Antibacterial discovery in actinomycetes strains with mutations in RNA polymerase or ribosomal protein S12

Nature Biotechnology

Volumn 27, Issue 5, 2009, Pages 462-464

  Hosaka, Takeshi ^a,c   Ohnishi Kameyama, Mayumi ^a   Muramatsu, Hideyuki ^b   Murakami, Kana ^b   Tsurumi, Yasuhisa ^b,d   Kodani, Shinya ^a,e   Yoshida, Mitsuru ^a   Fujie, Akihiko ^b   Ochi, Kozo ^a  

^a NATIONAL FOOD RESEARCH INSTITUTE   (Japan)

^b ASTELLAS PHARMA INC   (Japan)

^c SHINSHU UNIVERSITY   (Japan)

^d NATIONAL INSTITUTE OF TECHNOLOGY AND EVALUATION   (Japan)

^e SHIZUOKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBACTERIAL COMPOUNDS; ANTIBACTERIALS; MUTANT STRAIN; RIBOSOMAL PROTEINS; RNA POLYMERASE; STREPTOMYCES SPECIES; UNKNOWN CLASS;

RNA;

NUCLEIC ACIDS;

ANTIINFECTIVE AGENT; PIPERIDAMYCIN; RIBOSOME PROTEIN; RNA POLYMERASE; UNCLASSIFIED DRUG; DNA DIRECTED RNA POLYMERASE; RIBOSOMAL PROTEIN S12;

ACTINOBACTERIA; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIUM ISOLATION; BACTERIUM MUTANT; DRUG STRUCTURE; DRUG SYNTHESIS; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; RPOB GENE; RPSL GENE; STRAIN DIFFERENCE; STREPTOMYCES; CHEMISTRY; DRUG DEVELOPMENT; GENETICS; METABOLISM; MUTATION;

ACTINOBACTERIA (CLASS); BACTERIA (MICROORGANISMS); STREPTOMYCES;

ACTINOBACTERIA; ANTI-BACTERIAL AGENTS; DNA-DIRECTED RNA POLYMERASES; DRUG DISCOVERY; MUTATION; RIBOSOMAL PROTEINS; STREPTOMYCES;

EID: 66149185679     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.1538     Document Type: Article

References (15)

1. Bentley, S.D. et al. Nature 417, 141-147 (2002).
2. Ikeda, H. et al. Nat. Biotechnol. 21, 526-531 (2003).
3. Oliynyk, M. et al. Nat. Biotechnol. 25, 447-453 (2007).
4. Ohnishi, Y. et al. J. Bacteriol. 190, 4050-4060 (2008).
5. Clardy, J., Fischbach, M.A. & Walsh, C.T. Nat. Biotechnol. 24, 1541-1550 (2006).
6. Bode, H.B. & Muller, R. Angew. Chem. Int. Edn Engl. 44, 6828-6846 (2005).
7. Bode, H.B., Bethe, B., Höfs, R. & Zeeck, A. ChemBioChem 3, 619-627 (2002).
8. Ochi, K. et al. Adv. Appl. Microbiol. 56, 155-184 (2004).
9. Shima, J., Hesketh, A., Okamoto, S., Kawamoto, S. & Ochi, K. J. Bacteriol. 178, 7276-7284 (1996).
10. Hu, H., Zhang, Q. & Ochi, K. J. Bacteriol. 184, 3984-3991 (2002).
11. Hosaka, T., Xu, J. & Ochi, K. Mol. Microbiol. 61, 883-897 (2006).
12. Wang, G., Hosaka, T. & Ochi, K. Appl. Environ. Microbiol. 74, 2834-2840 (2008).
13. Tamehiro, N. et al. Appl. Environ. Microbiol. 69, 6412-6417 (2003).
14. Rigali, S. et al. EMBO Rep. 9, 670-675 (2008).
15. Tala, A. et al. J. Bacteriol. 191, 805-814 (2009).