메뉴 건너뛰기




Volumn 15, Issue 9, 2014, Pages 591-600

RNAi screening comes of age: Improved techniques and complementary approaches

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; UNTRANSLATED RNA;

EID: 84906702408     PISSN: 14710072     EISSN: 14710080     Source Type: Journal    
DOI: 10.1038/nrm3860     Document Type: Review
Times cited : (261)

References (104)
  • 1
    • 33845755467 scopus 로고    scopus 로고
    • Illuminating the silence: Understanding the structure and function of small rnas
    • Rana, T. M. Illuminating the silence: Understanding the structure and function of small RNAs. Nature Rev. Mol. Cell Biol. 8, 23-36 (2007).
    • (2007) Nature Rev. Mol. Cell Biol , vol.8 , pp. 23-36
    • Rana, T.M.1
  • 2
    • 45549089565 scopus 로고    scopus 로고
    • The art and design of genetic screens: RNA interference
    • Boutros, M. & Ahringer, J. The art and design of genetic screens: RNA interference. Nature Rev. Genetics 9, 554-566 (2008).
    • (2008) Nature Rev. Genetics , vol.9 , pp. 554-566
    • Boutros, M.1    Ahringer, J.2
  • 3
    • 1542320541 scopus 로고    scopus 로고
    • The art and design of genetic screens: Mammalian culture cells
    • Grimm, S. The art and design of genetic screens: Mammalian culture cells. Nature reviews. Genetics 5, 179-189 (2004).
    • (2004) Nature Reviews. Genetics , vol.5 , pp. 179-189
    • Grimm, S.1
  • 4
    • 84859392832 scopus 로고    scopus 로고
    • RNA interference in Caenorhabditis elegans: Uptake, mechanism, and regulation
    • Zhuang, J. J. & Hunter, C. P. RNA interference in Caenorhabditis elegans: Uptake, mechanism, and regulation. Parasitology 139, 560-573 (2012).
    • (2012) Parasitology , vol.139 , pp. 560-573
    • Zhuang, J.J.1    Hunter, C.P.2
  • 6
    • 84934439055 scopus 로고    scopus 로고
    • Designing efficient and specific endoribonuclease-prepared siRNAs
    • Surendranath, V., Theis, M., Habermann, B. H. & Buchholz, F. Designing efficient and specific endoribonuclease-prepared siRNAs. Methods Mol. Biol. 942, 193-204 (2013).
    • (2013) Methods Mol. Biol , vol.942 , pp. 193-204
    • Surendranath, V.1    Theis, M.2    Habermann, B.H.3    Buchholz, F.4
  • 7
    • 77953626646 scopus 로고    scopus 로고
    • Genomic screening with RNAi: Results and challenges
    • Mohr, S., Bakal, C. & Perrimon, N. Genomic screening with RNAi: Results and challenges. Annu. Rev. Biochem. 79, 37-64 (2010).
    • (2010) Annu. Rev. Biochem , vol.79 , pp. 37-64
    • Mohr, S.1    Bakal, C.2    Perrimon, N.3
  • 8
    • 84876430637 scopus 로고    scopus 로고
    • Cell-based genomic screening: Elucidating virus-host interactions
    • Panda, D. & Cherry, S. Cell-based genomic screening: Elucidating virus-host interactions. Curr. Opin. Virol. 2, 784-792 (2012).
    • (2012) Curr. Opin. Virol , vol.2 , pp. 784-792
    • Panda, D.1    Cherry, S.2
  • 9
    • 68049139405 scopus 로고    scopus 로고
    • What have RNAi screens taught us about viral-host interactions
    • Cherry, S. What have RNAi screens taught us about viral-host interactions? Curr. Opin. Microbiol. 12, 446-452 (2009).
    • (2009) Curr Opin. Microbiol , vol.12 , pp. 446-452
    • Cherry, S.1
  • 10
    • 45849151106 scopus 로고    scopus 로고
    • Genomic rnai screening in drosophila s2 cells: What have we learned about host-pathogen interactions
    • Cherry, S. Genomic RNAi screening in Drosophila S2 cells: What have we learned about host-pathogen interactions? Curr. Opin. Microbiol. 11, 262-270 (2008).
    • (2008) Curr Opin. Microbiol , vol.11 , pp. 262-270
    • Cherry, S.1
  • 13
    • 84883788686 scopus 로고    scopus 로고
    • UP TORR: Online tool for accurate and Up to Date annotation of RNAi Reagents
    • Hu, Y. et al. UP TORR: Online tool for accurate and Up to Date annotation of RNAi Reagents. Genetics 195, 37-45 (2013).
    • (2013) Genetics , vol.195 , pp. 37-45
    • Hu, Y.1
  • 14
    • 84908498272 scopus 로고    scopus 로고
    • Genetic screens in Caenorhabditis elegans models for neurodegenerative diseases
    • Sin, O., Michels, H. & Nollen, E. A. Genetic screens in Caenorhabditis elegans models for neurodegenerative diseases. Biochim. Biophys. Acta http: //dx.doi. org/10.1016/j.bbadis.2014.01.015 (2014).
    • (2014) Biochim. Biophys. Acta
    • Sin, O.1    Michels, H.2    Nollen, E.A.3
  • 15
    • 33646188259 scopus 로고    scopus 로고
    • 3 utr seed matches, but not overall identity, are associated with rnai off-Targets
    • Birmingham, A. et al. 3 UTR seed matches, but not overall identity, are associated with RNAi off-Targets. Nature Methods 3, 199-204 (2006).
