Tetarimycin A, an MRSA-active antibiotic identified through induced expression of environmental DNA gene clusters

Journal of the American Chemical Society

Volumn 134, Issue 48, 2012, Pages 19552-19555

  Kallifidas, Dimitris ^a   Kang, Hahk Soo ^a   Brady, Sean F ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHETIC GENE CLUSTER; ENVIRONMENTAL SAMPLE; FUNCTIONAL CHARACTERIZATION; GENE CLUSTERS; GENE SILENCING; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; NATURAL PRODUCTS; OVER-EXPRESSION; POLYKETIDES; REGULATORY PROTEIN; SECONDARY METABOLITES;

ANTIBIOTICS; BACTERIA; CLONING; GENES; KETONES; TRANSCRIPTION FACTORS;

DNA;

ANTIBIOTIC AGENT; STREPTOMYCES ANTIBIOTIC REGULATORY PROTEIN; TETARIMYCIN A; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; BACTERIUM CULTURE; BIOSYNTHESIS; DRUG SCREENING; GENE CLUSTER; HIGH THROUGHPUT SCREENING; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NONHUMAN; PROMOTER REGION; PROTEIN EXPRESSION; SEQUENCE ANALYSIS; STREPTOMYCES ALBUS; STRUCTURE ACTIVITY RELATION; TRANSCRIPTION INITIATION;

ANTI-BACTERIAL AGENTS; BACTERIA; BASE SEQUENCE; CLONING, MOLECULAR; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; PHYLOGENY; POLYCYCLIC COMPOUNDS; STAPHYLOCOCCUS AUREUS;

EID: 84870714378     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja3093828     Document Type: Article

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