-
1
-
-
51349085004
-
Developmental origins of disease and determinants of chromatin structure: Maternal diet modifies the primate fetal epigenome
-
Aagaard-Tillery KM, Grove K, Bishop J, Ke X, Fu Q, McKnight R, and Lane RH. Developmental origins of disease and determinants of chromatin structure: maternal diet modifies the primate fetal epigenome. J Mol Endocrinol 41: 91-102, 2008.
-
(2008)
J Mol Endocrinol
, vol.41
, pp. 91-102
-
-
Aagaard-Tillery, K.M.1
Grove, K.2
Bishop, J.3
Ke, X.4
Fu, Q.5
McKnight, R.6
Lane, R.H.7
-
2
-
-
80051914543
-
The lipogenesis pathway as a cancer target
-
Abramson HN. The lipogenesis pathway as a cancer target. J Med Chem 54: 5615-5638, 2011.
-
(2011)
J Med Chem
, vol.54
, pp. 5615-5638
-
-
Abramson, H.N.1
-
3
-
-
84867123432
-
Cancer cell growth and survival as a systemlevel property sustained by enhanced glycolysis and mitochondrial metabolic remodeling
-
Alberghina L, Gaglio D, Gelfi C, Moresco RM, Mauri G, Bertolazzi P, Messa C, Gilardi MC, Chiaradonna F, and Vanoni M. Cancer cell growth and survival as a systemlevel property sustained by enhanced glycolysis and mitochondrial metabolic remodeling. Front Physiol 3: 362, 2012.
-
(2012)
Front Physiol
, vol.3
, pp. 362
-
-
Alberghina, L.1
Gaglio, D.2
Gelfi, C.3
Moresco, R.M.4
Mauri, G.5
Bertolazzi, P.6
Messa, C.7
Gilardi, M.C.8
Chiaradonna, F.9
Vanoni, M.10
-
4
-
-
33746872880
-
Mitochondria and cancer: Is there a morphological connection?
-
Alirol E and Martinou JC. Mitochondria and cancer: is there a morphological connection? Oncogene 25: 4706-4716, 2006.
-
(2006)
Oncogene
, vol.25
, pp. 4706-4716
-
-
Alirol, E.1
Martinou, J.C.2
-
5
-
-
79960574987
-
Energy metabolism in H460 lung cancer cells: Effects of histone deacetylase inhibitors
-
Amoedo ND, Rodrigues MF, Pezzuto P, Galina A, da Costa RM, de Almeida FC, El-Bacha T, and Rumjanek FD. Energy metabolism in H460 lung cancer cells: effects of histone deacetylase inhibitors. PLoS One 6: e22264, 2011.
-
(2011)
PLoS One
, vol.6
-
-
Amoedo, N.D.1
Rodrigues, M.F.2
Pezzuto, P.3
Galina, A.4
Da Costa, R.M.5
De Almeida, F.C.6
El-Bacha, T.7
Rumjanek, F.D.8
-
6
-
-
84872225149
-
PGC1alpha and mitochondrial metabolism - Emerging concepts and relevance in ageing and neurodegenerative disorders
-
Austin S and St.-Pierre J. PGC1alpha and mitochondrial metabolism - emerging concepts and relevance in ageing and neurodegenerative disorders. J Cell Sci 125: 4963-4971, 2012.
-
(2012)
J Cell Sci
, vol.125
, pp. 4963-4971
-
-
Austin, S.1
St.-Pierre, J.2
-
7
-
-
84855753309
-
Selective repression of MEF2 activity by PKA-dependent proteolysis of HDAC4
-
Backs J, Worst BC, Lehmann LH, Patrick DM, Jebessa Z, Kreusser MM, Sun Q, Chen L, Heft C, Katus HA, and Olson EN. Selective repression of MEF2 activity by PKA-dependent proteolysis of HDAC4. J Cell Biol 195: 403-415, 2011.
-
(2011)
J Cell Biol
, vol.195
, pp. 403-415
-
-
Backs, J.1
Worst, B.C.2
Lehmann, L.H.3
Patrick, D.M.4
Jebessa, Z.5
Kreusser, M.M.6
Sun, Q.7
Chen, L.8
Heft, C.9
Katus, H.A.10
Olson, E.N.11
-
8
-
-
84857222410
-
Histone deacetylase inhibition increases levels of choline kinase alpha and phosphocholine facilitating noninvasive imaging in human cancers
-
Beloueche-Babari M, Arunan V, Troy H, te Poele RH, te Fong AC, Jackson LE, Payne GS, Griffiths JR, Judson IR, Workman P, Leach MO, and Chung YL. Histone deacetylase inhibition increases levels of choline kinase alpha and phosphocholine facilitating noninvasive imaging in human cancers. Cancer Res 72: 990-1000, 2012.
-
(2012)
Cancer Res
, vol.72
, pp. 990-1000
-
-
Beloueche-Babari, M.1
Arunan, V.2
Troy, H.3
Te Poele, R.H.4
Te Fong, A.C.5
Jackson, L.E.6
Payne, G.S.7
Griffiths, J.R.8
Judson, I.R.9
Workman, P.10
Leach, M.O.11
Chung, Y.L.12
-
9
-
-
33745918951
-
TIGAR, a p53-inducible regulator of glycolysis and apoptosis
-
Bensaad K, Tsuruta A, Selak MA, Vidal MN, Nakano K, Bartrons R, Gottlieb E, and Vousden KH. TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell 126: 107-120, 2006.
-
(2006)
Cell
, vol.126
, pp. 107-120
-
-
Bensaad, K.1
Tsuruta, A.2
Selak, M.A.3
Vidal, M.N.4
Nakano, K.5
Bartrons, R.6
Gottlieb, E.7
Vousden, K.H.8
-
10
-
-
84865117354
-
Defective mitochondrial morphology and bioenergetic function in mice lacking the transcription factor Yin Yang 1 in skeletal muscle
-
Blattler SM, Verdeguer F, Liesa M, Cunningham JT, Vogel RO, Chim H, Liu H, Romanino K, Shirihai OS, Vazquez F, Ruegg MA, Shi Y, and Puigserver P. Defective mitochondrial morphology and bioenergetic function in mice lacking the transcription factor Yin Yang 1 in skeletal muscle. Mol Cell Biol 32: 3333-3346, 2012.
-
(2012)
Mol Cell Biol
, vol.32
, pp. 3333-3346
-
-
Blattler, S.M.1
Verdeguer, F.2
Liesa, M.3
Cunningham, J.T.4
Vogel, R.O.5
Chim, H.6
Liu, H.7
Romanino, K.8
Shirihai, O.S.9
Vazquez, F.10
Ruegg, M.A.11
Shi, Y.12
Puigserver, P.13
-
11
-
-
84875978060
-
HDAC inhibitors induce tumor-cell-selective pro-apoptotic transcriptional responses
-
Bolden JE, Shi W, Jankowski K, Kan CY, Cluse L, Martin BP, MacKenzie KL, Smyth GK, and Johnstone RW. HDAC inhibitors induce tumor-cell-selective pro-apoptotic transcriptional responses. Cell Death Dis 4: e519, 2013.
-
(2013)
Cell Death Dis
, vol.4
, pp. e519
-
-
Bolden, J.E.1
Shi, W.2
Jankowski, K.3
Kan, C.Y.4
Cluse, L.5
Martin, B.P.6
MacKenzie, K.L.7
Smyth, G.K.8
Johnstone, R.W.9
-
12
-
-
0035839844
-
Translocations involving c-myc and c-myc function
-
Boxer LM and Dang CV. Translocations involving c-myc and c-myc function. Oncogene 20: 5595-5610, 2001.
-
(2001)
Oncogene
, vol.20
, pp. 5595-5610
-
-
Boxer, L.M.1
Dang, C.V.2
-
14
-
-
20544449673
-
The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid beta-oxidation
-
Buzzai M, Bauer DE, Jones RG, Deberardinis RJ, Hatzivassiliou G, Elstrom RL, and Thompson CB. The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid beta-oxidation. Oncogene 24: 4165-4173, 2005.
-
(2005)
Oncogene
, vol.24
, pp. 4165-4173
-
-
Buzzai, M.1
Bauer, D.E.2
Jones, R.G.3
Deberardinis, R.J.4
Hatzivassiliou, G.5
Elstrom, R.L.6
Thompson, C.B.7
-
15
-
-
84861701419
-
A review of methionine dependency and the role of methionine restriction in cancer growth control and life-span extension
-
Cavuoto P and Fenech MF. A review of methionine dependency and the role of methionine restriction in cancer growth control and life-span extension. Cancer Treat Rev 38: 726-736, 2012.
