Paradigm shift in discovering next-generation anti-infective agents: Targeting quorum sensing, c-di-GMP signaling and biofilm formation in bacteria with small molecules

Future Medicinal Chemistry

Volumn 2, Issue 6, 2010, Pages 1005-1035

  Sintim, Herman O ^a   Smith, Jacqueline Ai ^a   Wang, Jingxin ^a   Nakayama, Shizuka ^a   Yan, Lei ^a  

^a Bldg 142   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; AMOXICILLIN PULSYS; ANTIINFECTIVE AGENT; AZASITE; BESIVANCE; BETA LACTAM ANTIBIOTIC; BIRICODAR; CEFALOTIN; CHLORAMPHENICOL; CIPROFLOXACIN; CLAVULANIC ACID; CLINDAMYCIN; CYCLIC GMP; DALFOPRISTIN; DAPTOMYCIN; DORIPENEM; ERYTHROMYCIN; IMIPENEM; LINEZOLID; METICILLIN; PENICILLIN G; POLYMYXIN B; QUINUPRISTIN; RESERPINE; RETAPAMULIN; RIFAMPICIN; RIFAXIMIN; STREPTOMYCIN; SULBACTAM; SULFAMIDOCHRYSOIDINE; TAZOBACTAM; TELITHROMYCIN; TETRACYCLINE; TIGECYCLINE; TOBRAMYCIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANCOMYCIN; VIBATIV; VIRULENCE FACTOR;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC THERAPY; BIOFILM; DRUG INDICATION; DRUG STRUCTURE; ESCHERICHIA COLI; HUMAN; MOLECULE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; PSEUDOMONAS AERUGINOSA; QUORUM SENSING; REVIEW; RHIZOBIUM RADIOBACTER; SALMONELLA TYPHIMURIUM; SIGNAL TRANSDUCTION; STAPHYLOCOCCUS AUREUS; VIBRIO CHOLERAE; VIBRIO FISCHERI;

ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIA; BACTERIAL INFECTIONS; BACTERIAL PHYSIOLOGICAL PHENOMENA; BIOFILMS; CYCLIC GMP; DRUG DISCOVERY; HUMANS; QUORUM SENSING; SIGNAL TRANSDUCTION; SMALL MOLECULE LIBRARIES;

EID: 77953633873     PISSN: 17568919     EISSN: None     Source Type: Journal    
DOI: 10.4155/fmc.10.185     Document Type: Review

References (237)

1. Arias CA, Murray BE. Antibiotic-resistant bugs in the 21st century - a clinical super challenge. N. Engl. J. Med. 360(5), 439-443 (2009).
2. von Nussbaum F, Brands M, Hinzen B, Weigand S, Häbich D. Antibacterial natural products in medicinal chemistry - exodus or revival? Angew. Chem. Int. Ed. 45(31), 5072-5129 (2006).
3. Jevons MP. 'Celbenin'-resistant Staphylococci. Br. Med. J. 1(5219), 124-125 (1961).
4. Watanabe T, Watanabe M. Transduction of streptomycin resistance in Salmonella typhimurium. J. Gen. Microbiol. 21, 16-29 (1959).
5. Ramsey CH, Edwards PR. Resistance of Salmonellae isolated in 1959 and 1960 to tetracyclines and chloramphenicol. Appl. Microbiol. 9(5), 389-391 (1961).
6. Franklin TJ, Godfrey A. Resistance of Escherichia coli to tetracyclines. Biochem. J. 94, 54-60 (1965).
7. Haddy RI, Gordon RC, Shamiyeh L, Wofford R, Fechner L, Sahanek E. Erythromycin resistance in group A b-hemolytic Streptococci. Pediatr. Infect. Dis. 1(4), 236-238 (1982).
8. Shlaes DM, Marino J, Jacobs MR. Infection caused by vancomycin-resistant Streptococcus sanguis II. Antimicrob. Agents Chemother. 25(4), 527-528 (1984).
9. Uttley AH, Collins CH, Naidoo J, George RC. Vancomycin-resistant enterococci. Lancet 331(8575-8576), 57-58 (1988).
10. Sevag MG, Green MN. The mechanism of resistance to sulfonamides. I. Factors controlling the formation of arylamine from tryptophane by Staphylococcus aureus. J. Bacteriol. 48(6), 615-622 (1944).
11. Barber M, Whitehead JE. Bacteriophage types in penicillin-resistant staphylococcal infection. Br. Med. J. 2(4627), 565-569 (1949).
12. Gilleland HE Jr, Murray RG. Ultrastructural study of polymyxin-resistant isolates of Pseudomonas aeruginosa. J. Bacteriol. 125(1), 267-281 (1976).
13. Kaatz GW, Seo SM. Mechanism of ciprofloxacin resistance in Pseudomonas aeruginosa. J. Infect. Dis. 158(3), 537-541 (1988).
14. Benner EJ, Bennett JV, Brodie JL, Kirby WM. Inactivation of cephalothin and cephaloridine by Staphylococcus aureus. J. Bacteriol. 90(6), 1599-1604 (1965).
15. Ezekiel DH, Hutchins JE. Mutations affecting RNA polymerase associated with rifampicin resistance in Escherichia coli. Nature 220(5164), 276-277 (1968).
16. Tally FP, Snydman DR, Gorbach SL, Malamy MH. Plasmid-mediated, transferable resistance to clindamycin and erythromycin in Bacteroides fragilis. J. Infect. Dis. 139(1), 83-88 (1979).
17. Cuchural GJ Jr, Malamy MH, Tally FP. b-lactamase-mediated imipenem resistance in Bacteroides fragilis. Antimicrob. Agents Chemother. 30(5), 645-648 (1986).
18. Schmitz FJ, Sadurski R, Stattfeld A, Kray A, Verhoef J, Fluit AC. Cross-resistance analyses and molecular typing of Staphylococcus aureus and Streptococcus spp. isolates resistant to quinupristin/dalfopristin. J. Antimicrob. Chemother. 44(6), 847-849 (1999).
19. Tsiodras S, Gold HS, Sakoulas G et al. Linezolid resistance in a clinical isolate of Staphylococcus aureus. Lancet 358(9277), 207-208 (2001).
20. Sabol K, Patterson JE, Lewis JS II, Owens A, Cadena J, Jorgensen JH. Emergence of daptomycin resistance in Enterococcus faecium during daptomycin therapy. Antimicrob. Agents Chemother. 49(4), 1664-1665 (2005).
21. Sabath LD, Wheeler N, Laverdiere M, Blazevic D, Wilkinson BJ. A new type of penicillin resistance of Staphylococcus aureus. Lancet 1(8009), 443-447 (1977).
22. Fisher JF, Meroueh SO, Mobashery S. Bacterial resistance to b-lactam antibiotics. compelling opportunism, compelling opportunity. Chem. Rev. 105(2), 395-424 (2005).
