 156
    • 27544461055 scopus 로고    scopus 로고
    • G.U.E.S.S. - A generally useful estimate of solvent systems for CCC
    • Friesen J.B., Pauli G.F. G.U.E.S.S. - A generally useful estimate of solvent systems for CCC. J Liq Chromatog RelTechnol 2005, 28:2777-2806.
    • (2005) J Liq Chromatog RelTechnol , vol.28 , pp. 2777-2806
    • Friesen, J.B.1    Pauli, G.F.2
  • 158
    • 84885084934 scopus 로고    scopus 로고
    • High-resolution MS, MS/MS, and UV database of fungal secondary metabolitees as a dereplicatoin protocol for bioactive natural products
    • El-Elimat T., Figueroa M., Ehrmann B.M., Cech N.B., Pearce C.J., Oberlies N.H., et al. High-resolution MS, MS/MS, and UV database of fungal secondary metabolitees as a dereplicatoin protocol for bioactive natural products. J Nat Prod 2013, 76:1709-1716.
    • (2013) J Nat Prod , vol.76 , pp. 1709-1716
    • El-Elimat, T.1    Figueroa, M.2    Ehrmann, B.M.3    Cech, N.B.4    Pearce, C.J.5    Oberlies, N.H.6
  • 159
    • 84900848248 scopus 로고    scopus 로고
    • Mass spectrometry of natural products: current, emerging and future technologies
    • Bouslimani A., Sanchez L.M., Garg N., Dorrenstein P.C. Mass spectrometry of natural products: current, emerging and future technologies. Nat Prod Rep 2014, 31:718-729.
    • (2014) Nat Prod Rep , vol.31 , pp. 718-729
    • Bouslimani, A.1    Sanchez, L.M.2    Garg, N.3    Dorrenstein, P.C.4
  • 160
    • 84906678559 scopus 로고    scopus 로고
    • NRPquest: coupling mass spectrometry and genome mining for nonribosomal peptide discovery
    • Mohimani H., Liu W.-T., Kersten R.D., Moore B.S., Dorrestein P.C., Pevzner P.A. NRPquest: coupling mass spectrometry and genome mining for nonribosomal peptide discovery. J Nat Prod 2014, 77:1902-1909.
    • (2014) J Nat Prod , vol.77 , pp. 1902-1909
    • Mohimani, H.1    Liu, W.-T.2    Kersten, R.D.3    Moore, B.S.4    Dorrestein, P.C.5    Pevzner, P.A.6
  • 161
    • 0027430002 scopus 로고
    • The taxol supply crisis. New NCI policies for handling the large-scale production of novel natural product anticancer and anti-HIV agents
    • Cragg G.M., Schepartz S.A., Suffness M., Grever M.R. The taxol supply crisis. New NCI policies for handling the large-scale production of novel natural product anticancer and anti-HIV agents. J Nat Prod 1993, 56:1657-1668.
    • (1993) J Nat Prod , vol.56 , pp. 1657-1668
    • Cragg, G.M.1    Schepartz, S.A.2    Suffness, M.3    Grever, M.R.4
  • 162
    • 0001686427 scopus 로고
    • Industrial production of shikonin and berberine
    • Wiley, Chichester, G. Bock, J. Marsh
    • Fujita Y. Industrial production of shikonin and berberine. Applications of plant cell and tissue culture 1988, 157-174. Wiley, Chichester. G. Bock, J. Marsh (Eds.).
    • (1988) Applications of plant cell and tissue culture , pp. 157-174
    • Fujita, Y.1
  • 163
    • 0343979550 scopus 로고
    • An economic and technical assessment of the use of plant cell cultures for natural product synthesis on an industrial scale
    • Wiley, Chichester, D.J. Chadwick, J. Marsh
    • Fowler M.W., Cresswell R.C., Stafford A.M. An economic and technical assessment of the use of plant cell cultures for natural product synthesis on an industrial scale. Bioactive compounds from plants 1990, 228-238. Wiley, Chichester. D.J. Chadwick, J. Marsh (Eds.).
    • (1990) Bioactive compounds from plants , pp. 228-238
    • Fowler, M.W.1    Cresswell, R.C.2    Stafford, A.M.3
  • 164
    • 23044497194 scopus 로고    scopus 로고
    • Taxol and its analogs
    • CRC Press/Taylor and Francis, Boca Raton, FL, G.M. Cragg, D.G.I. Kingston, D.J. Newman (Eds.), 2nd ed.
    • Kingston D.G.I Taxol and its analogs. Anticancer agents from natural products 2012, 123-175. CRC Press/Taylor and Francis, Boca Raton, FL. 2nd ed. G.M. Cragg, D.G.I. Kingston, D.J. Newman (Eds.).
    • (2012) Anticancer agents from natural products , pp. 123-175
    • Kingston, D.G.I.1
  • 166
    • 33646455779 scopus 로고    scopus 로고
    • Aeroponic and hydroponic systems for medicinal herb, rhizome, and root crops
    • Hayden A.L. Aeroponic and hydroponic systems for medicinal herb, rhizome, and root crops. HortScience 2006, 41:536-538.
    • (2006) HortScience , vol.41 , pp. 536-538
    • Hayden, A.L.1
  • 167
    • 79952902467 scopus 로고    scopus 로고
    • Unusual withanolides from aeroponically grown Withania somnifera
    • Xu Y.M., Gao S., Bunting D.P., Gunatilaka A.A.L. Unusual withanolides from aeroponically grown Withania somnifera. Phytochemistry 2011, 72:518-522.
    • (2011) Phytochemistry , vol.72 , pp. 518-522
    • Xu, Y.M.1    Gao, S.2    Bunting, D.P.3    Gunatilaka, A.A.L.4
  • 168
    • 0842306927 scopus 로고    scopus 로고
    • Large-scale synthesis of the anti-cancer marine natural product (+)-discodermolide. Part 5: linkage of fragments C1-6 and C7-24 and finale
    • Mickel S.J., Niederer D., Daeffler R., Osmani A., Kuesters E., Schmid E., et al. Large-scale synthesis of the anti-cancer marine natural product (+)-discodermolide. Part 5: linkage of fragments C1-6 and C7-24 and finale. Org Process Res Dev 2004, 8:122-130.
    • (2004) Org Process Res Dev , vol.8 , pp. 122-130
    • Mickel, S.J.1    Niederer, D.2    Daeffler, R.3    Osmani, A.4    Kuesters, E.5    Schmid, E.6
  • 169
    • 84892881928 scopus 로고    scopus 로고
    • Discovery of E7389: a fully synthetic macrocyclic ketone analog of halichondrin B
    • CRC Press/Taylor and Francis, Boca Raton, FL, G.M. Cragg, D.G.I. Kingston, D.J. Newman (Eds.), 2nd ed.
    • Yu M.J., Kishi Y., Littlefield B.A. Discovery of E7389: a fully synthetic macrocyclic ketone analog of halichondrin B. Anticancer agents from natural products 2012, 317-345. CRC Press/Taylor and Francis, Boca Raton, FL. 2nd ed. G.M. Cragg, D.G.I. Kingston, D.J. Newman (Eds.).
    • (2012) Anticancer agents from natural products , pp. 317-345
    • Yu, M.J.1    Kishi, Y.2    Littlefield, B.A.3
  • 170
    • 67650675111 scopus 로고    scopus 로고
    • Impact of natural products on developing new anti-cancer agents
    • Cragg G.M., Grothaus P.G., Newman D.J. Impact of natural products on developing new anti-cancer agents. Chem Rev 2009, 109:3012-3043.
    • (2009) Chem Rev , vol.109 , pp. 3012-3043
    • Cragg, G.M.1    Grothaus, P.G.2    Newman, D.J.3
  • 172
    • 84860354911 scopus 로고    scopus 로고
    • Strategies and challenges involved in the discovery of new chemical entities during early-stage tuberculosis drug discovery
    • Coxon G.D., Cooper C.B., Gillespie S.H., McHugh T.D. Strategies and challenges involved in the discovery of new chemical entities during early-stage tuberculosis drug discovery. J Infect Dis 2012, 205:S258-S264.
    • (2012) J Infect Dis , vol.205 , pp. S258-S264
    • Coxon, G.D.1    Cooper, C.B.2    Gillespie, S.H.3    McHugh, T.D.4
  • 173
    • 37049229035 scopus 로고
    • Inhibition of the renin-angiotensinogen reaction by pepstatin
    • Gross F., Lazar J., Orth H. Inhibition of the renin-angiotensinogen reaction by pepstatin. Science 1972, 175:656.
