-
1
-
-
7144248725
-
Plant antitumor agents: 1. The isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor from Camptotheca acuminata
-
Wall, M.E., Wani, M.C., Cook, C.E., Palmer, K.H., McPhail, A.T., and Sim, G.A. (1966) Plant antitumor agents: 1. The isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor from Camptotheca acuminata. Journal of the American Chemical Society, 88, 3888-3890.
-
(1966)
Journal of the American Chemical Society
, vol.88
, pp. 3888-3890
-
-
Wall, M.E.1
Wani, M.C.2
Cook, C.E.3
Palmer, K.H.4
McPhail, A.T.5
Sim, G.A.6
-
2
-
-
23644461357
-
Alternative administration of camptothecin analogues
-
Glaberman, U., Rabinowitz, I., and Verschraegen, C.F. (2005) Alternative administration of camptothecin analogues. Expert Opinion on Drug Delivery, 2, 323-333.
-
(2005)
Expert Opinion on Drug Delivery
, vol.2
, pp. 323-333
-
-
Glaberman, U.1
Rabinowitz, I.2
Verschraegen, C.F.3
-
3
-
-
0022340594
-
Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I
-
Hsiang, Y.H., Hertzberg, R., Hecht, S., and Liu, L.F. (1985) Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. The Journal of Biological Chemistry, 260, 14873-14878.
-
(1985)
The Journal of Biological Chemistry
, vol.260
, pp. 14873-14878
-
-
Hsiang, Y.H.1
Hertzberg, R.2
Hecht, S.3
Liu, L.F.4
-
4
-
-
0026099599
-
Synthesis of water-soluble (aminoalkyl) camptothecin analogues: inhibition of topoisomerase I and antitumor activity
-
Kingsbury, W.D., Boehm, J.C., Jakas, D.R., Holden, K.G., Hecht, S.M., Gallagher, G., Caranfa, M.J., McCabe, F.L., Faucette, L.F., and Johnson, R.K. (1991) Synthesis of water-soluble (aminoalkyl) camptothecin analogues: inhibition of topoisomerase I and antitumor activity. Journal of Medicinal Chemistry, 34, 98-107.
-
(1991)
Journal of Medicinal Chemistry
, vol.34
, pp. 98-107
-
-
Kingsbury, W.D.1
Boehm, J.C.2
Jakas, D.R.3
Holden, K.G.4
Hecht, S.M.5
Gallagher, G.6
Caranfa, M.J.7
McCabe, F.L.8
Faucette, L.F.9
Johnson, R.K.10
-
5
-
-
0025996996
-
Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11
-
Kawato, Y., Aonuma, M., Hirota, Y., Kuga, H., and Sato, K. (1991) Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11. Cancer Research, 51, 4187-4191.
-
(1991)
Cancer Research
, vol.51
, pp. 4187-4191
-
-
Kawato, Y.1
Aonuma, M.2
Hirota, Y.3
Kuga, H.4
Sato, K.5
-
6
-
-
0036304427
-
Current perspectives on the clinical experience, pharmacology, and continued development of the camptothecins
-
Garcia-Carbonero, R. and Supko, J.G. (2002) Current perspectives on the clinical experience, pharmacology, and continued development of the camptothecins. Clinical Cancer Research, 8, 641-661.
-
(2002)
Clinical Cancer Research
, vol.8
, pp. 641-661
-
-
Garcia-carbonero, R.1
Supko, J.G.2
-
7
-
-
0029144306
-
Metabolism of irinotecan to SN-38 in a tissue-isolated tumor model
-
Atsumi, R., Okazaki, O., and Hakusui, H. (1995) Metabolism of irinotecan to SN-38 in a tissue-isolated tumor model. Biological & Pharmaceutical Bulletin, 18, 1024.
-
(1995)
Biological & Pharmaceutical Bulletin
, vol.18
, pp. 1024
-
-
Atsumi, R.1
Okazaki, O.2
Hakusui, H.3
-
8
-
-
77950588535
-
Cancer therapies utilizing the camptothecins: a review on the in vivo literature
-
Venditto, V.J. and Simanek, E.E. (2010) Cancer therapies utilizing the camptothecins: a review on the in vivo literature. Molecular Pharmaceutics, 7 (2), 307-349.
-
(2010)
Molecular Pharmaceutics
, vol.7
, Issue.2
, pp. 307-349
-
-
Venditto, V.J.1
Simanek, E.E.2
-
9
-
-
67649373026
-
Diflomotecan, a promising homocamptothecin for cancer therapy
-
Kroep, J.R. and Gelderblom, H. (2009) Diflomotecan, a promising homocamptothecin for cancer therapy. Expert Opinion on Investigational Drugs, 18 (1), 69-75.
-
(2009)
Expert Opinion on Investigational Drugs
, vol.18
, Issue.1
, pp. 69-75
-
-
Kroep, J.R.1
Gelderblom, H.2
-
10
-
-
0038149018
-
Synthesis and pharmacological evaluation of novel non-lactone analogues of camptothecin
-
Hautefaye, P., Cimetiere, B., Pierre, A., Leonce, S., Hickman, J., Laine, W., Bailly, C., and Lavielle, G. (2003) Synthesis and pharmacological evaluation of novel non-lactone analogues of camptothecin. Bioorganic & Medicinal Chemistry Letters, 13, 2731-2735.
-
(2003)
Bioorganic & Medicinal Chemistry Letters
, vol.13
, pp. 2731-2735
-
-
Hautefaye, P.1
Cimetiere, B.2
Pierre, A.3
Leonce, S.4
Hickman, J.5
Laine, W.6
Bailly, C.7
Lavielle, G.8
-
11
-
-
34547182993
-
Novel stable camptothecin derivatives replacing the E-ring lactone by a ketone function are potent inhibitors of topoisomerase I and promising antitumor drugs
-
Lansiaux, A., Leonce, S., Kraus-Berthier, L., Bal-Mahieu, C., Mazinghien, R., Didier, S., David-Cordonnier, M.-H., Hautefaye, P., Lavielle, G., Bailly, C., Hickman, J.A., and Pierre, A. (2007) Novel stable camptothecin derivatives replacing the E-ring lactone by a ketone function are potent inhibitors of topoisomerase I and promising antitumor drugs. Molecular Pharmacology, 72, 311-319.
-
(2007)
Molecular Pharmacology
, vol.72
, pp. 311-319
-
-
Lansiaux, A.1
Leonce, S.2
Kraus-berthier, L.3
Bal-mahieu, C.4
Mazinghien, R.5
Didier, S.6
David-cordonnier, M.-H.7
Hautefaye, P.8
Lavielle, G.9
Bailly, C.10
Hickman, J.A.11
Pierre, A.12
-
12
-
-
84926432642
-
DNA topoisomerases and cancer
-
(Y. Pommier), Springer, New York
-
Champoux, J.J. (2012) DNA topoisomerases and cancer, in Human DNA Topoisomerase I: Structure, Enzymology and Biology (ed. Y. Pommier), Springer, New York, pp. 53-69.
-
(2012)
Human DNA Topoisomerase I: Structure, Enzymology and Biology
, pp. 53-69
-
-
Champoux, J.J.1
-
13
-
-
0015222656
-
Interaction between DNA and an Escherichia coli protein v
-
Wang, J.C. (1971) Interaction between DNA and an Escherichia coli protein v. Journal of Molecular Biology, 55, 523-533.
-
(1971)
Journal of Molecular Biology
, vol.55
, pp. 523-533
-
-
Wang, J.C.1
-
14
-
-
0018882091
-
Type II DNA topoisomerases: enzymes that can unknot a topologically knotted DNA molecule via a reversible double-strand break
-
Liu, L.F., Liu, C.-C., and Alberts, B.M. (1980) Type II DNA topoisomerases: enzymes that can unknot a topologically knotted DNA molecule via a reversible double-strand break. Cell, 19, 697-707.
-
(1980)
Cell
, vol.19
, pp. 697-707
-
-
Liu, L.F.1
Liu, C.-C.2
Alberts, B.M.3
-
15
-
-
77954187741
-
DNA topoisomerases and their poisoning by anticancer and antibacterial drugs
-
Pommier, Y., Leo, E., Zhang, H., and Marchand, C. (2010) DNA topoisomerases and their poisoning by anticancer and antibacterial drugs. Chemistry & Biology, 17, 421-433.
-
(2010)
Chemistry & Biology
, vol.17
, pp. 421-433
-
-
Pommier, Y.1
Leo, E.2
Zhang, H.3
Marchand, C.4
-
16
-
-
84926457045
-
Unraveling the catalytic mechanism of topoisomerase V, Senior Honors Thesis
-
Northwestern University, Chicago, IL
-
Gast, A. (2010) Unraveling the catalytic mechanism of topoisomerase V, Senior Honors Thesis, Northwestern University, Chicago, IL, pp. 1-65.
-
(2010)
, pp. 1-65
-
-
Gast, A.1
-
17
-
-
63349107052
-
Structural studies of type I topoisomerases
-
Baker, N.M., Rajan, R., and Mondragón, A. (2009) Structural studies of type I topoisomerases. Nucleic Acids Research, 37, 693-701.
-
(2009)
Nucleic Acids Research
, vol.37
, pp. 693-701
-
-
Baker, N.M.1
Rajan, R.2
Mondragón, A.3
-
18
-
-
2442599792
-
Structure, molecular mechanisms, and evolutionary relationships in DNA topoisomerases
-
Corbett, K.D. and Berger, J.M. (2004) Structure, molecular mechanisms, and evolutionary relationships in DNA topoisomerases. Annual Review of Biophysics and Biomolecular Structure, 33, 95-118.
-
(2004)
Annual Review of Biophysics and Biomolecular Structure
, vol.33
, pp. 95-118
-
-
Corbett, K.D.1
Berger, J.M.2
-
19
-
-
84855347756
-
Interfacial inhibitors: targeting macromolecular complexes
-
Pommier, Y. and Marchand, C. (2012) Interfacial inhibitors: targeting macromolecular complexes. Nature Reviews. Drug Discovery, 11, 25-36.
-
(2012)
Nature Reviews. Drug Discovery
, vol.11
, pp. 25-36
-
-
Pommier, Y.1
Marchand, C.2
-
20
-
-
0037180432
-
The mechanism of topoisomerase I poisoning by a camptothecin analog
-
Staker, B.L., Hjerrild, K., Feese, M.D., Behnke, C.A., Burgin, A.B., and Stewart, L. (2002) The mechanism of topoisomerase I poisoning by a camptothecin analog. Proceedings of the National Academy of Sciences of the United States of America, 99, 15387-15392.
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, pp. 15387-15392
-
-
Staker, B.L.1
Hjerrild, K.2
Feese, M.D.3
Behnke, C.A.4
Burgin, A.B.5
Stewart, L.6
-
21
-
-
17144371295
-
Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex
-
Staker, B.L., Feese, M.D., Cushman, M., Pommier, Y., Zembower, D., Stewart, L., and Burgin, A.B. (2005) Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex. Journal of Medicinal Chemistry, 48 (7), 2336-2345.