    • (2006) Nature Methods , vol.3 , pp. 199-204
    • Birmingham, A.1
  • 16
    • 68349112682 scopus 로고    scopus 로고
    • Statistical methods for analysis of high-Throughput RNA interference screens
    • Birmingham, A. et al. Statistical methods for analysis of high-Throughput RNA interference screens. Nature Methods 6, 569-575 (2009).
    • (2009) Nature Methods , vol.6 , pp. 569-575
    • Birmingham, A.1
  • 17
    • 33747794587 scopus 로고    scopus 로고
    • Genome-scale loss of function screening with a lentiviral RNAi library
    • Root, D. E., Hacohen, N., Hahn, W. C., Lander, E. S. & Sabatini, D. M. Genome-scale loss of function screening with a lentiviral RNAi library. Nature Methods 3, 715-719 (2006).
    • (2006) Nature Methods , vol.3 , pp. 715-719
    • Root, D.E.1    Hacohen, N.2    Hahn, W.C.3    Lander, E.S.4    Sabatini, D.M.5
  • 18
    • 84867594876 scopus 로고    scopus 로고
    • RNAi screening: New approaches, understandings, and organisms
    • Mohr, S. E. & Perrimon, N. RNAi screening: New approaches, understandings, and organisms. Wiley Interdiscip. Rev. RNA 3, 145-158 (2012).
    • (2012) Wiley Interdiscip Rev. RNA , vol.3 , pp. 145-158
    • Mohr, S.E.1    Perrimon, N.2
  • 19
    • 84867772824 scopus 로고    scopus 로고
    • Genome-wide rnai longevity screens in caenorhabditis elegans
    • Yanos, M. E., Bennett, C. F. & Kaeberlein, M. Genome-wide RNAi longevity screens in Caenorhabditis elegans. Curr. Genom. 13, 508-518 (2012).
    • (2012) Curr. Genom , vol.13 , pp. 508-518
    • Yanos, M.E.1    Bennett, C.F.2    Kaeberlein, M.3
  • 20
    • 79251469386 scopus 로고    scopus 로고
    • Vigilance and validation: Keys to success in rnai screening
    • Sigoillot, F. D. & King, R. W. Vigilance and validation: Keys to success in RNAi screening. ACS Chem. Biol. 6, 47-60 (2011).
    • (2011) ACS Chem. Biol , vol.6 , pp. 47-60
    • Sigoillot, F.D.1    King, R.W.2
  • 21
    • 84857856280 scopus 로고    scopus 로고
    • Genetic regulators of a pluripotent adult stem cell system in planarians identified by RNAi and clonal analysis
    • Wagner, D. E., Ho, J. J. & Reddien, P. W. Genetic regulators of a pluripotent adult stem cell system in planarians identified by RNAi and clonal analysis. Cell Stem Cell 10, 299-311 (2012).
    • (2012) Cell Stem Cell , vol.10 , pp. 299-311
    • Wagner, D.E.1    Ho, J.J.2    Reddien, P.W.3
  • 22
    • 84867686201 scopus 로고    scopus 로고
    • An rnai screen reveals intestinal regulators of branching morphogenesis, differentiation, and stem cell proliferation in planarians
    • Forsthoefel, D. J. et al. An RNAi screen reveals intestinal regulators of branching morphogenesis, differentiation, and stem cell proliferation in planarians. Dev. Cell 23, 691-704 (2012).
    • (2012) Dev. Cell , vol.23 , pp. 691-704
    • Forsthoefel, D.J.1
  • 23
    • 80051504285 scopus 로고    scopus 로고
    • The maintenance and regeneration of the planarian excretory system are regulated by egfr signaling
    • Rink, J. C., Vu, H. T. & Sanchez Alvarado, A. The maintenance and regeneration of the planarian excretory system are regulated by EGFR signaling. Development 138, 3769-3780 (2011).
    • (2011) Development , vol.138 , pp. 3769-3780
    • Rink, J.C.1    Vu, H.T.2    Sanchez Alvarado, A.3
  • 24
    • 84895900845 scopus 로고    scopus 로고
    • Genome-wide dissection of the quorum sensing signalling pathway in Trypanosoma brucei
    • Mony, B. M. et al. Genome-wide dissection of the quorum sensing signalling pathway in Trypanosoma brucei. Nature 505, 681-685 (2014).
    • (2014) Nature , vol.505 , pp. 681-685
    • Mony, B.M.1
  • 25
    • 33749023011 scopus 로고    scopus 로고
    • Minimizing the risk of reporting false positives in large-scale RNAi screens
    • Echeverri, C. J. et al. Minimizing the risk of reporting false positives in large-scale RNAi screens. Nature Methods 3, 777-779 (2006).
    • (2006) Nature Methods , vol.3 , pp. 777-779
    • Echeverri, C.J.1
  • 26
    • 84876573362 scopus 로고    scopus 로고
    • GenomeRNAi: A database for cell-based and in vivo RNAi phenotypes, 2013 update
    • Schmidt, E. E. et al. GenomeRNAi: A database for cell-based and in vivo RNAi phenotypes, 2013 update. Nucleic Acids Res. 41, D1021-D1026 (2013).