    • (1972) Science , vol.175 , pp. 656
    • Gross, F.1    Lazar, J.2    Orth, H.3
  • 174
    • 0024535339 scopus 로고
    • Human immunodeficiency virus protease. Bacterial expression and characterization of the purified aspartic protease
    • Darke P.L., Leu C.-T., Davis L.J., Heimbach J.C., Diehl R.E., Hill W.S., et al. Human immunodeficiency virus protease. Bacterial expression and characterization of the purified aspartic protease. J Biol Chem 1989, 264:2307-2312.
    • (1989) J Biol Chem , vol.264 , pp. 2307-2312
    • Darke, P.L.1    Leu, C.-T.2    Davis, L.J.3    Heimbach, J.C.4    Diehl, R.E.5    Hill, W.S.6
  • 175
    • 0000273282 scopus 로고
    • A stereocontrolled synthesis of hydroxyethylene dipeptide isosteres using novel, chiral aminoalkyl epoxides and .gamma.-(aminoalkyl)-.gamma.-lactones
    • Evans B.E., Rittle K.E., Homnick C.F., Springer J.P., Hirshfield J., Veber D.F. A stereocontrolled synthesis of hydroxyethylene dipeptide isosteres using novel, chiral aminoalkyl epoxides and .gamma.-(aminoalkyl)-.gamma.-lactones. J Org Chem 1985, 50:4615-4625.
    • (1985) J Org Chem , vol.50 , pp. 4615-4625
    • Evans, B.E.1    Rittle, K.E.2    Homnick, C.F.3    Springer, J.P.4    Hirshfield, J.5    Veber, D.F.6
  • 176
    • 0026010259 scopus 로고
    • Design and synthesis of HIV protease inhibitors. Variations of the carboxyterminus of the HIV protease inhibitor L-682,679
    • DeSolms S.J., Giuliani E.A., Guare J.P., Vacca J.P., Sanders W.M., Graham S.L., et al. Design and synthesis of HIV protease inhibitors. Variations of the carboxyterminus of the HIV protease inhibitor L-682,679. J Med Chem 1991, 34:2852-2857.
    • (1991) J Med Chem , vol.34 , pp. 2852-2857
    • DeSolms, S.J.1    Giuliani, E.A.2    Guare, J.P.3    Vacca, J.P.4    Sanders, W.M.5    Graham, S.L.6
  • 178
    • 0014211618 scopus 로고
    • On the size of the active site of proteases. I. Papain
    • Schechter I., Berger A. On the size of the active site of proteases. I. Papain. Biochem Biophys Res Commun 1967, 27:157-162.
    • (1967) Biochem Biophys Res Commun , vol.27 , pp. 157-162
    • Schechter, I.1    Berger, A.2
  • 179
    • 0033941893 scopus 로고    scopus 로고
    • Structure-based drug design: the discovery of novel non-peptide orally active inhibitors of human renin
    • Rahuel J., Rasetti V., Maibaum J., Rueger H., Goschke R., Cohen N.-C., et al. Structure-based drug design: the discovery of novel non-peptide orally active inhibitors of human renin. Chem Biol 2000, 7:493-504.
    • (2000) Chem Biol , vol.7 , pp. 493-504
    • Rahuel, J.1    Rasetti, V.2    Maibaum, J.3    Rueger, H.4    Goschke, R.5    Cohen, N.-C.6
  • 181
    • 33749985149 scopus 로고    scopus 로고
    • Oral renin inhibitors
    • Stassen J.A., Li Y., Richart T. Oral renin inhibitors. Lancet 2006, 368:1449-1456.
    • (2006) Lancet , vol.368 , pp. 1449-1456
    • Stassen, J.A.1    Li, Y.2    Richart, T.3
  • 182
    • 78149259520 scopus 로고    scopus 로고
    • Direct renin inhibiotrs as a new therapy for hypertension
    • Webb R.L., Schiering N., Sedrani R., Maibaum J. Direct renin inhibiotrs as a new therapy for hypertension. J Med Chem 2010, 53:7490-7520.
    • (2010) J Med Chem , vol.53 , pp. 7490-7520
    • Webb, R.L.1    Schiering, N.2    Sedrani, R.3    Maibaum, J.4
  • 184
    • 84863107521 scopus 로고    scopus 로고
    • Dual inhibitors for aspartic proteases HIV-1 PR and Renin: advancements in AIDS-hypertension-diabetes via molecular dynamics, inhibition assays, and binding free energy calculations
    • Tzoupis H., Leonis G., Megariotis G., Supuran C.T., Mavromoustakos T., Papadopoulos M.G. Dual inhibitors for aspartic proteases HIV-1 PR and Renin: advancements in AIDS-hypertension-diabetes via molecular dynamics, inhibition assays, and binding free energy calculations. J Med Chem 2012, 55:5784-5796.
    • (2012) J Med Chem , vol.55 , pp. 5784-5796
    • Tzoupis, H.1    Leonis, G.2    Megariotis, G.3    Supuran, C.T.4    Mavromoustakos, T.5    Papadopoulos, M.G.6
  • 185
    • 84867733139 scopus 로고    scopus 로고
    • A total synthesis of aliskiren
    • Nam G., Ko S.Y. A total synthesis of aliskiren. Helv Chim Acta 2012, 95:1937-1945.
    • (2012) Helv Chim Acta , vol.95 , pp. 1937-1945
    • Nam, G.1    Ko, S.Y.2
  • 186
    • 84904330469 scopus 로고    scopus 로고
    • Structure-based design of substituted piperidines as a new class of highly efficacious oral direct renin inhibitors
    • Ehara T., Irie O., Kosaka T., Kanazawa T., Breitenstein W., Grosche P., et al. Structure-based design of substituted piperidines as a new class of highly efficacious oral direct renin inhibitors. ACS Med Chem Lett 2014, 5:787-792.
    • (2014) ACS Med Chem Lett , vol.5 , pp. 787-792
    • Ehara, T.1    Irie, O.2    Kosaka, T.3    Kanazawa, T.4    Breitenstein, W.5    Grosche, P.6
  • 187
    • 84905734495 scopus 로고    scopus 로고
    • Solid-phase peptide synthesis: an overview focused on the preparation of biologically relevant peptides
    • Palomo J.M. Solid-phase peptide synthesis: an overview focused on the preparation of biologically relevant peptides. RSC Adv 2014, 4:32658-32672.
    • (2014) RSC Adv , vol.4 , pp. 32658-32672
    • Palomo, J.M.1
  • 188
    • 34547828238 scopus 로고    scopus 로고
    • NCX 6560: a nitric oxide-releasing derivative of atorvastatin, inhibits cholesterol biosynthesis and shows anti-inflammatory and anti-thrombotic properties
    • Momi S., Impagnatiello F., Guzzetta M., Caracchini R., Guglielmini G., Olivieri R., et al. NCX 6560: a nitric oxide-releasing derivative of atorvastatin, inhibits cholesterol biosynthesis and shows anti-inflammatory and anti-thrombotic properties. Eur J Pharmacol 2007, 570:115-124.
    • (2007) Eur J Pharmacol , vol.570 , pp. 115-124
    • Momi, S.1    Impagnatiello, F.2    Guzzetta, M.3    Caracchini, R.4    Guglielmini, G.5    Olivieri, R.6
  • 189
    • 84887360636 scopus 로고    scopus 로고
    • Nitric oxide-donating atorvastatin attenuates neutrophil recruitment during vascular inflammation independent of changes in plasma cholesterol
    • Baetta R., Granata A., Miglietta D., Oliva F., Arnaboldi L., Bonomo A., et al. Nitric oxide-donating atorvastatin attenuates neutrophil recruitment during vascular inflammation independent of changes in plasma cholesterol. Cardiovasc Drugs Ther 2013, 27:211-219.
    • (2013) Cardiovasc Drugs Ther , vol.27 , pp. 211-219
    • Baetta, R.1    Granata, A.2    Miglietta, D.3    Oliva, F.4    Arnaboldi, L.5    Bonomo, A.6
  • 190
    • 84877139699 scopus 로고    scopus 로고
    • A highly productive, whole cell DERA chemoenzymatic process for production of key lactonized side-chain intermediates in statin synthesis
    • Oslaj M., Cluzeau J., Orkic D., Kopitar G., Mrak P., Casar Z. A highly productive, whole cell DERA chemoenzymatic process for production of key lactonized side-chain intermediates in statin synthesis. PLoS one 2013, 8:e62250.