-
(2012)
Cancer Treat Rev
, vol.38
, pp. 726-736
-
-
Cavuoto, P.1
Fenech, M.F.2
-
16
-
-
84872055680
-
Acute beta-adrenergic activation triggers nuclear import of histone deacetylase 5 and delays G(q)-induced transcriptional activation
-
Chang CW, Lee L, Yu D, Dao K, Bossuyt J, and Bers DM. Acute beta-adrenergic activation triggers nuclear import of histone deacetylase 5 and delays G(q)-induced transcriptional activation. J Biol Chem 288: 192-204, 2013.
-
(2013)
J Biol Chem
, vol.288
, pp. 192-204
-
-
Chang, C.W.1
Lee, L.2
Yu, D.3
Dao, K.4
Bossuyt, J.5
Bers, D.M.6
-
17
-
-
4544358659
-
Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development
-
Chang S, McKinsey TA, Zhang CL, Richardson JA, Hill JA, and Olson EN. Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development. Mol Cell Biol 24: 8467-8476, 2004.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 8467-8476
-
-
Chang, S.1
McKinsey, T.A.2
Zhang, C.L.3
Richardson, J.A.4
Hill, J.A.5
Olson, E.N.6
-
18
-
-
2942735131
-
SENP1 enhances androgen receptor-dependent transcription through desumoylation of histone deacetylase 1
-
Cheng J, Wang D, Wang Z, and Yeh ET. SENP1 enhances androgen receptor-dependent transcription through desumoylation of histone deacetylase 1. Mol Cell Biol 24: 6021-6028, 2004.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 6021-6028
-
-
Cheng, J.1
Wang, D.2
Wang, Z.3
Yeh, E.T.4
-
19
-
-
33748967370
-
Expression of transforming K-Ras oncogene affects mitochondrial function and morphology in mouse fibroblasts
-
Chiaradonna F, Gaglio D, Vanoni M, and Alberghina L. Expression of transforming K-Ras oncogene affects mitochondrial function and morphology in mouse fibroblasts. Biochim Biophys Acta 1757: 1338-1356, 2006.
-
(2006)
Biochim Biophys Acta
, vol.1757
, pp. 1338-1356
-
-
Chiaradonna, F.1
Gaglio, D.2
Vanoni, M.3
Alberghina, L.4
-
20
-
-
84855719307
-
From cancer metabolism to new biomarkers and drug targets
-
Chiaradonna F, Moresco RM, Airoldi C, Gaglio D, Palorini R, Nicotra F, Messa C, and Alberghina L. From cancer metabolism to new biomarkers and drug targets. Biotechnol Adv 30: 30-51, 2012.
-
(2012)
Biotechnol Adv
, vol.30
, pp. 30-51
-
-
Chiaradonna, F.1
Moresco, R.M.2
Airoldi, C.3
Gaglio, D.4
Palorini, R.5
Nicotra, F.6
Messa, C.7
Alberghina, L.8
-
21
-
-
79953044882
-
HDAC inhibition decreases the expression of EGFR in colorectal cancer cells
-
Chou CW, Wu MS, Huang WC, and Chen CC. HDAC inhibition decreases the expression of EGFR in colorectal cancer cells. PLoS One 6: e18087, 2011.
-
(2011)
PLoS One
, vol.6
-
-
Chou, C.W.1
Wu, M.S.2
Huang, W.C.3
Chen, C.C.4
-
22
-
-
68949212379
-
Lysine acetylation targets protein complexes and co-regulates major cellular functions
-
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, and Mann M. Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science 325: 834-840, 2009.
-
(2009)
Science
, vol.325
, pp. 834-840
-
-
Choudhary, C.1
Kumar, C.2
Gnad, F.3
Nielsen, M.L.4
Rehman, M.5
Walther, T.C.6
Olsen, J.V.7
Mann, M.8
-
23
-
-
80054788317
-
Histone modifiers in cancer: Friends or foes?
-
Cohen I, Poreba E, Kamieniarz K, and Schneider R. Histone modifiers in cancer: friends or foes? Genes Cancer 2: 631-647, 2011.
-
(2011)
Genes Cancer
, vol.2
, pp. 631-647
-
-
Cohen, I.1
Poreba, E.2
Kamieniarz, K.3
Schneider, R.4
-
24
-
-
84867550050
-
Molecular pathways: The complexity of the epigenome in cancer and recent clinical advances
-
Conte M and Altucci L. Molecular pathways: the complexity of the epigenome in cancer and recent clinical advances. Clin Cancer Res 18: 5526-5534, 2011.
-
(2011)
Clin Cancer Res
, vol.18
, pp. 5526-5534
-
-
Conte, M.1
Altucci, L.2
-
25
-
-
0018371969
-
Different accessibilities in chromatin to histone acetylase
-
Cousens LS, Gallwitz D, and Alberts BM. Different accessibilities in chromatin to histone acetylase. J Biol Chem 254: 1716-1723, 1979.
-
(1979)
J Biol Chem
, vol.254
, pp. 1716-1723
-
-
Cousens, L.S.1
Gallwitz, D.2
Alberts, B.M.3
-
26
-
-
36749081539
-
mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex
-
Cunningham JT, Rodgers JT, Arlow DH, Vazquez F, Mootha VK, and Puigserver P. mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. Nature 450: 736-740, 2007.
-
(2007)
Nature
, vol.450
, pp. 736-740
-
-
Cunningham, J.T.1
Rodgers, J.T.2
Arlow, D.H.3
Vazquez, F.4
Mootha, V.K.5
Puigserver, P.6
-
27
-
-
0037452677
-
Regulation of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 alpha) and mitochondrial function by MEF2 and HDAC5
-
Czubryt MP, McAnally J, Fishman GI, and Olson EN. Regulation of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 alpha) and mitochondrial function by MEF2 and HDAC5. Proc Natl Acad Sci U S A 100: 1711-1716, 2003.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 1711-1716
-
-
Czubryt, M.P.1
McAnally, J.2
Fishman, G.I.3
Olson, E.N.4
-
28
-
-
70350728803
-
MYC-induced cancer cell energy metabolism and therapeutic opportunities
-
Dang CV, Le A, and Gao P. MYC-induced cancer cell energy metabolism and therapeutic opportunities. Clin Cancer Res 15: 6479-6483, 2009.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 6479-6483
-
-
Dang, C.V.1
Le, A.2
Gao, P.3
-
29
-
-
30944463110
-
A high-fat diet impairs liver regeneration in C57BL/6 mice through overexpression of the NF-kappaB inhibitor, IkappaBalpha
-
DeAngelis RA, Markiewski MM, Taub R, and Lambris JD. A high-fat diet impairs liver regeneration in C57BL/6 mice through overexpression of the NF-kappaB inhibitor, IkappaBalpha. Hepatology 42: 1148-1157, 2005.
-
(2005)
Hepatology
, vol.42
, pp. 1148-1157
-
-
DeAngelis, R.A.1
Markiewski, M.M.2
Taub, R.3
Lambris, J.D.4
-
30
-
-
75149148563
-
Q's next: The diverse functions of glutamine in metabolism, cell biology and cancer
-
DeBerardinis RJ and Cheng T. Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer. Oncogene 29: 313-324, 2010.
-
(2010)
Oncogene
, vol.29
, pp. 313-324
-
-
DeBerardinis, R.J.1
Cheng, T.2
-
31
-
-
37449024702
-
The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation
-
DeBerardinis RJ, Lum JJ, Hatzivassiliou G, and Thompson CB. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab 7: 11-20, 2008.
-
(2008)
Cell Metab
, vol.7
, pp. 11-20
-
-
DeBerardinis, R.J.1
Lum, J.J.2
Hatzivassiliou, G.3
Thompson, C.B.4
-
32
-
-
79952666779
-
STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction
-
Demaria M, Giorgi C, Lebiedzinska M, Esposito G, D'Angeli L, Bartoli A, Gough DJ, Turkson J, Levy DE, Watson CJ, Wieckowski MR, Provero P, Pinton P, and Poli V. A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction. Aging (Albany NY) 2: 823-842, 2010.
-
(2010)
Aging (Albany NY)
, vol.2
, pp. 823-842
-
-
Demaria, M.1
Giorgi, C.2
Lebiedzinska, M.3
Esposito, G.4
D'Angeli, L.5
Bartoli, A.6
Gough, D.J.7
Turkson, J.8
Levy, D.E.9
Watson, C.J.10
Wieckowski, M.R.11
Provero, P.12
Pinton, P.13
Poli, V.A.14
-
33
-
-
44349157832
-
Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
-
Dewhirst MW, Cao Y, and Moeller B. Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response. Nat Rev Cancer 8: 425-437, 2008.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 425-437
-
-
Dewhirst, M.W.1
Cao, Y.2
Moeller, B.3
-
34
-
-
84870389262
-
The Warburg effect dictates the mechanism of butyrate-mediated histone acetylation and cell proliferation
-
Donohoe DR, Collins LB, Wali A, Bigler R, Sun W, and Bultman SJ. The Warburg effect dictates the mechanism of butyrate-mediated histone acetylation and cell proliferation. Mol Cell 48: 612-626, 2012.