-
(2005)
Journal of Medicinal Chemistry
, vol.48
, Issue.7
, pp. 2336-2345
-
-
Staker, B.L.1
Feese, M.D.2
Cushman, M.3
Pommier, Y.4
Zembower, D.5
Stewart, L.6
Burgin, A.B.7
-
22
-
-
33644970269
-
A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of topoisomerase I-DNA covalent complexes
-
Marchand, C., Antony, S., Kohn, K.W., Cushman, M., Ioanoviciu, A., Staker, B.L., Burgin, A.B., Stewart, L., and Pommier, Y. (2006) A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of topoisomerase I-DNA covalent complexes. Molecular Cancer Therapeutics, 5 (2), 287-295.
-
(2006)
Molecular Cancer Therapeutics
, vol.5
, Issue.2
, pp. 287-295
-
-
Marchand, C.1
Antony, S.2
Kohn, K.W.3
Cushman, M.4
Ioanoviciu, A.5
Staker, B.L.6
Burgin, A.B.7
Stewart, L.8
Pommier, Y.9
-
23
-
-
0032580961
-
Differential effects of camptothecin derivatives on topoisomerase I-mediated DNA structure modification
-
Wang, X., Wang, L.-K., Kingsbury, W.D., Johnson, R.K., and Hecht, S.M. (1998) Differential effects of camptothecin derivatives on topoisomerase I-mediated DNA structure modification. Biochemistry, 37 (26), 9399-9408.
-
(1998)
Biochemistry
, vol.37
, Issue.26
, pp. 9399-9408
-
-
Wang, X.1
Wang, L.-K.2
Kingsbury, W.D.3
Johnson, R.K.4
Hecht, S.M.5
-
24
-
-
0032489634
-
Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA
-
Redinbo, M.R., Stewart, L., Kuhn, P., Champoux, J.J., and Hol, W.G. (1998) Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA. Science, 279, 1504-1513.
-
(1998)
Science
, vol.279
, pp. 1504-1513
-
-
Redinbo, M.R.1
Stewart, L.2
Kuhn, P.3
Champoux, J.J.4
Hol, W.G.5
-
25
-
-
0026329950
-
Modeling of antibody combining sites
-
Padlan, E.A. and Kabat, E.A. (1991) Modeling of antibody combining sites. Methods in Enzymology, 203, 3-21.
-
(1991)
Methods in Enzymology
, vol.203
, pp. 3-21
-
-
Padlan, E.A.1
Kabat, E.A.2
-
26
-
-
0037022183
-
Human topoisomerase I inhibition: docking camptothecin and derivatives into a structure-based active site model
-
Laco, G.S., Collins, J.R., Luke, B.T., Kroth, H., Sayer, J.M., Jerina, D.M., and Pommier, Y. (2002) Human topoisomerase I inhibition: docking camptothecin and derivatives into a structure-based active site model. Biochemistry, 41 (5), 1428-1435.
-
(2002)
Biochemistry
, vol.41
, Issue.5
, pp. 1428-1435
-
-
Laco, G.S.1
Collins, J.R.2
Luke, B.T.3
Kroth, H.4
Sayer, J.M.5
Jerina, D.M.6
Pommier, Y.7
-
27
-
-
0035928802
-
A structural model for the ternary cleavable complex formed between human topoisomerase I, DNA, and camptothecin
-
Kerrigan, J.E. and Pilch, D.S. (2001) A structural model for the ternary cleavable complex formed between human topoisomerase I, DNA, and camptothecin. Biochemistry, 40 (33), 9792-9798.
-
(2001)
Biochemistry
, vol.40
, Issue.33
, pp. 9792-9798
-
-
Kerrigan, J.E.1
Pilch, D.S.2
-
28
-
-
58849133822
-
Persistence of camptothecin analog-topoisomerase I-DNA ternary complexes: a molecular dynamics study
-
Siu, Fung-Ming and Che, Chi-Ming (2008) Persistence of camptothecin analog-topoisomerase I-DNA ternary complexes: a molecular dynamics study. Journal of the American Chemical Society, 130, 17928-17937.
-
(2008)
Journal of the American Chemical Society
, vol.130
, pp. 17928-17937
-
-
Siu, F.-M.1
Che, C.2
-
29
-
-
2542425518
-
Mechanisms of camptothecin resistance by human topoisomerase I mutations
-
Chrencik, J.E., Staker, B.L., Burgin, A.B., Pourquier, P., Pommier, Y., Stewart, L., and Redinbo, M.R. (2004) Mechanisms of camptothecin resistance by human topoisomerase I mutations. Journal of Molecular Biology, 339 (4), 773-784.
-
(2004)
Journal of Molecular Biology
, vol.339
, Issue.4
, pp. 773-784
-
-
Chrencik, J.E.1
Staker, B.L.2
Burgin, A.B.3
Pourquier, P.4
Pommier, Y.5
Stewart, L.6
Redinbo, M.R.7
-
30
-
-
0024560495
-
Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: evidence for a specific receptor site and a relation to antitumor activity
-
Jaxel, C., Kohn, K.W., Wani, M.C., Wall, M.E., and Pommier, Y. (1989) Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: evidence for a specific receptor site and a relation to antitumor activity. Cancer Research, 49, 1465-1469.
-
(1989)
Cancer Research
, vol.49
, pp. 1465-1469
-
-
Jaxel, C.1
Kohn, K.W.2
Wani, M.C.3
Wall, M.E.4
Pommier, Y.5
-
31
-
-
34548763143
-
Nonclassic functions of human topoisomerase I: genome-wide and pharmacologic analyses
-
Miao, Z.H., Player, A., Shankavaram, U., Wang, Y.H., Zimonjic, D.B., Lorenzi, P.L., Liao, Z.Y., Liu, H., Shimura, T., Zhang, H.L., Meng, L.H., Zhang, Y.W., Kawasaki, E.S., Popescu, N.C., Aladjem, M.I., Goldstein, D.J., Weinstein, J.N., and Pommier, Y. (2007) Nonclassic functions of human topoisomerase I: genome-wide and pharmacologic analyses. Cancer Research, 67 (18), 8752-8761.
-
(2007)
Cancer Research
, vol.67
, Issue.18
, pp. 8752-8761
-
-
Miao, Z.H.1
Player, A.2
Shankavaram, U.3
Wang, Y.H.4
Zimonjic, D.B.5
Lorenzi, P.L.6
Liao, Z.Y.7
Liu, H.8
Shimura, T.9
Zhang, H.L.10
Meng, L.H.11
Zhang, Y.W.12
Kawasaki, E.S.13
Popescu, N.C.14
Aladjem, M.I.15
Goldstein, D.J.16
Weinstein, J.N.17
Pommier, Y.18
-
32
-
-
0028006314
-
Elevation of topoisomerase I messenger RNA, protein, and catalytic activity in human tumors: demonstration of tumor-type specificity and implications for cancer chemotherapy
-
Husain, I., Mohler, J.L., Seigler, H.F., and Besterman, J.M. (1994) Elevation of topoisomerase I messenger RNA, protein, and catalytic activity in human tumors: demonstration of tumor-type specificity and implications for cancer chemotherapy. Cancer Research, 54 (2), 539-546.
-
(1994)
Cancer Research
, vol.54
, Issue.2
, pp. 539-546
-
-
Husain, I.1
Mohler, J.L.2
Seigler, H.F.3
Besterman, J.M.4
-
33
-
-
0028267240
-
Camptothecins: from bench research to hospital wards
-
Potmesil, M. (1994) Camptothecins: from bench research to hospital wards. Cancer Research, 54 (6), 1431-1439.
-
(1994)
Cancer Research
, vol.54
, Issue.6
, pp. 1431-1439
-
-
Potmesil, M.1
-
34
-
-
84864722456
-
Histone deacetylase inhibitors in the treatment of cancer: overview and perspectives
-
Giannini, G., Cabri, W., Fattorusso, C., and Rodriquez, M. (2012) Histone deacetylase inhibitors in the treatment of cancer: overview and perspectives. Future Medicinal Chemistry, 4 (11), 1439-1460.
-
(2012)
Future Medicinal Chemistry
, vol.4
, Issue.11
, pp. 1439-1460
-
-
Giannini, G.1
Cabri, W.2
Fattorusso, C.3
Rodriquez, M.4
-
35
-
-
0034821939
-
Role of transport proteins in drug absorption, distribution and excretion
-
Ayrton, A. and Morgan, P. (2001) Role of transport proteins in drug absorption, distribution and excretion. Xenobiotica; The Fate of Foreign Compounds in Biological Systems, 31, 469-497.
-
(2001)
Xenobiotica; The Fate of Foreign Compounds in Biological Systems
, vol.31
, pp. 469-497
-
-
Ayrton, A.1
Morgan, P.2
-
36
-
-
0344394180
-
Mechanisms of resistance to topoisomerase I targeting drugs
-
Rasheed, Z.A. and Rubin, E.H. (2003) Mechanisms of resistance to topoisomerase I targeting drugs. Oncogene, 22, 7296-7304.
-
(2003)
Oncogene
, vol.22
, pp. 7296-7304
-
-
Rasheed, Z.A.1
Rubin, E.H.2
-
38
-
-
33749034730
-
Topoisomerase I inhibitors: camptothecins and beyond
-
Pommier, Y. (2006) Topoisomerase I inhibitors: camptothecins and beyond. Nature Reviews. Cancer, 6 (10), 789-802.
-
(2006)
Nature Reviews. Cancer
, vol.6
, Issue.10
, pp. 789-802
-
-
Pommier, Y.1
-
39
-
-
74949123158
-
DNA topoisomerase I inhibition by camptothecin induces escape of RNA polymerase II from promoter-proximal pause site, antisense transcription and histone acetylation at the human HIF-1a gene locus
-
Baranello, L., Bertozzi, D., Fogli, M.V., Pommier, Y., and Capranico, G. (2010) DNA topoisomerase I inhibition by camptothecin induces escape of RNA polymerase II from promoter-proximal pause site, antisense transcription and histone acetylation at the human HIF-1a gene locus. Nucleic Acids Research, 38 (1), 159-171.
-
(2010)
Nucleic Acids Research
, vol.38
, Issue.1
, pp. 159-171
-
-
Baranello, L.1
Bertozzi, D.2
Fogli, M.V.3
Pommier, Y.4
Capranico, G.5
-
40
-
-
84855807682
-
Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons
-
Huang, H.S., Allen, J.A., Mabb, A.M., King, I.F., Miriyala, J., Taylor-Blake, B., Sciaky, N., Dutton, J.W., Lee, H.-M., Chen, X., Jin, J., Bridges, A.S., Zylka, M.J., Roth, B.L., and Philpot, B.D. (2012) Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons. Nature, 481, 185-189.
-
(2012)
Nature
, vol.481
, pp. 185-189
-
-
Huang, H.S.1
Allen, J.A.2
Mabb, A.M.3
King, I.F.4
Miriyala, J.5
Taylor-blake, B.6
Sciaky, N.7
Dutton, J.W.8
Lee, H.-M.9
Chen, X.10
Jin, J.11
Bridges, A.S.12
Zylka, M.J.13
Roth, B.L.14
Philpot, B.D.15
-
41
-
-
67649366436
-
Novel camptothecin derivatives as topoisomerase I inhibitors
-
Basili, S. and Moro, S. (2009) Novel camptothecin derivatives as topoisomerase I inhibitors. Expert Opinion on Therapeutic Patents, 19, 555-574.
-
(2009)
Expert Opinion on Therapeutic Patents
, vol.19
, pp. 555-574
-
-
Basili, S.1
Moro, S.2
-
42
-
-
45849107634
-
Topoisomerase I inhibitors for the treatment of brain tumors
-
Feun, L. and Savaraj, N. (2008) Topoisomerase I inhibitors for the treatment of brain tumors. Expert Review of Anticancer Therapy, 8 (5), 707-716.
