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Volumn 42, Issue 3, 2003, Pages 355-357
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Salinosporamide A: A highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus Salinospora
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Author keywords
Cytotoxicity; Inhibitors; Natural products; Proteases; Structure elucidation
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Indexed keywords
CELLS;
TOXICITY;
TUMORS;
MARINE ACTINOMYCETE;
MICROBIOLOGY;
OMURALIDE;
PROTEASOME INHIBITOR;
SALINOSPORAMIDE A;
UNCLASSIFIED DRUG;
ARTICLE;
BACTERIOPLANKTON;
CANCER CELL CULTURE;
CRYSTAL STRUCTURE;
CYTOTOXICITY;
DRUG ISOLATION;
DRUG SCREENING;
DRUG STRUCTURE;
ENZYME INHIBITION;
HUMAN;
HUMAN CELL;
IN VITRO STUDY;
METABOLITE;
NONHUMAN;
NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;
SALINOSPORA;
TAXONOMY;
X RAY DIFFRACTION;
ACTINOMYCETALES;
ADENOCARCINOMA;
COLONIC NEOPLASMS;
CRYSTALLOGRAPHY, X-RAY;
CYSTEINE ENDOPEPTIDASES;
HUMANS;
INHIBITORY CONCENTRATION 50;
LACTONES;
MAGNETIC RESONANCE SPECTROSCOPY;
MODELS, MOLECULAR;
MOLECULAR STRUCTURE;
MULTIENZYME COMPLEXES;
PROTEASE INHIBITORS;
PROTEASOME ENDOPEPTIDASE COMPLEX;
PYRROLES;
TUMOR CELLS, CULTURED;
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EID: 0037455147
PISSN: 14337851
EISSN: None
Source Type: Journal
DOI: 10.1002/anie.200390115 Document Type: Article |
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Times cited : (960)
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References (12)
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