    • (2013) PLoS one , vol.8 , pp. e62250
    • Oslaj, M.1    Cluzeau, J.2    Orkic, D.3    Kopitar, G.4    Mrak, P.5    Casar, Z.6
  • 191
    • 84902000106 scopus 로고    scopus 로고
    • Engineered, highly productive biosynthesis of artificial, lactonized statin side-chain building blocks: the hidden potential of Escherichia coli unleashed
    • Vajdic T., Oslaj M., Kopitar G., Mrak P. Engineered, highly productive biosynthesis of artificial, lactonized statin side-chain building blocks: the hidden potential of Escherichia coli unleashed. Metab Eng 2014, 24:160-172.
    • (2014) Metab Eng , vol.24 , pp. 160-172
    • Vajdic, T.1    Oslaj, M.2    Kopitar, G.3    Mrak, P.4
  • 192
    • 4644336659 scopus 로고    scopus 로고
    • ISA-247 - Calcineurin inhibitor treatment of renal transplant rejection treatment of psoriasis
    • McIntyre J.A., Castaner J. ISA-247 - Calcineurin inhibitor treatment of renal transplant rejection treatment of psoriasis. Drugs Future 2004, 29:680-686.
    • (2004) Drugs Future , vol.29 , pp. 680-686
    • McIntyre, J.A.1    Castaner, J.2
  • 193
    • 84655163434 scopus 로고    scopus 로고
    • Organozirconium chemistry on cyclosporin: a novel process for the highly stereoselective synthesis of (E)-ISA247 (Voclosporin) and close analogues
    • Maeng J.H., Yang Z.C., Manning D.D., Masih L., Cao Y.Y., Pattamana K.G., et al. Organozirconium chemistry on cyclosporin: a novel process for the highly stereoselective synthesis of (E)-ISA247 (Voclosporin) and close analogues. Synthesis 2012, 44:63-68.
    • (2012) Synthesis , vol.44 , pp. 63-68
    • Maeng, J.H.1    Yang, Z.C.2    Manning, D.D.3    Masih, L.4    Cao, Y.Y.5    Pattamana, K.G.6
  • 194
    • 0028943870 scopus 로고
    • Design, synthesis, and structure-activity relationships of 2-substituted-2-amino-1,3-propanediols - discovery of a novel immunosuppressant, FTY720
    • Adachi K., Kohara T., Nakao N., Arita M., Chiba K., Mishina T., et al. Design, synthesis, and structure-activity relationships of 2-substituted-2-amino-1,3-propanediols - discovery of a novel immunosuppressant, FTY720. Bioorg Med Chem Lett 1995, 5:853-856.
    • (1995) Bioorg Med Chem Lett , vol.5 , pp. 853-856
    • Adachi, K.1    Kohara, T.2    Nakao, N.3    Arita, M.4    Chiba, K.5    Mishina, T.6
  • 195
    • 79955408396 scopus 로고    scopus 로고
    • Fingolimod (FTY720): a recently approved multiple sclerosis drug based on a fungal secondary metabolite
    • Strader C.R., Pearce C.J., Oberlies N.H. Fingolimod (FTY720): a recently approved multiple sclerosis drug based on a fungal secondary metabolite. J Nat Prod 2011, 74:900-907.
    • (2011) J Nat Prod , vol.74 , pp. 900-907
    • Strader, C.R.1    Pearce, C.J.2    Oberlies, N.H.3
  • 197
    • 84939835153 scopus 로고    scopus 로고
    • FTY720/Fingolimod, a sphingosine analogue, reduces amyloid-beta production in neurons.
    • Takasugi N, Sasaki T, Ebinuma I, Osawa S, Isshiki H, Takeo K, et al. FTY720/Fingolimod, a sphingosine analogue, reduces amyloid-beta production in neurons.
    • Takasugi, N.1    Sasaki, T.2    Ebinuma, I.3    Osawa, S.4    Isshiki, H.5    Takeo, K.6
  • 199
    • 27744534829 scopus 로고    scopus 로고
    • (5R)-5-hydroxytriptolide (LLDT-8), a novel triptolide analog mediates immunosuppressive effects in vitro and in vivo
    • Zhou R., Zhang F., He P.L., Zhou W.L., Wu Q.L., Xu J.Y., et al. (5R)-5-hydroxytriptolide (LLDT-8), a novel triptolide analog mediates immunosuppressive effects in vitro and in vivo. Int Immunopharmacol 2005, 5:1895-1903.
    • (2005) Int Immunopharmacol , vol.5 , pp. 1895-1903
    • Zhou, R.1    Zhang, F.2    He, P.L.3    Zhou, W.L.4    Wu, Q.L.5    Xu, J.Y.6
  • 200
    • 84865964525 scopus 로고    scopus 로고
    • Immunosuppressant discovery from Tripterygium wilfordii Hook f: the novel triptolide analog (5R)-5-hydroxytriptolide (LLDT-8)
    • Tang W., Zuo J.P. Immunosuppressant discovery from Tripterygium wilfordii Hook f: the novel triptolide analog (5R)-5-hydroxytriptolide (LLDT-8). Acta Pharmacol Sin 2012, 33:1112-1118.
    • (2012) Acta Pharmacol Sin , vol.33 , pp. 1112-1118
    • Tang, W.1    Zuo, J.P.2
  • 201
    • 0027367598 scopus 로고
    • Reduction of MS-related scotoma by new class of potassium channel blockers from Ruta graveolens
    • Bohuslavizki K.H., Hinck-Kneip C., Kniep A., Koppenhofer E., Reimers A. Reduction of MS-related scotoma by new class of potassium channel blockers from Ruta graveolens. Neuroopthalmol 1993, 13:191-198.
    • (1993) Neuroopthalmol , vol.13 , pp. 191-198
    • Bohuslavizki, K.H.1    Hinck-Kneip, C.2    Kniep, A.3    Koppenhofer, E.4    Reimers, A.5
  • 202
    • 0028046402 scopus 로고
    • Mode of action of psoralens, benzofurans, acridones and coumarins on the ionic currents in intact myelinated nerve firbres and its significance in demyelating diseases
    • Bohuslavizki K.H., Hansel W., Kniep A., Koppenhofer E., Niemoller K., Sanmann K. Mode of action of psoralens, benzofurans, acridones and coumarins on the ionic currents in intact myelinated nerve firbres and its significance in demyelating diseases. Gen Physiol Biophys 1994, 13:309-328.
    • (1994) Gen Physiol Biophys , vol.13 , pp. 309-328
    • Bohuslavizki, K.H.1    Hansel, W.2    Kniep, A.3    Koppenhofer, E.4    Niemoller, K.5    Sanmann, K.6
  • 203
    • 27544454783 scopus 로고    scopus 로고
    • Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of effector memory T cells in autoimmune diseases
    • Schmitz A., Sankaranarayanan A., Azam P., Schmidt-Lassen K., Homerick D., Hänsel W., et al. Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of effector memory T cells in autoimmune diseases. Mol Pharmacol 2005, 68:1254-1270.
    • (2005) Mol Pharmacol , vol.68 , pp. 1254-1270
    • Schmitz, A.1    Sankaranarayanan, A.2    Azam, P.3    Schmidt-Lassen, K.4    Homerick, D.5    Hänsel, W.6
  • 205
    • 33845903833 scopus 로고    scopus 로고
    • Drugs for bad bugs: confronting the challenges of antibacterial discovery
    • Payne D.J., Gwynn M.N., Holmes D.J., Pompliano D.L. Drugs for bad bugs: confronting the challenges of antibacterial discovery. Nat Rev Drug Discov 2007, 6:29-40.
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 29-40
    • Payne, D.J.1    Gwynn, M.N.2    Holmes, D.J.3    Pompliano, D.L.4
  • 206
    • 33748767151 scopus 로고    scopus 로고
    • Macrolide antibiotic, treatment of C difficile-associated diarrhea
    • Revill P., Serradell N., Bolos J., Tiacumicin B. Macrolide antibiotic, treatment of C difficile-associated diarrhea. Drugs Future 2006, 31:494-497.
    • (2006) Drugs Future , vol.31 , pp. 494-497
    • Revill, P.1    Serradell, N.2    Bolos, J.3    Tiacumicin, B.4
  • 207
    • 3042658714 scopus 로고    scopus 로고
    • Hydrophobic vancomycin derivatives with improved ADME properties: discovery of telavancin (TD-6424)
    • Leadbetter M.R., Adams S.M., Bazzini B., Fatheree P.R., Karr D.E., Krause K.M., et al. Hydrophobic vancomycin derivatives with improved ADME properties: discovery of telavancin (TD-6424). J Antibiot 2004, 57:326-336.