    • (2013) Nucleic Acids Res , vol.41
    • Schmidt, E.E.1
  • 27
    • 84859218649 scopus 로고    scopus 로고
    • A bioinformatics method identifies prominent off-Targeted transcripts in RNAi screens
    • Sigoillot, F. D. et al. A bioinformatics method identifies prominent off-Targeted transcripts in RNAi screens. Nature Methods 9, 363-366 (2012).
    • (2012) Nature Methods , vol.9 , pp. 363-366
    • Sigoillot, F.D.1
  • 28
    • 84861752176 scopus 로고    scopus 로고
    • Sirna off-Target effects in genome-wide screens identify signaling pathway members
    • Buehler, E. et al. siRNA off-Target effects in genome-wide screens identify signaling pathway members. Scientif. Rep. 2, 428 (2012).
    • (2012) Scientif. Rep , vol.2 , pp. 428
    • Buehler, E.1
  • 29
    • 84887881978 scopus 로고    scopus 로고
    • Systematic analysis of RNAi reports identifies dismal commonality at gene-level & reveals an unprecedented enrichment in pooled shRNA screens
    • Bhinder, B. & Djaballah, H. Systematic analysis of RNAi reports identifies dismal commonality at gene-level & reveals an unprecedented enrichment in pooled shRNA screens. Comb.Chem. High Throughput Screen 16, 665-681 (2013).
    • (2013) Comb.Chem. High Throughput Screen , vol.16 , pp. 665-681
    • Bhinder, B.1    Djaballah, H.2
  • 30
    • 67249143012 scopus 로고    scopus 로고
    • Host cell factors in HIV replication: Meta-Analysis of genome-wide studies
    • Bushman, F. D. et al. Host cell factors in HIV replication: Meta-Analysis of genome-wide studies. PLoS Pathog. 5, e1000437 (2009).
    • (2009) PLoS Pathog , vol.5
    • Bushman, F.D.1
  • 31
    • 84864326893 scopus 로고    scopus 로고
    • Molecular biology use and abuse of rnai to study mammalian gene function
    • Kaelin, W. G. Jr. Molecular biology. Use and abuse of RNAi to study mammalian gene function. Science 337, 421-422 (2012).
    • (2012) Science , vol.337 , pp. 421-422
    • Kaelin Jr., W.G.1
  • 32
    • 3042767202 scopus 로고    scopus 로고
    • Micrornas: Small rnas with a big role in gene regulation
    • He, L. & Hannon, G. J. MicroRNAs: Small RNAs with a big role in gene regulation. Nature Rev. Genetics 5, 522-531 (2004).
    • (2004) Nature Rev. Genetics , vol.5 , pp. 522-531
    • He, L.1    Hannon, G.J.2
  • 33
    • 0347444723 scopus 로고    scopus 로고
    • Micrornas: Genomics, biogenesis, mechanism, and function
    • Bartel, D. P. MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell 116, 281-297 (2004).
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 34
    • 84897002829 scopus 로고    scopus 로고
    • Specific inhibition of diverse pathogens in human cells by synthetic microRNA-like oligonucleotides inferred from RNAi screens
    • Franceschini, A. et al. Specific inhibition of diverse pathogens in human cells by synthetic microRNA-like oligonucleotides inferred from RNAi screens. Proc. Natl Acad. Sci. USA http: Dx.doi.org/10.1073/ pnas.1402353111 (2014).
    • (2014) Proc. Natl Acad. Sci. USA
    • Franceschini, A.1
  • 35
    • 57349134691 scopus 로고    scopus 로고
    • Chemical modification of siRNAs for in vivo use
    • Behlke, M. A. Chemical modification of siRNAs for in vivo use. Oligonucleotides 18, 305-319 (2008).
    • (2008) Oligonucleotides , vol.18 , pp. 305-319
    • Behlke, M.A.1
  • 36
    • 84902301560 scopus 로고    scopus 로고
    • Online GESS: Prediction of miRNA-like off-Target effects in large-scale RNAi screen data by seed region analysis
    • Yilmazel, B. et al. Online GESS: Prediction of miRNA-like off-Target effects in large-scale RNAi screen data by seed region analysis. BMC Bioinformat. 15, 192 (2014).
    • (2014) BMC Bioinformat , vol.15 , pp. 192
    • Yilmazel, B.1
  • 37
    • 84871265164 scopus 로고    scopus 로고
    • C911: A bench-level control for sequence specific sirna off-Target effects
    • Buehler, E., Chen, Y. C. & Martin, S. C911: A bench-level control for sequence specific siRNA off-Target effects. PloS ONE 7, e51942 (2012).
    • (2012) PloS ONE , vol.7
    • Buehler, E.1    Chen, Y.C.2    Martin, S.3
  • 38
    • 67349251607 scopus 로고    scopus 로고
    • Rapid creation and quantitative monitoring of high coverage shRNA libraries
    • Bassik, M. C. et al. Rapid creation and quantitative monitoring of high coverage shRNA libraries. Nature Methods 6, 443-445 (2009).
    • (2009) Nature Methods , vol.6 , pp. 443-445
    • Bassik, M.C.1
  • 39
    • 84896898658 scopus 로고    scopus 로고
    • Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1 deficient cancers
    • Hoffman, G. R. et al. Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1 deficient cancers. Proc. Natl Acad. Sci. USA 111, 3128-3133 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. 3128-3133
    • Hoffman, G.R.1
  • 40
    • 79952697845 scopus 로고    scopus 로고
    • Functional identification of optimized RNAi triggers using a massively parallel sensor assay
    • Fellmann, C. et al. Functional identification of optimized RNAi triggers using a massively parallel sensor assay. Mol. Cell 41, 733-746 (2011).
