Discovery and synthetic refactoring of tryptophan dimer gene clusters from the environment

Journal of the American Chemical Society

Volumn 135, Issue 47, 2013, Pages 17906-17912

  Chang, Fang Yuan ^a   Ternei, Melinda A ^a   Calle, Paula Y ^a   Brady, Sean F ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOINFORMATICS ANALYSIS; BIOSYNTHETIC GENE CLUSTER; CHROMOPYRROLIC ACID; FUNCTIONAL OUTPUTS; GENE CLUSTERS; REFACTORINGS; SOIL ENVIRONMENT; SYNTHASE GENE;

AMINO ACIDS; BIOCHEMISTRY; BIOINFORMATICS; LIBRARIES;

GENES;

AMPICILLIN; ANTIBIOTIC AGENT; AT2433 A1; BE 54017; BORREGOMYCIN A; CARBAZOLE DERIVATIVE; CHROMOPYRROLIC ACID SYNTHASE; CYTOTOXIN; DIMER; DNA; ERDASPORINE; IMINE; INDOLE DERIVATIVE; K 252A; KANAMYCIN; PYRUVIC ACID DERIVATIVE; REBECCAMYCIN; SPECTINOMYCIN; STAUROSPORINE; SYNTHETASE; TRYPTOPHAN; UNCLASSIFIED DRUG; VIOLACEIN;

ARTICLE; BACTERIAL GENE; BACTERIUM CULTURE; BIOINFORMATICS; BIOSYNTHESIS; CELL STRAIN HCT116; CHEMICAL STRUCTURE; CONTROLLED STUDY; COSMID; CULTURE MEDIUM; CYTOTOXICITY; DIMERIZATION; DNA LIBRARY; ENVIRONMENT; ENVIRONMENTAL DNA LIBRARY; ESCHERICHIA COLI; ESP GENE; GENE CLUSTER; GENE SEQUENCE; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATION; PHYLOGENETIC TREE; POLYMERASE CHAIN REACTION; SOIL; SOIL MICROFLORA; STAPHYLOCOCCUS AUREUS;

CELL LINE; COMPUTATIONAL BIOLOGY; ENVIRONMENT; ENZYMES; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GENE LIBRARY; GENES, BACTERIAL; HUMANS; MULTIGENE FAMILY; SOIL MICROBIOLOGY; TRYPTOPHAN;

EID: 84889261817     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja408683p     Document Type: Article

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