23. Finlay J, Miller L, Poupard JA. A review of the antimicrobial activity of clavulanate. Antimicrob. Chemother. 52(1), 18-23 (2003).
24. Imtiaz U, Billings EM, Knox JR, Mobashery S. A structure-based analysis of the inhibition of class A b-lactamases by sulbactam. Biochemistry 33(19), 5728-5738 (1994).
25. Rasheed JK, Jay C, Metchock B et al. Evolution of extended-spectrum b-lactam resistance (SHV-8) in a strain of Escherichia coli during multiple episodes of bacteremia. Antimicrob. Agents Chemother. 41(3), 647-653 (1997).
26. Shaw KJ, Rather PN, Hare RS, Miller GH. Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes. Microbiol. Mol. Biol. Rev. 57(1), 138-163 (1993).
27. Gonzales RD, Schreckenberger PC, Graham MB, Kelkar S, DenBesten K, Quinn JP. Infections due to vancomycin-resistant Enterococcus faecium resistant to linezolid. Lancet 357(9263). 1179 (2001).
28. Hiramatsu K, Hanaki H, Ino T, Yabuta K, Oguri T, Tenover FC. Methicillin-resistant Staphylococus aureus clinical strain with reduced vancomycin susceptibility. J. Antimicrob. Chemother. 40(1), 135-136 (1997).
29. Cetinkaya Y, Falk PF, Mayhall CG. Vancomycin-resistant enterococci. Clin. Microbiol. Rev. 13(4), 686-707 (2000).
30. Sulavik MC, Houseweart C, Cramer C et al. Antibiotic susceptibility profiles of Escherichia coli strains lacking multidrug efflux pump genes. Antimicrob. Agents Chemother. 45(4), 1126-1136 (2001).
31. Poole K, Krebes K, McNally C, Neshat S. Multiple antibiotic resistance in Pseudomonas aeruginosa. evidence for involvement of an efflux operon. J. Bacteriol. 175(22), 7363-7372 (1993).
32. Ziha-Zarifi I, Llanes C, Köhler T, Pechere JC, Plesiat P. In vivo emergence of multidrug-resistant mutants of Pseudomonas aeruginosa overexpressing the active efflux system MexA-MexB-OprM. Antimicrob. Agents Chemother. 43(2), 287-291 (1999).
33. Kaatz GW, Seo SM. Mechanisms of fluoroquinolone resistance in genetically related strains of Staphylococcus aureus. Antimicrob. Agents Chemother. 41(12), 2733-2737 (1997).
34. Piddock LJ. Multidrug-resistance efflux pumps-not just for resistance. Nat. Rev. Microbiol. 4(8), 629-636 (2006).
35. Hsieh PC, Siegel SA, Rogers B, Davis D, Lewis K. Bacteria lacking a multidrug pump. a sensitive tool for drug discovery. Proc. Natl Acad. Sci. USA 95(12), 6602-6606 (1998).
36. Mullin S, Mani N, Grossman TH. Inhibition of antibiotic efflux in bacteria by the novel multidrug resistance inhibitors biricodar (VX-710) and timcodar (VX-853). Antimicrob. Agents Chemother. 48(11), 4171-4176 (2004).
37. Pumbwe L, Chang A, Smith RL, Wexler HM. Clinical significance of overexpression of multiple RND-family efflux pumps in Bacteroides fragilis isolates. J. Antimicrob. Chemother. 58(3), 543-548 (2006).
38. Miyamae S, Ueda O, Yoshimura F, Hwang J, Tanaka Y, Nikaido H. A MATE family multidrug efflux transporter pumps out fluoroquinolones in Bacteroides thetaiotaomicron. Antimicrob. Agents Chemother. 45(12), 3341-3346 (2001).
39. Debono M, Abbott BJ, Molloy RM et al. Enzymatic and chemical modifications of lipopeptide antibiotic A21978C. The synthesis and evaluation of daptomycin (LY146032). J. Antibiot. (Tokyo) 41(8), 1093-1105 (1988).
40. Tally FP, DeBruin MF. Development of daptomycin for gram-positive infections. J. Antimicrob. Chemother. 46(4), 523-526 (2000).
41. Brickner SJ, Hutchinson DK, Barbachyn MR et al. Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multidrug-resistant gram-positive bacterial infections. J. Med. Chem. 39(3), 673-679 (1996).
42. Barbachyn MR, Ford CW. Oxazolidinone structure-activity relationships leading to linezolid. Angew. Chem. Int. Ed. 42(18), 2010-2023 (2003).
43. Jones RN, Della-Latta P, Lee LV, Biedenbach DJ. Linezolid-resistant Enterococcus faecium isolated from a patient without prior exposure to an oxazolidinone. Report from the SENTRY Antimicrobial Surveillance Program. Diagn. Microbiol. Infect. Dis. 42(2), 137-139 (2002).
44. Hayden MK, Rezai K, Hayes RA, Lolans K, Quinn JP, Weinstein RA. Development of Daptomycin resistance in vivo in methicillin-resistant Staphylococcus aureus. J. Clin. Microbiol. 43(10), 5285-5287 (2005).
45. Owens J. 2006 drug approvals. finding the niche. Nat. Rev. Drug Discov. 6(2), 99-101 (2007).
46. Hughes B. 2007 FDA drug approvals: a year of flux. Nat. Rev. Drug Discov. 7(2), 107-109 (2008).
47. Hughes B. 2008 FDA drug approvals. Nat. Rev. Drug Discov. 8(2), 93-96 (2009).
48. Yan K, Madden L, Choudhry AE, Voigt CS, Copeland RA, Gontarek RR. Biochemical characterization of the interactions of the novel pleuromutilin derivative retapamulin with bacterial ribosomes. Antimicrob. Agents Chemother. 50(11), 3875-3881 (2006).
49. Givskov M, Hentzer M. Jamming bacterial communication: new strategies to combat bacterial infections and the development of biofilm. In: Bacterial Cell-to-Cell Communication: Role in Virulence and Pathogenesis. Demuth DR, Lamont RJ (Eds.). Cambridge University Press, Cambridge, UK, 65-90 (2006).
50. Kulesekara H, Lee V, Brencic A et al. Analysis of Pseudomonas aeruginosa diguanylate cyclases and phosphodiesterases reveals a role for bis-(3́-5́)-cyclic-GMP in virulence. Proc. Natl Acad. Sci. USA 103(8), 2839-2844 (2006).
51. Jenal U. Cyclic di-guanosine-monophosphate comes of age: a novel secondary messenger involved in modulating cell surface structures in bacteria? Curr. Opin. Microbiol. 7(2), 185-191 (2004).
52. Chan WC, Coyle BJ, Williams P. Virulence regulation and quorum sensing in staphylococcal infections: competitive AgrC antagonists as quorum sensing inhibitors. J. Med. Chem. 47(19), 4633-4641 (2004).
53. Ji G, Beavis R, Novick RP. Bacterial interference caused by autoinducing peptide variants. Science 276(5321), 2027-2030 (1997).
