Engineered, highly productive biosynthesis of artificial, lactonized statin side-chain building blocks: The hidden potential of Escherichia coli unleashed

Metabolic Engineering

Volumn 24, Issue , 2014, Pages 160-172

  Vajdič, Tadeja ^a,b   Ošlaj, Matej ^a   Kopitar, Gregor ^a   Mrak, Peter ^a  

^a Lek Pharmaceuticals dd   (Slovenia)

^b Cadonic Consultancy Services LLC   (Slovenia)

Author keywords

Artificial biosynthetic pathway; DERA; Escherichia coli; Glucose dehydrogenase; Pathway engineering; PQQ; Respiratory chain; Super statins; Whole cell

Indexed keywords

BIOCHEMISTRY; BIOSYNTHESIS; CHAINS; ESCHERICHIA COLI; ESTERS; GLUCOSE; OXIDATION; REACTION INTERMEDIATES; REGIOSELECTIVITY; STEREOCHEMISTRY;

BIOSYNTHETIC PATHWAY; DERA; GLUCOSE DEHYDROGENASE; PATHWAY ENGINEERINGS; PQQ; RESPIRATORY CHAINS; SUPER-STATINS; WHOLE CELL;

CELL ENGINEERING;

ATORVASTATIN; DEOXYRIBOSEPHOSPHATE ALDOLASE; FRUCTOSE BISPHOSPHATE ALDOLASE; GLUCOSE DEHYDROGENASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LACTONE DERIVATIVE; OXYGEN; PITAVASTATIN; PYRROLOQUINOLINEQUINONE; ROSUVASTATIN; UNCLASSIFIED DRUG; ESCHERICHIA COLI PROTEIN; LACTONE;

ARTICLE; BACTERIUM CULTURE; CONTROLLED STUDY; DRUG SYNTHESIS; ELECTRON TRANSPORT; ENZYME ACTIVITY; ESCHERICHIA COLI; GENE OVEREXPRESSION; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RESPIRATORY CHAIN; WHOLE CELL; ENZYMOLOGY; GENETICS; METABOLIC ENGINEERING; METABOLISM;

ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LACTONES; METABOLIC ENGINEERING;

EID: 84902000106     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2014.05.012     Document Type: Article

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