    • (2004) J Antibiot , vol.57 , pp. 326-336
    • Leadbetter, M.R.1    Adams, S.M.2    Bazzini, B.3    Fatheree, P.R.4    Karr, D.E.5    Krause, K.M.6
  • 208
    • 0029081629 scopus 로고
    • New semisynthetic glycopeptides MDL 63,246 and MDL 63,042, and other amide derivatives of antibiotic A-40,926 active against highly glycopeptide-resistant VanA enterococci
    • Malabarba A., Ciabatti R., Scotti R., Goldstein B.P., Ferrari P., Kurz M., et al. New semisynthetic glycopeptides MDL 63,246 and MDL 63,042, and other amide derivatives of antibiotic A-40,926 active against highly glycopeptide-resistant VanA enterococci. J Antibiot 1995, 48:869-883.
    • (1995) J Antibiot , vol.48 , pp. 869-883
    • Malabarba, A.1    Ciabatti, R.2    Scotti, R.3    Goldstein, B.P.4    Ferrari, P.5    Kurz, M.6
  • 210
    • 8944258105 scopus 로고    scopus 로고
    • Reductive alkylation of glycopeptide antibiotics: synthesis and antibacterial activity
    • Cooper R.D., Snyder N.J., Zweifel M.J., Staszak M.A., Wilkie S.C., Nicas T.I., et al. Reductive alkylation of glycopeptide antibiotics: synthesis and antibacterial activity. J Antibiot 1996, 49:575-581.
    • (1996) J Antibiot , vol.49 , pp. 575-581
    • Cooper, R.D.1    Snyder, N.J.2    Zweifel, M.J.3    Staszak, M.A.4    Wilkie, S.C.5    Nicas, T.I.6
  • 211
    • 84883191725 scopus 로고    scopus 로고
    • Emerging drugs on methicillin-resistant Staphylococcus aureus
    • Liapikou A., Torres A. Emerging drugs on methicillin-resistant Staphylococcus aureus. Exp Opin Emerg Drugs 2013, 18:291-305.
    • (2013) Exp Opin Emerg Drugs , vol.18 , pp. 291-305
    • Liapikou, A.1    Torres, A.2
  • 212
    • 51349140042 scopus 로고    scopus 로고
    • Therapeutic effect against human xenograft tumors in nude mice by the third generation microtubule stabilizing epothilones
    • Chou T.-C., Zhang X., Zhong Z.-Y., Li Y., Feng L., Eng S., et al. Therapeutic effect against human xenograft tumors in nude mice by the third generation microtubule stabilizing epothilones. Proc Natl Acad Sci U S A 2008, 105:13157-13162.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 13157-13162
    • Chou, T.-C.1    Zhang, X.2    Zhong, Z.-Y.3    Li, Y.4    Feng, L.5    Eng, S.6
  • 213
    • 77956034361 scopus 로고    scopus 로고
    • On the reach of chemical synthesis: creation of a mini-pipeline from an academic laboratory
    • Wilson R.M., Danishefsky S.J. On the reach of chemical synthesis: creation of a mini-pipeline from an academic laboratory. Angew Chem Int Ed 2010, 49:6032-6056.
    • (2010) Angew Chem Int Ed , vol.49 , pp. 6032-6056
    • Wilson, R.M.1    Danishefsky, S.J.2
  • 214
    • 84926467435 scopus 로고    scopus 로고
    • Chemistry and biology of epothilones
    • Wiley-VCH Verlag, Weinheim, Germany, S. Hanessian (Ed.)
    • Altmann K.-H., Schinzer D. Chemistry and biology of epothilones. Natural products in medicinal chemistry 2014, 83-125. Wiley-VCH Verlag, Weinheim, Germany. S. Hanessian (Ed.).
    • (2014) Natural products in medicinal chemistry , pp. 83-125
    • Altmann, K.-H.1    Schinzer, D.2
  • 215
    • 79955907533 scopus 로고    scopus 로고
    • Chemistry and biology of kahalalides
    • Gao J., Hamann M.T. Chemistry and biology of kahalalides. Chem Rev 2011, 111:3208-3235.
    • (2011) Chem Rev , vol.111 , pp. 3208-3235
    • Gao, J.1    Hamann, M.T.2
  • 216
    • 81555208983 scopus 로고    scopus 로고
    • Meta-omic characterization of the marine Invertebrate microbial consortium that produces the chemotherapeutic natural product ET-743
    • Rath C.M., Janto B., Earl J., Ahmed A., Hu F.Z., Hiller L., et al. Meta-omic characterization of the marine Invertebrate microbial consortium that produces the chemotherapeutic natural product ET-743. ACS Chem Biol 2011, 6:1244-1256.
    • (2011) ACS Chem Biol , vol.6 , pp. 1244-1256
    • Rath, C.M.1    Janto, B.2    Earl, J.3    Ahmed, A.4    Hu, F.Z.5    Hiller, L.6
  • 217
    • 0015211527 scopus 로고
    • Plant antitumor agents. VI. The Isolation and structure of Taxol, a novel antileukemic and antitumor agent from Taxus brevifolia
    • Wani M.C., Taylor H.L., Wall M.E., Coggon P., McPhail A.T. Plant antitumor agents. VI. The Isolation and structure of Taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. J Am Chem Soc 1971, 93:2325-2327.
    • (1971) J Am Chem Soc , vol.93 , pp. 2325-2327
    • Wani, M.C.1    Taylor, H.L.2    Wall, M.E.3    Coggon, P.4    McPhail, A.T.5
  • 218
    • 0018387446 scopus 로고
    • Promotion of microtubule assembly in vitro by taxol
    • Schiff P.B., Fant J., Horwitz S.B. Promotion of microtubule assembly in vitro by taxol. Nature 1979, 277:665-667.
    • (1979) Nature , vol.277 , pp. 665-667
    • Schiff, P.B.1    Fant, J.2    Horwitz, S.B.3
  • 219
    • 77956791953 scopus 로고
    • Taxol: from discovery to therapeutic use
    • Academic Press, Academic Press, San Diego, J.A. Bristol (Ed.)
    • Suffness M. Taxol: from discovery to therapeutic use. Ann Rep Med Chem 1993, 305-314. Academic Press, Academic Press, San Diego. J.A. Bristol (Ed.).
    • (1993) Ann Rep Med Chem , pp. 305-314
    • Suffness, M.1
  • 220
    • 67449100079 scopus 로고    scopus 로고
    • The top pharmaceuticals that changed the world
    • Jacoby M. The top pharmaceuticals that changed the world. C&E News 2005;83:(25), 120.
    • (2005) C&E News , vol.83 , Issue.25 , pp. 120
    • Jacoby, M.1
  • 221
    • 9144226265 scopus 로고    scopus 로고
    • Structure-activity relationships of taxoids
    • Taylor & Francis, London, H. Itokawa, K.-H. Lee
    • Wang X., Itokawa H., Lee K.-H. Structure-activity relationships of taxoids. Taxus: the genus taxus 2003, Taylor & Francis, London, p. 298-86. H. Itokawa, K.-H. Lee (Eds.).
    • (2003) Taxus: the genus taxus , pp. 298-386
    • Wang, X.1    Itokawa, H.2    Lee, K.-H.3
  • 222
    • 1442310087 scopus 로고    scopus 로고
    • A tale of two tumor targets: topoisomerase I and tubulin. The Wall and Wani contribution to cancer chemotherapy
    • Cragg G.M., Newman D.J. A tale of two tumor targets: topoisomerase I and tubulin. The Wall and Wani contribution to cancer chemotherapy. J Nat Prod 2004, 67:232-244.
    • (2004) J Nat Prod , vol.67 , pp. 232-244
    • Cragg, G.M.1    Newman, D.J.2
  • 223
    • 33751234911 scopus 로고    scopus 로고
    • Recent progress in the development of docetaxel and paclitaxel analogues
    • Dubois J. Recent progress in the development of docetaxel and paclitaxel analogues. Expert Opin Ther Patents 2006, 16:1481-1496.
    • (2006) Expert Opin Ther Patents , vol.16 , pp. 1481-1496
    • Dubois, J.1
  • 225
    • 84926483780 scopus 로고    scopus 로고
    • Taxol, taxoids, and related taxanes
    • Wiley-VCH Verlag, Weinheim, Germany, S. Hanessian (Ed.)
    • Ojima I., Kamath A., Seitz J.D. Taxol, taxoids, and related taxanes. Natural products in medicinal chemistry 2014, 127-180. Wiley-VCH Verlag, Weinheim, Germany. S. Hanessian (Ed.).