54. Wright JS III, Jin R, Novick RP. Transient interference with staphylococcal quorum sensing blocks abscess formation. Proc. Natl Acad. Sci. USA 102(5), 1691-1696 (2005).
55. Whiteley M, Lee KM, Greenberg EP. Identification of genes controlled by quorum sensing in Pseudomonas aeruginosa. Proc. Natl Acad. Sci. USA 96(24) 13904-13909 (1999).
56. Pearson JP, Gray KM, Passador L et al. Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes. Proc. Natl Acad. Sci. USA 91(1), 197-201 (1994).
57. Smith RS, Iglewski BH. P. aeruginosa quorum-sensing systems and virulence. Curr. Opin. Microbiol. 6(1), 56-60 (2003).
58. Ahmer BM, van Reeuwijk J, Timmers CD, Valentine PJ, Heffron F. Salmonella typhimurium encodes an SdiA homolog, a putative quorum sensor of the LuxR family, that regulates genes on the virulence plasmid. J. Bacteriol. 180(5), 1185-1193 (1998).
59. Michael B, Smith JN, Swift S, Heffron F, Ahmer BMM. SdiA of Salmonella enterica is a LuxR homolog that detects mixed microbial communities. J.Bacteriol. 183(19) 5733-5742 (2001).
60. Janssens JC, Metzger K, Daniels R et al. Synthesis of N-acyl homoserine lactone analogues reveals strong activators of SdiA, the Salmonella enterica serovar Typhimurium LuxR homologue. Appl. Environ. Microbiol. 73(2), 535-544 (2007).
61. Cvitkovitch DG, Li YH, Ellen RP. Quorum sensing and biofilm formation in Streptococcal infections. J. Clin. Invest. 112(11), 1626-1632 (2003).
62. Davies DG, Parsek MR, Pearson JP, Iglewski BH, Costerton JW, Greenberg EP. The involvement of cell-to-cell signals in the development of a bacterial biofilm. Science 280(5361), 295-298 (1998).
63. Singh PK, Schaefer AL, Parsek MR, Moninger TO, Welsh MJ, Greenberg EP. Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms. Nature 407(6805), 762-764 (2000).
64. Rickard AH, Palmer RJ Jr, Blehert DS et al. Autoinducer 2: a concentration-dependent signal for mutualistic bacterial biofilm growth. Mol. Microbiol. 60(6), 1446-1456 (2006).
65. Ahmed NA, Petersen FC, Scheie AA. AI-2 quorum sensing affects antibiotic susceptibility in Streptococcus anginosus. J. Antimicrob. Chemother. 60(1), 49-53 (2007).
66. Waters CM, Bassler BL. Quorum sensing: cell-to-cell communication in bacteria. Ann. Rev. Cell Dev. Biol. 21, 319-346 (2005).
67. Federle MJ, Bassler BL. Interspecies communication in bacteria. J. Clin. Invest. 112(9),1291-1299 (2003).
68. Hughes DT, Sperandio V. Inter-kingdom signaling: communication between bacteria and their hosts. Nat. Rev. Microbiol. 6(2), 111-120 (2008).
69. Walters M, Sircili MP, Sperandio V. AI-3 synthesis is not dependent on luxS in Escherichia coli. J. Bacteriol. 188(16), 5668-5681 (2006).
70. Cámara M, Hardman A, Williams P, Milton D. Quorum sensing in Vibrio cholerae. Nat. Genet. 32(2), 217-218 (2002).
71. Higgins DA, Pomianek ME, Kraml CM, Taylor RK, Semmelhack MF, Bassler BL. The major Vibrio cholerae autoinducer and its role in virulence factor production. Nature 450(7171), 883-886 (2007).
72. Clarke MB, Sperandio V. LuxS-dependent regulation of Escherichia coli virulence. In: Bacterial Cell-to-Cell Communication: Role in Virulence and Pathogenesis. Demuth DR, Lamont RJ (Eds). Cambridge University Press, Cambridge, UK, 159-168 (2006).
73. Nakayama J, Cao Y, Horii T et al. Gelatinase biosynthesis-activating pheromone: a peptide lactone that mediates a quorum sensing in Enterococcus faecalis. Mol. Microbiol. 41(1), 145-154 (2001).
74. Geske GD, O'Neill JC, Blackwell HE. Expanding dialogues: from natural autoinducers to non-natural analogues that modulate quorum sensing in Gram-negative bacteria. Chem. Soc. Rev. 37, 1432-1447 (2008).
75. Horinouchi S, Ohnishi Y, Kang DK. The A factor regulatory cascade and cAMP in the regulation of physiological and morphological development in Streptomyces griseus. J. Ind. Microbiol. Biotechnol. 27, 177-182 (2001).
76. Pesci EC, Milbank JB, Pearson JP et al. Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa. Proc. Natl Acad. Sci. USA 96(20), 11229-11234 (1999).
77. Vendeville A, Winzer K, Heurlier K, Tang CM, Hardie KR. Making 'sense' of metabolism: autoinducer-2, LuxS and pathogenic bacteria. Nat. Rev. Microbiol. 3(5), 383-396 (2005).
78. Xavier KB, Bassler BL. LuxS quorum sensing: more than just a numbers game. Curr. Opin. Microbiol. 6(2), 191-197 (2003).
79. Chen X, Schauder S, Potier N et al. Structural identification of a bacterial quorum-sensing signal containing boron. Nature 415(6871), 545-549 (2002).
80. Miller ST, Xavier KB, Campagna SR et al. Salmonella typhimurium recognizes a chemically distinct form of the bacterial quorum-sensing signal AI-2. Mol. Cell 15(5), 677-687 (2004).
81. Xue T, Zhao L, Sun H, Zhou, X, Sun B. LsrR-binding site recognition and regulatory characteristics in Escherichia coli AI-2 quorum sensing. Cell Res. 19(11), 1258-1268 (2009).
82. Kim SY, Lee SE, Kim YR et al. Regulation of Vibrio vulnificus virulence by the LuxS quorum-sensing system. Mol. Microbiol. 48(6), 1647-1664 (2003).
83. Shin NR, Lee DY, Shin SJ, Kim KS, Yoo HS. Regulation of proinflammatory mediator production in RAW264.7 macrophage by Vibrio vulnificus LuxS and SmcR. FEMS Immunol. Med. Microbiol. 41, 169-176 (2004).
84. Coulthurst SJ, Leopold Kurz C, Salmond GPC. luxS mutants of Serratia defective in autoinducer-2-dependent 'quorum sensing' show strain-dependent impacts on virulence and production of carbapenem and prodigiosin. Microbiol. 150, 1901-1910 (2004).
85. Ohtani K, Hayashi H, Shimizu T. The luxS gene is involved in cell-cell signalling for toxin production in Clostridium perfringens. Mol. Microbiol. 44(1), 171-179 (2002).