-
(2008)
Expert Review of Anticancer Therapy
, vol.8
, Issue.5
, pp. 707-716
-
-
Feun, L.1
Savaraj, N.2
-
44
-
-
32544454332
-
Pharmacokinetics and biodistribution of the camptothecin-polymer conjugate IT-101 in rats and tumor-bearing mice
-
Schluep, T., Cheng, J., Khin, K.T. et al. (2006) Pharmacokinetics and biodistribution of the camptothecin-polymer conjugate IT-101 in rats and tumor-bearing mice. Cancer Chemotherapy and Pharmacology, 7, 654-662.
-
(2006)
Cancer Chemotherapy and Pharmacology
, vol.7
, pp. 654-662
-
-
Schluep, T.1
Cheng, J.2
Khin, K.T.3
-
45
-
-
33645087362
-
Preclinical efficacy of the camptothecin-polymer conjugate IT-101 in multiple cancer models
-
Schluep, T., Hwang, J., Cheng, J. et al. (2006) Preclinical efficacy of the camptothecin-polymer conjugate IT-101 in multiple cancer models. Clinical Cancer Research, 12, 1606-1614.
-
(2006)
Clinical Cancer Research
, vol.12
, pp. 1606-1614
-
-
Schluep, T.1
Hwang, J.2
Cheng, J.3
-
46
-
-
84887139072
-
A phase 1 study of XMT-1001, a novel water soluble camptothecin conjugate, given as an intravenous infusion once every three weeks to patients with advanced solid tumors
-
Sausville, E.A., Garbo, L.E., Weiss, G.J., Shkolny, D., Yurkovetskiy, A.V., Bethune, C., Ramanathan, R., and Fram, R.J. (2009) A phase 1 study of XMT-1001, a novel water soluble camptothecin conjugate, given as an intravenous infusion once every three weeks to patients with advanced solid tumors.. Molecular Cancer Therapeutics, 8 (12), B52. www.mersana.com/objects/docs/AACR_Poster_2009_11-02-09.pdf.
-
(2009)
Molecular Cancer Therapeutics
, vol.8
, Issue.12
, pp. B52
-
-
Sausville, E.A.1
Garbo, L.E.2
Weiss, G.J.3
Shkolny, D.4
Yurkovetskiy, A.V.5
Bethune, C.6
Ramanathan, R.7
Fram, R.J.8
-
47
-
-
84861555008
-
Metabolic difference of CZ48 in human and mouse liver microsomes
-
Liu, X., DeJesus, A., Cao, Z., Vardeman, D., and Giovanella, B. (2012) Metabolic difference of CZ48 in human and mouse liver microsomes. International Journal of Molecular Sciences, 13, 5498-5505.
-
(2012)
International Journal of Molecular Sciences
, vol.13
, pp. 5498-5505
-
-
Liu, X.1
DeJesus, A.2
Cao, Z.3
Vardeman, D.4
Giovanella, B.5
-
48
-
-
0025663422
-
Equilibrium kinetics of the new experimental anti-tumour compound SK&F 104864-A in aqueous solution
-
Underberg, W.J., Goossen, R.M., Smith, B. R., and Beijnen, J.H. (1990) Equilibrium kinetics of the new experimental anti-tumour compound SK&F 104864-A in aqueous solution. Journal of Pharmaceutical and Biomedical Analysis, 8, 681-683.
-
(1990)
Journal of Pharmaceutical and Biomedical Analysis
, vol.8
, pp. 681-683
-
-
Underberg, W.J.1
Goossen, R.M.2
Smith, B.R.3
Beijnen, J.H.4
-
49
-
-
58749092817
-
A phase III trial of topotecan and whole brain radiation therapy for patients with CNS-metastases due to lung cancer
-
Neuhaus, T., Ko, Y., Muller, R.P., Grabenbauer, G.G., Hedde, J.P., Schueller, H., Kocher, M., Stier, S., and Fietkau, R. (2009) A phase III trial of topotecan and whole brain radiation therapy for patients with CNS-metastases due to lung cancer. British Journal of Cancer, 100, 291-297.
-
(2009)
British Journal of Cancer
, vol.100
, pp. 291-297
-
-
Neuhaus, T.1
Ko, Y.2
Muller, R.P.3
Grabenbauer, G.G.4
Hedde, J.P.5
Schueller, H.6
Kocher, M.7
Stier, S.8
Fietkau, R.9
-
50
-
-
0036390879
-
Update on the role of topotecan in the treatment of recurrent ovarian cancer
-
Herzog, T.J. (2002) Update on the role of topotecan in the treatment of recurrent ovarian cancer. Oncologist, 7 (Suppl. 5), 3-10.
-
(2002)
Oncologist
, vol.7
, pp. 3-10
-
-
Herzog, T.J.1
-
51
-
-
77955532240
-
Systematic review of topotecan (Hycamtin) in relapsed small cell lung cancer
-
Riemsma, R., Simons, J.P., Bashir, Z., Gooch, C.L., and Kleijnen, J. (2010) Systematic review of topotecan (Hycamtin) in relapsed small cell lung cancer. BMC Cancer, 10, 436.
-
(2010)
BMC Cancer
, vol.10
, pp. 436
-
-
Riemsma, R.1
Simons, J.P.2
Bashir, Z.3
Gooch, C.L.4
Kleijnen, J.5
-
52
-
-
77951058314
-
Enhancement of radiation induced DNA damage and inhibition of its repair by a novel camptothecin analog
-
Huang, G., Wang, H., and Yang, L.X. (2010) Enhancement of radiation induced DNA damage and inhibition of its repair by a novel camptothecin analog. Anticancer Research, 30, 937-944.
-
(2010)
Anticancer Research
, vol.30
, pp. 937-944
-
-
Huang, G.1
Wang, H.2
Yang, L.X.3
-
53
-
-
0025899645
-
Synthesis and antitumor activity of 20(S)-camptothecin derivatives: carbamate-linked, water-soluble derivatives of 7-ethyl-10-hydroxycamptothecin
-
Sawada, S., Okajima, S., Aiyama, R., Nokata, K.-I., Furata, T., Yokpkura, T., Sugimo, E., Yamaguchi, K., and Miyasaka, T. (1991) Synthesis and antitumor activity of 20(S)-camptothecin derivatives: carbamate-linked, water-soluble derivatives of 7-ethyl-10-hydroxycamptothecin. Chemical & Pharmaceutical Bulletin, 39 (6), 1446-1450.
-
(1991)
Chemical & Pharmaceutical Bulletin
, vol.39
, Issue.6
, pp. 1446-1450
-
-
Sawada, S.1
Okajima, S.2
Aiyama, R.3
Nokata, K.-I.4
Furata, T.5
Yokpkura, T.6
Sugimo, E.7
Yamaguchi, K.8
Miyasaka, T.9
-
54
-
-
0034892379
-
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11)
-
Mathijssen, R.H., van Alphen, R.J., Verweij, J., Loos, W.J., Nooter, K., Stoter, G., and Sparreboom, A. (2001) Clinical pharmacokinetics and metabolism of irinotecan (CPT-11). Clinical Cancer Research, 7 (8), 2182-2194.
-
(2001)
Clinical Cancer Research
, vol.7
, Issue.8
, pp. 2182-2194
-
-
Mathijssen, R.H.1
van Alphen, R.J.2
Verweij, J.3
Loos, W.J.4
Nooter, K.5
Stoter, G.6
Sparreboom, A.7
-
55
-
-
0025851286
-
Phase I study of weekly intravenous infusions of CPT-11, a new derivative of camptothecin, in the treatment of advanced non-small-cell lung cancer
-
Negoro, S., Fukuoka, M., Masuda, N., Takada, M., Kusunoki, Y., Matsui, K., Takifuji, N., Kudoh, S., Niitani, H., and Taguchi, T. (1991) Phase I study of weekly intravenous infusions of CPT-11, a new derivative of camptothecin, in the treatment of advanced non-small-cell lung cancer. Journal of the National Cancer Institute, 83 (16), 1164-1168.
-
(1991)
Journal of the National Cancer Institute
, vol.83
, Issue.16
, pp. 1164-1168
-
-
Negoro, S.1
Fukuoka, M.2
Masuda, N.3
Takada, M.4
Kusunoki, Y.5
Matsui, K.6
Takifuji, N.7
Kudoh, S.8
Niitani, H.9
Taguchi, T.10
-
56
-
-
41549105038
-
Novel delivery of SN38 markedly inhibits tumor growth in xenografts, including a camptothecin-11 -refractory model
-
Sapra, P., Zhao, H., Mehlig, M., Malaby, J., Kraft, P., Longley, C., Greenberger, L.M., Ivan, D., and Horak, I.D. (2008) Novel delivery of SN38 markedly inhibits tumor growth in xenografts, including a camptothecin-11 -refractory model. Clinical Cancer Research, 14, 1888-1896.
-
(2008)
Clinical Cancer Research
, vol.14
, pp. 1888-1896
-
-
Sapra, P.1
Zhao, H.2
Mehlig, M.3
Malaby, J.4
Kraft, P.5
Longley, C.6
Greenberger, L.M.7
Ivan, D.8
Horak, I.D.9
-
57
-
-
84875969630
-
Poly(ethylene glycol)-prodrug conjugates: concept, design, and applications
-
Banerjee, S.S., Aher, N., Patil, R., and Jayant Khandare, J. (2012) Poly(ethylene glycol)-prodrug conjugates: concept, design, and applications. Journal of Drug Delivery, 2012, 1-17.
-
(2012)
Journal of Drug Delivery
, vol.2012
, pp. 1-17
-
-
Banerjee, S.S.1
Aher, N.2
Patil, R.3
Jayant Khandare, J.4
-
58
-
-
42949130549
-
Novel prodrugs of SN38 using multiarm poly (ethylene glycol) linkers
-
Zhao, H., Rubio, B., Sapra, P., Wu, D., Reddy, P., Sai, P., Martinez, A., Gao, Y., Lozanguiez, Y., Longley, C., Greenberger, L.M., and Horak, I.D. (2008) Novel prodrugs of SN38 using multiarm poly (ethylene glycol) linkers. Bioconjugate Chemistry, 19 (4), 849-859.
-
(2008)
Bioconjugate Chemistry
, vol.19
, Issue.4
, pp. 849-859
-
-
Zhao, H.1
Rubio, B.2
Sapra, P.3
Wu, D.4
Reddy, P.5
Sai, P.6
Martinez, A.7
Gao, Y.8
Lozanguiez, Y.9
Longley, C.10
Greenberger, L.M.11
Horak, I.D.12
-
59
-
-
0033110137
-
A phase II clinical and pharmacological study of oral 9-nitrocamptothecin in patients with refractory epithelial ovarian, tubal or peritoneal cancer
-
Verschraegen, C.F., Gupta, E., Loyer, E., Kavanagh, J.J., Kudelka, A.P., Freedman, R.S., Edwards, C.L., Harris, N., Steger, M., Steltz, V., Giovanella, B.C., and Stehlin, J.S. (1999) A phase II clinical and pharmacological study of oral 9-nitrocamptothecin in patients with refractory epithelial ovarian, tubal or peritoneal cancer. Anti-Cancer Drugs, 10 (4), 375-383.