    • (2014) Natural products in medicinal chemistry , pp. 127-180
    • Ojima, I.1    Kamath, A.2    Seitz, J.D.3
  • 226
    • 0000052734 scopus 로고
    • Taxol and taxotere: discovery, chemistry, and structure-activity relationships
    • Guenard D., Gueritte-Voegelein F., Potier P. Taxol and taxotere: discovery, chemistry, and structure-activity relationships. Acc Chem Res 1993, 26:160-167.
    • (1993) Acc Chem Res , vol.26 , pp. 160-167
    • Guenard, D.1    Gueritte-Voegelein, F.2    Potier, P.3
  • 227
    • 33747887418 scopus 로고    scopus 로고
    • Abraxane, a novel Cremophor-free, albumin-bound particle form of paclitaxel for the treatment of advanced non-small-cell lung cancer
    • Green M.R., Manikhas G.M., Orlov S., Afanasyev B., Makhson A.M., Bhar P., et al. Abraxane, a novel Cremophor-free, albumin-bound particle form of paclitaxel for the treatment of advanced non-small-cell lung cancer. Ann Oncol 2006, 17:1263-1268.
    • (2006) Ann Oncol , vol.17 , pp. 1263-1268
    • Green, M.R.1    Manikhas, G.M.2    Orlov, S.3    Afanasyev, B.4    Makhson, A.M.5    Bhar, P.6
  • 229
    • 84885563888 scopus 로고    scopus 로고
    • Novel taxanes: cabazitaxel case study
    • Wiley-VCH Verlag, Weinheim, Germany, J. Fischer, C.R. Ganellin, D.P. Rotella
    • Bouchard H., Semiond D., Risse M.-L., Vrignaud P. Novel taxanes: cabazitaxel case study. Analogue-based drug discovery III 2013, 319-341. Wiley-VCH Verlag, Weinheim, Germany. J. Fischer, C.R. Ganellin, D.P. Rotella (Eds.).
    • (2013) Analogue-based drug discovery III , pp. 319-341
    • Bouchard, H.1    Semiond, D.2    Risse, M.-L.3    Vrignaud, P.4
  • 230
    • 84888219788 scopus 로고    scopus 로고
    • Larotaxel with Cisplatin in the first-line treatment of locally advanced/metastatic urothelial tract or bladder cancer: a randomized, active-controlled, phase III trial (CILAB)
    • Sternberg C.N., Skoneczna I.A., Castellano D., Theodore C., Blais N., Voog E., et al. Larotaxel with Cisplatin in the first-line treatment of locally advanced/metastatic urothelial tract or bladder cancer: a randomized, active-controlled, phase III trial (CILAB). Oncology 2013, 85:208-215.
    • (2013) Oncology , vol.85 , pp. 208-215
    • Sternberg, C.N.1    Skoneczna, I.A.2    Castellano, D.3    Theodore, C.4    Blais, N.5    Voog, E.6
  • 231
    • 59149092286 scopus 로고    scopus 로고
    • Phase II study of ortataxel in taxane-resistant breast cancer
    • Beer M., Lenaz L., Amadori D. Phase II study of ortataxel in taxane-resistant breast cancer. J Clin Oncol 2008, 26. Abstract 1066.
    • (2008) J Clin Oncol , pp. 26
    • Beer, M.1    Lenaz, L.2    Amadori, D.3
  • 232
    • 84866735036 scopus 로고    scopus 로고
    • Phase II study of NK105, a paclitaxel-incorporating micellar nanoparticle, for previously treated advanced or recurrent gastric cancer
    • Kato K., Chin K., Yoshikawa T., Yamaguchi K., Tsuji Y., Esaki T., et al. Phase II study of NK105, a paclitaxel-incorporating micellar nanoparticle, for previously treated advanced or recurrent gastric cancer. Invest New Drugs 2012, 30:1621-1627.
    • (2012) Invest New Drugs , vol.30 , pp. 1621-1627
    • Kato, K.1    Chin, K.2    Yoshikawa, T.3    Yamaguchi, K.4    Tsuji, Y.5    Esaki, T.6
  • 233
    • 43649092756 scopus 로고    scopus 로고
    • Phase III trial comparing paclitaxel poliglumex vs docetaxel in the second-line treatment of non-small-cell lung cancer
    • Paz-Ares L., Ross H., O'Brien M., Riviere A., Gatzemeier U., Von Pawel J., et al. Phase III trial comparing paclitaxel poliglumex vs docetaxel in the second-line treatment of non-small-cell lung cancer. Br J Cancer 2008, 98:1608-1613.
    • (2008) Br J Cancer , vol.98 , pp. 1608-1613
    • Paz-Ares, L.1    Ross, H.2    O'Brien, M.3    Riviere, A.4    Gatzemeier, U.5    Von Pawel, J.6
  • 235
    • 0026011121 scopus 로고
    • The chemical and biological route from podophyllotoxin glucoside to etoposide: ninth cain memorial award lecture
    • Stahelin H.F., von Wartburg A. The chemical and biological route from podophyllotoxin glucoside to etoposide: ninth cain memorial award lecture. Cancer Res 1991, 51:5-15.
    • (1991) Cancer Res , vol.51 , pp. 5-15
    • Stahelin, H.F.1    von Wartburg, A.2
  • 236
    • 0032168167 scopus 로고    scopus 로고
    • Etoposide: four decades of development of a topoisomerase II inhibitor
    • Hande K.R. Etoposide: four decades of development of a topoisomerase II inhibitor. Eur J Cancer 1998, 34:1514-1521.
    • (1998) Eur J Cancer , vol.34 , pp. 1514-1521
    • Hande, K.R.1
  • 237
    • 33544458497 scopus 로고    scopus 로고
    • Podophyllotoxin and analogs
    • CRC Press, Boca Raton, FL, G.M. Cragg, D.G.I. Kingston, D.J. Newman (Eds.), 2nd ed.
    • Lee K.-H., Xiao Z. Podophyllotoxin and analogs. Anticancer agents from natural products 2012, 95-122. CRC Press, Boca Raton, FL. 2nd ed. G.M. Cragg, D.G.I. Kingston, D.J. Newman (Eds.).
    • (2012) Anticancer agents from natural products , pp. 95-122
    • Lee, K.-H.1    Xiao, Z.2
  • 238
    • 84981860375 scopus 로고
    • Role of chance observation in chemotherapy: vinca rosea
    • Noble R.L., Beer C.T., Cutts J.H. Role of chance observation in chemotherapy: vinca rosea. Ann NY Acad Sci 1958, 76:882-894.
    • (1958) Ann NY Acad Sci , vol.76 , pp. 882-894
    • Noble, R.L.1    Beer, C.T.2    Cutts, J.H.3
  • 239
    • 0028802499 scopus 로고
    • The role of vindesine in oncology: recommendations after 10 years' experience
    • Dancey J., Steward W.P. The role of vindesine in oncology: recommendations after 10 years' experience. Anti-Cancer Drugs 1995, 6:625-636.
    • (1995) Anti-Cancer Drugs , vol.6 , pp. 625-636
    • Dancey, J.1    Steward, W.P.2
  • 240
    • 84878442860 scopus 로고    scopus 로고
    • Long-term survival results of a randomized phase III trial of vinflunine plus best supportive care versus best supportive care alone in advanced urothelial carcinoma patients after failure of platinum-based chemotherapy
    • Bellmunt J., Fougeray R., Rosenberg J.E., von der Maase H., Schutz F.A., Salhi Y., et al. Long-term survival results of a randomized phase III trial of vinflunine plus best supportive care versus best supportive care alone in advanced urothelial carcinoma patients after failure of platinum-based chemotherapy. Ann Oncol 2013, 24:1466-1472.
    • (2013) Ann Oncol , vol.24 , pp. 1466-1472
    • Bellmunt, J.1    Fougeray, R.2    Rosenberg, J.E.3    von der Maase, H.4    Schutz, F.A.5    Salhi, Y.6
  • 241
    • 33544468303 scopus 로고    scopus 로고
    • The vinca alkaloids
    • CRC Press, Boca Raton, FL, G.M. Cragg, D.G.I. Kingston, D.J. Newman (Eds.), 2nd ed.
    • Gueritte F., Fahy J. The vinca alkaloids. Anticancer agents from natural products 2012, 177-198. CRC Press, Boca Raton, FL. 2nd ed. G.M. Cragg, D.G.I. Kingston, D.J. Newman (Eds.).