    • (2011) Mol. Cell , vol.41 , pp. 733-746
    • Fellmann, C.1
  • 41
    • 14044262340 scopus 로고    scopus 로고
    • RNA interference rescue by bacterial artificial chromosome transgenesis in mammalian tissue culture cells
    • Kittler, R. et al. RNA interference rescue by bacterial artificial chromosome transgenesis in mammalian tissue culture cells. Proc. Natl Acad. Sci. USA 102, 2396-2401 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 2396-2401
    • Kittler, R.1
  • 42
    • 72449143602 scopus 로고    scopus 로고
    • Cross-species RNAi rescue platform in Drosophila melanogaster
    • Kondo, S., Booker, M. & Perrimon, N. Cross-species RNAi rescue platform in Drosophila melanogaster. Genetics 183, 1165-1173 (2009).
    • (2009) Genetics , vol.183 , pp. 1165-1173
    • Kondo, S.1    Booker, M.2    Perrimon, N.3
  • 43
    • 77749245950 scopus 로고    scopus 로고
    • In vivo RNAi rescue in Drosophila melanogaster with genomic transgenes from Drosophila pseudoobscura
    • Langer, C. C., Ejsmont, R. K., Schonbauer, C., Schnorrer, F. & Tomancak, P. In vivo RNAi rescue in Drosophila melanogaster with genomic transgenes from Drosophila pseudoobscura. PloS ONE 5, e8928 (2010).
    • (2010) PloS ONE , vol.5
    • Langer, C.C.1    Ejsmont, R.K.2    Schonbauer, C.3    Schnorrer, F.4    Tomancak, P.5
  • 44
    • 84897840443 scopus 로고    scopus 로고
    • A synthetic lethal screen identifies FAT1 as an antagonist of caspase 8 in extrinsic apoptosis
    • Kranz, D. & Boutros, M. A synthetic lethal screen identifies FAT1 as an antagonist of caspase 8 in extrinsic apoptosis. EMBO J. 33, 181-197 (2014).
    • (2014) EMBO J. , vol.33 , pp. 181-197
    • Kranz, D.1    Boutros, M.2
  • 45
    • 84879264708 scopus 로고    scopus 로고
    • Zfn talen, and crispr/cas-based methods for genome engineering
    • Gaj, T., Gersbach, C. A. & Barbas, C. F. 3rd. ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering. Trends Biotechnol. 31, 397-405 (2013).
    • (2013) Trends Biotechnol , vol.31 , pp. 397-405
    • Gaj, T.1    Gersbach, C.A.2    Barbas III, C.F.3
  • 46
    • 84902095352 scopus 로고    scopus 로고
    • Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells
    • Wu, X. et al. Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells. Nature Biotech. 32, 670-676 (2014).
    • (2014) Nature Biotech , vol.32 , pp. 670-676
    • Wu, X.1
  • 47
    • 84885398906 scopus 로고    scopus 로고
    • A CRISPR CASe for high-Throughput silencing
    • Heintze, J., Luft, C. & Ketteler, R. A CRISPR CASe for high-Throughput silencing. Frontiers Genet. 4, 193 (2013).
    • (2013) Frontiers Genet , vol.4 , pp. 193
    • Heintze, J.1    Luft, C.2    Ketteler, R.3
  • 48
    • 65549169178 scopus 로고    scopus 로고
    • Discovery of insect and human dengue virus host factors
    • Sessions, O. M. et al. Discovery of insect and human dengue virus host factors. Nature 458, 1047-1050 (2009).
    • (2009) Nature , vol.458 , pp. 1047-1050
    • Sessions, O.M.1
  • 49
    • 80052609464 scopus 로고    scopus 로고
    • Comparative RNAi screening identifies a conserved core metazoan actinome by phenotype
    • Rohn, J. L. et al. Comparative RNAi screening identifies a conserved core metazoan actinome by phenotype. J. Cell Biol. 194, 789-805 (2011
    • (2011) J. Cell Biol , vol.194 , pp. 789-805
    • Rohn, J.L.1
  • 50
    • 84876008551 scopus 로고    scopus 로고
    • A genome-wide RNA interference screen identifies new regulators of androgen receptor function in prostate cancer cells
    • Imberg-Kazdan, K. et al. A genome-wide RNA interference screen identifies new regulators of androgen receptor function in prostate cancer cells. Genome Res. 23, 581-591 (2013).
    • (2013) Genome Res , vol.23 , pp. 581-591
    • Imberg-Kazdan, K.1
  • 51
    • 84884217072 scopus 로고    scopus 로고
    • Conserved regulators of nucleolar size revealed by global phenotypic analyses
    • Neumuller, R. A. et al. Conserved regulators of nucleolar size revealed by global phenotypic analyses. Sci. Signal. 6, ra70 (2013).
    • (2013) Sci. Signal , vol.6
    • Neumuller, R.A.1
  • 52
    • 67650646092 scopus 로고    scopus 로고
    • Exploring the conservation of synthetic lethal genetic interaction networks
    • Dixon, S. J., Andrews, B. J. & Boone, C. Exploring the conservation of synthetic lethal genetic interaction networks. Commun. Integr. Biol. 2, 78-81 (2009).