-
(2012)
Mol Cell
, vol.48
, pp. 612-626
-
-
Donohoe, D.R.1
Collins, L.B.2
Wali, A.3
Bigler, R.4
Sun, W.5
Bultman, S.J.6
-
35
-
-
77953664293
-
Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function
-
Dowling DP, Gattis SG, Fierke CA, and Christianson DW. Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function. Biochemistry 49: 5048-5056, 2010.
-
(2010)
Biochemistry
, vol.49
, pp. 5048-5056
-
-
Dowling, D.P.1
Gattis, S.G.2
Fierke, C.A.3
Christianson, D.W.4
-
36
-
-
77955483125
-
Activation of a metabolic gene regulatory network downstream of mTOR complex 1
-
Duvel K, Yecies JL, Menon S, Raman P, Lipovsky AI, Souza AL, Triantafellow E, Ma Q, Gorski R, Cleaver S, Vander Heiden MG, MacKeigan JP, Finan PM, Clish CB, Murphy LO, and Manning BD. Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Mol Cell 39: 171-183, 2010.
-
(2010)
Mol Cell
, vol.39
, pp. 171-183
-
-
Duvel, K.1
Yecies, J.L.2
Menon, S.3
Raman, P.4
Lipovsky, A.I.5
Souza, A.L.6
Triantafellow, E.7
Ma, Q.8
Gorski, R.9
Cleaver, S.10
Vander Heiden, M.G.11
MacKeigan, J.P.12
Finan, P.M.13
Clish, C.B.14
Murphy, L.O.15
Manning, B.D.16
-
37
-
-
2542561169
-
Akt stimulates aerobic glycolysis in cancer cells
-
Elstrom RL, Bauer DE, Buzzai M, Karnauskas R, Harris MH, Plas DR, Zhuang H, Cinalli RM, Alavi A, Rudin CM, and Thompson CB. Akt stimulates aerobic glycolysis in cancer cells. Cancer Res 64: 3892-3899, 2004.
-
(2004)
Cancer Res
, vol.64
, pp. 3892-3899
-
-
Elstrom, R.L.1
Bauer, D.E.2
Buzzai, M.3
Karnauskas, R.4
Harris, M.H.5
Plas, D.R.6
Zhuang, H.7
Cinalli, R.M.8
Alavi, A.9
Rudin, C.M.10
Thompson, C.B.11
-
38
-
-
27944448727
-
Dual regulation of c-Myc by p300 via acetylation-dependent control of Myc protein turnover and coactivation of Myc-induced transcription
-
Faiola F, Liu X, Lo S, Pan S, Zhang K, Lymar E, Farina A, and Martinez E. Dual regulation of c-Myc by p300 via acetylation-dependent control of Myc protein turnover and coactivation of Myc-induced transcription. Mol Cell Biol 25: 10220-10234, 2005.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 10220-10234
-
-
Faiola, F.1
Liu, X.2
Lo, S.3
Pan, S.4
Zhang, K.5
Lymar, E.6
Farina, A.7
Martinez, E.8
-
39
-
-
12944250922
-
Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A
-
Fang X, Yu SX, Lu Y, Bast RC, Jr., Woodgett JR, and Mills GB. Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A. Proc Natl Acad Sci U S A 97: 11960-11965, 2000.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 11960-11965
-
-
Fang, X.1
Yu, S.X.2
Lu, Y.3
Bast, R.C.4
Woodgett, J.R.5
Mills, G.B.6
-
40
-
-
84872159532
-
AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo
-
Faubert B, Boily G, Izreig S, Griss T, Samborska B, Dong Z, Dupuy F, Chambers C, Fuerth BJ, Viollet B, Mamer OA, Avizonis D, DeBerardinis RJ, Siegel PM, and Jones RG. AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo. Cell Metab 17: 113-124, 2013.
-
(2013)
Cell Metab
, vol.17
, pp. 113-124
-
-
Faubert, B.1
Boily, G.2
Izreig, S.3
Griss, T.4
Samborska, B.5
Dong, Z.6
Dupuy, F.7
Chambers, C.8
Fuerth, B.J.9
Viollet, B.10
Mamer, O.A.11
Avizonis, D.12
DeBerardinis, R.J.13
Siegel, P.M.14
Jones, R.G.15
-
41
-
-
84860709659
-
FOXO3a regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression
-
Ferber EC, Peck B, Delpuech O, Bell GP, East P, and Schulze A. FOXO3a regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression. Cell Death Differ 19: 968-979, 2011.
-
(2011)
Cell Death Differ
, vol.19
, pp. 968-979
-
-
Ferber, E.C.1
Peck, B.2
Delpuech, O.3
Bell, G.P.4
East, P.5
Schulze, A.6
-
42
-
-
18544387930
-
Isolation and characterization of a novel class II histone deacetylase, HDAC10
-
Fischer DD, Cai R, Bhatia U, Asselbergs FA, Song C, Terry R, Trogani N, Widmer R, Atadja P, and Cohen D. Isolation and characterization of a novel class II histone deacetylase, HDAC10. J Biol Chem 277: 6656-6666, 2002.
-
(2002)
J Biol Chem
, vol.277
, pp. 6656-6666
-
-
Fischer, D.D.1
Cai, R.2
Bhatia, U.3
Asselbergs, F.A.4
Song, C.5
Terry, R.6
Trogani, N.7
Widmer, R.8
Atadja, P.9
Cohen, D.10
-
43
-
-
0035929621
-
Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo
-
Fischle W, Dequiedt F, Fillion M, Hendzel MJ, Voelter W, and Verdin E. Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo. J Biol Chem 276: 35826-35835, 2001.
-
(2001)
J Biol Chem
, vol.276
, pp. 35826-35835
-
-
Fischle, W.1
Dequiedt, F.2
Fillion, M.3
Hendzel, M.J.4
Voelter, W.5
Verdin, E.6
-
44
-
-
0041590889
-
MYC recruits the TIP60 histone acetyltransferase complex to chromatin
-
Frank SR, Parisi T, Taubert S, Fernandez P, Fuchs M, Chan HM, Livingston DM, and Amati B. MYC recruits the TIP60 histone acetyltransferase complex to chromatin. EMBO Rep 4: 575-580, 2003.
-
(2003)
EMBO Rep
, vol.4
, pp. 575-580
-
-
Frank, S.R.1
Parisi, T.2
Taubert, S.3
Fernandez, P.4
Fuchs, M.5
Chan, H.M.6
Livingston, D.M.7
Amati, B.8
-
45
-
-
84862908644
-
Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway
-
Freed-Pastor WA, Mizuno H, Zhao X, Langerod A, Moon SH, Rodriguez-Barrueco R, Barsotti A, Chicas A, Li W, Polotskaia A, Bissell MJ, Osborne TF, Tian B, Lowe SW, Silva JM, Borresen-Dale AL, Levine AJ, Bargonetti J, and Prives C. Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. Cell 148: 244-258, 2012.
-
(2012)
Cell
, vol.148
, pp. 244-258
-
-
Freed-Pastor, W.A.1
Mizuno, H.2
Zhao, X.3
Langerod, A.4
Moon, S.H.5
Rodriguez-Barrueco, R.6
Barsotti, A.7
Chicas, A.8
Li, W.9
Polotskaia, A.10
Bissell, M.J.11
Osborne, T.F.12
Tian, B.13
Lowe, S.W.14
Silva, J.M.15
Borresen-Dale, A.L.16
Levine, A.J.17
Bargonetti, J.18
Prives, C.19
-
46
-
-
84869106554
-
Inhibition of class I histone deacetylases unveils a mitochondrial signature and enhances oxidative metabolism in skeletal muscle and adipose tissue
-
Galmozzi A, Mitro N, Ferrari A, Gers E, Gilardi F, Godio C, Cermenati G, Gualerzi A, Donetti E, Rotili D, Valente S, Guerrini U, Caruso D, Mai A, Saez E, De Fabiani E, and Crestani M. Inhibition of class I histone deacetylases unveils a mitochondrial signature and enhances oxidative metabolism in skeletal muscle and adipose tissue. Diabetes 62: 732-742, 2012.