    • (2012) Anticancer agents from natural products , pp. 177-198
    • Gueritte, F.1    Fahy, J.2
  • 242
    • 0031682217 scopus 로고    scopus 로고
    • Camptothecin and taxol: discovery to clinic
    • Wall M.E. Camptothecin and taxol: discovery to clinic. Med Res Rev 1998, 18:299-314.
    • (1998) Med Res Rev , vol.18 , pp. 299-314
    • Wall, M.E.1
  • 243
    • 84922070033 scopus 로고    scopus 로고
    • Camptothecin and its analogs
    • CRC Press, Boca Raton, FL, G.M. Cragg, D.G.I. Kingston, D.J. Newman (Eds.), 2nd ed.
    • Rahier N.J., Thomas C.J., Hecht S.M. Camptothecin and its analogs. Anticancer agents from natural products 2012, 5-25. CRC Press, Boca Raton, FL. 2nd ed. G.M. Cragg, D.G.I. Kingston, D.J. Newman (Eds.).
    • (2012) Anticancer agents from natural products , pp. 5-25
    • Rahier, N.J.1    Thomas, C.J.2    Hecht, S.M.3
  • 244
    • 84926442927 scopus 로고    scopus 로고
    • Camptothecin and Analogs
    • Wiley-VCH Verlag, Weinheim, Germany, S. Hanessian (Ed.)
    • Giannini G. Camptothecin and Analogs. Natural products in medicinal chemistry 2014, 181-224. Wiley-VCH Verlag, Weinheim, Germany. S. Hanessian (Ed.).
    • (2014) Natural products in medicinal chemistry , pp. 181-224
    • Giannini, G.1
  • 245
    • 84873617893 scopus 로고    scopus 로고
    • Ingenol mebutate: a new option for actinic keratosis treatment
    • Gras J. Ingenol mebutate: a new option for actinic keratosis treatment. Drugs Today 2013, 49:15-22.
    • (2013) Drugs Today , vol.49 , pp. 15-22
    • Gras, J.1
  • 246
    • 23044497194 scopus 로고    scopus 로고
    • Homoharringtonine and related compounds
    • CRC Press, Boca Raton, FL, G.M. Cragg, D.G.I. Kingston, D.J. Newman (Eds.), 2nd ed.
    • Itokawa H., Hitotsuyanagi Y., Lee K.-H. Homoharringtonine and related compounds. Anticancer agents from natural products 2012, 65-93. CRC Press, Boca Raton, FL. 2nd ed. G.M. Cragg, D.G.I. Kingston, D.J. Newman (Eds.).
    • (2012) Anticancer agents from natural products , pp. 65-93
    • Itokawa, H.1    Hitotsuyanagi, Y.2    Lee, K.-H.3
  • 247
    • 84898757160 scopus 로고    scopus 로고
    • Omacetaxine: a protein translation inhibitor for treatment of chronic myelogenous leukemia
    • Gandhi V., Plunkett W., Cortes J.E. Omacetaxine: a protein translation inhibitor for treatment of chronic myelogenous leukemia. Clin Cancer Res 2014, 20:1735-1740.
    • (2014) Clin Cancer Res , vol.20 , pp. 1735-1740
    • Gandhi, V.1    Plunkett, W.2    Cortes, J.E.3
  • 248
    • 23044497194 scopus 로고    scopus 로고
    • The discovery and development of the combretastatins
    • CRC Press, Boca Raton, FL, G.M. Cragg, D.G.I. Kingston, D.J. Newman (Eds.), 2nd ed.
    • Pinney K.G., Pettit G.R., Trawick M.L., Jelinek C., Chaplin D.J. The discovery and development of the combretastatins. Anticancer agents from natural products 2012, 27-63. CRC Press, Boca Raton, FL. 2nd ed. G.M. Cragg, D.G.I. Kingston, D.J. Newman (Eds.).
    • (2012) Anticancer agents from natural products , pp. 27-63
    • Pinney, K.G.1    Pettit, G.R.2    Trawick, M.L.3    Jelinek, C.4    Chaplin, D.J.5
  • 249
    • 77956301345 scopus 로고    scopus 로고
    • Combretastatin A4 phosphate: a novel vascular disrupting agent
    • Nagaiah G., Remick S.C. Combretastatin A4 phosphate: a novel vascular disrupting agent. Future Oncol 2010, 6:1219-1228.
    • (2010) Future Oncol , vol.6 , pp. 1219-1228
    • Nagaiah, G.1    Remick, S.C.2
  • 250
    • 0022709534 scopus 로고
    • Halichondrins - antitumor polyether macrolides from a marine sponge
    • Hirata Y., Uemura D. Halichondrins - antitumor polyether macrolides from a marine sponge. Pure Appl Chem 1986, 58:701-710.
    • (1986) Pure Appl Chem , vol.58 , pp. 701-710
    • Hirata, Y.1    Uemura, D.2
  • 251
    • 0026356420 scopus 로고
    • Antineoplastic agents. 219. Isolation and structure of the cell growth inhibitory constituents from the western Pacific marine sponge Axinella sp
    • Pettit G.R., Herald C.L., Boyd M.R., Leet J.E., Dufresne C., Doubek D.L., et al. Antineoplastic agents. 219. Isolation and structure of the cell growth inhibitory constituents from the western Pacific marine sponge Axinella sp. J Med Chem 1991, 34:3339-3340.
    • (1991) J Med Chem , vol.34 , pp. 3339-3340
    • Pettit, G.R.1    Herald, C.L.2    Boyd, M.R.3    Leet, J.E.4    Dufresne, C.5    Doubek, D.L.6
  • 254
    • 84882354548 scopus 로고    scopus 로고
    • From micrograms to grams: scale-up synthesis of eribulin mesylate
    • Yu M.J., Zheng W., Seletsky B.M. From micrograms to grams: scale-up synthesis of eribulin mesylate. Nat Prod Rep 2013, 30:1158-1164.
    • (2013) Nat Prod Rep , vol.30 , pp. 1158-1164
    • Yu, M.J.1    Zheng, W.2    Seletsky, B.M.3
  • 255
    • 84873411865 scopus 로고    scopus 로고
    • Process development of halaven®: synthesis of the C1-C13 fragment from d -(-)-gulono-1,4-lactone
    • Chase C.E., Fang F.G., Lewis B.M., Wilke G.D., Schnaderbeck M.J., Zhu X. Process development of halaven®: synthesis of the C1-C13 fragment from d -(-)-gulono-1,4-lactone. Synlett 2013, 24:323-326.
    • (2013) Synlett , vol.24 , pp. 323-326
    • Chase, C.E.1    Fang, F.G.2    Lewis, B.M.3    Wilke, G.D.4    Schnaderbeck, M.J.5    Zhu, X.6
  • 256
    • 84873571042 scopus 로고    scopus 로고
    • Process development of halaven®: synthesis of the C14-C35 fragment via iterative Nozaki-Hiyama-Kishi reaction-Williamson ether cyclization
    • Austad B.C., Benayoud F., Calkins T.L., Campagnaa S., Chase C.E., Choi H.-W., et al. Process development of halaven®: synthesis of the C14-C35 fragment via iterative Nozaki-Hiyama-Kishi reaction-Williamson ether cyclization. Synlett 2013, 24:327-332.
    • (2013) Synlett , vol.24 , pp. 327-332
    • Austad, B.C.1    Benayoud, F.2    Calkins, T.L.3    Campagnaa, S.4    Chase, C.E.5    Choi, H.-W.6
  • 257
    • 84873570526 scopus 로고    scopus 로고
    • Commercial manufacture of halaven®: chemoselective transformations en route to structurally complex macrocyclic ketones
    • Austad B.C., Calkins T.L., Chase C.E., Fang F.G., Horstmann T.E., Hu Y., et al. Commercial manufacture of halaven®: chemoselective transformations en route to structurally complex macrocyclic ketones. Synlett 2013, 24:333-337.
    • (2013) Synlett , vol.24 , pp. 333-337
    • Austad, B.C.1    Calkins, T.L.2    Chase, C.E.3    Fang, F.G.4    Horstmann, T.E.5    Hu, Y.6
  • 258
    • 84907042024 scopus 로고    scopus 로고
    • Combating malaria with plant molecules: a brief update
    • Negi A.S., Gupta A., Hamid A.A. Combating malaria with plant molecules: a brief update. Curr Med Chem 2014, 21:458-500.
    • (2014) Curr Med Chem , vol.21 , pp. 458-500
    • Negi, A.S.1    Gupta, A.2    Hamid, A.A.3
  • 260
    • 0021948029 scopus 로고
    • Qinghaosu (artemisinin): an antimalarial drug from China
    • Klayman D.L. Qinghaosu (artemisinin): an antimalarial drug from China. Science 1985, 228:1049-1055.