    • (2009) Commun. Integr. Biol , vol.2 , pp. 78-81
    • Dixon, S.J.1    Andrews, B.J.2    Boone, C.3
  • 53
    • 84861989206 scopus 로고    scopus 로고
    • Functional repurposing revealed by comparing S pombe and S cerevisiae genetic interactions
    • Frost, A. et al. Functional repurposing revealed by comparing S. pombe and S. cerevisiae genetic interactions. Cell 149, 1339-1352 (2012).
    • (2012) Cell , vol.149 , pp. 1339-1352
    • Frost, A.1
  • 54
    • 84863653627 scopus 로고    scopus 로고
    • Identification of genes that promote or antagonize somatic homolog pairing using a high-Throughput FISH-based screen
    • Joyce, E. F., Williams, B. R., Xie, T. & Wu, C. T. Identification of genes that promote or antagonize somatic homolog pairing using a high-Throughput FISH-based screen. PLoS Genet. 8, e1002667 (2012).
    • (2012) PLoS Genet , vol.8
    • Joyce, E.F.1    Williams, B.R.2    Xie, T.3    Wu, C.T.4
  • 55
    • 84880328076 scopus 로고    scopus 로고
    • A screen for morphological complexity identifies regulators of switch-like transitions between discrete cell shapes
    • Yin, Z. et al. A screen for morphological complexity identifies regulators of switch-like transitions between discrete cell shapes. Nature Cell Biol. 15, 860-871 (2013).
    • (2013) Nature Cell Biol , vol.15 , pp. 860-871
    • Yin, Z.1
  • 56
    • 77949424084 scopus 로고    scopus 로고
    • Systems survey of endocytosis by multiparametric image analysis
    • Collinet, C. et al. Systems survey of endocytosis by multiparametric image analysis. Nature 464, 243-249 (2010).
    • (2010) Nature , vol.464 , pp. 243-249
    • Collinet, C.1
  • 57
    • 84877303028 scopus 로고    scopus 로고
    • Mapping genetic interactions in human cancer cells with RNAi and multiparametric phenotyping
    • Laufer, C., Fischer, B., Billmann, M., Huber, W. & Boutros, M. Mapping genetic interactions in human cancer cells with RNAi and multiparametric phenotyping. Nature Methods 10, 427-431 (2013).
    • (2013) Nature Methods , vol.10 , pp. 427-431
    • Laufer, C.1    Fischer, B.2    Billmann, M.3    Huber, W.4    Boutros, M.5
  • 58
    • 84873918966 scopus 로고    scopus 로고
    • Integration of chemical and RNAi multiparametric profiles identifies triggers of intracellular mycobacterial killing
    • Sundaramurthy, V. et al. Integration of chemical and RNAi multiparametric profiles identifies triggers of intracellular mycobacterial killing. Cell Host Microbe 13, 129-142 (2013).
    • (2013) Cell Host Microbe , vol.13 , pp. 129-142
    • Sundaramurthy, V.1
  • 59
    • 84860187343 scopus 로고    scopus 로고
    • Single-cell analysis of population context advances RNAi screening at multiple levels
    • Snijder, B. et al. Single-cell analysis of population context advances RNAi screening at multiple levels. Mol. Systems Biol. 8, 579 (2012).
    • (2012) Mol. Systems Biol , vol.8 , pp. 579
    • Snijder, B.1
  • 60
    • 0026666791 scopus 로고
    • Ordering gene function: The interpretation of epistasis in regulatory hierarchies
    • Avery, L. & Wasserman, S. Ordering gene function: The interpretation of epistasis in regulatory hierarchies. Trends Genet. 8, 312-316 (1992).
    • (1992) Trends Genet , vol.8 , pp. 312-316
    • Avery, L.1    Wasserman, S.2
  • 61
    • 77956054446 scopus 로고    scopus 로고
    • Synthetic genetic array (SGA) analysis in Saccharomyces cerevisiae and Schizosaccharomyces pombe
    • Baryshnikova, A. et al. Synthetic genetic array (SGA) analysis in Saccharomyces cerevisiae and Schizosaccharomyces pombe. Methods Enzymol. 470, 145-179 (2010).
    • (2010) Methods Enzymol , vol.470 , pp. 145-179
    • Baryshnikova, A.1
  • 62
    • 79953289737 scopus 로고    scopus 로고
    • Mapping of signaling networks through synthetic genetic interaction analysis by rnai
    • Horn, T. et al. Mapping of signaling networks through synthetic genetic interaction analysis by RNAi. Nature Methods 8, 341-346 (2011).
    • (2011) Nature Methods , vol.8 , pp. 341-346
    • Horn, T.1
  • 63
    • 66149091940 scopus 로고    scopus 로고
    • A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene
    • Luo, J. et al. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. Cell 137, 835-848 (2009).
    • (2009) Cell , vol.137 , pp. 835-848
    • Luo, J.1
  • 64
    • 84865015653 scopus 로고    scopus 로고
    • Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies
    • Steckel, M. et al. Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies. Cell Res. 22, 1227-1245 (2012).