-
(1999)
Anti-Cancer Drugs
, vol.10
, Issue.4
, pp. 375-383
-
-
Verschraegen, C.F.1
Gupta, E.2
Loyer, E.3
Kavanagh, J.J.4
Kudelka, A.P.5
Freedman, R.S.6
Edwards, C.L.7
Harris, N.8
Steger, M.9
Steltz, V.10
Giovanella, B.C.11
Stehlin, J.S.12
-
60
-
-
23244443466
-
A phase I study of concurrent 9-nitro-20(S)-camptothecin (9 NC/orathecin) and radiation therapy in the treatment of locally advanced adenocarcinoma of the pancreas
-
Tedesco, K.L., Berlin, J., Rothenberg, M., Choy, H., Wyman, K., Scott Pearson, A., Daniel Beauchamp, R., Merchant, N., Lockhart, A.C., Shyr, Y., Caillouette, C., and Chakravarthy, B. (2005) A phase I study of concurrent 9-nitro-20(S)-camptothecin (9 NC/orathecin) and radiation therapy in the treatment of locally advanced adenocarcinoma of the pancreas. Radiotherapy & Oncology, 76 (1), 54-58.
-
(2005)
Radiotherapy & Oncology
, vol.76
, Issue.1
, pp. 54-58
-
-
Tedesco, K.L.1
Berlin, J.2
Rothenberg, M.3
Choy, H.4
Wyman, K.5
Scott Pearson, A.6
Daniel Beauchamp, R.7
Merchant, N.8
Lockhart, A.C.9
Shyr, Y.10
Caillouette, C.11
Chakravarthy, B.12
-
61
-
-
79952783035
-
14-Aminocamptothecins: their synthesis, preclinical activity, and potential use for cancer treatment
-
Duan, J.-X., Cai, X., Meng, F., Sun, J.D., Liu, Q., Jung, D., Jiao, H., Matteucci, J., Jung, B., Bhupathi, D., Ahluwalia, D., Huang, H., Hart, C.P., and Matteucci, M. (2011) 14-Aminocamptothecins: their synthesis, preclinical activity, and potential use for cancer treatment. Journal of Medicinal Chemistry, 54, 1715-1723.
-
(2011)
Journal of Medicinal Chemistry
, vol.54
, pp. 1715-1723
-
-
Duan, J.-X.1
Cai, X.2
Meng, F.3
Sun, J.D.4
Liu, Q.5
Jung, D.6
Jiao, H.7
Matteucci, J.8
Jung, B.9
Bhupathi, D.10
Ahluwalia, D.11
Huang, H.12
Hart, C.P.13
Matteucci, M.14
-
62
-
-
0036399299
-
Camptothecins: a review of their chemotherapeutic potential
-
Ulukan, H. and Swaan, P.W. (2002) Camptothecins: a review of their chemotherapeutic potential. Drugs, 62, 2039-2057.
-
(2002)
Drugs
, vol.62
, pp. 2039-2057
-
-
Ulukan, H.1
Swaan, P.W.2
-
63
-
-
9644281612
-
Phase II study of OSI-211 (liposomal lurtotecan) in patients with metastatic or loco-regional recurrent squamous cell carcinoma of the head and neck
-
Duffaud, F., Borner, M., Chollet, P., Vermorken, J.B., Bloch, J., Degardin, M., Rolland, F., Dittrich, C., Baron, B., Lacombe, D., and Fumoleau, P. (2004) Phase II study of OSI-211 (liposomal lurtotecan) in patients with metastatic or loco-regional recurrent squamous cell carcinoma of the head and neck. European Journal of Cancer (Oxford, England: 1990), 40 (18), 2748-2752.
-
(2004)
European Journal of Cancer (Oxford, England: 1990)
, vol.40
, Issue.18
, pp. 2748-2752
-
-
Duffaud, F.1
Borner, M.2
Chollet, P.3
Vermorken, J.B.4
Bloch, J.5
Degardin, M.6
Rolland, F.7
Dittrich, C.8
Baron, B.9
Lacombe, D.10
Fumoleau, P.11
-
64
-
-
0033911713
-
Antitumor efficacy, pharmacokinetics, and biodistribution of NX 211: a low-clearance liposomal formulation of lurtotecan
-
Emerson, D.L., Bendele, R., Brown, E., Chiang, S., Desjardins, J.P., Dihel, L.C., Gill, S.C., Hamilton, M., LeRay, J.D., Moon-McDermott, L., Moynihan, K., Richardson, F.C., Tomkinson, B., Luzzio, M.J., and Baccanari, D. (2000) Antitumor efficacy, pharmacokinetics, and biodistribution of NX 211: a low-clearance liposomal formulation of lurtotecan. Clinical Cancer Research, 6 (7), 2903-2912.
-
(2000)
Clinical Cancer Research
, vol.6
, Issue.7
, pp. 2903-2912
-
-
Emerson, D.L.1
Bendele, R.2
Brown, E.3
Chiang, S.4
Desjardins, J.P.5
Dihel, L.C.6
Gill, S.C.7
Hamilton, M.8
LeRay, J.D.9
Moon-mcDermott, L.10
Moynihan, K.11
Richardson, F.C.12
Tomkinson, B.13
Luzzio, M.J.14
Baccanari, D.15
-
65
-
-
0035281536
-
Phase I and pharmacokinetic study of exatecan mesylate (DX-8951f): a novel camptothecin analog
-
Royce, M.E., Hoff, P.M., Dumas, P., Lassere, Y., Lee, J.J., Coyle, J., Ducharme, M.P., De Jager, R., and Pazdur, R. (2001) Phase I and pharmacokinetic study of exatecan mesylate (DX-8951f): a novel camptothecin analog. Journal of Clinical Oncology, 19 (5), 1493-1500.
-
(2001)
Journal of Clinical Oncology
, vol.19
, Issue.5
, pp. 1493-1500
-
-
Royce, M.E.1
Hoff, P.M.2
Dumas, P.3
Lassere, Y.4
Lee, J.J.5
Coyle, J.6
Ducharme, M.P.7
De Jager, R.8
Pazdur, R.9
-
66
-
-
33749071359
-
Randomized phase III study of exatecan and gemcitabine compared with gemcitabine alone in untreated advanced pancreatic cancer
-
Abou-Alfa, G.K., Letourneau, R., Harker, G., Modiano, M., Hurwitz, H., Tchekmedyian, N.S., Feit, K., Ackerman, J., De Jager, R.L., Eckhardt, S.G., and O'Reilly, E.M. (2006) Randomized phase III study of exatecan and gemcitabine compared with gemcitabine alone in untreated advanced pancreatic cancer. Journal of Clinical Oncology, 24 (27), 4441-4447.
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.27
, pp. 4441-4447
-
-
Abou-alfa, G.K.1
Letourneau, R.2
Harker, G.3
Modiano, M.4
Hurwitz, H.5
Tchekmedyian, N.S.6
Feit, K.7
Ackerman, J.8
De Jager, R.L.9
Eckhardt, S.G.10
O'Reilly, E.M.11
-
67
-
-
0042889292
-
A phase II study of intravenous exatecan mesylate (DX-8951f) administered daily for 5 days every 3 weeks to patients with metastatic breast carcinoma
-
Esteva, F.J., Rivera, E., Cristofanilli, M., Valero, V., Royce, M., Duggal, A., Colucci, P., DeJager, R., and Hortobagyi, G.N. (2003) A phase II study of intravenous exatecan mesylate (DX-8951f) administered daily for 5 days every 3 weeks to patients with metastatic breast carcinoma. Cancer, 98 (5), 900-907.
-
(2003)
Cancer
, vol.98
, Issue.5
, pp. 900-907
-
-
Esteva, F.J.1
Rivera, E.2
Cristofanilli, M.3
Valero, V.4
Royce, M.5
Duggal, A.6
Colucci, P.7
DeJager, R.8
Hortobagyi, G.N.9
-
68
-
-
0742321775
-
A phase II study of intravenous exatecan mesylate (DX-8951f) administered daily for 5 days every 3 weeks to patients with advanced ovarian, tubal or peritoneal cancer resistant to platinum, taxane and topotecan
-
Verschraegen, C.F., Kudelka, A.P., Hu, W., Vincent, M., Kavanagh, J.J., Loyer, E., Bastien, L., Duggal, A., and De Jager, R. (2004) A phase II study of intravenous exatecan mesylate (DX-8951f) administered daily for 5 days every 3 weeks to patients with advanced ovarian, tubal or peritoneal cancer resistant to platinum, taxane and topotecan. Cancer Chemotherapy and Pharmacology, 53 (1), 1-7.
-
(2004)
Cancer Chemotherapy and Pharmacology
, vol.53
, Issue.1
, pp. 1-7
-
-
Verschraegen, C.F.1
Kudelka, A.P.2
Hu, W.3
Vincent, M.4
Kavanagh, J.J.5
Loyer, E.6
Bastien, L.7
Duggal, A.8
De Jager, R.9
-
69
-
-
18744367197
-
Phase III results of exatecan (DX-8951f) versus gemcitabine (Gem) in chemotherapy-naive patients with advanced pancreatic cancer (APC)
-
Cheverton, P.F.H., Andras, C., Salek, T., Geddes, C., Bodoky, G., Valle, J., and Humblet, Y. (2004) Phase III results of exatecan (DX-8951f) versus gemcitabine (Gem) in chemotherapy-naive patients with advanced pancreatic cancer (APC). Journal of Clinical Oncology, 22, 4005.
-
(2004)
Journal of Clinical Oncology
, vol.22
, pp. 4005
-
-
Cheverton, P.F.H.1
Andras, C.2
Salek, T.3
Geddes, C.4
Bodoky, G.5
Valle, J.6
Humblet, Y.7
-
70
-
-
33749071359
-
Randomized phase III study of exatecan and gemcitabine compared with gemcitabine alone in untreated advanced pancreatic cancer
-
Abou-Alfa, G.K., Letourneau, R., Harker, G., Modiano, M., Hurwitz, H., Tchekmedyian, N.S., Feit, K., Ackerman, J., De Jager, R.L., Eckhardt, S.G., and O'Reilly, E.M. (2006) Randomized phase III study of exatecan and gemcitabine compared with gemcitabine alone in untreated advanced pancreatic cancer. Journal of Clinical Oncology, 24 (27), 4441-4447.
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.27
, pp. 4441-4447
-
-
Abou-alfa, G.K.1
Letourneau, R.2
Harker, G.3
Modiano, M.4
Hurwitz, H.5
Tchekmedyian, N.S.6
Feit, K.7
Ackerman, J.8
De Jager, R.L.9
Eckhardt, S.G.10
O'Reilly, E.M.11
-
71
-
-
75449090831
-
Clinical pharmacokinetics of the new oral camptothecin gimatecan: the inter-patient variability is related to alpha1-acid glycoprotein plasma levels
-
Frapolli, R., Zucchetti, M., Sessa, C., Marsoni, S., Viganó, L., Locatelli, A., Rulli, E., Compagnoni, A., Bello, E., Pisano, C., Carminati, P., and D'Incalci, M. (2010) Clinical pharmacokinetics of the new oral camptothecin gimatecan: the inter-patient variability is related to alpha1-acid glycoprotein plasma levels. European Journal of Cancer (Oxford, England: 1990), 46 (3), 505-516.
