Genome mining in streptomyces avermitilis: Cloning and characterization of sav-76, the synthase for a new sesquiterpene, avermitilol

Journal of the American Chemical Society

Volumn 132, Issue 26, 2010, Pages 8850-8851

  Chou, Wayne K W ^a   Fanizza, Immacolata ^a   Uchiyama, Takuma ^b   Komatsu, Mamoru ^b   Ikeda, Haruo ^b   Cane, David E ^a  

^a BROWN UNIVERSITY   (United States)

^b KITASATO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ABSOLUTE CONFIGURATION; BICYCLOGERMACRENE; BIOCHEMICAL FUNCTIONS; DELETION MUTANTS; FARNESYL DIPHOSPHATE; GENOME MINING; GERMACRENE; GERMACRENE B; N-TERMINALS; NMR ANALYSIS; RECOMBINANT PROTEIN; SECONDARY METABOLITES; SESQUITERPENES; STEADY-STATE KINETICS; STREPTOMYCES AVERMITILIS; SYNTHASES; SYNTHETIC GENES; TRANSFORMANTS; VIRIDIFLOROL;

CLONING; ESCHERICHIA COLI; ESTERS; GENES; KETONES; METABOLITES; OLEFINS; PROTEINS; STEREOCHEMISTRY;

CYCLIZATION;

AVERMITILOL; FARNESYL DIPHOSPHATE; KETONE DERIVATIVE; MAGNESIUM ION; RECOMBINANT PROTEIN; SAV 76 PROTEIN; SESQUITERPENE DERIVATIVE; SYNTHETASE; TERPENOID DERIVATIVE; UNCLASSIFIED DRUG; VIRIDIFLOROL; ISOPRENOID PHOSPHATE; SESQUITERPENE; TERPENE SYNTHASE; TRANSFERASE;

AMINO TERMINAL SEQUENCE; ARTICLE; BACTERIAL GENE; BACTERIAL GENOME; BIOCHEMISTRY; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYCLIZATION; DELETION MUTANT; GENE EXPRESSION; HETERONUCLEAR MULTIPLE BOND CORRELATION; HETERONUCLEAR MULTIPLE QUANTUM COHERENCE; INCUBATION TIME; KINETICS; METABOLITE; MOLECULAR CLONING; NONHUMAN; NUCLEAR OVERHAUSER EFFECT; PROMOTER REGION; STEADY STATE; STEREOCHEMISTRY; STREPTOMYCES; STREPTOMYCES AVERMITILIS; AMINO ACID SEQUENCE; BIOCATALYSIS; CHEMISTRY; ENZYMOLOGY; GENETICS; METABOLISM;

ALKYL AND ARYL TRANSFERASES; AMINO ACID SEQUENCE; BIOCATALYSIS; CLONING, MOLECULAR; CYCLIZATION; GENOME, BACTERIAL; POLYISOPRENYL PHOSPHATES; SESQUITERPENES; STREPTOMYCES;

EID: 77954303579     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja103087w     Document Type: Article

References (13)

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