    • (2012) Cell Res , vol.22 , pp. 1227-1245
    • Steckel, M.1
  • 65
    • 79961062492 scopus 로고    scopus 로고
    • Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer
    • Cheung, H. W. et al. Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer. Proc. Natl Acad. Sci. USA 108, 12372-12377 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 12372-12377
    • Cheung, H.W.1
  • 66
    • 84862195351 scopus 로고    scopus 로고
    • COLT-Cancer: Functional genetic screening resource for essential genes in human cancer cell lines
    • Koh, J. L. et al. COLT-Cancer: Functional genetic screening resource for essential genes in human cancer cell lines. Nucleic Acids Res. 40, D957-D963 (2012).
    • (2012) Nucleic Acids Res , vol.40
    • Koh, J.L.1
  • 67
    • 84865202966 scopus 로고    scopus 로고
    • Essential gene profiles in breast, pancreatic, and ovarian cancer cells
    • Marcotte, R. et al. Essential gene profiles in breast, pancreatic, and ovarian cancer cells. Cancer Discov. 2, 172-189 (2012).
    • (2012) Cancer Discov , vol.2 , pp. 172-189
    • Marcotte, R.1
  • 68
    • 80055000824 scopus 로고    scopus 로고
    • RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
    • Zuber, J. et al. RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. Nature 478, 524-528 (2011).
    • (2011) Nature , vol.478 , pp. 524-528
    • Zuber, J.1
  • 69
    • 84884129997 scopus 로고    scopus 로고
    • RNAi screens in mice identify physiological regulators of oncogenic growth
    • Beronja, S. et al. RNAi screens in mice identify physiological regulators of oncogenic growth. Nature 501, 185-190 (2013).
    • (2013) Nature , vol.501 , pp. 185-190
    • Beronja, S.1
  • 70
    • 56349121125 scopus 로고    scopus 로고
    • An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer
    • Zender, L. et al. An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer. Cell 135, 852-864 (2008).
    • (2008) Cell , vol.135 , pp. 852-864
    • Zender, L.1
  • 71
    • 84880011146 scopus 로고    scopus 로고
    • In Vivo RNAi screening identifies a leukemia-specific dependence on integrin β 3 signaling
    • Miller, P. G. et al. In Vivo RNAi screening identifies a leukemia-specific dependence on integrin β 3 signaling. Cancer Cell 24, 45-58 (2013).
    • (2013) Cancer Cell , vol.24 , pp. 45-58
    • Miller, P.G.1
  • 72
    • 84876206165 scopus 로고    scopus 로고
    • A Direct in vivo RNAi screen identifies MKK4 as a key regulator of liver regeneration
    • Wuestefeld, T. et al. A Direct in vivo RNAi screen identifies MKK4 as a key regulator of liver regeneration. Cell 153, 389-401 (2013).
    • (2013) Cell , vol.153 , pp. 389-401
    • Wuestefeld, T.1
  • 73
    • 80051513341 scopus 로고    scopus 로고
    • An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance
    • Zuber, J. et al. An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance. Genes Dev. 25, 1628-1640 (2011).
    • (2011) Genes Dev , vol.25 , pp. 1628-1640
    • Zuber, J.1
  • 74
    • 84887053305 scopus 로고    scopus 로고
    • Accelerating cancer modeling with RNAi and nongermline genetically engineered mouse models
    • Livshits, G. & Lowe, S. W. Accelerating cancer modeling with RNAi and nongermline genetically engineered mouse models. Cold Spring Harbor Protoc. http: //dx.doi.org/10.1101/pdb.top069856 (2013).
    • (2013) Cold Spring Harbor Protoc
    • Livshits, G.1    Lowe, S.W.2
  • 75
    • 33646123992 scopus 로고    scopus 로고
    • Secretion of Wnt ligands requires Evi, a conserved transmembrane protein
    • Bartscherer, K., Pelte, N., Ingelfinger, D. & Boutros, M. Secretion of Wnt ligands requires Evi, a conserved transmembrane protein. Cell 125, 523-533 (2006).
    • (2006) Cell , vol.125 , pp. 523-533
    • Bartscherer, K.1    Pelte, N.2    Ingelfinger, D.3    Boutros, M.4
  • 76
    • 78149472321 scopus 로고    scopus 로고
    • A genome-wide Drosophila screen for heat nociception identifies a2d3 as an evolutionarily conserved pain gene
    • Neely, G. G. et al. A genome-wide Drosophila screen for heat nociception identifies a2d3 as an evolutionarily conserved pain gene. Cell 143, 628-638 (2010).
    • (2010) Cell , vol.143 , pp. 628-638
    • Neely, G.G.1
  • 77
    • 84863247568 scopus 로고    scopus 로고
    • Stringent analysis of gene function and protein-protein interactions using fluorescently tagged genes
    • Neumuller, R. A. et al. Stringent analysis of gene function and protein-protein interactions using fluorescently tagged genes. Genetics 190, 931-940 (2012).
    • (2012) Genetics , vol.190 , pp. 931-940
    • Neumuller, R.A.1
  • 78
    • 79961238713 scopus 로고    scopus 로고
    • Shaping cells and organs in Drosophila by opposing roles of fat body-secreted Collagen IV and perlecan
    • Pastor-Pareja, J. C. & Xu, T. Shaping cells and organs in Drosophila by opposing roles of fat body-secreted Collagen IV and perlecan. Dev. Cell 21, 245-256 (2011).
    • (2011) Dev. Cell , vol.21 , pp. 245-256
    • Pastor-Pareja, J.C.1    Xu, T.2
  • 79
    • 80052287311 scopus 로고    scopus 로고
    • MiMIC: A highly versatile transposon insertion resource for engineering Drosophila melanogaster genes
    • Venken, K. J. et al. MiMIC: A highly versatile transposon insertion resource for engineering Drosophila melanogaster genes. Nature Methods 8, 737-743 (2011).