-
(2012)
Diabetes
, vol.62
, pp. 732-742
-
-
Galmozzi, A.1
Mitro, N.2
Ferrari, A.3
Gers, E.4
Gilardi, F.5
Godio, C.6
Cermenati, G.7
Gualerzi, A.8
Donetti, E.9
Rotili, D.10
Valente, S.11
Guerrini, U.12
Caruso, D.13
Mai, A.14
Saez, E.15
De Fabiani, E.16
Crestani, M.17
-
47
-
-
70349205564
-
PTEN/AKT pathway involved in histone deacetylases inhibitor induced cell growth inhibition and apoptosis of oral squamous cell carcinoma cells
-
Gan YH and Zhang S. PTEN/AKT pathway involved in histone deacetylases inhibitor induced cell growth inhibition and apoptosis of oral squamous cell carcinoma cells. Oral Oncol 45: e150-e154, 2009.
-
(2009)
Oral Oncol
, vol.45
, pp. e150-e154
-
-
Gan, Y.H.1
Zhang, S.2
-
48
-
-
84874403639
-
Targeting transcription factor SALL4 in acute myeloid leukemia by interrupting its interaction with an epigenetic complex
-
Gao C, Dimitrov T, Yong KJ, Tatetsu H, Jeong HW, Luo HR, Bradner JE, Tenen DG, and Chai L. Targeting transcription factor SALL4 in acute myeloid leukemia by interrupting its interaction with an epigenetic complex. Blood 121: 1413-1421, 2013.
-
(2013)
Blood
, vol.121
, pp. 1413-1421
-
-
Gao, C.1
Dimitrov, T.2
Yong, K.J.3
Tatetsu, H.4
Jeong, H.W.5
Luo, H.R.6
Bradner, J.E.7
Tenen, D.G.8
Chai, L.9
-
49
-
-
0037067696
-
Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family
-
Gao L, Cueto MA, Asselbergs F, and Atadja P. Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family. J Biol Chem 277: 25748-25755, 2002.
-
(2002)
J Biol Chem
, vol.277
, pp. 25748-25755
-
-
Gao, L.1
Cueto, M.A.2
Asselbergs, F.3
Atadja, P.4
-
50
-
-
0031723957
-
Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO
-
Gelmetti V, Zhang J, Fanelli M, Minucci S, Pelicci PG, and Lazar MA. Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO. Mol Cell Biol 18: 7185-7191, 1998.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 7185-7191
-
-
Gelmetti, V.1
Zhang, J.2
Fanelli, M.3
Minucci, S.4
Pelicci, P.G.5
Lazar, M.A.6
-
51
-
-
80055077899
-
HDAC4 protein regulates HIF1alpha protein lysine acetylation and cancer cell response to hypoxia
-
Geng H, Harvey CT, Pittsenbarger J, Liu Q, Beer TM, Xue C, and Qian DZ. HDAC4 protein regulates HIF1alpha protein lysine acetylation and cancer cell response to hypoxia. J Biol Chem 286: 38095-38102, 2011.
-
(2011)
J Biol Chem
, vol.286
, pp. 38095-38102
-
-
Geng, H.1
Harvey, C.T.2
Pittsenbarger, J.3
Liu, Q.4
Beer, T.M.5
Xue, C.6
Qian, D.Z.7
-
52
-
-
79960050610
-
PTEN tumor suppressor network in PI3K-Akt pathway control
-
Georgescu MM. PTEN tumor suppressor network in PI3K-Akt pathway control. Genes Cancer 1: 1170-1177, 2010.
-
(2010)
Genes Cancer
, vol.1
, pp. 1170-1177
-
-
Georgescu, M.M.1
-
53
-
-
34547897023
-
Histone deacetylases and cancer
-
Glozak MA and Seto E. Histone deacetylases and cancer. Oncogene 26: 5420-5432, 2007.
-
(2007)
Oncogene
, vol.26
, pp. 5420-5432
-
-
Glozak, M.A.1
Seto, E.2
-
54
-
-
33644507479
-
Transcription factor YY1: Structure, function, and therapeutic implications in cancer biology
-
Gordon S, Akopyan G, Garban H, and Bonavida B. Transcription factor YY1: structure, function, and therapeutic implications in cancer biology. Oncogene 25: 1125-1142, 2006.
-
(2006)
Oncogene
, vol.25
, pp. 1125-1142
-
-
Gordon, S.1
Akopyan, G.2
Garban, H.3
Bonavida, B.4
-
55
-
-
67649988989
-
Mitochondrial STAT3 supports Ras-dependent oncogenic transformation
-
Gough DJ, Corlett A, Schlessinger K, Wegrzyn J, Larner AC, and Levy DE. Mitochondrial STAT3 supports Ras-dependent oncogenic transformation. Science 324: 1713-1716, 2009.
-
(2009)
Science
, vol.324
, pp. 1713-1716
-
-
Gough, D.J.1
Corlett, A.2
Schlessinger, K.3
Wegrzyn, J.4
Larner, A.C.5
Levy, D.E.6
-
56
-
-
1842830815
-
Microarray profiling of the effects of histone deacetylase inhibitors on gene expression in cancer cell lines
-
Gray SG, Qian CN, Furge K, Guo X, and Teh BT. Microarray profiling of the effects of histone deacetylase inhibitors on gene expression in cancer cell lines. Int J Oncol 24: 773-795, 2004.
-
(2004)
Int J Oncol
, vol.24
, pp. 773-795
-
-
Gray, S.G.1
Qian, C.N.2
Furge, K.3
Guo, X.4
Teh, B.T.5
-
57
-
-
1842578986
-
Molecular evolution of the histone deacetylase family: Functional implications of phylogenetic analysis
-
Gregoretti IV, Lee YM, and Goodson HV. Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis. J Mol Biol 338: 17-31, 2004.
-
(2004)
J Mol Biol
, vol.338
, pp. 17-31
-
-
Gregoretti, I.V.1
Lee, Y.M.2
Goodson, H.V.3
-
59
-
-
0034608955
-
Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization
-
Grozinger CM and Schreiber SL. Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization. Proc Natl Acad Sci U S A 97: 7835-7840, 2000.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 7835-7840
-
-
Grozinger, C.M.1
Schreiber, S.L.2
-
60
-
-
0030797585
-
Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
-
Gu W and Roeder RG. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell 90: 595-606, 1997.
-
(1997)
Cell
, vol.90
, pp. 595-606
-
-
Gu, W.1
Roeder, R.G.2
-
61
-
-
84862019471
-
Regulation of STAT3 by histone deacetylase-3 in diffuse large B-cell lymphoma: Implications for therapy
-
Gupta M, Han JJ, Stenson M, Wellik L, and Witzig TE. Regulation of STAT3 by histone deacetylase-3 in diffuse large B-cell lymphoma: implications for therapy. Leukemia 26: 1356-1364, 2012.
-
(2012)
Leukemia
, vol.26
, pp. 1356-1364
-
-
Gupta, M.1
Han, J.J.2
Stenson, M.3
Wellik, L.4
Witzig, T.E.5
-
62
-
-
67650572769
-
Epigenetic control of skull morphogenesis by histone deacetylase 8
-
Haberland M, Mokalled MH, Montgomery RL, and Olson EN. Epigenetic control of skull morphogenesis by histone deacetylase 8. Genes Dev 23: 1625-1630, 2009.
-
(2009)
Genes Dev
, vol.23
, pp. 1625-1630
-
-
Haberland, M.1
Mokalled, M.H.2
Montgomery, R.L.3
Olson, E.N.4
-
63
-
-
57749170458
-
The many roles of histone deacetylases in development and physiology: Implications for disease and therapy
-
Haberland M, Montgomery RL, and Olson EN. The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat Rev Genet 10: 32-42, 2009.
-
(2009)
Nat Rev Genet
, vol.10
, pp. 32-42
-
-
Haberland, M.1
Montgomery, R.L.2
Olson, E.N.3
-
64
-
-
69949113620
-
Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate
-
Hait NC, Allegood J, Maceyka M, Strub GM, Harikumar KB, Singh SK, Luo C, Marmorstein R, Kordula T, Milstien S, and Spiegel S. Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. Science 325: 1254-1257, 2009.
-
(2009)
Science
, vol.325
, pp. 1254-1257
-
-
Hait, N.C.1
Allegood, J.2
Maceyka, M.3
Strub, G.M.4
Harikumar, K.B.5
Singh, S.K.6
Luo, C.7
Marmorstein, R.8
Kordula, T.9
Milstien, S.10
Spiegel, S.11
-
65
-
-
84876320551
-
LKB1 and AMPK and the cancer-metabolism link-ten years after
-
Hardie DG and Alessi DR. LKB1 and AMPK and the cancer-metabolism link-ten years after. BMC Biol 11: 36, 2013.
