Platensimycin is a selective FabF inhibitor with potent antibiotic properties

Nature

Volumn 441, Issue 7091, 2006, Pages 358-361

  Wang, Jun ^a   Soisson, Stephen M ^a   Young, Katherine ^a   Shoop, Wesley ^a,b   Kodali, Srinivas ^a   Galgoci, Andrew ^a   Painter, Ronald ^a   Parthasarathy, Gopalakrishnan ^a   Tang, Yui S ^a   Cummings, Richard ^a   Ha, Sookhee ^a   Dorso, Karen ^a   Motyl, Mary ^a   Jayasuriya, Hiranthi ^a   Ondeyka, John ^a   Herath, Kithsiri ^a   Zhang, Chaowei ^a   Hernandez, Lorraine ^a   Allocco, John ^a   Basilio, Ángela ^a   Tormo, José R ^a   Genilloud, Olga ^a   Vicente, Francisca ^a   Pelaez, Fernando ^a   Colwell, Lawrence ^a   Lee, Sang Ho ^a   Michael, Bruce ^a   Felcetto, Thomas ^a   Gill, Charles ^a   Silver, Lynn L ^a,c   Hermes, Jeffery D ^a   Bartizal, Ken ^a   Barrett, John ^a   Schmatz, Dennis ^a   Becker, Joseph W ^a   Cully, Doris ^a   Singh, Sheo B ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

^b DUPONT COMPANY   (United States)

^c LL Silver Consulting LLC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLATION; BACTERIA; BIOSYNTHESIS; CONFORMATIONS; PROTEINS; X RAY CRYSTALLOGRAPHY;

ANTIBIOTIC-RESISTANT STRAINS; PLATENSIMYCIN; STREPTOMYCES PLATENSIS; VIVO EFFICACY;

ANTIBIOTICS;

3 OXOACYL ACYL CARRIER PROTEIN SYNTHASE; ANTIBIOTIC AGENT; PLATENSIMYCIN; UNCLASSIFIED DRUG; ACETAMIDE DERIVATIVE; ADAMANTANE; AMINOBENZOIC ACID DERIVATIVE; AMINOGLYCOSIDE; ANILIDE; ANTIINFECTIVE AGENT; APOPROTEIN; BACTERIAL PROTEIN; LINEZOLID; LIPID; OXAZOLIDINONE DERIVATIVE;

ANTIBIOTIC RESISTANCE; ANTIBIOTICS; BACTERIAL DISEASE; FATTY ACID; LIPID; PROTEIN; RODENT;

ACYLATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; CONFORMATION; CONTROLLED STUDY; CROSS RESISTANCE; DRUG MECHANISM; DRUG POTENCY; DRUG TARGETING; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION; STREPTOMYCES; STREPTOMYCES PLATENSIS; X RAY CRYSTALLOGRAPHY; ANIMAL; BIOSYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; ENZYME SPECIFICITY; METABOLISM; MICROBIOLOGICAL EXAMINATION;

BACTERIA (MICROORGANISMS); POSIBACTERIA; STAPHYLOCOCCUS AUREUS; STREPTOMYCES PLATENSIS;

3-OXOACYL-(ACYL-CARRIER-PROTEIN) SYNTHASE; ACETAMIDES; ADAMANTANE; AMINOBENZOIC ACIDS; AMINOGLYCOSIDES; ANILIDES; ANIMALS; ANTI-BACTERIAL AGENTS; APOPROTEINS; BACTERIAL PROTEINS; CRYSTALLOGRAPHY, X-RAY; LIPIDS; MICE; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; OXAZOLIDINONES; STREPTOMYCES; SUBSTRATE SPECIFICITY;

EID: 33744994317     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature04784     Document Type: Article

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