    • (2011) Nature Methods , vol.8 , pp. 737-743
    • Venken, K.J.1
  • 80
    • 84888255506 scopus 로고    scopus 로고
    • Neuron-specific feeding RNAi in C elegans and its use in a screen for essential genes required for GABA neuron function
    • Firnhaber, C. & Hammarlund, M. Neuron-specific feeding RNAi in C. elegans and its use in a screen for essential genes required for GABA neuron function. PLoS Genet. 9, e1003921 (2013).
    • (2013) PLoS Genet , vol.9
    • Firnhaber, C.1    Hammarlund, M.2
  • 81
    • 34548013965 scopus 로고    scopus 로고
    • Establishment of a tissue-specific RNAi system in C elegans
    • Qadota, H. et al. Establishment of a tissue-specific RNAi system in C. elegans. Gene 400, 166-173 (2007).
    • (2007) Gene , vol.400 , pp. 166-173
    • Qadota, H.1
  • 82
    • 84904654756 scopus 로고    scopus 로고
    • Optimized crispr/cas tools for efficient germline and somatic genome engineering in drosophila
    • Port, F., Chen, H. M., Lee, T. & Bullock, S. L. Optimized CRISPR/Cas tools for efficient germline and somatic genome engineering in Drosophila. Proc. Natl Acad. Sci. USA http: //dx.doi.org/10.1073/pnas.1405500111 (2014).
    • (2014) Proc. Natl Acad. Sci. USA
    • Port, F.1    Chen, H.M.2    Lee, T.3    Bullock, S.L.4
  • 83
    • 61449172037 scopus 로고    scopus 로고
    • Systematic and integrative analysis of large gene lists using david bioinformatics resources
    • Huang da, W., Sherman, B. T. & Lempicki, R. A. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nature Protoc. 4, 44-57 (2009).
    • (2009) Nature Protoc , vol.4 , pp. 44-57
    • Huang Da, W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 84
    • 84875142412 scopus 로고    scopus 로고
    • Protein complex-based analysis framework for high-Throughput data sets
    • Vinayagam, A. et al. Protein complex-based analysis framework for high-Throughput data sets. Sci. Signal. 6, rs5 (2013).
    • (2013) Sci. Signal , vol.6
    • Vinayagam, A.1
  • 85
    • 84887319601 scopus 로고    scopus 로고
    • The Hippo signaling pathway interactome
    • Kwon, Y. et al. The Hippo signaling pathway interactome. Science 342, 737-740 (2013).
    • (2013) Science , vol.342 , pp. 737-740
    • Kwon, Y.1
  • 86
    • 84856455440 scopus 로고    scopus 로고
    • On target: A public repository for large-scale RNAi experiments
    • Shamu, C. E., Wiemann, S. & Boutros, M. On target: A public repository for large-scale RNAi experiments. Nature Cell Biol. 14, 115 (2012).
    • (2012) Nature Cell Biol , vol.14 , pp. 115
    • Shamu, C.E.1    Wiemann, S.2    Boutros, M.3
  • 87
    • 70849098603 scopus 로고    scopus 로고
    • Haploid genetic screens in human cells identify host factors used by pathogens
    • Carette, J. E. et al. Haploid genetic screens in human cells identify host factors used by pathogens. Science 326, 1231-1235 (2009).
    • (2009) Science , vol.326 , pp. 1231-1235
    • Carette, J.E.1
  • 88
    • 80052851832 scopus 로고    scopus 로고
    • Ebola virus entry requires the cholesterol transporter niemann-pick c1
    • Carette, J E. et al. Ebola virus entry requires the cholesterol transporter Niemann-Pick C1. Nature 477, 340-343 (2011).
    • (2011) Nature , vol.477 , pp. 340-343
    • Carette, J.E.1
  • 89
    • 84884903662 scopus 로고    scopus 로고
    • A reversible gene trap collection empowers haploid genetics in human cells
    • Burckstummer, T. et al. A reversible gene trap collection empowers haploid genetics in human cells. Nature Methods 10, 965-971 (2013).
    • (2013) Nature Methods , vol.10 , pp. 965-971
    • Burckstummer, T.1
  • 90
    • 84877707375 scopus 로고    scopus 로고
    • One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering
    • Wang, H. et al. One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell 153, 910-918 (2013).
    • (2013) Cell , vol.153 , pp. 910-918
    • Wang, H.1
  • 91
    • 84892749369 scopus 로고    scopus 로고
    • Genetic screens in human cells using the CRISPR Cas9 system
    • Wang, T., Wei, J. J., Sabatini, D. M. & Lander, E. S. Genetic screens in human cells using the CRISPR Cas9 system. Science 343, 80-84 (2014).
    • (2014) Science , vol.343 , pp. 80-84
    • Wang, T.1    Wei, J.J.2    Sabatini, D.M.3    Lander, E.S.4
  • 92
    • 84892765883 scopus 로고    scopus 로고
    • Genome-scale CRISPR Cas9 knockout screening in human cells
    • Shalem, O. et al. Genome-scale CRISPR Cas9 knockout screening in human cells. Science 343, 84-87 (2014).