-
(2010)
European Journal of Cancer (Oxford, England: 1990)
, vol.46
, Issue.3
, pp. 505-516
-
-
Frapolli, R.1
Zucchetti, M.2
Sessa, C.3
Marsoni, S.4
Viganó, L.5
Locatelli, A.6
Rulli, E.7
Compagnoni, A.8
Bello, E.9
Pisano, C.10
Carminati, P.11
D'Incalci, M.12
-
72
-
-
24944437153
-
The novel lipophilic camptothecin analogue gimatecan is very active in vitro in human neuroblastoma: a comparative study with SN38 and topotecan
-
Di Francesco, A.M., Riccardi, A., Barone, G., Rutella, S., Meco, D., Frapolli, R., Zucchetti, M., D'Incalci, M., Pisano, C., Carminati, P., and Riccardi, R. (2005) The novel lipophilic camptothecin analogue gimatecan is very active in vitro in human neuroblastoma: a comparative study with SN38 and topotecan. Biochemical Pharmacology, 70 (8), 1125-1136.
-
(2005)
Biochemical Pharmacology
, vol.70
, Issue.8
, pp. 1125-1136
-
-
Di Francesco, A.M.1
Riccardi, A.2
Barone, G.3
Rutella, S.4
Meco, D.5
Frapolli, R.6
Zucchetti, M.7
D'Incalci, M.8
Pisano, C.9
Carminati, P.10
Riccardi, R.11
-
73
-
-
77951947510
-
Phase II of oral gimatecan in patients with recurrent epithelial ovarian, fallopian tube or peritoneal cancer, previously treated with platinum and taxanes
-
Pecorelli, S., Ray-Coquard, I., Tredan, O., Colombo, N., Parma, G., Tisi, G., Katsarós, D., Lhommé, C., Lissoni, A.A., Vermorken, J.B., du Bois, A., Poveda, A., Frigerio, L., Barbieri, P., Carminati, P., Brienza, S., and Guastalla, J.P. (2010) Phase II of oral gimatecan in patients with recurrent epithelial ovarian, fallopian tube or peritoneal cancer, previously treated with platinum and taxanes. Annals of Oncology, 21 (4), 759-765.
-
(2010)
Annals of Oncology
, vol.21
, Issue.4
, pp. 759-765
-
-
Pecorelli, S.1
Ray-coquard, I.2
Tredan, O.3
Colombo, N.4
Parma, G.5
Tisi, G.6
Katsarós, D.7
Lhommé, C.8
Lissoni, A.A.9
Vermorken, J.B.10
du Bois, A.11
Poveda, A.12
Frigerio, L.13
Barbieri, P.14
Carminati, P.15
Brienza, S.16
Guastalla, J.P.17
-
74
-
-
79955498417
-
Phase II study of belotecan, a camptothecin analogue, in combination with carboplatin for the treatment of recurrent ovarian cancer
-
Choi, C.H., Lee, Y.Y., Song, T.J., Park, H.S., Kim, M.K., Kim, T.J., Lee, J.W., Lee, J.H., Bae, D.S., and Kim, B.G. (2011) Phase II study of belotecan, a camptothecin analogue, in combination with carboplatin for the treatment of recurrent ovarian cancer. Cancer, 117 (10), 2104-2111.
-
(2011)
Cancer
, vol.117
, Issue.10
, pp. 2104-2111
-
-
Choi, C.H.1
Lee, Y.Y.2
Song, T.J.3
Park, H.S.4
Kim, M.K.5
Kim, T.J.6
Lee, J.W.7
Lee, J.H.8
Bae, D.S.9
Kim, B.G.10
-
75
-
-
84856700926
-
Phase II study of combined belotecan and cisplatin as first-line chemotherapy in patients with extensive disease of small cell lung cancer
-
Hong, J., Jung, M., Kim, Y.J., Sym, S.J., Kyung, S.Y., Park, J., Lee, S.P., Park, J.W., Cho, E.K., Jeong, S.H., Shin, D.B., and Lee, J.H. (2012) Phase II study of combined belotecan and cisplatin as first-line chemotherapy in patients with extensive disease of small cell lung cancer. Cancer Chemotherapy and Pharmacology, 69 (1), 215-220.
-
(2012)
Cancer Chemotherapy and Pharmacology
, vol.69
, Issue.1
, pp. 215-220
-
-
Hong, J.1
Jung, M.2
Kim, Y.J.3
Sym, S.J.4
Kyung, S.Y.5
Park, J.6
Lee, S.P.7
Park, J.W.8
Cho, E.K.9
Jeong, S.H.10
Shin, D.B.11
Lee, J.H.12
-
76
-
-
79952845378
-
Metabolic pathways of the camptothecin analog AR-67
-
Horn, J., Milewska, M., Arnold, S.M., and Leggas, M. (2011) Metabolic pathways of the camptothecin analog AR-67. Drug Metabolism and Disposition, 39 (4), 683-692.
-
(2011)
Drug Metabolism and Disposition
, vol.39
, Issue.4
, pp. 683-692
-
-
Horn, J.1
Milewska, M.2
Arnold, S.M.3
Leggas, M.4
-
77
-
-
73949141120
-
Antitumor activities and pharmacokinetics of silatecans DB-67 and DB-91
-
Yeh, T.K., Li, C.M., Chen, C.P., Chuu, J.J., Huang, C.L., Wang, H.S., Shen, C.C., Lee, T.Y., Chang, C.Y., Chang, C.M., Chao, Y.S., Lin, C.T., Chang, J.Y., and Chen, C.T. (2010) Antitumor activities and pharmacokinetics of silatecans DB-67 and DB-91. Pharmacological Research, 61 (2), 108-115.
-
(2010)
Pharmacological Research
, vol.61
, Issue.2
, pp. 108-115
-
-
Yeh, T.K.1
Li, C.M.2
Chen, C.P.3
Chuu, J.J.4
Huang, C.L.5
Wang, H.S.6
Shen, C.C.7
Lee, T.Y.8
Chang, C.Y.9
Chang, C.M.10
Chao, Y.S.11
Lin, C.T.12
Chang, J.Y.13
Chen, C.T.14
-
78
-
-
0037025915
-
Asymmetric total synthesis of (20R)-homocamptothecin, substituted homocamptothecins and homosilatecans
-
Gabarda, A.E., Du, W., Isarno, T., Tangirala, R.S., and Curran, D.P. (2002) Asymmetric total synthesis of (20R)-homocamptothecin, substituted homocamptothecins and homosilatecans. Tetrahedron, 58, 6329-6341.
-
(2002)
Tetrahedron
, vol.58
, pp. 6329-6341
-
-
Gabarda, A.E.1
Du, W.2
Isarno, T.3
Tangirala, R.S.4
Curran, D.P.5
-
79
-
-
1542441944
-
DRF-1042, a novel orally active camptothecin (CPT) analog: safety, pharmacokinetic (PK) and pharmacodynamic evaluation in a phase I dose escalation study
-
Abstract 384
-
Chatterjee, A., Digumarti, R., Mamidi, R.N., Katneni, K., Upreti, V.V., Uppalapati, S., Jiwatani, S., Srinivas, N.R., and Subramaniam, S. (2002) DRF-1042, a novel orally active camptothecin (CPT) analog: safety, pharmacokinetic (PK) and pharmacodynamic evaluation in a phase I dose escalation study. Proceedings of the American Society of Clinical Oncology, 21, Abstract 384.
-
(2002)
Proceedings of the American Society of Clinical Oncology
, vol.21
-
-
Chatterjee, A.1
Digumarti, R.2
Mamidi, R.N.3
Katneni, K.4
Upreti, V.V.5
Uppalapati, S.6
Jiwatani, S.7
Srinivas, N.R.8
Subramaniam, S.9
-
80
-
-
20144387082
-
Safety, tolerability, and pharmacokinetics of a capsule formulation of DRF-1042, a novel camptothecin analog, in refractory cancer patients in a bridging phase I study
-
Chatterjee, A., Digumarti, R., Katneni, K., Upreti, V.V., Mamidi, R.N.V.S., Mullangi, R., Surath, A., Srinivas, M.L., Uppalapati, S., Jiwatani, S., and Srinivas, N.R. (2005) Safety, tolerability, and pharmacokinetics of a capsule formulation of DRF-1042, a novel camptothecin analog, in refractory cancer patients in a bridging phase I study. Journal of Clinical Pharmacology, 45, 453-460.
-
(2005)
Journal of Clinical Pharmacology
, vol.45
, pp. 453-460
-
-
Chatterjee, A.1
Digumarti, R.2
Katneni, K.3
Upreti, V.V.4
Mamidi, R.N.V.S.5
Mullangi, R.6
Surath, A.7
Srinivas, M.L.8
Uppalapati, S.9
Jiwatani, S.10
Srinivas, N.R.11
-
81
-
-
84863768731
-
Namitecan: a hydrophilic camptothecin with a promising preclinical profile
-
Beretta, G.L., Zuco, V., De Cesare, M., Perego, P., and Zaffaroni, N. (2012) Namitecan: a hydrophilic camptothecin with a promising preclinical profile. Current Medicinal Chemistry, 19 (21), 3488-3501.
-
(2012)
Current Medicinal Chemistry
, vol.19
, Issue.21
, pp. 3488-3501
-
-
Beretta, G.L.1
Zuco, V.2
De Cesare, M.3
Perego, P.4
Zaffaroni, N.5
-
82
-
-
51049111458
-
Preclinical profile of antitumor activity of a novel hydrophilic camptothecin, ST1968
-
Pisano, C., De Cesare, M., Beretta, G.L., Zuco, V., Pratesi, G., Penco, S., Vesci, L., Foderá, R., Ferrara, F.F., Guglielmi, M.B., Carminati, P., Dallavalle, S., Morini, G., Merlini, L., Orlandi, A., and Zunino, F. (2008) Preclinical profile of antitumor activity of a novel hydrophilic camptothecin, ST1968. Molecular Cancer Therapeutics, 7 (7), 2051-2059.
-
(2008)
Molecular Cancer Therapeutics
, vol.7
, Issue.7
, pp. 2051-2059
-
-
Pisano, C.1
De Cesare, M.2
Beretta, G.L.3
Zuco, V.4
Pratesi, G.5
Penco, S.6
Vesci, L.7
Foderá, R.8
Ferrara, F.F.9
Guglielmi, M.B.10
Carminati, P.11
Dallavalle, S.12
Morini, G.13
Merlini, L.14
Orlandi, A.15
Zunino, F.16
-
83
-
-
84861234062
-
The curative efficacy of namitecan (ST1968) in preclinical models of pediatric sarcoma is associated with antiangiogenic effects
-
Cassinelli, G., Zuco, V., Petrangolini, G., De Cesare, M., Tortoreto, M., Lanzi, C., Cominetti, D., Zaffaroni, N., Orlandi, A., Passeri, D., Meco, D., Di Francesco, A. M., Riccardi, R., Bucci, F., Pisano, C., and Zunino, F. (2012) The curative efficacy of namitecan (ST1968) in preclinical models of pediatric sarcoma is associated with antiangiogenic effects. Biochemical Pharmacology, 84 (2), 163-171.