-
(2013)
BMC Biol
, vol.11
, pp. 36
-
-
Hardie, D.G.1
Alessi, D.R.2
-
66
-
-
34248208217
-
Histone deacetylase 2 modulates p53 transcriptional activities through regulation of p53-DNA binding activity
-
Harms KL and Chen X. Histone deacetylase 2 modulates p53 transcriptional activities through regulation of p53-DNA binding activity. Cancer Res 67: 3145-3152, 2007.
-
(2007)
Cancer Res
, vol.67
, pp. 3145-3152
-
-
Harms, K.L.1
Chen, X.2
-
67
-
-
0036359548
-
Hypoxia - A key regulatory factor in tumour growth
-
Harris AL. Hypoxia - a key regulatory factor in tumour growth. Nat Rev Cancer 2: 38-47, 2002.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 38-47
-
-
Harris, A.L.1
-
68
-
-
77950371052
-
Protein kinase C-related kinase targets nuclear localization signals in a subset of class IIa histone deacetylases
-
Harrison BC, Huynh K, Lundgaard GL, Helmke SM, Perryman MB, and McKinsey TA. Protein kinase C-related kinase targets nuclear localization signals in a subset of class IIa histone deacetylases. FEBS Lett 584: 1103-1110, 2010.
-
(2010)
FEBS Lett
, vol.584
, pp. 1103-1110
-
-
Harrison, B.C.1
Huynh, K.2
Lundgaard, G.L.3
Helmke, S.M.4
Perryman, M.B.5
McKinsey, T.A.6
-
69
-
-
0031280071
-
Fiber-derived butyrate and the prevention of colon cancer
-
Hassig CA, Tong JK, and Schreiber SL. Fiber-derived butyrate and the prevention of colon cancer. Chem Biol 4: 783-789, 1997.
-
(1997)
Chem Biol
, vol.4
, pp. 783-789
-
-
Hassig, C.A.1
Tong, J.K.2
Schreiber, S.L.3
-
70
-
-
84872276165
-
Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome
-
Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, and Coon JJ. Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome. Mol Cell 49: 186-199, 2013.
-
(2013)
Mol Cell
, vol.49
, pp. 186-199
-
-
Hebert, A.S.1
Dittenhafer-Reed, K.E.2
Yu, W.3
Bailey, D.J.4
Selen, E.S.5
Boersma, M.D.6
Carson, J.J.7
Tonelli, M.8
Balloon, A.J.9
Higbee, A.J.10
Westphall, M.S.11
Pagliarini, D.J.12
Prolla, T.A.13
Assadi-Porter, F.14
Roy, S.15
Denu, J.M.16
Coon, J.J.17
-
71
-
-
0027170789
-
Sodium butyrate causes an increase in the block to transcriptional elongation in the c-myc gene in SW837 rectal carcinoma cells
-
Heruth DP, Zirnstein GW, Bradley JF, and Rothberg PG. Sodium butyrate causes an increase in the block to transcriptional elongation in the c-myc gene in SW837 rectal carcinoma cells. J Biol Chem 268: 20466-20472, 1993.
-
(1993)
J Biol Chem
, vol.268
, pp. 20466-20472
-
-
Heruth, D.P.1
Zirnstein, G.W.2
Bradley, J.F.3
Rothberg, P.G.4
-
72
-
-
16244418734
-
A new role for the von Hippel-Lindau tumor suppressor protein: Stimulation of mitochondrial oxidative phosphorylation complex biogenesis
-
Hervouet E, Demont J, Pecina P, Vojtiskova A, Houstek J, Simonnet H, and Godinot C. A new role for the von Hippel-Lindau tumor suppressor protein: stimulation of mitochondrial oxidative phosphorylation complex biogenesis. Carcinogenesis 26: 531-539, 2005.
-
(2005)
Carcinogenesis
, vol.26
, pp. 531-539
-
-
Hervouet, E.1
Demont, J.2
Pecina, P.3
Vojtiskova, A.4
Houstek, J.5
Simonnet, H.6
Godinot, C.7
-
73
-
-
84868347619
-
L-carnitine is an endogenous HDAC inhibitor selectively inhibiting cancer cell growth in vivo and in vitro
-
Huang H, Liu N, Guo H, Liao S, Li X, Yang C, Liu S, Song W, Liu C, Guan L, Li B, Xu L, Zhang C, Wang X, Dou QP, and Liu J. L-carnitine is an endogenous HDAC inhibitor selectively inhibiting cancer cell growth in vivo and in vitro. PLoS One 7: e49062, 2012.
-
(2012)
PLoS One
, vol.7
-
-
Huang, H.1
Liu, N.2
Guo, H.3
Liao, S.4
Li, X.5
Yang, C.6
Liu, S.7
Song, W.8
Liu, C.9
Guan, L.10
Li, B.11
Xu, L.12
Zhang, C.13
Wang, X.14
Dou, Q.P.15
Liu, J.16
-
74
-
-
84875001039
-
Identification of the general transcription factor Yin Yang 1 as a novel and specific binding partner for S6 kinase 2
-
Ismail HM, Myronova O, Tsuchiya Y, Niewiarowski A, Tsaneva I, and Gout I. Identification of the general transcription factor Yin Yang 1 as a novel and specific binding partner for S6 kinase 2. Cell Signal 25: 1054-1063, 2013.
-
(2013)
Cell Signal
, vol.25
, pp. 1054-1063
-
-
Ismail, H.M.1
Myronova, O.2
Tsuchiya, Y.3
Niewiarowski, A.4
Tsaneva, I.5
Gout, I.6
-
75
-
-
0037112901
-
MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation
-
Ito A, Kawaguchi Y, Lai CH, Kovacs JJ, Higashimoto Y, Appella E, and Yao TP. MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation. EMBO J 21: 6236-6245, 2002.
-
(2002)
EMBO J
, vol.21
, pp. 6236-6245
-
-
Ito, A.1
Kawaguchi, Y.2
Lai, C.H.3
Kovacs, J.J.4
Higashimoto, Y.5
Appella, E.6
Yao, T.P.7
-
76
-
-
84861420588
-
Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation
-
Jain M, Nilsson R, Sharma S, Madhusudhan N, Kitami T, Souza AL, Kafri R, Kirschner MW, Clish CB, and Mootha VK. Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. Science 336: 1040-1044, 2012.
-
(2012)
Science
, vol.336
, pp. 1040-1044
-
-
Jain, M.1
Nilsson, R.2
Sharma, S.3
Madhusudhan, N.4
Kitami, T.5
Souza, A.L.6
Kafri, R.7
Kirschner, M.W.8
Clish, C.B.9
Mootha, V.K.10
-
77
-
-
78049299533
-
Intracellular sodium sensing: SIK1 network, hormone action and high blood pressure
-
Jaitovich A and Bertorello AM. Intracellular sodium sensing: SIK1 network, hormone action and high blood pressure. Biochim Biophys Acta 1802: 1140-1149, 2010.
-
(2010)
Biochim Biophys Acta
, vol.1802
, pp. 1140-1149
-
-
Jaitovich, A.1
Bertorello, A.M.2
-
78
-
-
84861857806
-
The role of skeletal muscle glycogen breakdown for regulation of insulin sensitivity by exercise
-
Jensen J, Rustad PI, Kolnes AJ, and Lai YC. The role of skeletal muscle glycogen breakdown for regulation of insulin sensitivity by exercise. Front Physiol 2: 112, 2011.
-
(2011)
Front Physiol
, vol.2
, pp. 112
-
-
Jensen, J.1
Rustad, P.I.2
Kolnes, A.J.3
Lai, Y.C.4
-
79
-
-
84873678601
-
Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence
-
Jiang P, Du W, Mancuso A, Wellen KE, and Yang X. Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence. Nature 493: 689-693, 2013.
-
(2013)
Nature
, vol.493
, pp. 689-693
-
-
Jiang, P.1
Du, W.2
Mancuso, A.3
Wellen, K.E.4
Yang, X.5
-
80
-
-
79952280229
-
p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase
-
Jiang P, Du W, Wang X, Mancuso A, Gao X, Wu M, and Yang X. p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase. Nat Cell Biol 13: 310-316, 2011.
-
(2011)
Nat Cell Biol
, vol.13
, pp. 310-316
-
-
Jiang, P.1
Du, W.2
Wang, X.3
Mancuso, A.4
Gao, X.5
Wu, M.6
Yang, X.7
-
81
-
-
0028673348
-
Inhibition of cell cycle progression by sodium butyrate in normal rat kidney fibroblasts is altered by expression of the adenovirus 5 early 1A gene
-
Joensuu T and Mester J. Inhibition of cell cycle progression by sodium butyrate in normal rat kidney fibroblasts is altered by expression of the adenovirus 5 early 1A gene. Biosci Rep 14: 291-300, 1994.
