Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection

Nature Biotechnology

Volumn 26, Issue 2, 2008, Pages 225-233

  Nguyen, TuAnh ^a   Ishida, Keishi ^b   Jenke Kodama, Holger ^c   Dittmann, Elke ^c   Gurgui, Cristian ^a   Hochmuth, Thomas ^a   Taudien, Stefan ^d   Platzer, Matthias ^d   Hertweck, Christian ^b   Piel, Jörn ^a  

^a UNIVERSITY OF BONN   (Germany)

^b HANS KNÖLL INSTITUTE   (Germany)

^c HUMBOLDT UNIVERSITY   (Germany)

^d FRITZ LIPMANN INSTITUTE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL INFORMATION; MARINE SPONGES; MOSAIC STRUCTURES; PATHWAY DISSECTION; POLYKETIDE SYNTHASES (PKSS); SUBSTRATE SPECIFIC KETOSYNTHASE;

BIOACTIVITY; BIOSYNTHESIS; DNA; ENZYME ACTIVITY; OCEAN HABITATS;

ENZYME KINETICS;

BACTERIAL ENZYME; KETOSYNTHASE; NATURAL PRODUCT; SYNTHETASE; TRANS ACYLTRANSFERASE POLYKETIDE SYNTHASE; UNCLASSIFIED DRUG;

ARTICLE; BURKHOLDERIA; BURKHOLDERIA THAILANDESIS; CONTROLLED STUDY; ENZYME STRUCTURE; GENOME; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; BIOLOGICAL PRODUCTS; BURKHOLDERIA; CATALYSIS; DRUG DESIGN; ENZYME ACTIVATION; MOLECULAR SEQUENCE DATA; POLYKETIDE SYNTHASES; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ANALYSIS, PROTEIN; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS); BURKHOLDERIA THAILANDENSIS;

EID: 38949203821     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt1379     Document Type: Article

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