-
(2012)
Biochemical Pharmacology
, vol.84
, Issue.2
, pp. 163-171
-
-
Cassinelli, G.1
Zuco, V.2
Petrangolini, G.3
De Cesare, M.4
Tortoreto, M.5
Lanzi, C.6
Cominetti, D.7
Zaffaroni, N.8
Orlandi, A.9
Passeri, D.10
Meco, D.11
Di Francesco, A.M.12
Riccardi, R.13
Bucci, F.14
Pisano, C.15
Zunino, F.16
-
84
-
-
33747129180
-
Synthesis and biological assays of E-ring analogs of camptothecin and homocamptothecin
-
Tangirala, R.S., Antony, S., Agama, K., Pommier, Y., Anderson, B.D., Bevins, R., and Curran, D.P. (2006) Synthesis and biological assays of E-ring analogs of camptothecin and homocamptothecin. Bioorganic & Medicinal Chemistry, 14 (18), 6202-6212.
-
(2006)
Bioorganic & Medicinal Chemistry
, vol.14
, Issue.18
, pp. 6202-6212
-
-
Tangirala, R.S.1
Antony, S.2
Agama, K.3
Pommier, Y.4
Anderson, B.D.5
Bevins, R.6
Curran, D.P.7
-
85
-
-
0034049602
-
Homocamptothecin, an E-ring-modified camptothecin, exerts more potent antiproliferative activity than other topoisomerase I inhibitors in human colon cancers obtained from surgery and maintained in vitro under histotypical culture conditions
-
Patrick Philippart, P., Luke Harper, L., Chaboteaux, C., Decaestecker, C., Bronckart, Y., Gordover, L., Lesueur-Ginot, L., Malonne, H., Lavergne, O., Bigg, D.C.H., da Costa, P.M., and Kiss, R. (2000) Homocamptothecin, an E-ring-modified camptothecin, exerts more potent antiproliferative activity than other topoisomerase I inhibitors in human colon cancers obtained from surgery and maintained in vitro under histotypical culture conditions. Clinical Cancer Research, 6, 1557.
-
(2000)
Clinical Cancer Research
, vol.6
, pp. 1557
-
-
Patrick Philippart, P.1
Luke Harper, L.2
Chaboteaux, C.3
Decaestecker, C.4
Bronckart, Y.5
Gordover, L.6
Lesueur-ginot, L.7
Malonne, H.8
Lavergne, O.9
Bigg, D.C.H.10
da Costa, P.M.11
Kiss, R.12
-
86
-
-
84856077668
-
Predictive ability of a semi-mechanistic model for neutropenia in the development of novel anti-cancer agents: two case studies
-
Soto, E., Keizer, R.J., Trocóniz, I.F., Huitema, A.D., Beijnen, J.H., Schellens, J. H., Wanders, J., Cendrós, J.M., Obach, R., Peraire, C., Friberg, L.E., and Karlsson, M.O. (2011) Predictive ability of a semi-mechanistic model for neutropenia in the development of novel anti-cancer agents: two case studies. Investigational New Drugs, 29 (5), 984-995.
-
(2011)
Investigational New Drugs
, vol.29
, Issue.5
, pp. 984-995
-
-
Soto, E.1
Keizer, R.J.2
Trocóniz, I.F.3
Huitema, A.D.4
Beijnen, J.H.5
Schellens, J.H.6
Wanders, J.7
Cendrós, J.M.8
Obach, R.9
Peraire, C.10
Friberg, L.E.11
Karlsson, M.O.12
-
87
-
-
61449216100
-
A multi-centre dose-escalation and pharmacokinetic study of diflomotecan in patients with advanced malignancy
-
Graham, J.S., Falk, S., Samuel, L.M., Cendros, J.M., and Evans, T.R. (2009) A multi-centre dose-escalation and pharmacokinetic study of diflomotecan in patients with advanced malignancy. Cancer Chemotherapy and Pharmacology, 63 (5), 945-952.
-
(2009)
Cancer Chemotherapy and Pharmacology
, vol.63
, Issue.5
, pp. 945-952
-
-
Graham, J.S.1
Falk, S.2
Samuel, L.M.3
Cendros, J.M.4
Evans, T.R.5
-
88
-
-
3142686746
-
BN80927: a novel homocamptothecin that inhibits proliferation of human tumor cells in vitro and in vivo
-
Demarquay, D., Huchet, M., Coulomb, H., Lesueur-Ginot, L., Lavergne, O., Camara, J., Kasprzyk, P.G., Prévost, G., and Bigg, D.C. (2004) BN80927: a novel homocamptothecin that inhibits proliferation of human tumor cells in vitro and in vivo. Cancer Research, 64 (14), 4942-4949.
-
(2004)
Cancer Research
, vol.64
, Issue.14
, pp. 4942-4949
-
-
Demarquay, D.1
Huchet, M.2
Coulomb, H.3
Lesueur-ginot, L.4
Lavergne, O.5
Camara, J.6
Kasprzyk, P.G.7
Prévost, G.8
Bigg, D.C.9
-
89
-
-
84866552473
-
Population pharmacokinetic/ pharmacodynamic modeling of drug-induced adverse effects of a novel homocamptothecin analog, elomotecan (BN80927), in a phase I dose finding study in patients with advanced solid tumors
-
Trocóniz, I.F., Cendrós, J.M., Soto, E., Pruñonosa, J., Perez-Mayoral, A., Peraire, C., Principe, P., Delavault, P., Cvitkovic, F., Lesimple, T., and Obach, R. (2012) Population pharmacokinetic/ pharmacodynamic modeling of drug-induced adverse effects of a novel homocamptothecin analog, elomotecan (BN80927), in a phase I dose finding study in patients with advanced solid tumors. Cancer Chemotherapy and Pharmacology, 70 (2), 239-250.
-
(2012)
Cancer Chemotherapy and Pharmacology
, vol.70
, Issue.2
, pp. 239-250
-
-
Trocóniz, I.F.1
Cendrós, J.M.2
Soto, E.3
Pruñonosa, J.4
Perez-mayoral, A.5
Peraire, C.6
Principe, P.7
Delavault, P.8
Cvitkovic, F.9
Lesimple, T.10
Obach, R.11
-
90
-
-
84875964231
-
Evolution in medicinal chemistry of E-ring-modified Camptothecin analogs as anticancer agents
-
Huang, Q., Wang, L., and Lu, W. (2013) Evolution in medicinal chemistry of E-ring-modified Camptothecin analogs as anticancer agents. European Journal of Medicinal Chemistry, 63 (2013) 746-757.
-
(2013)
European Journal of Medicinal Chemistry
, vol.63
, Issue.2013
, pp. 746-757
-
-
Huang, Q.1
Wang, L.2
Lu, W.3
-
91
-
-
84864415641
-
Synthesis and biological evaluation of new homocamptothecin analogs
-
Luo, Y., Yu, S., Tong, L., Huang, Q., Lu, W., and Chen, Y. (2012) Synthesis and biological evaluation of new homocamptothecin analogs. European Journal of Medicinal Chemistry, 54, 281-286.
-
(2012)
European Journal of Medicinal Chemistry
, vol.54
, pp. 281-286
-
-
Luo, Y.1
Yu, S.2
Tong, L.3
Huang, Q.4
Lu, W.5
Chen, Y.6
-
92
-
-
0015219869
-
Total synthesis of D,L-camptothecin
-
Stork, G. and Schultz, A.G.J. (1971) Total synthesis of D,L-camptothecin. Journal of the American Chemical Society, 93 (16), 4074-4075.
-
(1971)
Journal of the American Chemical Society
, vol.93
, Issue.16
, pp. 4074-4075
-
-
Stork, G.1
Schultz, A.G.J.2
-
93
-
-
0343302641
-
Nucleophilic additions to allenes: new synthesis of alpha-pyridones
-
Danishefsky, S.J., Etheredge, S.J., Volkmann, R., Eggler, J., and Quick, J. (1971) Nucleophilic additions to allenes: new synthesis of alpha-pyridones. Journal of the American Chemical Society, 93, 5575-5576.
-
(1971)
Journal of the American Chemical Society
, vol.93
, pp. 5575-5576
-
-
Danishefsky, S.J.1
Etheredge, S.J.2
Volkmann, R.3
Eggler, J.4
Quick, J.5
-
94
-
-
0016849267
-
Total synthesis of natural 20(S)-camptothecin
-
Corey, E.J., Crouse, D.N., and Anderson, J.E. (1975) Total synthesis of natural 20(S)-camptothecin. The Journal of Organic Chemistry, 40 (14), 2140-2141.
-
(1975)
The Journal of Organic Chemistry
, vol.40
, Issue.14
, pp. 2140-2141
-
-
Corey, E.J.1
Crouse, D.N.2
Anderson, J.E.3
-
95
-
-
0024353912
-
Asymmetric synthesis of (S)-camptothecin
-
Ejima, A., Terasawa, H., Sugimori, M., and Tagawa, H. (1989) Asymmetric synthesis of (S)-camptothecin. Tetrahedron Letters, 30, 2639-2640.
-
(1989)
Tetrahedron Letters
, vol.30
, pp. 2639-2640
-
-
Ejima, A.1
Terasawa, H.2
Sugimori, M.3
Tagawa, H.4
-
96
-
-
33745737662
-
Review camptothecin: current perspectives
-
Li, Q.Y., Zu, Y.G., Shi, R.Z., and Yao, L.P. (2006) Review camptothecin: current perspectives. Current Medicinal Chemistry, 13 (17), 2021-2039.
-
(2006)
Current Medicinal Chemistry
, vol.13
, Issue.17
, pp. 2021-2039
-
-
Li, Q.Y.1
Zu, Y.G.2
Shi, R.Z.3
Yao, L.P.4
-
97
-
-
0141927373
-
Towards new anticancer drugs: a decade of advances in synthesis of camptothecins and related alkaloids
-
Du, W. (2003) Towards new anticancer drugs: a decade of advances in synthesis of camptothecins and related alkaloids. Tetrahedron, 59, 8649-8687.
-
(2003)
Tetrahedron
, vol.59
, pp. 8649-8687
-
-
Du, W.1
-
98
-
-
0035961055
-
A practical six-step synthesis of (S)-camptothecin
-
Comins, D.L. and Nolan, J.M. (2001) A practical six-step synthesis of (S)-camptothecin. Organic Letters, 3 (26), 4255-4257.
-
(2001)
Organic Letters
, vol.3
, Issue.26
, pp. 4255-4257
-
-
Comins, D.L.1
Nolan, J.M.2
-
99
-
-
0007660828
-
New 4{thorn}1 radical annulations: a formal total synthesis of ({thorn})-camptothecin
-
Curran, D.P. and Liu, H. (1992) New 4{thorn}1 radical annulations: a formal total synthesis of ({thorn})-camptothecin. Journal of the American Chemical Society, 114, 5863-5864.
-
(1992)
Journal of the American Chemical Society
, vol.114
, pp. 5863-5864
-
-
Curran, D.P.1
Liu, H.2
-
100
-
-
0035840992
-
Switching enantiofacial selectivities using one chiral source: catalytic enantioselective synthesis of the key intermediate for (20S)-camptothecin family by (S)-selective cyanosilylation of ketones
-
Yabu, K., Masumoto, S., Yamasaki, S., Hamashima, Y., Kanai, M., Du, W., Curran, D.P., and Shibasaki, M. (2001) Switching enantiofacial selectivities using one chiral source: catalytic enantioselective synthesis of the key intermediate for (20S)-camptothecin family by (S)-selective cyanosilylation of ketones. Journal of the American Chemical Society, 123 (40), 9908-9909.