86. Winzer K, Hardie KR, Burgess N et al. LuxS. its role in central metabolism and the in vitro synthesis of 4-hydroxy-5-methyl-3-(2H)- furanone. Microbiol. 148(Pt 4), 909-922 (2002).
87. Tavender TJ, Halliday NM, Hardie KR Winzer K. LuxS-independent formation of AI-2 from ribulose-5-phosphate. BMC Microbiol. 8(98), 2188-2198 (2008).
88. Hauck T, Hübner Y, Brühlmann F, Schwab W. Alternative pathway for the formation of 4,5-dihydroxy-2,3- pentanedione, the proposed precursor of 4-hydroxy-5-methyl-3(2H)-furanone as well as autoinducer-2, and its detection as natural constituent of tomato fruit. Biochim. Biophys. Acta. 1623(2-3), 109-119 (2003).
89. Li J, Wang L, Hashimoto Y et al. A stochastic model of Escherichia coli AI-2 quorum signal circuit reveals alternative synthesis pathways. Mol. Syst. Biol. 2, 67 (2006).
90. Pesci EC, Pearson JP, Seed PC, Iglewski BH. Regulation of las and rhl quorum sensing in Pseudomonas aeruginosa. J. Bacteriol. 179(10), 3127-3132 (1997).
91. Chugani SA, Whiteley M, Lee KM, D'Argenio D, Manoil C, Greenberg EP. QscR, a modulator of quorum-sensing signal synthesis and virulence in Pseudomonas aeruginosa. Proc. Natl Acad. Sci. USA 98(5), 2752-2757 (2001).
92. Ledgham F, Ventre I, Soscia C, Foglino M, Sturgis JN, Lazdunski A. Interaction of the quorum sensing regulator QscR: interation with itself and the other regulators of Pseudomonas aeruginosa LasR and RhlR. Mol. Microbiol. 48(1), 199-210 (2003).
93. Wagner VE, Bushnell D, Passador L, Brooks AI, Iglewski BH. Microarry analysis of Pseudomonas aeruginosa quorum-sensing regulons: effects of growth phase and environment. J. Bacteriol. 185(7), 2080-2095 (2003).
94. Schuster M, Lostroh CP, Ogi T, Greenberg EP. Identification, timing, and signal specificity of Pseudomonas aeruginosa quorum-controlled genes: a transcriptome analysis. J. Bacteriol. 185(7), 2066-2079 (2003).
95. Smith RS, Iglewski BH. Pseudomonas aeruginosa quorum sensing as a potential antimicrobial target. J. Clin. Invest. 112(10), 1460-1465 (2003).
96. Gambello MJ, Iglewski BH. Cloning and characterization of the Pseudomonas aeruginosa lasR gene, a transcriptional activator of elastase expression. J. Bacteriol. 173(9), 3000-3009 (1991).
97. Kessler E, Safrin M, Gustin JK, Ohman DE. Elastase and the LasA protease of Pseudomonas aeruginosa are secreted with their propeptides. J. Biol. Chem. 273(46), 30225-30231 (1998).
98. Gambello MJ, Kaye S, Iglewski BH. LasR of Pseudomonas aeruginosa is a transcriptional activator of the alkaline protease gene (apr) and an enhancer of exotoxin A expression. Infect. Immun. 61(4), 1180-1184 (1993).
99. Chapon-Hervé V, Akrim M, Latifi A, Williams P, Lazdunski A, Bally M. Regulation of the xcp secretion pathway by multiple quorum-sensing modulons in Pseudomonas aeruginosa. Mol. Microbiol. 24(6), 1169-1178 (1997).
100. Holden MTG, Chhabra SR, de Nys R et al. Quorum-sensing cross talks: isolation and chemical characterization of cyclic dipeptides from Pseudomonas aeruginosa and other gram-negative bacteria. Mol. Microbiol. 33(6), 1254-1266 (1999).
101. Campbell J, Lin Q, Geske GD, Blackwell HE. New and unexpected insights into the modulation of LuxR-type quorum sensing by cyclic dipeptides. ACS Chem. Biol. 4(12), 1051-1059 (2009).
102. Novick RP. Autoinduction and signal transduction in the regulation of staphylococcal virulence. Mol. Microbiol. 48(6), 1429-1449 (2003).
103. Yarwood JM. Quorum-sensing-dependent regulation of staphylococcal virulence and biofilm development. In: Bacterial Cell-to-Cell Communication: Role in Virulence and Pathogenesis. Demuth DR, Lamont RJ (Eds). Cambridge University Press, Cambridge, UK, 199-266 (2006).
104. Cheung AL, Zhang G. Global regulation of virulence determinants in Staphylococcus aureus by the SarA protein family. Front. Biosci. 7, d1825-1842 (2002).
105. Xavier KB, Miller ST, Lu W et al. Phosphorylation and processing of the quorum-sensing molecule autoinducer-2 in enteric bacteria. ACS Chem. Biol. 2(2) 128-136 (2007).
106. Novick RP, Jiang D. The staphylococcal saeRS system coordinates environmental signals with agr quorum sensing. Microbiology 149(Pt 10), 2709-2717 (2003).
107. Lee MS, Morrison DA. Identification of a new regulator in Streptococcus pneumoniae linking quorum sensing to competence for genetic transformation. J. Bacteriol. 181(16), 5004-5016 (1999).
108. Lazazzera BA, Solomon JM, Grossman AD. An exported peptide functions intracellularly to contribute to cell density signaling in B. subtilis. Cell 89(6), 917-925 (1997).
109. Kelly RC, Bolitho ME, Higgins DA et al. The Vibrio cholerae quorum-sensing autoinducer CAI-1:analysis of the biosynthetic enzyme CqsA. Nat. Chem. Biol. 5(12), 891-895 (2009).
110. Wang L, Hashimoto Y, Tsao CY, Valdes JJ, Bentley WE. Cyclic AMP (cAMP) and cAMP receptor protein influence both synthesis and uptake of extracellular autoinducer 2 in Escherichia coli. J. Bacteriol. 187(6), 2066-2076 (2005).
111. Moré MI, Finger LD, Stryker JL, Fuqua C, Eberhard A, Winans SC. Enzymatic synthesis of a quorum-sensing autoinducer through use of defined substrates. Science 272(5268), 1655-1658 (1996).
112. Schauder S, Shokat K, Surette MG, Bassler BL. The LuxS family of bacterial autoinducers: biosynthesis of a novel quorum-sensing signal molecule. Mol. Microbiol. 41(2) 463-476 (2001).
113. Musk DJ Jr, Hergenrother PJ. Chemical coutermeasures for the control of bacterial biofilms: effective compounds and promising targets. Curr. Med. Chem. 13(18), 2163-2177 (2006).
114. Singh V, Evans GB, Lenz DH et al. Femtomolar transition state analogue inhibitors of 5́-methylthioadenosine/ S-adenosylhomocysteine nucleosidase from Escherichia coli. J. Biol. Chem. 280(18), 18265-18273 (2005).
115. Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL. Transition state analogs of 5́ methylthioadenosine nucleosidase discrupt quorum sensing. Nature Chem. Biol. 5(4), 251-257 (2009).
116. Gopishetty B, Zhu J, Rajan R et al. Probing the catalytic mechanism of S-ribosylhomocysteinase (LuxS) with catalytic intermediates and substrate analogues. J. Am. Chem. Soc. 131(3), 1243-1250 (2009).
117. Alfaro JF, Zhang T, Wynn DP, Karschner EL, Zhou ZS. Synthesis of LuxS inhibitors targeting bacterial cell-cell communication. Org. Lett. 6(18), 3043-3046 (2004).
118. Shen G, Rajan R, Zhu J, Bell CE, Pei D. Design and synthesis of substrate and intermediate analogue inhibitors of S-ribosylhomocysteinase. J. Med. Chem. 49(10), 3003-3011 (2006).
119. Wnuk SF, Roert J, Sobczak AJ et al. Inhibition of S-ribosylhomocysteinase (LuxS) by substrate analogues modified at the ribosyl C-3 position. Bioorg. Med. Chem. 17(18), 6699-6706 (2009).
120. Han X, Lu C. Biological activity and identification of a peptide inhibitor of LuxS from Streptococcus suis serotype 2. FEMS Microbiol. Lett. 294(1), 16-23 (2009).
121. Lyon GJ, Wright JS, Muir TW, Novick RP. Key determinants of receptor activation in the agr autoinducing peptides of Staphylococcus aureus. Biochemistry 41(31), 10095-10104 (2002).
122. Scott RJ, Lian LY, Muharram SH et al. Side-chain-to-tail thiolactone peptide inhibitors of the staphylococcal quorum-sensing system. Bioorg. Med. Chem. Lett. 13(15), 2449-2453 (2003).
123. Geske GD, O'Neill JC, Miller DM, Mattmann ME, Blackwell HE. Modulation of bacterial quorum sensing with synthetic ligands: systematic evaluation of N-acylated homoserine lactones in multiple species and new insights into their mechanisms of action. J. Am. Chem. Soc. 129(44), 13613-13625 (2007).
124. Smith KM, Bu Y, Suga H. Induction and inhibition of Pseudomonas aeruginosa quorum sensing by synthetic autoinducer analogs. Chem. Biol. 10, 81-89 (2003).
125. Smith KM, Bu Y, Suga H. Library screening for synthetic agonists and antagonists of a Pseudomonas aeruginosa autoinducer. Chem. Biol. 10(6), 563-571 (2003). (Pubitemid 36774641)
126. Persson T, Givskov M, Nielsen J. Quorum sensing inhibition: targeting chemical communication in Gram-negative bacteria. Curr. Med. Chem. 12(26), 3103-3115 (2005).
127. Swern LR, Swem DL, O'Loughlin CT et al. A quorum-sensing antagoist targets both membrane-bound and cytoplasmic receptors and controls bacterial pathogenicity. Mol. Cell. 35(2), 143-153 (2009).
128. Ni N, Li M, Wang J, Wang B. Inhibitors and antagonists of bacterial quorum sensing. Med. Res. Rev. 29(1), 66-124 (2009).
129. Lowery CA, Park J, Kaufmann GF, Janda KD. An unexpected switch in the modulation of AI-2-based quorum sensing discovered through synthetic 4,5-dihydroxy-2,3-pentanedione analogues. J. Am. Chem. Soc. 130(29), 9200-9201 (2008).
130. Ganin H, Tang X, Meijler MM. Inhibiton of Pseudomonas aeruginosa quorum sensing by AI-2 analogs. Bioorg. Med. Chem. Lett. 19(14), 3941-3944 (2009).
131. Smith JAI, Wang J, Nguyen-Mau SM, Lee V, Sintim HO. Biological screening of a diverse set of AI-2 analogs in Vibrio harveyi suggests that receptors which are involved in synergistic agonism of AI-2 and analogues are promiscuous. Chem. Commun. 7(35), 7033-7035 (2009).
132. Geske GD, Wezeman RJ, Siegel AP, Blackwell HE. Small molecule inhibitors of bacterial quorum sensing and biofilm formation. J. Am. Chem. Soc. 127(37), 12762-12763 (2005).
133. Williams SC, Patterson EK, Carty NL, Griswold JA, Hamood AN, Rumbaugh KP. Pseudomonas aeruginosa autoinducer enters and functions in mammalian cells. J. Bacteriol. 186(8), 2281-2287 (2004).
134. Smith RS, Fedyk ER, Springer TA, Mukaida N, Iglewski BH, Phipps RP. IL-8 production in human lung fibroblasts and epithelial cells activated by the Pseudomonas autoinducer N-3-oxododecanoyl homoserine lactone is transcriptionally regulated by NF-kB and activator protein-2. J. Immunol. 167, 366-374 (2001).
135. Schuster M, Greenberg EP. LuxR-type proteins in Pseudomonas aeruginosa quorum sensing: distinct mechanisms with global implications. In: Cell-Cell Communication in Bacteria. Winans SC, Bassler BL (Eds). ASM Press, Washington, DC, USA, 133-144 (2008).
136. Schuster M, Urbanowski ML, Greenberg EP. Promoter specificity in Pseudomonas aeruginosa quorum sensing revealed by DNA binding of purified LasR. Proc. Natl Acad. Sci. USA 101(45), 15833-15839 (2004).
137. Weingart CL, White CE, Liu S et al. Direct binding of the quorum sensing regulator CepR of Burkhoderia cenocepacia to two target promoters in vitro. Mol. Microbiol. 57(2), 452-467 (2005).
138. Urbanowski ML, Lostroh CP, Greenberg EP. Reversibile acyl-homoserine lactone binding to purified Vibrio fischeri LuxR protein. J. Bacteriol. 186(3), 631-637 (2004).
139. Lee JH, Lequette Y, Greenberg EP. Activity of purified QscR, a Pseudomonas aeruginosa orphan quorum-sensing transcription factor. Mol. Microbiol. 59(2), 602-609 (2006).
140. Medina G, Juárez K, Valderrama B, Soberón-Chávez G. Mechanism of Pseudomonas aeruginosa RhlR transcriptional regulation of the rhlAB promoter. J. Bacteriol. 185(20), 5976-5983 (2003). (Pubitemid 37248449)
141. Castang S, Reverchon S, Gouet P, Nasser W. Direct evidence for the modulation of the activity of the Erwinia chrysanthemi quorum-sensing regulator ExpR by acylhomoserine lactone pheromone. J. Biol. Chem. 281(40), 29972-29987 (2006).
142. Wagner VE, Iglewski BH. Quorum sensing and regulation of Pseudomonas aeruginosa infections. In: Bacterial Cell-to-Cell Communication: Role in Virulence and Pathogenesis. Demuth DR, Lamont RJ (Eds). Cambridge University Press, Cambridge, UK, 1-15 (2006).