-
(1994)
Biosci Rep
, vol.14
, pp. 291-300
-
-
Joensuu, T.1
Mester, J.2
-
82
-
-
84879574177
-
The functional interactome landscape of the human histone deacetylase family
-
Joshi P, Greco TM, Guise AJ, Luo Y, Yu F, Nesvizhskii AI, and Cristea IM. The functional interactome landscape of the human histone deacetylase family. Mol Syst Biol 9: 672, 2013.
-
(2013)
Mol Syst Biol
, vol.9
, pp. 672
-
-
Joshi, P.1
Greco, T.M.2
Guise, A.J.3
Luo, Y.4
Yu, F.5
Nesvizhskii, A.I.6
Cristea, I.M.7
-
83
-
-
0034617261
-
Histone deacetylases specifically downregulate p53-dependent gene activation
-
Juan LJ, Shia WJ, Chen MH, Yang WM, Seto E, Lin YS, and Wu CW. Histone deacetylases specifically downregulate p53-dependent gene activation. J Biol Chem 275: 20436-20443, 2000.
-
(2000)
J Biol Chem
, vol.275
, pp. 20436-20443
-
-
Juan, L.J.1
Shia, W.J.2
Chen, M.H.3
Yang, W.M.4
Seto, E.5
Lin, Y.S.6
Wu, C.W.7
-
84
-
-
84875755814
-
Influence of metabolism on epigenetics and disease
-
Kaelin WG, Jr., and McKnight SL. Influence of metabolism on epigenetics and disease. Cell 153: 56-69, 2013.
-
(2013)
Cell
, vol.153
, pp. 56-69
-
-
Kaelin, W.G.1
McKnight, S.L.2
-
85
-
-
4744368147
-
Histone deacetylase 7 associates with hypoxia-inducible factor 1alpha and increases transcriptional activity
-
Kato H, Tamamizu-Kato S, and Shibasaki F. Histone deacetylase 7 associates with hypoxia-inducible factor 1alpha and increases transcriptional activity. J Biol Chem 279: 41966-41974, 2004.
-
(2004)
J Biol Chem
, vol.279
, pp. 41966-41974
-
-
Kato, H.1
Tamamizu-Kato, S.2
Shibasaki, F.3
-
86
-
-
84878273525
-
The physiological roles of histone deacetylase (HDAC) 1 and 2: Complex co-stars with multiple leading parts
-
Kelly RD and Cowley SM. The physiological roles of histone deacetylase (HDAC) 1 and 2: complex co-stars with multiple leading parts. Biochem Soc Trans 41: 741-749, 2013.
-
(2013)
Biochem Soc Trans
, vol.41
, pp. 741-749
-
-
Kelly, R.D.1
Cowley, S.M.2
-
87
-
-
0035048449
-
Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes
-
Kim MS, Kwon HJ, Lee YM, Baek JH, Jang JE, Lee SW, Moon EJ, Kim HS, Lee SK, Chung HY, Kim CW, and Kim KW. Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes. Nat Med 7: 437-443, 2001.
-
(2001)
Nat Med
, vol.7
, pp. 437-443
-
-
Kim, M.S.1
Kwon, H.J.2
Lee, Y.M.3
Baek, J.H.4
Jang, J.E.5
Lee, S.W.6
Moon, E.J.7
Kim, H.S.8
Lee, S.K.9
Chung, H.Y.10
Kim, C.W.11
Kim, K.W.12
-
88
-
-
33746992118
-
Substrate and functional diversity of lysine acetylation revealed by a proteomics survey
-
Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, Cheng T, Kho Y, Xiao H, Xiao L, Grishin NV, White M, Yang XJ, and Zhao Y. Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Mol Cell 23: 607-618, 2006.
-
(2006)
Mol Cell
, vol.23
, pp. 607-618
-
-
Kim, S.C.1
Sprung, R.2
Chen, Y.3
Xu, Y.4
Ball, H.5
Pei, J.6
Cheng, T.7
Kho, Y.8
Xiao, H.9
Xiao, L.10
Grishin, N.V.11
White, M.12
Yang, X.J.13
Zhao, Y.14
-
89
-
-
18444370302
-
The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase
-
Kirsh O, Seeler JS, Pichler A, Gast A, Muller S, Miska E, Mathieu M, Harel-Bellan A, Kouzarides T, Melchior F, and Dejean A. The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase. EMBO J 21: 2682-2691, 2002.
-
(2002)
EMBO J
, vol.21
, pp. 2682-2691
-
-
Kirsh, O.1
Seeler, J.S.2
Pichler, A.3
Gast, A.4
Muller, S.5
Miska, E.6
Mathieu, M.7
Harel-Bellan, A.8
Kouzarides, T.9
Melchior, F.10
Dejean, A.11
-
90
-
-
0036500993
-
Systems biology: A brief overview
-
Kitano H. Systems biology: a brief overview. Science 295: 1662-1664, 2002.
-
(2002)
Science
, vol.295
, pp. 1662-1664
-
-
Kitano, H.1
-
91
-
-
41949120723
-
Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks
-
Knutson SK, Chyla BJ, Amann JM, Bhaskara S, Huppert SS, and Hiebert SW. Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks. EMBO J 27: 1017-1028, 2008.
-
(2008)
EMBO J
, vol.27
, pp. 1017-1028
-
-
Knutson, S.K.1
Chyla, B.J.2
Amann, J.M.3
Bhaskara, S.4
Huppert, S.S.5
Hiebert, S.W.6
-
92
-
-
33644780111
-
Histone deacetylase inhibitors induce VHL and ubiquitin-independent proteasomal degradation of hypoxia-inducible factor 1alpha
-
Kong X, Lin Z, Liang D, Fath D, Sang N, and Caro J. Histone deacetylase inhibitors induce VHL and ubiquitin-independent proteasomal degradation of hypoxia-inducible factor 1alpha. Mol Cell Biol 26: 2019-2028, 2006.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 2019-2028
-
-
Kong, X.1
Lin, Z.2
Liang, D.3
Fath, D.4
Sang, N.5
Caro, J.6
-
93
-
-
0037136563
-
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
-
Kops GJ, Dansen TB, Polderman PE, Saarloos I, Wirtz KW, Coffer PJ, Huang TT, Bos JL, Medema RH, and Burgering BM. Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature 419: 316-321, 2002.
-
(2002)
Nature
, vol.419
, pp. 316-321
-
-
Kops, G.J.1
Dansen, T.B.2
Polderman, P.E.3
Saarloos, I.4
Wirtz, K.W.5
Coffer, P.J.6
Huang, T.T.7
Bos, J.L.8
Medema, R.H.9
Burgering, B.M.10
-
94
-
-
84872168313
-
Acetylated Sp1 inhibits PTEN expression through binding to PTEN core promoter and recruitment of HDAC1 and promotes cancer cell migration and invasion
-
Kou XX, Hao T, Meng Z, Zhou YH, and Gan YH. Acetylated Sp1 inhibits PTEN expression through binding to PTEN core promoter and recruitment of HDAC1 and promotes cancer cell migration and invasion. Carcinogenesis 34: 58-67, 2013.
-
(2013)
Carcinogenesis
, vol.34
, pp. 58-67
-
-
Kou, X.X.1
Hao, T.2
Meng, Z.3
Zhou, Y.H.4
Gan, Y.H.5
-
95
-
-
21144444486
-
HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor
-
Kovacs JJ, Murphy PJ, Gaillard S, Zhao X, Wu JT, Nicchitta CV, Yoshida M, Toft DO, Pratt WB, and Yao TP. HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor. Mol Cell 18: 601-607, 2005.
-
(2005)
Mol Cell
, vol.18
, pp. 601-607
-
-
Kovacs, J.J.1
Murphy, P.J.2
Gaillard, S.3
Zhao, X.4
Wu, J.T.5
Nicchitta, C.V.6
Yoshida, M.7
Toft, D.O.8
Pratt, W.B.9
Yao, T.P.10
-
96
-
-
79957913253
-
Combining histone deacetylase inhibitor vorinostat with aurora kinase inhibitors enhances lymphoma cell killing with repression of c-Myc, hTERT, and microRNA levels
-
Kretzner L, Scuto A, Dino PM, Kowolik CM, Wu J, Ventura P, Jove R, Forman SJ, Yen Y, and Kirschbaum MH. Combining histone deacetylase inhibitor vorinostat with aurora kinase inhibitors enhances lymphoma cell killing with repression of c-Myc, hTERT, and microRNA levels. Cancer Res 71: 3912-3920, 2011.