    • (1985) Science , vol.228 , pp. 1049-1055
    • Klayman, D.L.1
  • 262
    • 84891607293 scopus 로고    scopus 로고
    • A plausible mechanism for the antimalarial activity of artemisinin: a computational approach
    • Shandilya A., Chacko S., Jayaram B., Ghosh I. A plausible mechanism for the antimalarial activity of artemisinin: a computational approach. Sci Rep 2013, 3:2513.
    • (2013) Sci Rep , vol.3 , pp. 2513
    • Shandilya, A.1    Chacko, S.2    Jayaram, B.3    Ghosh, I.4
  • 263
    • 84876784070 scopus 로고    scopus 로고
    • High-level semi-synthetic production of the potent antimalarial artemisinin
    • Paddon C.J., Westfall P.J., Pitera D.J., Benjamin K., Fisher K., McPhee D., et al. High-level semi-synthetic production of the potent antimalarial artemisinin. Nature 2013, 496:528-532.
    • (2013) Nature , vol.496 , pp. 528-532
    • Paddon, C.J.1    Westfall, P.J.2    Pitera, D.J.3    Benjamin, K.4    Fisher, K.5    McPhee, D.6
  • 264
    • 84871637203 scopus 로고    scopus 로고
    • A facile and scalable synthesis of qinghaosu (artemisinin)
    • Chen H.-J., Han W.-B., Hao H.-D., Wu Y. A facile and scalable synthesis of qinghaosu (artemisinin). Tetrahedron 2013, 69:1112-1114.
    • (2013) Tetrahedron , vol.69 , pp. 1112-1114
    • Chen, H.-J.1    Han, W.-B.2    Hao, H.-D.3    Wu, Y.4
  • 267
    • 84875742946 scopus 로고    scopus 로고
    • Synthesis and antimalarial efficacy of two-carbon-linked, artemisinin-derived trioxane dimers in combination with known antimalarial drugs
    • Mott B.T., Tripathi A., Siegler M.A., Moore C.D., Sullivan D.J., Posner G.H. Synthesis and antimalarial efficacy of two-carbon-linked, artemisinin-derived trioxane dimers in combination with known antimalarial drugs. J Med Chem 2013, 56:2630-2641.
    • (2013) J Med Chem , vol.56 , pp. 2630-2641
    • Mott, B.T.1    Tripathi, A.2    Siegler, M.A.3    Moore, C.D.4    Sullivan, D.J.5    Posner, G.H.6
  • 268
    • 77954687214 scopus 로고    scopus 로고
    • Recent developments in research on terrestrial plants used for the treatment of malaria
    • Wright C.W. Recent developments in research on terrestrial plants used for the treatment of malaria. Nat Prod Rep 2010, 27:961-968.
    • (2010) Nat Prod Rep , vol.27 , pp. 961-968
    • Wright, C.W.1
  • 269
    • 79953093108 scopus 로고    scopus 로고
    • Antiplasmodial natural products
    • Nogueira C.R., Lopes L.M.X. Antiplasmodial natural products. Molecules 2011, 16:2146-2190.
    • (2011) Molecules , vol.16 , pp. 2146-2190
    • Nogueira, C.R.1    Lopes, L.M.X.2
  • 270
  • 271
    • 84893931872 scopus 로고    scopus 로고
    • Recent progress with microtubule stabilizers: new compounds, binding modes, and cellular activities
    • Rohena C.C., Mooberry S.L. Recent progress with microtubule stabilizers: new compounds, binding modes, and cellular activities. Nat Prod Rep 2014, 31:335-355.
    • (2014) Nat Prod Rep , vol.31 , pp. 335-355
    • Rohena, C.C.1    Mooberry, S.L.2
  • 274
    • 0024239320 scopus 로고
    • Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists
    • Evans B.E., Rittle K.E., Bock M.G., DiPardo R.M., Fredinger R.M., Whitter W.L., et al. Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists. J Med Chem 1988, 2235-2246.
    • (1988) J Med Chem , pp. 2235-2246
    • Evans, B.E.1    Rittle, K.E.2    Bock, M.G.3    DiPardo, R.M.4    Fredinger, R.M.5    Whitter, W.L.6
  • 275
    • 0034684250 scopus 로고    scopus 로고
    • Natural product-like combinatorial libraries based on privileged structures. 1. General principles and solid-phase synthesis of benzopyrans
    • Nicolaou K.C., Pfefferkorn J.A., Roecker A.J., Cao G.Q., Barluenga S., Mitchell H.J. Natural product-like combinatorial libraries based on privileged structures. 1. General principles and solid-phase synthesis of benzopyrans. J Am Chem Soc 2000, 122:9939-9953.
    • (2000) J Am Chem Soc , vol.122 , pp. 9939-9953
    • Nicolaou, K.C.1    Pfefferkorn, J.A.2    Roecker, A.J.3    Cao, G.Q.4    Barluenga, S.5    Mitchell, H.J.6
  • 276
    • 0034684225 scopus 로고    scopus 로고
    • Natural product-like combinatorial libraries based on privileged structures. 2. Construction of a 10,000-membered benzopyran library by directed split-and-pool chemistry using NanoKans and optical encoding
    • Nicolaou K.C., Pfefferkorn J.A., Mitchell H.J., Roecker A.J., Barluenga S., Cao G.Q., et al. Natural product-like combinatorial libraries based on privileged structures. 2. Construction of a 10,000-membered benzopyran library by directed split-and-pool chemistry using NanoKans and optical encoding. J Am Chem Soc 2000, 122:9954-9967.
    • (2000) J Am Chem Soc , vol.122 , pp. 9954-9967
    • Nicolaou, K.C.1    Pfefferkorn, J.A.2    Mitchell, H.J.3    Roecker, A.J.4    Barluenga, S.5    Cao, G.Q.6
  • 277
    • 0034684186 scopus 로고    scopus 로고
    • Natural product-like combinatorial libraries based on privileged structures. 3. The "libraries from libraries" principle for diversity enhancement of benzopyran libraries
    • Nicolaou K.C., Pfefferkorn J.A., Barluenga S., Mitchell H.J., Roecker A.J., Cao G.-Q. Natural product-like combinatorial libraries based on privileged structures. 3. The "libraries from libraries" principle for diversity enhancement of benzopyran libraries. J Am Chem Soc 2000, 122:9968-9976.
    • (2000) J Am Chem Soc , vol.122 , pp. 9968-9976
    • Nicolaou, K.C.1    Pfefferkorn, J.A.2    Barluenga, S.3    Mitchell, H.J.4    Roecker, A.J.5    Cao, G.-Q.6
  • 278
    • 0034681559 scopus 로고    scopus 로고
    • Selenium-based solid-phase synthesis of benzopyrans II: applications to combinatorial synthesis of medicinally relevant small organic molecules
    • Nicolaou K.C., Cao G.Q., Pfefferkorn J.A. Selenium-based solid-phase synthesis of benzopyrans II: applications to combinatorial synthesis of medicinally relevant small organic molecules. Angew Chem Int Ed 2000, 39:739-743.
    • (2000) Angew Chem Int Ed , vol.39 , pp. 739-743
    • Nicolaou, K.C.1    Cao, G.Q.2    Pfefferkorn, J.A.3
  • 279
    • 0037119336 scopus 로고    scopus 로고
    • From protein domains to drug candidates: natural products as guiding principles in the design and synthesis of compound libraries
    • Breinbauer R., Vetter I.R., Waldmann H. From protein domains to drug candidates: natural products as guiding principles in the design and synthesis of compound libraries. Angew Chem Int Ed 2002, 41:2878-2890.
    • (2002) Angew Chem Int Ed , vol.41 , pp. 2878-2890
    • Breinbauer, R.1    Vetter, I.R.2    Waldmann, H.3
  • 280
    • 17044421362 scopus 로고    scopus 로고
    • Protein structure similarity clustering and natural product structure as guiding principles in drug discovery
    • Koch M.A., Waldmann H. Protein structure similarity clustering and natural product structure as guiding principles in drug discovery. Drug Discov Today 2005, 10:471-483.
    • (2005) Drug Discov Today , vol.10 , pp. 471-483
    • Koch, M.A.1    Waldmann, H.2
  • 281
    • 84906766592 scopus 로고    scopus 로고
    • Biology-oriented synthesis: harnessing the power of evolution
    • Van Hattum H., Waldmann H. Biology-oriented synthesis: harnessing the power of evolution. J Am Chem Soc 2014, 136:11853-11859.