143. Lewenza S, Conway B, Greenberg EP, Sokol PA. Quorum sensing in Burkholderia cenocepacia: identification of the LuxRI homologs CepRI. J. Bacteriol. 181(3), 748-756 (1999).
144. Aharoni A, Gaidukov L, Yagur S et al. Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression and catalytic specialization. Proc. Natl Acad. Sci. USA 101(2), 482-487 (2004).
145. Kharsonsky O, Tawfik DS. Structure- reactivity studies of serum paraoxonase PON1 suggest that its native activity is lactonase. Biochem. 44(16), 6371-6382 (2005).
146. Greenberg EP, Chun CK, Ozer EA, Welsh MJ, Zabner J. Inactivation of a Pseudomonas aeruginosa quorum-sensing signal by human airway epithelia. Proc. Natl Acad. Sci. USA 101(10), 3587-3590 (2004).
147. Yang F, Wang L-H, Wang J et al. Quorum quenching enzyme activity is widely conserved in the sera of mammalian species. FEBS Lett. 579(17), 3713-3717 (2005).
148. Jakubowski H. Calcium-dependent human serum homocysteine thiolactone hydrolase. A protective mechanism against protein N-homocysteinylation. J. Biol. Chem. 275(6), 3957-3962 (2000).
149. Müh U, Schuster M, Heim R, Singh A, Olson ER, Greenberg EP. Novel Pseudomonas aeruginosa quorum-sensing inhibitors identified in an ultra-high-throughput screen. Antimicrob. Agent Chemother. 50(11), 3674-3679 (2006).
150. Persson T, Hansen TH, Rasmussen TB, Skindersø ME, Givskov M, Nielsen J. Rational design and synthesis of new quorum-sensing inhibitors derived from acylated homoserine lactones and natural products from garlic. Org. Biomol. Chem. 3(2), 253-262 (2005).
151. Rasko DA, Moreira CG, Li DR et al. Targeting QseC signaling and virulence for antibiotic development. Science 321(5892), 1078-1080 (2008).
152. Janssens JC, Steenackers H, Robijns S et al. Brominated furanones inhibit biofilm formation by Salmonella enterica serovar typhimurium. Appl. Environ. Microbiol. 74(21), 6639-6648 (2008).
153. Hentzer M, Riedel K, Rasmussen TB et al. Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound. Microbiology 148(Pt 1), 87-102 (2002).
154. Wu H, Song Z, Hentzer M et al. Synthetic furanones inhibit quorum sensing and enhance bacterial clearance in Pseudomonas aeruginosa lung infection in mice. J. Antimicrob. Chemother. 53(6), 1054-1061 (2004).
155. Defoirdt T, Miyamoto CM, Wood TK et al. The natural furanone (5Z)-4-bromo-5- (bromomethylene)-3-butyl-2(5H)-furanone disrupts quorum sensing-regulated gene expression in Vibrio harveyi by decreasing the DNA-binding activity of the transcriptional regulator protein luxR. Environ. Microbiol. 9(10), 2486-2495 (2007).
156. Zang T, Lee BWK, Cannon LM et al. A naturally occurring brominated furanone covalently modifies and inactivates LuxS. Bioorg. Med. Chem. Lett. 19(21), 6200-6204 (2009).
157. Rasmussen TB, Bjarnsholt T, Skindersoe ME et al. Screening for quorum-sensing inhibitors (QSI) by use of a novel genetic system, the QSI selector. J. Bacteriol. 187(5), 1799 - 1814 (2005).
158. Rasmussen TB, Skindersoe ME, Bjarnsholt T et al. Identity and effects of quorum-sensing inhibitors produced by Penicillium species. Microbiology 151(Pt 5), 1325-1340 (2005).
159. Skindersoe ME, Ettinger-Epstein P, Rasmussen TB et al. Quorum sensing antagonism from marine organisms. Marin. Biotech. 10(1), 56-63 (2008).
160. Brackman G, Defoirdt T, Miyamoto C et al. Cinnamaldehyde and cinnamaldehye derivatives reduce virulence in Vibrio spp. by decreasing the DNA-binding activity of the quorum sensing response regulator LuxR. BMC Microbiol. DOI: 10.1186/1471-2180- 2188-12149 (2008) (Epub ahead of print).
161. De Lamo Marin S, Xu Y, Meiljer MM, Janda KD. Antibody catalyzed hydrolysis of a quorum sensing signal found in Gram-negative bacteria. Bioorg. Med. Chem. Lett. 17(6), 1549-1552 (2007).
162. Kapadnis PB, Hall E, Ramstedt M et al. Towards quorum-quenching catalytic antibodies. Chem. Comm. 538-540 (2009).
163. Kaufmann GF, Sartorio R, Lee SH et al. Antibody interference with N-acyl homoserine lactone-mediated bacterial quorum sensing. J. Am. Chem. Soc. 128(9), 2802-2803 (2006).
164. Park J, Jagasia R, Kaufmann GF et al. Infection control by antibody disruption of bacterial quorum sensing signaling. Chem. Biol. 14(10), 1119-1127 (2007).
165. Miyairi S, Tateda K, Fuse ET et al. Immunization with 3-oxododecanoyl-l-homoserine lactone-protein conjugate protects mice from lethal Pseudomonas aeruginosa lung infection. J. Med. Microbiol. 55(Pt 10), 1381-1387 (2006).
166. Sun D, Accavitti MA, Bryers JD. Inhibition of biofilm formation by monoclonal antibodies against Staphylococcus epidermidis RP62A accumulation-associated protein. Clin. Diagn. Lab. Immunol. 12(1), 93-100 (2005).
167. Sio CF, Otten LG, Cool RH et al. Quorum quenching by an N-acyl-homoserine lactone acylase from Pseudomonas aeruginosa PAO1. Infect. Immun. 74(3), 1673-1682 (2006).
168. Dong YH, Wang LH, Xu JL, Zhang HB, Zhang XF, Zhang LH. Quenching quorum-sensing-dependent bacterial infection by an N-acyl homoserine lactonase. Nature 411(6839), 813-817 (2001).
169. Roy V, Fernandes R, Tsao C-Y, Bentley WE. Cross species quorum quenching using a native AI-2 processing enzyme. ACS Chem. Bio. DOI: 10.1021/cb9002738 (2009) (Epub ahead of print).
170. Ukkonen P, Varis K, Jernfors M et al. Treatment of acute otitis media with an antiadhesive oligosaccharide: a randomised, double-blind, placebo-controlled trial. Lancet 356(9239), 1398-1402 (2000).
171. Kunz C, Rodriguez-Palmero M, Koletzko B, Jensen R. Nutritional and biochemical properties of human milk, Part I: general aspects, proteins, and carbohydrates. Clin. Perinatol. 26(2), 307-333 (1999).
172. Newburg DS. Are all human milks created equal? Variation in human milk oligosaccharides. J. Pediatr. Gastroenterol. Nutr. 30(2), 131-133 (2000).