-
(2011)
Cancer Res
, vol.71
, pp. 3912-3920
-
-
Kretzner, L.1
Scuto, A.2
Dino, P.M.3
Kowolik, C.M.4
Wu, J.5
Ventura, P.6
Jove, R.7
Forman, S.J.8
Yen, Y.9
Kirschbaum, M.H.10
-
97
-
-
0034002793
-
Fatty-acid synthase and human cancer: New perspectives on its role in tumor biology
-
Kuhajda FP. Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology. Nutrition 16: 202-208, 2000.
-
(2000)
Nutrition
, vol.16
, pp. 202-208
-
-
Kuhajda, F.P.1
-
98
-
-
45549095542
-
Myc-mediated transcriptional repression by recruitment of histone deacetylase
-
Kurland JF and Tansey WP. Myc-mediated transcriptional repression by recruitment of histone deacetylase. Cancer Res 68: 3624-3629, 2008.
-
(2008)
Cancer Res
, vol.68
, pp. 3624-3629
-
-
Kurland, J.F.1
Tansey, W.P.2
-
99
-
-
18444414332
-
Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression
-
Lagger G, O'Carroll D, Rembold M, Khier H, Tischler J, Weitzer G, Schuettengruber B, Hauser C, Brunmeir R, Jenuwein T, and Seiser C. Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression. EMBO J 21: 2672-2681, 2002.
-
(2002)
EMBO J
, vol.21
, pp. 2672-2681
-
-
Lagger, G.1
O'Carroll, D.2
Rembold, M.3
Khier, H.4
Tischler, J.5
Weitzer, G.6
Schuettengruber, B.7
Hauser, C.8
Brunmeir, R.9
Jenuwein, T.10
Seiser, C.11
-
100
-
-
84877965001
-
Regulation of mTORC1 and its impact on gene expression at a glance
-
Laplante M and Sabatini DM. Regulation of mTORC1 and its impact on gene expression at a glance. J Cell Sci 126: 1713-1719, 2013.
-
(2013)
J Cell Sci
, vol.126
, pp. 1713-1719
-
-
Laplante, M.1
Sabatini, D.M.2
-
101
-
-
84862229806
-
Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression
-
Latham T, Mackay L, Sproul D, Karim M, Culley J, Harrison DJ, Hayward L, Langridge-Smith P, Gilbert N, and Ramsahoye BH. Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression. Nucleic Acids Res 40: 4794-4803, 2012.
-
(2012)
Nucleic Acids Res
, vol.40
, pp. 4794-4803
-
-
Latham, T.1
Mackay, L.2
Sproul, D.3
Karim, M.4
Culley, J.5
Harrison, D.J.6
Hayward, L.7
Langridge-Smith, P.8
Gilbert, N.9
Ramsahoye, B.H.10
-
102
-
-
0019457724
-
Amino acids and glucose utilization by different metabolic pathways in ascites-tumour cells
-
Lazo PA. Amino acids and glucose utilization by different metabolic pathways in ascites-tumour cells. Eur J Biochem 117: 19-25, 1981.
-
(1981)
Eur J Biochem
, vol.117
, pp. 19-25
-
-
Lazo, P.A.1
-
103
-
-
0346725952
-
Negative regulation of histone deacetylase 8 activity by cyclic AMP-dependent protein kinase A
-
Lee H, Rezai-Zadeh N, and Seto E. Negative regulation of histone deacetylase 8 activity by cyclic AMP-dependent protein kinase A. Mol Cell Biol 24: 765-773, 2004.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 765-773
-
-
Lee, H.1
Rezai-Zadeh, N.2
Seto, E.3
-
104
-
-
84862915067
-
Metastasis-associated protein 1/nucleosome remodeling and histone deacetylase complex in cancer
-
Li DQ, Pakala SB, Nair SS, Eswaran J, and Kumar R. Metastasis-associated protein 1/nucleosome remodeling and histone deacetylase complex in cancer. Cancer Res 72: 387-394, 2012.
-
(2012)
Cancer Res
, vol.72
, pp. 387-394
-
-
Li, D.Q.1
Pakala, S.B.2
Nair, S.S.3
Eswaran, J.4
Kumar, R.5
-
105
-
-
84877851087
-
AMPK: A contextual oncogene or tumor suppressor?
-
Liang J and Mills GB. AMPK: a contextual oncogene or tumor suppressor? Cancer Res 73: 2929-2935, 2013.
-
(2013)
Cancer Res
, vol.73
, pp. 2929-2935
-
-
Liang, J.1
Mills, G.B.2
-
106
-
-
84920114720
-
Acetylation control of cancer cell metabolism
-
Lin R, Zhou X, Huang W, Zhao D, Lv L, Xiong Y, Guan KL, and Lei QY. Acetylation control of cancer cell metabolism. Curr Pharm Des 13: 1-7, 2013.
-
(2013)
Curr Pharm Des
, vol.13
, pp. 1-7
-
-
Lin, R.1
Zhou, X.2
Huang, W.3
Zhao, D.4
Lv, L.5
Xiong, Y.6
Guan, K.L.7
Lei, Q.Y.8
-
107
-
-
84863012559
-
Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPK
-
Lin YY, Kiihl S, Suhail Y, Liu SY, Chou YH, Kuang Z, Lu JY, Khor CN, Lin CL, Bader JS, Irizarry R, and Boeke JD. Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPK. Nature 482: 251-255, 2012.
-
(2012)
Nature
, vol.482
, pp. 251-255
-
-
Lin, Y.Y.1
Kiihl, S.2
Suhail, Y.3
Liu, S.Y.4
Chou, Y.H.5
Kuang, Z.6
Lu, J.Y.7
Khor, C.N.8
Lin, C.L.9
Bader, J.S.10
Irizarry, R.11
Boeke, J.D.12
-
108
-
-
0034676439
-
Deacetylation of p53 modulates its effect on cell growth and apoptosis
-
Luo J, Su F, Chen D, Shiloh A, and Gu W. Deacetylation of p53 modulates its effect on cell growth and apoptosis. Nature 408: 377-381, 2000.
-
(2000)
Nature
, vol.408
, pp. 377-381
-
-
Luo, J.1
Su, F.2
Chen, D.3
Shiloh, A.4
Gu, W.5
-
109
-
-
79959371914
-
Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth
-
Lv L, Li D, Zhao D, Lin R, Chu Y, Zhang H, Zha Z, Liu Y, Li Z, Xu Y, Wang G, Huang Y, Xiong Y, Guan KL, and Lei QY. Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth. Mol Cell 42: 719-730, 2011.
-
(2011)
Mol Cell
, vol.42
, pp. 719-730
-
-
Lv, L.1
Li, D.2
Zhao, D.3
Lin, R.4
Chu, Y.5
Zhang, H.6
Zha, Z.7
Liu, Y.8
Li, Z.9
Xu, Y.10
Wang, G.11
Huang, Y.12
Xiong, Y.13
Guan, K.L.14
Lei, Q.Y.15
-
110
-
-
77955643796
-
The clinical development of histone deacetylase inhibitors as targeted anticancer drugs
-
Marks PA. The clinical development of histone deacetylase inhibitors as targeted anticancer drugs. Expert Opin Investig Drugs 19: 1049-1066, 2010.
-
(2010)
Expert Opin Investig Drugs
, vol.19
, pp. 1049-1066
-
-
Marks, P.A.1
-
111
-
-
4344688693
-
Histone deacetylase inhibitors
-
Marks PA, Richon VM, Miller T, and Kelly WK. Histone deacetylase inhibitors. Adv Cancer Res 91: 137-168, 2004.
-
(2004)
Adv Cancer Res
, vol.91
, pp. 137-168
-
-
Marks, P.A.1
Richon, V.M.2
Miller, T.3
Kelly, W.K.4
-
112
-
-
78149468828
-
Transcriptional upregulation of histone deacetylase 2 promotes Myc-induced oncogenic effects
-
Marshall GM, Gherardi S, Xu N, Neiron Z, Trahair T, Scarlett CJ, Chang DK, Liu PY, Jankowski K, Iraci N, Haber M, Norris MD, Keating J, Sekyere E, Jonquieres G, Stossi F, Katzenellenbogen BS, Biankin AV, Perini G, and Liu T. Transcriptional upregulation of histone deacetylase 2 promotes Myc-induced oncogenic effects. Oncogene 29: 5957-5968, 2010.
-
(2010)
Oncogene
, vol.29
, pp. 5957-5968
-
-
Marshall, G.M.1
Gherardi, S.2
Xu, N.3
Neiron, Z.4
Trahair, T.5
Scarlett, C.J.6
Chang, D.K.7
Liu, P.Y.8
Jankowski, K.9
Iraci, N.10
Haber, M.11
Norris, M.D.12
Keating, J.13
Sekyere, E.14
Jonquieres, G.15
Stossi, F.16
Katzenellenbogen, B.S.17
Biankin, A.V.18
Perini, G.19
Liu, T.20
more..