    • (2014) Science , vol.343 , pp. 84-87
    • Shalem, O.1
  • 93
    • 84898665052 scopus 로고    scopus 로고
    • Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library
    • Koike-Yusa, H., Li, Y., Tan, E. P., Velasco-Herrera Mdel, C. & Yusa, K. Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library. Nature Biotech. 32, 267-273 (2014).
    • (2014) Nature Biotech , vol.32 , pp. 267-273
    • Koike-Yusa, H.1    Li, Y.2    Tan, E.P.3    Velasco-Herrera Mdel, C.4    Yusa, K.5
  • 94
    • 84896731736 scopus 로고    scopus 로고
    • CRISPR-based technologies: Prokaryotic defense weapons repurposed
    • Terns, R. M. & Terns, M. P. CRISPR-based technologies: Prokaryotic defense weapons repurposed. Trends Genet 30, 111-118 (2014).
    • (2014) Trends Genet , vol.30 , pp. 111-118
    • Terns, R.M.1    Terns, M.P.2
  • 95
    • 77956378342 scopus 로고    scopus 로고
    • Combined agonist-Antagonist genome-wide functional screening identifies broadly active antiviral microRNAs
    • Santhakumar, D. et al. Combined agonist-Antagonist genome-wide functional screening identifies broadly active antiviral microRNAs. Proc. Natl Acad. Sci. USA 107, 13830-13835 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 13830-13835
    • Santhakumar, D.1
  • 96
    • 84866357155 scopus 로고    scopus 로고
    • MicroRNA 520/373 family functions as a tumor suppressor in estrogen receptor negative breast cancer by targeting NF ?B and TGF-β signaling pathways
    • Keklikoglou, I. et al. MicroRNA 520/373 family functions as a tumor suppressor in estrogen receptor negative breast cancer by targeting NF ?B and TGF-β signaling pathways. Oncogene 31, 4150-4163 (2012).
    • (2012) Oncogene , vol.31 , pp. 4150-4163
    • Keklikoglou, I.1
  • 97
    • 84892953786 scopus 로고    scopus 로고
    • High-Throughput screens identify microRNAs essential for HER2 positive breast cancer cell growth
    • Leivonen, S. K. et al. High-Throughput screens identify microRNAs essential for HER2 positive breast cancer cell growth. Mol. Oncol. 8, 93-104 (2014).
    • (2014) Mol. Oncol , vol.8 , pp. 93-104
    • Leivonen, S.K.1
  • 98
    • 84890367567 scopus 로고    scopus 로고
    • A high-Throughput screen identifies miRNA inhibitors regulating lung cancer cell survival and response to paclitaxel
    • Du, L. et al. A high-Throughput screen identifies miRNA inhibitors regulating lung cancer cell survival and response to paclitaxel. RNA Biol. 10, 1700-1713 (2013).
    • (2013) RNA Biol , vol.10 , pp. 1700-1713
    • Du, L.1
  • 99
    • 84877832362 scopus 로고    scopus 로고
    • Identification of miRNA modulators to PARP inhibitor response
    • Neijenhuis, S., Bajrami, I., Miller, R., Lord, C. J. & Ashworth, A. Identification of miRNA modulators to PARP inhibitor response. DNA Repair 12, 394-402 (2013).
    • (2013) DNA Repair , vol.12 , pp. 394-402
    • Neijenhuis, S.1    Bajrami, I.2    Miller, R.3    Lord, C.J.4    Ashworth, A.5
  • 100
    • 77957557692 scopus 로고    scopus 로고
    • Candidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy
    • Otto, E. A. et al. Candidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy. Nature Genet. 42, 840-850 (2010).
    • (2010) Nature Genet , vol.42 , pp. 840-850
    • Otto, E.A.1
  • 101
    • 84892149837 scopus 로고    scopus 로고
    • To switch or not to switch: At the origin of repeat expansion disease
    • Mirkin, E. V. & Mirkin, S. M. To switch or not to switch: At the origin of repeat expansion disease. Mol. Cell 53, 1-3 (2014).
    • (2014) Mol. Cell , vol.53 , pp. 1-3
    • Mirkin, E.V.1    Mirkin, S.M.2
  • 102
    • 84875590101 scopus 로고    scopus 로고
    • Long noncoding RNAs: Past, present, and future
    • Kung, J. T., Colognori, D. & Lee, J. T. Long noncoding RNAs: Past, present, and future. Genetics 193, 651-669 (2013).
    • (2013) Genetics , vol.193 , pp. 651-669
    • Kung, J.T.1    Colognori, D.2    Lee, J.T.3
  • 103
    • 84887869938 scopus 로고    scopus 로고
    • A high-Throughput-compatible 3D microtissue co culture system for phenotypic RNAi screening applications
    • Thoma, C. R. et al. A high-Throughput-compatible 3D microtissue co culture system for phenotypic RNAi screening applications. J. Biomolecular Screen. 18, 1330-1337 (2013).
    • (2013) J. Biomolecular Screen , vol.18 , pp. 1330-1337
    • Thoma, C.R.1
  • 104
    • 84866883066 scopus 로고    scopus 로고
    • Validation of the cancer biochip system as a 3d sirna screening tool for breast cancer targets
    • Marhefka, J. N. & Abbud-Antaki, R. A. Validation of the Cancer BioChip System as a 3D siRNA screening tool for breast cancer targets. PloS ONE 7, e46086 (2012
    • (2012) PloS ONE , vol.7
    • Marhefka, J.N.1    Abbud-Antaki, R.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.