173. Basha S, Rai P, Poon V et al. Polyvalent inhibitors of anthrax toxin that target host receptors. Proc. Natl Acad. Sci. USA 103(36), 13509-13513 (2006).
174. Firon N, Ofek I, Sharon N. Carbohydrate specificity of the surface lectins of Escherichia coli, Klebsiella pneumoniae and Salmonella typhimurium. Carbohydr. Res. 120, 235-249 (1983).
175. Mysore JV, Wigginton T, Simon PM, Zopf D, Heman-Ackah LM, Dubois A. Treatment of Helicobacter pylori infection in rhesus monkeys using a novel anti-adhesion compound. Gastroenterol. 117(6), 1316-1325 (1999).
176. Foo LY, Lu Y, Howell AB, Vorsa N. A-type proanthocyanidin trimers from cranberry that inhibit adherence of uropathogenic P-fimbriated Escherichia coli. J. Nat. Prod. 63(9), 1225-1228 (2000).
177. Suree N, Yi SW, Thieu W et al. Discovery and structure-activity relationship analysis of Staphylococcus aureus sortase A inhibitors. Bioorg. Med. Chem. 17(20), 7174-7185 (2009).
178. Pinkner JS, Remaut H, Buelens F et al. Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria. Proc. Natl Acad. Sci. USA 103(47), 17897-17902 (2006).
179. Aberg V, Almqvist F. Pilicides-small molecules targeting bacterial virulence Org. Biomol. Chem. 5(12), 1827-1834 (2007).
180. Tseng TT, Tyler BM, Setubal JC. Protein secretion systems in bacterial-host associations, and their description in the gene ontology. BMC Microbiol. 9(Suppl. 1), S2 (2009).
181. Sandkvist M. Type II secretion and pathogenesis. Infect. Immun. 69(6), 3523-3535 (2001).
182. Galán JE, Wolf-Watz H. Protein delivery into eukaryotic cells by type III secretion machines. Nature 444(7119), 567-573 (2006).
183. Cascales E, Christie PJ. The versatile bacterial type IV secretion systems. Nat. Rev. Microbiol. 1(2), 137-149 (2003).
184. Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D. Type V protein secretion pathway: the autotransporter story. Microbiol. Mol. Biol. Rev. 68(4), 692-744 (2004).
185. Pukatzki S, Ma AT, Sturtevant D et al. Identification of a conserved bacterial protein secretion system in Vibrio cholerae using the Dictyostelium host model system. Proc. Natl Acad. Sci. USA 103(5), 1528-1533 (2006).
186. Cascales E. The Type VI secretion toolkit. EMBO Rep. 9(8), 735-741 (2008).
187. Sperandio V, Mellies JL, Nguyen W, Shin S, Kaper JB. Quorum sensing controls expression of the type III secretion gene transcription and protein secretion in enterohemorrhagic and enteropathogenic Escherichia coli. Proc. Natl Acad. Sci. USA 96(26) 15196-15201 (1999).
188. Gauthier A, Robertson ML, Lowden M, Ibarra JA, Puente JL, Finlay BB. Transcriptional inhibitor of virulence factors in enteropathogenic Escherichia coli. Antimicrob. Agents Chemother. 49(10), 4101-4109 (2005)
189. Henke JM, Bassler BL. Quorum sensing regulates Type III secretion in Vibrio harveyi and Vibrio parahaemolyticus J. Bacteriol. 186(12), 3794-3805 (2004).
190. Kauppi AM, Nordfelth R, Uvell H, Wolf-Watz H, Elofsson M. Targeting bacterial virulence: inhibitors of type III secretion in Yersinia. Chem. Biol. 10(3), 241-249 (2003). (Pubitemid 36380281)
191. Hung DT, Shakhnovich EA, Pierson E, Mekalanos JJ. Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization. Science 310(5748), 670-674 (2005).
192. Kitov PI, Sadowska JM, Mulvey G et al. Shiga-like toxins are neutralized by tailored multivalent carbohydrate ligands. Nature 403(6770), 669-672 (2000).
193. Simpson LS, Burdine L, Dutta AK, Feranchak AP, Kodadek T. Selective toxin sequestrants for the treatment of bacterial infection. J. Am. Chem. Soc. 131(16), 5760-5762 (2009).
194. Merritt EA, Hol WG. AB5 toxins. Curr. Opin. Struct. Biol. 5(2), 165-171 (1995).
195. Kiran MD, Adikesavan NV, Cirioni O et al. Discovery of a quorum-sensing inhibitor of drug-resistant staphylococcal infections by structure-based virtual screening. Mol. Pharmacol. 73(5), 1578-1586 (2008).
196. Peters L, König GM, Wright AD et al. Secondary metabolites of Flustra foliacea and their influence on bacteria. Appl. Environ. Microbiol. 69(6), 3469-3475 (2003).
197. Böttcher T, Sieber SA. b-lactones as specific inhibitors of ClpP attenuate the production of extracellular virulence factors of Staphylococcus aureus. J. Am. Chem. Soc. 130(44), 14400-14401 (2008).
198. Frees D, Qazi SN, Hill PJ, Ingmer H. Alternative roles of ClpX and ClpP in Staphylococcus aureus stress tolerance and virulence. Mol. Microbiol. 48(6), 1565-1578 (2003).
199. Zeng Z, Qian L, Cao L et al. Virtual screening for novel quorum sensing inhibitors to eradicate biofilm formation of Pseudomonas aeruginosa. Appl. Microbiol. Biotechnol. 79(1), 119-126 (2008).
200. Rogers SA, Melander C. Construction and screening of a 2-aminoimidazole library identifies a small molecule capable of inhibiting and dispersing bacterial biofilms across order, class, and phylum. Angew. Chem. Int. Ed. 47, 5229-5231 (2008).
201. Richards JJ, Huigens III RW, Ballard TE, Basso A, Cavanagh J, Melander, C. Inhibition and dispersion of proteobacterial biofilms. Chem. Commun. 14(14) 1698-1700 (2008).
202. Junker LM, Clardy J. High-throughput screens for small-molecule inhibitors of Pseudomonas aeruginosa biofilm development. Antimicrob. Agents Chemother. 51(10), 3582-3590 (2007).
203. Villain-Guillot P, Gualtieri M, Bastide L, Leonetti, JP. In vitro activities of different inhibitors of bacterial transcription against Staphylococcus epidermidis biofilm. Antimicrob. Agents Chemother. 51(9), 3117-3121 (2007).
204. Davies DG, Marques CNH. A fatty acid messenger is responsible for inducing dispersion in microbial biofilms. J. Bacteriol. 191(5), 1393-1403 (2009).
205. Nalca Y, Jänsch L, Bredenbruch F, Geffers R, Buer J, Häussler S. Quorum-sensing antagonistic activities of azithromycin in Pseudomonas aeruginosa PAO1: a global approach. Antimicrob. Agents Chemother. 50(5), 1680-1688 (2006).
