Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 15, 2011, Pages 6258-6263

  Laureti, Luisa ^a,b,d   Song, Lijiang ^c   Huang, Sheng ^a,b,e   Corre, Christophe ^c   Leblond, Pierre ^a,b   Challis, Gregory L ^c   Aigle, Bertrand ^a,b  

^a UNIVERSITÉ DE LORRAINE   (France)

^b UNIVERSITÉ DE LORRAINE   (France)

^c UNIVERSITY OF WARWICK   (United Kingdom)

^d UNIVERSITÉ PARIS DESCARTES   (France)

^e IOWA STATE UNIVERSITY   (United States)

Author keywords

Antibiotic; Anticancer agent; Genome mining; Silent gene cluster; Structure elucidation

Indexed keywords

ADENOSINE TRIPHOSPHATE; BIOACTIVE 51 MEMBERED MACROLIDE; HYDROXYL GROUP; MACROLIDE; POLYKETIDE SYNTHASE; STAMBOMYCIN A; STAMBOMYCIN B; STAMBOMYCIN C; STAMBOMYCIN D; UNCLASSIFIED DRUG;

ACTINOBACTERIA; BIOSYNTHESIS; CANCER CELL CULTURE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG STRUCTURE; GENE CLUSTER; GENE EXPRESSION; GENE SEQUENCE; GENOME; GENOMICS; HYDROXYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; REGULATOR GENE; STREPTOMYCES AMBOFACIENS; TRANSCRIPTION INITIATION;

STREPTOMYCES AMBOFACIENS;

EID: 79954997859     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1019077108     Document Type: Article

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