-
(2001)
Journal of the American Chemical Society
, vol.123
, Issue.40
, pp. 9908-9909
-
-
Yabu, K.1
Masumoto, S.2
Yamasaki, S.3
Hamashima, Y.4
Kanai, M.5
Du, W.6
Curran, D.P.7
Shibasaki, M.8
-
101
-
-
0037090145
-
Studies toward practical synthesis of (20S)-camptothecin family through catalytic enantioselective cyanosilylation of ketones: improved catalyst efficiency by ligand-tuning
-
Yabu, K., Masumoto, S., Kanai, M., Curran, D.P., and Shibasaki, M. (2002) Studies toward practical synthesis of (20S)-camptothecin family through catalytic enantioselective cyanosilylation of ketones: improved catalyst efficiency by ligand-tuning. Tetrahedron Letters, 43, 2923.
-
(2002)
Tetrahedron Letters
, vol.43
, pp. 2923
-
-
Yabu, K.1
Masumoto, S.2
Kanai, M.3
Curran, D.P.4
Shibasaki, M.5
-
102
-
-
0030570906
-
Novel syntheses of camptothecin alkaloids, Part I. Intramolecular [4{thorn}2] cycloadditions of N-arylimidates and 4H-3,1-benzoxazin-4-ones as 2-aza-1,3-dienes
-
Fortunak, J.M.C., Mastrocola, A.R., Mellinger, M., Sisti., N.J., Wood, J.L., and Zhuang, Z.-P. (1996) Novel syntheses of camptothecin alkaloids, Part I. Intramolecular [4{thorn}2] cycloadditions of N-arylimidates and 4H-3,1-benzoxazin-4-ones as 2-aza-1,3-dienes. Tetrahedron Letters, 37 (32), 5679.
-
(1996)
Tetrahedron Letters
, vol.37
, Issue.32
, pp. 5679
-
-
Fortunak, J.M.C.1
Mastrocola, A.R.2
Mellinger, M.3
Sisti, N.J.4
Wood, J.L.5
Zhuang, Z.-P.6
-
103
-
-
0037025924
-
Total synthesis of ({thorn})-camptothecin
-
Blagg, B.S.J. and Boger, D.L. (2002) Total synthesis of ({thorn})-camptothecin. Tetrahedron, 58, 6343-6349.
-
(2002)
Tetrahedron
, vol.58
, pp. 6343-6349
-
-
Blagg, B.S.J.1
Boger, D.L.2
-
104
-
-
0037131240
-
Addition of ester enolates to N-alkyl-2-fluoropyridinium salts: total synthesis of ({thorn}/-)-20-deoxycamptothecin and ({thorn})-camptothecin
-
Bennasar, M.L., Zulaica, E., Juan, C., Alonso, Y., and Bosch, J. (2002) Addition of ester enolates to N-alkyl-2-fluoropyridinium salts: total synthesis of ({thorn}/-)-20-deoxycamptothecin and ({thorn})-camptothecin. The Journal of Organic Chemistry, 67 (21), 7465-7474.
-
(2002)
The Journal of Organic Chemistry
, vol.67
, Issue.21
, pp. 7465-7474
-
-
Bennasar, M.L.1
Zulaica, E.2
Juan, C.3
Alonso, Y.4
Bosch, J.5
-
106
-
-
0030796897
-
Practical total synthesis of ({thorn})-camptothecin: the full story
-
Ciufolini, M.A. and Roschangar, F. (1997) Practical total synthesis of ({thorn})-camptothecin: the full story. Tetrahedron, 53 (32), 11049-11060.
-
(1997)
Tetrahedron
, vol.53
, Issue.32
, pp. 11049-11060
-
-
Ciufolini, M.A.1
Roschangar, F.2
-
107
-
-
0141940378
-
Practical synthesis of (20S)-({thorn}) camptothecin: the progenitor of a promising group of anticancer agents
-
Ciufolini, M.A. and Roschangar, F. (2000) Practical synthesis of (20S)-({thorn}) camptothecin: the progenitor of a promising group of anticancer agents. Targets in Heterocyclic Systems, 4, 25.
-
(2000)
Targets in Heterocyclic Systems
, vol.4
, pp. 25
-
-
Ciufolini, M.A.1
Roschangar, F.2
-
108
-
-
0032505228
-
A practical and efficient synthesis of (±)-camptothecin
-
Chavan, S.P. and Venkatraman, M.S. (1998) A practical and efficient synthesis of (±)-camptothecin. Tetrahedron Letters, 39 (37), 6745-6748.
-
(1998)
Tetrahedron Letters
, vol.39
, Issue.37
, pp. 6745-6748
-
-
Chavan, S.P.1
Venkatraman, M.S.2
-
109
-
-
0030845935
-
Practical asymmetric synthesis of (S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f] indolizine-3,6,10(4H)-trione, a key intermediate for the synthesis of irinotecan and other camptothecin analogs
-
Henegar, K.E., Ashford, S.W., Baughman, T. A., Sih, J.C.L., and Gu, R.L. (1997) Practical asymmetric synthesis of (S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f] indolizine-3,6,10(4H)-trione, a key intermediate for the synthesis of irinotecan and other camptothecin analogs. The Journal of Organic Chemistry, 62 (19), 6588-6597.
-
(1997)
The Journal of Organic Chemistry
, vol.62
, Issue.19
, pp. 6588-6597
-
-
Henegar, K.E.1
Ashford, S.W.2
Baughman, T.A.3
Sih, J.C.L.4
Gu, R.L.5
-
110
-
-
8644285382
-
Combined directed ortho metalation/cross-coupling strategies: synthesis of the tetracyclic A/B/C/D ring core of the antitumor agent camptothecin
-
Nguyen, T., Wicki, M.A., and Snieckus, V. (2004) Combined directed ortho metalation/cross-coupling strategies: synthesis of the tetracyclic A/B/C/D ring core of the antitumor agent camptothecin. The Journal of Organic Chemistry, 69 (23), 7816-7821.
-
(2004)
The Journal of Organic Chemistry
, vol.69
, Issue.23
, pp. 7816-7821
-
-
Nguyen, T.1
Wicki, M.A.2
Snieckus, V.3
-
111
-
-
22244439534
-
A novel, expeditious synthesis of racemic camptothecin
-
Anderson, R.J., Raolji, G.B., Kanazawa, A., and Greene, A.E. (2005) A novel, expeditious synthesis of racemic camptothecin. Organic Letters, 7 (14), 2989-2991.
-
(2005)
Organic Letters
, vol.7
, Issue.14
, pp. 2989-2991
-
-
Anderson, R.J.1
Raolji, G.B.2
Kanazawa, A.3
Greene, A.E.4
-
112
-
-
33749551270
-
Novel, efficient total synthesis of natural 20 (S)-camptothecin
-
Tang, C.J., Babjak, M., Anderson, R.J., Greene, A.E., and Kanazawa, A. (2006) Novel, efficient total synthesis of natural 20 (S)-camptothecin. Organic & Biomolecular Chemistry, 4 (20), 3757-3759.
-
(2006)
Organic & Biomolecular Chemistry
, vol.4
, Issue.20
, pp. 3757-3759
-
-
Tang, C.J.1
Babjak, M.2
Anderson, R.J.3
Greene, A.E.4
Kanazawa, A.5
-
113
-
-
0042881856
-
Synthesis of functionalized heteroaromatics: application to formal total synthesis of camptothecin
-
Murata, N., Sugihara, T., Kondo, Y., and Sakamoto, T. (1997) Synthesis of functionalized heteroaromatics: application to formal total synthesis of camptothecin. Synlett, 3, 298-300.
-
(1997)
Synlett
, vol.3
, pp. 298-300
-
-
Murata, N.1
Sugihara, T.2
Kondo, Y.3
Sakamoto, T.4
-
114
-
-
1642265750
-
A synthesis of camptothecin
-
Chavan, S.P. and Sivappa, R. (2004) A synthesis of camptothecin. Tetrahedron Letters, 45 (15), 3113-3115.
-
(2004)
Tetrahedron Letters
, vol.45
, Issue.15
, pp. 3113-3115
-
-
Chavan, S.P.1
Sivappa, R.2
-
115
-
-
84855533356
-
Total synthesis of camptothecin and SN-38
-
Yu, S., Huang, Q.Q., Luo, Y., and Lu, W. (2012) Total synthesis of camptothecin and SN-38. The Journal of Organic Chemistry, 77, 713-717.
-
(2012)
The Journal of Organic Chemistry
, vol.77
, pp. 713-717
-
-
Yu, S.1
Huang, Q.Q.2
Luo, Y.3
Lu, W.4
-
116
-
-
33751141093
-
Cascade radical reactions of isonitriles: a second-generation synthesis of (20S)-camptothecin, topotecan, irinotecan, and GI-147211C
-
Curran, D.P., Ko, S.B., and Josien, H. (1996) Cascade radical reactions of isonitriles: a second-generation synthesis of (20S)-camptothecin, topotecan, irinotecan, and GI-147211C. Angewandte Chemie -International Edition in English, 34 (23-24), 2683-2684.
-
(1996)
Angewandte Chemie -International Edition in English
, vol.34
, Issue.23-24
, pp. 2683-2684
-
-
Curran, D.P.1
Ko, S.B.2
Josien, H.3
-
117
-
-
0035098297
-
Modulation of camptothecin analogs in the treatment of cancer: a review
-
Kehrer, D.F., Soepenberg, O., Loos, W.J., Verweil, J., and Sparreboom, A. (2001) Modulation of camptothecin analogs in the treatment of cancer: a review. Anti-Cancer Drugs, 12, 89-105.
-
(2001)
Anti-Cancer Drugs
, vol.12
, pp. 89-105
-
-
Kehrer, D.F.1
Soepenberg, O.2
Loos, W.J.3
Verweil, J.4
Sparreboom, A.5
-
118
-
-
0034687256
-
Novel 7-substituted camptothecins with potent antitumor activity
-
Dallavalle, S., Delsoldato, T., Ferrari, A., Merlini, L., Penco, S., Carenini, N., Perego, P., De Cesare, M., Pratesi, G., and Zunino, F. (2000) Novel 7-substituted camptothecins with potent antitumor activity. Journal of Medicinal Chemistry, 43 (21), 3963-3969.
-
(2000)
Journal of Medicinal Chemistry
, vol.43
, Issue.21
, pp. 3963-3969
-
-
Dallavalle, S.1
Delsoldato, T.2
Ferrari, A.3
Merlini, L.4
Penco, S.5
Carenini, N.6
Perego, P.7
De Cesare, M.8
Pratesi, G.9
Zunino, F.10
-
119
-
-
79952783035
-
14-Aminocamptothecins: their synthesis, preclinical activity, and potential use for cancer treatment
-
Duan, J.X., Cai, X., Meng, F., Sun, J.D., Liu, Q., Jung, D., Jiao, H., Matteucci, J., Jung, B., Bhupathi, D., Ahluwalia, D., Huang, H., Hart, C.P., and Matteucci, M. (2011) 14-Aminocamptothecins: their synthesis, preclinical activity, and potential use for cancer treatment. Journal of Medicinal Chemistry, 54, 1715-1723.