    • (2014) J Am Chem Soc , vol.136 , pp. 11853-11859
    • Van Hattum, H.1    Waldmann, H.2
  • 283
    • 32644445634 scopus 로고    scopus 로고
    • A common protein fold topology shared by flavonoid biosynthetic enzymes and therapeutic targets
    • McArdle B.M., Campitelli M.R., Quinn R.J. A common protein fold topology shared by flavonoid biosynthetic enzymes and therapeutic targets. J Nat Prod 2006, 69:14-17.
    • (2006) J Nat Prod , vol.69 , pp. 14-17
    • McArdle, B.M.1    Campitelli, M.R.2    Quinn, R.J.3
  • 284
    • 42949160050 scopus 로고    scopus 로고
    • Natural products as leads to potential drugs: an old process or the new hope for drug discovery?
    • Newman D.J. Natural products as leads to potential drugs: an old process or the new hope for drug discovery?. J Med Chem 2008, 51:2589-2599.
    • (2008) J Med Chem , vol.51 , pp. 2589-2599
    • Newman, D.J.1
  • 285
    • 0142147275 scopus 로고    scopus 로고
    • Generating diverse skeletons of small molecules combinatorially
    • Burke M.D., Berger E.M., Schreiber S.L. Generating diverse skeletons of small molecules combinatorially. Science 2003, 302:613-618.
    • (2003) Science , vol.302 , pp. 613-618
    • Burke, M.D.1    Berger, E.M.2    Schreiber, S.L.3
  • 286
    • 3042799070 scopus 로고    scopus 로고
    • A planning strategy for diversity-oriented synthesis
    • Burke M.D., Schreiber S.L. A planning strategy for diversity-oriented synthesis. Angew Chem Int Ed 2004, 43:46-58.
    • (2004) Angew Chem Int Ed , vol.43 , pp. 46-58
    • Burke, M.D.1    Schreiber, S.L.2
  • 287
    • 58149358949 scopus 로고    scopus 로고
    • Molecular diversity by design
    • Schreiber S.L. Molecular diversity by design. Nature 2009, 457:153-154.
    • (2009) Nature , vol.457 , pp. 153-154
    • Schreiber, S.L.1
  • 288
    • 84905744955 scopus 로고    scopus 로고
    • Wiley Blackwell, Oxford, UK, A. Osbourn, R.J.M. Goss, G.T. Carter
    • Natural products: discourse, diversity, and design 2014, Wiley Blackwell, Oxford, UK. A. Osbourn, R.J.M. Goss, G.T. Carter (Eds.).
    • (2014) Natural products: discourse, diversity, and design
  • 289
    • 84926430190 scopus 로고    scopus 로고
    • ILS-920: a rapamycin analog for ischemic stroke
    • Wiley Blackwell, Oxford, UK, A. Osbourn, R.J.M. Goss, G.T. Carter
    • Graziani E.I. ILS-920: a rapamycin analog for ischemic stroke. Natural products: discourse, diversity, and design 2014, 469-481. Wiley Blackwell, Oxford, UK. A. Osbourn, R.J.M. Goss, G.T. Carter (Eds.).
    • (2014) Natural products: discourse, diversity, and design , pp. 469-481
    • Graziani, E.I.1
  • 290
    • 84926483143 scopus 로고    scopus 로고
    • BC265: a nonquinone ansamycin HSP90 inhibitor developed using biosynthetic medicinal chemistry
    • Wiley Blackwell, Oxford, UK
    • Gregory M.A., Moss S.J., Wilkinson B. BC265: a nonquinone ansamycin HSP90 inhibitor developed using biosynthetic medicinal chemistry. Natural products: discourse, diversity, and design 2014, 2014:483-496. Wiley Blackwell, Oxford, UK.
    • (2014) Natural products: discourse, diversity, and design , vol.2014 , pp. 483-496
    • Gregory, M.A.1    Moss, S.J.2    Wilkinson, B.3
  • 292
    • 52449110026 scopus 로고    scopus 로고
    • Optimizing natural products by biosynthetic engineering: discovery of nonquinone Hsp90 inhibitors
    • Zhang M.-Q., Gaisser S., Nur-E-Alam M., Sheehan L.S., Vousden W.A., Gaitatzis N., et al. Optimizing natural products by biosynthetic engineering: discovery of nonquinone Hsp90 inhibitors. J Med Chem 2008, 51:5494-5497.
    • (2008) J Med Chem , vol.51 , pp. 5494-5497
    • Zhang, M.-Q.1    Gaisser, S.2    Nur-E-Alam, M.3    Sheehan, L.S.4    Vousden, W.A.5    Gaitatzis, N.6
  • 293
    • 50149086997 scopus 로고    scopus 로고
    • Applications of metabolomics in drug discovery and development
    • Wishart D.S. Applications of metabolomics in drug discovery and development. Drugs R D 2008, 9:307-332.
    • (2008) Drugs R D , vol.9 , pp. 307-332
    • Wishart, D.S.1
  • 294
    • 84861179772 scopus 로고    scopus 로고
    • Microbial strain prioritization using metabolomics tools for the discovery of natural products
    • Hou Y., Braun D.R., Michel C.R., Klassen J.L., Adnani N., Wyche T.P., et al. Microbial strain prioritization using metabolomics tools for the discovery of natural products. Anal Chem 2012, 84:4277-4283.
    • (2012) Anal Chem , vol.84 , pp. 4277-4283
    • Hou, Y.1    Braun, D.R.2    Michel, C.R.3    Klassen, J.L.4    Adnani, N.5    Wyche, T.P.6
  • 295
    • 84934441555 scopus 로고    scopus 로고
    • Metabolomics and dereplication strategies in natural products
    • Tawfike A.F., Viegelmann C., Edrada-Ebel R. Metabolomics and dereplication strategies in natural products. Methods Mol Biol 2013, 1055:227-244.
    • (2013) Methods Mol Biol , vol.1055 , pp. 227-244
    • Tawfike, A.F.1    Viegelmann, C.2    Edrada-Ebel, R.3
  • 296
    • 84880778468 scopus 로고    scopus 로고
    • Metabolomics for the rapid dereplication of bioactive compounds from natural sources
    • Yuliana N.D., Janhangir M., Verpoorte R., Choi Y.H. Metabolomics for the rapid dereplication of bioactive compounds from natural sources. Phytochem Rev 2013, 12:293-304.
    • (2013) Phytochem Rev , vol.12 , pp. 293-304
    • Yuliana, N.D.1    Janhangir, M.2    Verpoorte, R.3    Choi, Y.H.4
  • 297
    • 84900859146 scopus 로고    scopus 로고
    • Secondary metabolomics: the impact of mass spectrometry-based approaches on the discovery and characterization of microbial natural products
    • Krug D., Müller R. Secondary metabolomics: the impact of mass spectrometry-based approaches on the discovery and characterization of microbial natural products. Nat Prod Rep 2014, 31:768-783.
    • (2014) Nat Prod Rep , vol.31 , pp. 768-783
    • Krug, D.1    Müller, R.2
  • 299
    • 84904116803 scopus 로고    scopus 로고
    • Microbial metabolomics: innovation, application, insight
    • Aldridge B.A., Rhee K.Y. Microbial metabolomics: innovation, application, insight. Curr Opin Microbiol 2014, 19:90-96.
    • (2014) Curr Opin Microbiol , vol.19 , pp. 90-96
    • Aldridge, B.A.1    Rhee, K.Y.2
  • 300
    • 84908079780 scopus 로고    scopus 로고
    • A systematic analysis of biosynthetic gene clusters in the human microbiome reveals a common family of antibiotics
    • Donia M.S., Cimermancic P., Schulze C.J., Wieland Brown L.C., Martin J., Mitreva M., et al. A systematic analysis of biosynthetic gene clusters in the human microbiome reveals a common family of antibiotics. Cell 2014, 158:1402-1414.
    • (2014) Cell , vol.158 , pp. 1402-1414
    • Donia, M.S.1    Cimermancic, P.2    Schulze, C.J.3    Wieland Brown, L.C.4    Martin, J.5    Mitreva, M.6
  • 301
    • 84939779534 scopus 로고    scopus 로고
    • Mining microbes for promising therapies: warp Drive Bio has industrialized its genomics platform in its hunt for natural products
    • Vence T. Mining microbes for promising therapies: warp Drive Bio has industrialized its genomics platform in its hunt for natural products. Gen Eng Biotech News 2013 2013, 33:12-14.
    • (2013) Gen Eng Biotech News 2013 , vol.33 , pp. 12-14
    • Vence, T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.