206. Garske LA, Beatson SA, Leech AJ, Walsh SL, Bell SC. Sub-inhibitory concentrations of ceftazidime and tobramycin reduce the quorum sensing signals of Pseudomonas aeruginosa. Pathology 36(6), 571-575 (2004).
207. Barb AW, Jiang L, Raetz CR, Zhou P. Structure of the deactylase LpxC bound to the antibiotic CHIR-090: time-dependent inhibition and specificity in ligand binding. Proc. Natl Acad. Sci. USA 104(47), 18433-18438 (2007).
208. Barb AW, McClerren AL, Snehelatha K, Reynolds CM, Zhou P, Raetz CR. Inhibition of lipid A biosynthesis as the primary mechanism of CHIR-090 antibiotic activity in Escherichia coli. Biochemistry 46(12), 3793-3802 (2007).
209. Wang J, Soisson SM, Young K et al. Platensimycin is a selective FabF inhibitor with potent antibiotic properties. Nature 441(7091), 358-361 (2006).
210. Wang J, Kodali S, Lee SH et al. Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties. Proc. Natl Acad. Sci. USA 104(18), 7612-7616 (2007).
211. McNulty J, Nair JJ, Capretta A. A synthesis of sulfonamide analogs of platensimycin employing a palladium-mediated carbonylation strategy. Tetrahedron Lett. 50(28), 4087-4091 (2009).
212. Nicolaou KC, Tria GS, Edmonds DJ, Kar M. Total synthese of (±)-platencin and (-)-platencin. J. Am. Chem. Soc. 131(43), 15909-15917 (2009).
213. Barykina OV, Rossi KL, Rybak MJ, Snider BB. Synthesis and antibacterial properties of (-)-nor-platencin. Org. Lett. 11(22), 5334-5337 (2009).
214. Wang J, Lee V, Sintim HO. Efforts towards the identification of simpler platensimycin analogues-the total synthesis of oxazinidinyl platensimycin. Chem. Eur. J. 15(12), 2747-2750 (2009).
215. Brinster S, Lamberet G, Staels B, Trieu-Cuot P, Gruss A, Poyart C. Type II fatty acid synthesis is not a suitable antibiotic target for Gram-positive pathogens. Nature 458(7234), 83-86 (2009).
216. de Boer P, Crossley R, Rothfield L. The essential bacterial cell-division protein FtsZ is a GTPase. Nature 359(6392), 254-256 (1992).
217. Dasgupta, D. Novel compound with potential of an antibacterial drug targets FtsZ protein. Biochem. J. 423(1), E1-E3 (2009).
218. Lusetti SL, Cox MM. The bacterial RecA protein and the recombinational DNA repair of stalled replication forks. Ann. Rev. Biochem. 71, 71-100 (2002).
219. Wigle TJ, Singleton SF. Directed molecular screening for RecA ATPase inhibitors. Bioorg. Med. Chem. Lett. 17(12), 3249-3253 (2007).
220. Lentzen G, Klinck R, Matassova N, Aboul-ela F, Murchie AIH. Structural basis for contrasting activities of ribosome binding thiazole antibiotics. Chem. Biol. 10(8), 769-778 (2003).
221. Nicolaou KC, Nevalainen M, Zak M, Bulat S, Bella M, Safina BS. Synthetic studies on thiostrepton: construction of thiostrepton analogues with the thiazoline-containing macrocycle. Angew. Chem. Int. Ed. 42(29), 3418-3424 (2003).
222. Kelly WL, Pan L, Li C. Thiostrepton biosynthesis: prototype for a new family of bacteriocins. J. Am. Chem. Soc. 131(12), 4327-4334 (2009).
223. Chatterjee C, Paul M, Xie L, van der Donk WA. Biosynthesis and mode of action of lantibiotics. Chem. Rev. 105(2), 633-684 (2005).
224. Delves-Broughton J, Blackburn P, Evans RJ, Hugenholtz J. Applications of the bacteriocin, nisin. Anton. Van Leeuwen. 69(2), 193-202 (1996).
225. Bregant S, Tabor AB. Orthogonally protected lanthionines: synthesis and use for the solid-phase synthesis of an analogues of nisin ring C. J. Org. Chem. 70(7), 2430-2438 (2005).
226. Li B, Yu JP, Brunzelle JS, Moll GN, van der Donk WA, Nair SK. Structure and mechanism of the lantibiotic cyclase involved in nisin biosynthesis. Science 311(5766), 1464-1467 (2006).
227. Chen DZ, Patel DV, Hackbarth CJ et al. Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor. Biochemistry, 39(6), 1256-1262 (2000).
228. Römling U, Gomelsky M, Galperin MY. C-di-GMP: the dawning of a novel bacterial signalling system. Mol. Microbiol. 57(3), 629-639 (2005).
229. Ross P, Weinhouse H, Aloni Y et al. Regulation of cellulose synthesis in Acetobacter xylinum by cyclic diguanylic acid. Nature 325(6101), 279-281 (1987).
230. Ueda A, Wood TK. Connecting quorum sensing, c-di-GMP, pel polysaccharide, and biofilm formation in Pseudomonas aeruginosa through tyrosine phosphatase TpbA (PA3885). PloS Pathogens 5(6), e1000483 (2009).
231. Waters CM, Lu W, Rabinowitz JD, Bassler BL. Quorum sensing controls biofilm formation in Vibrio cholerae through modulation of cyclic di-GMP levels and repression of vpsT. J. Bacteriol. 190(7), 2527-2536 (2008).
232. Lenz DH, Mok KC, Lilley BN, Kulkarni RV, Wingreen NS, Bassler BL. The small RNA chaperone Hfq and multiple small RNAs control quorum sensing in Vibrio harveyi and Vibrio cholerae. Cell 118(1), 69-82 (2004).
233. Hammer BK, Bassler BL. Regulatory small RNAs circumvent the conventional quorum sensing pathway in pandemic Vibrio cholerae. Proc. Natl Acad. Sci. USA 104(27), 11145-11149 (2007).
234. Kovacikova G, Lin W, Skorupski K. Dual regulation of genes involved in acetoin biosynthesis and motility/ biofilm formation by the virulence activator AphA and the acetate-responsive LysR-type regulator AlsR in Vibrio cholerae. Mol. Microbiol. 57(2), 420-433 (2005).
235. Kiburu I, Shurer A, Yan L, Sintim HO. A simple solid-phase synthesis of the ubiquitous bacterial signaling molecule, c-di-GMP and analogues. Mol. Biosyst. 4(6), 518-520 (2008).
236. Kohanski MA, Dwyer DJ, Hayete B, Lawrence CA, Collins JJ. A common mechanism of cellular death induced by bactericidal antibiotics. Cell 130(5), 797-810 (2007).
237. Chhabra SR, Harty C, Hooi DS et al. Synthetic analogues of the bacterial signal (quorum sensing) molecule N-(3- oxododecanoyl)-l-homoserine lactone as immune modulators. J. Med. Chem. 46(1), 97-104 (2003).