-
(2011)
Journal of Medicinal Chemistry
, vol.54
, pp. 1715-1723
-
-
Duan, J.X.1
Cai, X.2
Meng, F.3
Sun, J.D.4
Liu, Q.5
Jung, D.6
Jiao, H.7
Matteucci, J.8
Jung, B.9
Bhupathi, D.10
Ahluwalia, D.11
Huang, H.12
Hart, C.P.13
Matteucci, M.14
-
120
-
-
0032585548
-
Homocamptothecins: synthesis and antitumor activity of novel E-ring-modified camptothecin analogues
-
Lavergne, O., Lesueur-Ginot, L., Rodas, F.P., Kasprzyk, P.G., Pommier, J., Demarquay, D., Prevost, G., Ulibarri, G., Rolland, A., Schiano-Liberatore, A.M., Harnett, J., Pons, D., Camara, J., and Bigg, D.C. (1998) Homocamptothecins: synthesis and antitumor activity of novel E-ring-modified camptothecin analogues. Journal of Medicinal Chemistry, 41 (27), 5410-5419.
-
(1998)
Journal of Medicinal Chemistry
, vol.41
, Issue.27
, pp. 5410-5419
-
-
Lavergne, O.1
Lesueur-ginot, L.2
Rodas, F.P.3
Kasprzyk, P.G.4
Pommier, J.5
Demarquay, D.6
Prevost, G.7
Ulibarri, G.8
Rolland, A.9
Schiano-liberatore, A.M.10
Harnett, J.11
Pons, D.12
Camara, J.13
Bigg, D.C.14
-
121
-
-
0026316167
-
Synthesis and antitumor activity of 20(S)-camptothecin derivatives: A-ring modified and 7,10-disubstituted camptothecins
-
Sawada, S., Matsuoka, S., Nokata, K., Nagata, H., Furata, T., Yokokura, T., and Miyasaka, T. (1991) Synthesis and antitumor activity of 20(S)-camptothecin derivatives: A-ring modified and 7,10-disubstituted camptothecins. Chemical & Pharmaceutical Bulletin, 12, 3183-3188.
-
(1991)
Chemical & Pharmaceutical Bulletin
, vol.12
, pp. 3183-3188
-
-
Sawada, S.1
Matsuoka, S.2
Nokata, K.3
Nagata, H.4
Furata, T.5
Yokokura, T.6
Miyasaka, T.7
-
122
-
-
12444272662
-
14-Azacamptothecin: A potent water-soluble topoisomerase I poison
-
Cheng, K., Rahier, N.J., Eisenhauer, B.M., Gao, R., Thomas, S.J., and Hecht, S.M. (2005) 14-Azacamptothecin: A potent water-soluble topoisomerase I poison. Journal American Chemical Society, 127, 838-839.
-
(2005)
Journal American Chemical Society
, vol.127
, pp. 838-839
-
-
Cheng, K.1
Rahier, N.J.2
Eisenhauer, B.M.3
Gao, R.4
Thomas, S.J.5
Hecht, S.M.6
-
123
-
-
15044352473
-
Synthesis of 14-azacamptothecin, a water-soluble topoisomerase I poison
-
Rahier, N.J., Cheng, Gao, K.R., Eisenhauer, B.M., and Hecht, S.M. (2005) Synthesis of 14-azacamptothecin, a water-soluble topoisomerase I poison. Organic Letters, 7 (5), 835-837.
-
(2005)
Organic Letters
, vol.7
, Issue.5
, pp. 835-837
-
-
Rahier, N.J.1
Cheng, G.K.R.2
Eisenhauer, B.M.3
Hecht, S.M.4
-
124
-
-
0027930186
-
Differential interactions of camptothecin lactone and carboxylate forms with human blood components
-
Mi, Z. and Burke, T. (1994) Differential interactions of camptothecin lactone and carboxylate forms with human blood components. Biochemistry, 33, 10325-10336.
-
(1994)
Biochemistry
, vol.33
, pp. 10325-10336
-
-
Mi, Z.1
Burke, T.2
-
125
-
-
0028844445
-
Reduced albumin binding promotes the stability and activity of topotecan in human blood
-
Mi, Z., Malak, H., and Burke, T.G. (1995) Reduced albumin binding promotes the stability and activity of topotecan in human blood. Biochemistry, 34, 13722-13728.
-
(1995)
Biochemistry
, vol.34
, pp. 13722-13728
-
-
Mi, Z.1
Malak, H.2
Burke, T.G.3
-
127
-
-
72049083697
-
Novel tumor-targeted RGD peptide-camptothecin conjugates: synthesis and biological evaluation
-
Dal Pozzo, A., Ni, M.H., Esposito, E., Dallavalle, S., Musso, L., Bargiotti, A., Pisano, C., Vesci, L., Bucci, F., Castorina, M., Foderà, R., Giannini, G., Aulicino, C., and Penco, S. (2010) Novel tumor-targeted RGD peptide-camptothecin conjugates: synthesis and biological evaluation. Bioorganic & Medicinal Chemistry, 18 (1), 64-72.
-
(2010)
Bioorganic & Medicinal Chemistry
, vol.18
, Issue.1
, pp. 64-72
-
-
Dal Pozzo, A.1
Ni, M.H.2
Esposito, E.3
Dallavalle, S.4
Musso, L.5
Bargiotti, A.6
Pisano, C.7
Vesci, L.8
Bucci, F.9
Castorina, M.10
Foderà, R.11
Giannini, G.12
Aulicino, C.13
Penco, S.14
-
128
-
-
78649300912
-
3 integrin ligands: an approach to tumor-targeted therapy
-
3 integrin ligands: an approach to tumor-targeted therapy. Bioconjugate Chemistry, 21 (11), 1956-1967.
-
(2010)
Bioconjugate Chemistry
, vol.21
, Issue.11
, pp. 1956-1967
-
-
Dal Pozzo, A.1
Esposito, E.2
Ni, M.H.3
Muzi, L.4
Pisano, C.5
Bucci, F.6
Vesci, L.7
Castorina, M.8
Penco, S.9
-
129
-
-
77950254562
-
The synthesis of a c(RGDyK) targeted SN38 prodrug with an indolequinone structure for bioreductive drug release
-
Huang, B., Desai, A., Tang, S., Thomas, T.P., and Baker, J.R. (2010) The synthesis of a c(RGDyK) targeted SN38 prodrug with an indolequinone structure for bioreductive drug release. Organic Letters, 12, 1384-1387.
-
(2010)
Organic Letters
, vol.12
, pp. 1384-1387
-
-
Huang, B.1
Desai, A.2
Tang, S.3
Thomas, T.P.4
Baker, J.R.5
-
130
-
-
84866729904
-
Camptothecins in tumor homing via an RGD sequence mimetic
-
Alloatti, D., Giannini, G., Vesci, L., Castorina, M., Pisano, C., Badaloni, E., and Cabri, W. (2012) Camptothecins in tumor homing via an RGD sequence mimetic. Bioorganic & Medicinal Chemistry Letters, 22 (20), 6509-6512.
-
(2012)
Bioorganic & Medicinal Chemistry Letters
, vol.22
, Issue.20
, pp. 6509-6512
-
-
Alloatti, D.1
Giannini, G.2
Vesci, L.3
Castorina, M.4
Pisano, C.5
Badaloni, E.6
Cabri, W.7
-
131
-
-
84864456950
-
Direct fluorescence monitoring of the delivery and cellular uptake of a cancer-targeted RGD peptide-appended naphthalimide theragnostic prodrug
-
Lee, M.H., Kim, J.Y., Han, J.H., Bhuniya, S., Sessler, J.L., Kang, C., and Kim, J.S. (2012) Direct fluorescence monitoring of the delivery and cellular uptake of a cancer-targeted RGD peptide-appended naphthalimide theragnostic prodrug. Journal of the American Chemical Society, 134 (30), 12668-12674.
-
(2012)
Journal of the American Chemical Society
, vol.134
, Issue.30
, pp. 12668-12674
-
-
Lee, M.H.1
Kim, J.Y.2
Han, J.H.3
Bhuniya, S.4
Sessler, J.L.5
Kang, C.6
Kim, J.S.7
-
132
-
-
67049137555
-
Surface-functionalized ultrasmall superparamagnetic nanoparticles as magnetic delivery vectors for camptothecin
-
Cengelli, F., Grzyb, J.A., Montoro, A., Hofman, H., Hanessian, S., and Juillerat-Jeanneret, L. (2009) Surface-functionalized ultrasmall superparamagnetic nanoparticles as magnetic delivery vectors for camptothecin. ChemMedChem, 4 (6), 988-997.
-
(2009)
ChemMedChem
, vol.4
, Issue.6
, pp. 988-997
-
-
Cengelli, F.1
Grzyb, J.A.2
Montoro, A.3
Hofman, H.4
Hanessian, S.5
Juillerat-jeanneret, L.6
-
133
-
-
40949137366
-
Synthesis of chemically functionalized superparamagnetic nanoparticles as delivery vectors for chemotherapeutic drugs
-
Hanessian, S., Grzyb, J.A., Cengelli, F., and Juillerat-Jeanneret, L. (2008) Synthesis of chemically functionalized superparamagnetic nanoparticles as delivery vectors for chemotherapeutic drugs. Bioorganic & Medicinal Chemistry, 16 (6), 2921-2931.
-
(2008)
Bioorganic & Medicinal Chemistry
, vol.16
, Issue.6
, pp. 2921-2931
-
-
Hanessian, S.1
Grzyb, J.A.2
Cengelli, F.3
Juillerat-jeanneret, L.4
-
134
-
-
34547763658
-
Combination of HPLC "inverted chirality columns approach" and MS/MS detection for extreme enantiomeric excess determination even in absence of reference samples: application to camptothecin derivatives
-
Badaloni, E., Cabri, W., Ciogli, A., Deias, R., Gasparrini, F., Giorgi, F., Vigevani, A., and Villani, C. (2007) Combination of HPLC "inverted chirality columns approach" and MS/MS detection for extreme enantiomeric excess determination even in absence of reference samples: application to camptothecin derivatives. Analytical Chemistry, 79 (15), 6013-6019.
-
(2007)
Analytical Chemistry
, vol.79
, Issue.15
, pp. 6013-6019
-
-
Badaloni, E.1
Cabri, W.2
Ciogli, A.3
Deias, R.4
Gasparrini, F.5
Giorgi, F.6
Vigevani, A.7
Villani, C.8
-
135
-
-
36649036356
-
Synthesis and characterization of novel internal surface reversed-phase silica supports for high-performance liquid chromatography
-
Gasparrini, F., Ciogli, A., D'Acquarica, I., Misiti, D., Badaloni, E., Giorgi, F., and Vigevani, A. (2007) Synthesis and characterization of novel internal surface reversed-phase silica supports for high-performance liquid chromatography. Journal of Chromatography, 1176, 79-88.
-
(2007)
Journal of Chromatography
, vol.1176
, pp. 79-88
-
-
Gasparrini, F.1
Ciogli, A.2
D'Acquarica, I.3
Misiti, D.4
Badaloni, E.5
Giorgi, F.6
Vigevani, A.7
-
136
-
-
84869227114
-
Intranasal delivery of camptothecin-loaded Tat-modified nanomicells for treatment of intracranial brain tumors
-
Taki, H., Kanazawa, T., Akiyama, F., Takashima, Y., and Okada, H. (2012) Intranasal delivery of camptothecin-loaded Tat-modified nanomicells for treatment of intracranial brain tumors. Pharmaceuticals, 5, 1092-1102.
-
(2012)
Pharmaceuticals
, vol.5
, pp. 1092-1102
-
-
Taki, H.1
Kanazawa, T.2
Akiyama, F.3
Takashima, Y.4
Okada, H.5
|