Organozirconium chemistry on cyclosporin: A novel process for the highly stereoselective synthesis of (E)-ISA247 (voclosporin) and close analogues

Synthesis

Volumn 44, Issue 1, 2012, Pages 63-68

  Maeng, Jun Ho ^a   Yang, Zhicai ^a   Manning, David D ^a   Masih, Liaqat ^a   Cao, Yeyu ^a   Pattamana, Kevin G ^a   Bois, Frederic ^a   Molino, Bruce F ^a  

^a ALBANY MOLECULAR RESEARCH INC   (United States)

Author keywords

cyclosporin A; E diene; ISA247; organo zirconium chemistry; voclosporin

Indexed keywords

CLINICAL TRIAL; CYCLOSPORIN; CYCLOSPORIN A; DEUTERATED ANALOGUE; E -DIENE; IMMUNOSUPPRESSIVE AGENT; ISA247; KIDNEY TRANSPLANTS; LATE STAGE; ORGANOZIRCONIUM CHEMISTRY; STEREOSELECTIVE SYNTHESIS; VOCLOSPORIN;

DEUTERIUM; OLEFINS; STEREOCHEMISTRY; ZIRCONIUM;

STEREOSELECTIVITY;

CYCLOSPORIN A; ORGANOZIRCONIUM DERIVATIVE; UNCLASSIFIED DRUG; VOCLOSPORIN; ZIRCONIUM DERIVATIVE;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

EID: 84655163434     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/s-0031-1289616     Document Type: Article

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