-
113
-
-
33745149291
-
p53 regulates mitochondrial respiration
-
Matoba S, Kang JG, Patino WD, Wragg A, Boehm M, Gavrilova O, Hurley PJ, Bunz F, and Hwang PM. p53 regulates mitochondrial respiration. Science 312: 1650-1653, 2006.
-
(2006)
Science
, vol.312
, pp. 1650-1653
-
-
Matoba, S.1
Kang, J.G.2
Patino, W.D.3
Wragg, A.4
Boehm, M.5
Gavrilova, O.6
Hurley, P.J.7
Bunz, F.8
Hwang, P.M.9
-
114
-
-
84872783461
-
Histone acetylation regulates intracellular pH
-
McBrian MA, Behbahan IS, Ferrari R, Su T, Huang TW, Li K, Hong CS, Christofk HR, Vogelauer M, Seligson DB, and Kurdistani SK. Histone acetylation regulates intracellular pH. Mol Cell 49: 310-321, 2013.
-
(2013)
Mol Cell
, vol.49
, pp. 310-321
-
-
McBrian, M.A.1
Behbahan, I.S.2
Ferrari, R.3
Su, T.4
Huang, T.W.5
Li, K.6
Hong, C.S.7
Christofk, H.R.8
Vogelauer, M.9
Seligson, D.B.10
Kurdistani, S.K.11
-
115
-
-
42449161465
-
AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5
-
McGee SL, van Denderen BJ, Howlett KF, Mollica J, Schertzer JD, Kemp BE, and Hargreaves M. AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5. Diabetes 57: 860-867, 2008.
-
(2008)
Diabetes
, vol.57
, pp. 860-867
-
-
McGee, S.L.1
Van Denderen, B.J.2
Howlett, K.F.3
Mollica, J.4
Schertzer, J.D.5
Kemp, B.E.6
Hargreaves, M.7
-
116
-
-
73949091032
-
Liver regeneration after partial hepatectomy: Critical analysis of mechanistic dilemmas
-
Michalopoulos GK. Liver regeneration after partial hepatectomy: critical analysis of mechanistic dilemmas. Am J Pathol 176: 2-13, 2010.
-
(2010)
Am J Pathol
, vol.176
, pp. 2-13
-
-
Michalopoulos, G.K.1
-
117
-
-
84871650811
-
Metabolic reprogramming by class I and II histone deacetylases
-
Mihaylova MM and Shaw RJ. Metabolic reprogramming by class I and II histone deacetylases. Trends Endocrinol Metab 24: 48-57, 2013.
-
(2013)
Trends Endocrinol Metab
, vol.24
, pp. 48-57
-
-
Mihaylova, M.M.1
Shaw, R.J.2
-
118
-
-
79955815135
-
Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis
-
Mihaylova MM, Vasquez DS, Ravnskjaer K, Denechaud PD, Yu RT, Alvarez JG, Downes M, Evans RM, Montminy M, and Shaw RJ. Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis. Cell 145: 607-621, 2011.
-
(2011)
Cell
, vol.145
, pp. 607-621
-
-
Mihaylova, M.M.1
Vasquez, D.S.2
Ravnskjaer, K.3
Denechaud, P.D.4
Yu, R.T.5
Alvarez, J.G.6
Downes, M.7
Evans, R.M.8
Montminy, M.9
Shaw, R.J.10
-
119
-
-
30344477367
-
Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer
-
Minucci S and Pelicci PG. Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer. Nat Rev Cancer 6: 38-51, 2006.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 38-51
-
-
Minucci, S.1
Pelicci, P.G.2
-
120
-
-
84861547140
-
AlzPathway: A comprehensive map of signaling pathways of Alzheimer's disease
-
Mizuno S, Iijima R, Ogishima S, Kikuchi M, Matsuoka Y, Ghosh S, Miyamoto T, Miyashita A, Kuwano R, and Tanaka H. AlzPathway: a comprehensive map of signaling pathways of Alzheimer's disease. BMC Syst Biol 6: 52, 2012.
-
(2012)
BMC Syst Biol
, vol.6
, pp. 52
-
-
Mizuno, S.1
Iijima, R.2
Ogishima, S.3
Kikuchi, M.4
Matsuoka, Y.5
Ghosh, S.6
Miyamoto, T.7
Miyashita, A.8
Kuwano, R.9
Tanaka, H.10
-
121
-
-
34447511648
-
Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility
-
Montgomery RL, Davis CA, Potthoff MJ, Haberland M, Fielitz J, Qi X, Hill JA, Richardson JA, and Olson EN. Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility. Genes Dev 21: 1790-1802, 2007.
-
(2007)
Genes Dev
, vol.21
, pp. 1790-1802
-
-
Montgomery, R.L.1
Davis, C.A.2
Potthoff, M.J.3
Haberland, M.4
Fielitz, J.5
Qi, X.6
Hill, J.A.7
Richardson, J.A.8
Olson, E.N.9
-
122
-
-
55849084700
-
Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice
-
Montgomery RL, Potthoff MJ, Haberland M, Qi X, Matsuzaki S, Humphries KM, Richardson JA, Bassel-Duby R, and Olson EN. Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice. J Clin Invest 118: 3588-3597, 2008.
-
(2008)
J Clin Invest
, vol.118
, pp. 3588-3597
-
-
Montgomery, R.L.1
Potthoff, M.J.2
Haberland, M.3
Qi, X.4
Matsuzaki, S.5
Humphries, K.M.6
Richardson, J.A.7
Bassel-Duby, R.8
Olson, E.N.9
-
123
-
-
84871720518
-
Ceramide-orchestrated signalling in cancer cells
-
Morad SA and Cabot MC. Ceramide-orchestrated signalling in cancer cells. Nat Rev Cancer 13: 51-65, 2013.
-
(2013)
Nat Rev Cancer
, vol.13
, pp. 51-65
-
-
Morad, S.A.1
Cabot, M.C.2
-
124
-
-
11144237178
-
The pancreatic duodenal homeobox-1 protein (Pdx-1) interacts with histone deacetylases Hdac-1 and Hdac-2 on low levels of glucose
-
Mosley AL and Ozcan S. The pancreatic duodenal homeobox-1 protein (Pdx-1) interacts with histone deacetylases Hdac-1 and Hdac-2 on low levels of glucose. J Biol Chem 279: 54241-54247, 2004.
-
(2004)
J Biol Chem
, vol.279
, pp. 54241-54247
-
-
Mosley, A.L.1
Ozcan, S.2
-
125
-
-
56049123836
-
14-3-3 Regulates the nuclear import of class IIa histone deacetylases
-
Nishino TG, Miyazaki M, Hoshino H, Miwa Y, Horinouchi S, and Yoshida M. 14-3-3 regulates the nuclear import of class IIa histone deacetylases. Biochem Biophys Res Commun 377: 852-856, 2008.
-
(2008)
Biochem Biophys Res Commun
, vol.377
, pp. 852-856
-
-
Nishino, T.G.1
Miyazaki, M.2
Hoshino, H.3
Miwa, Y.4
Horinouchi, S.5
Yoshida, M.6
-
126
-
-
38449090544
-
PTEN inactivation in lung cancer cells and the effect of its recovery on treatment with epidermal growth factor receptor tyrosine kinase inhibitors
-
Noro R, Gemma A, Miyanaga A, Kosaihira S, Minegishi Y, Nara M, Kokubo Y, Seike M, Kataoka K, Matsuda K, Okano T, Yoshimura A, and Kudoh S. PTEN inactivation in lung cancer cells and the effect of its recovery on treatment with epidermal growth factor receptor tyrosine kinase inhibitors. Int J Oncol 31: 1157-1163, 2007.
-
(2007)
Int J Oncol
, vol.31
, pp. 1157-1163
-
-
Noro, R.1
Gemma, A.2
Miyanaga, A.3
Kosaihira, S.4
Minegishi, Y.5
Nara, M.6
Kokubo, Y.7
Seike, M.8
Kataoka, K.9
Matsuda, K.10
Okano, T.11
Yoshimura, A.12
Kudoh, S.13
-
127
-
-
84861878767
-
The role of CaMKII in regulating GLUT4 expression in skeletal muscle
-
Ojuka EO, Goyaram V, and Smith JA. The role of CaMKII in regulating GLUT4 expression in skeletal muscle. Am J Physiol Endocrinol Metab 303: E322-E331, 2012.
-
(2012)
Am J Physiol Endocrinol Metab
, vol.303
, pp. E322-E331
-
-
Ojuka, E.O.1
Goyaram, V.2
Smith, J.A.3
-
128
-
-
33748754795
-
PCAF modulates PTEN activity
-
Okumura K, Mendoza M, Bachoo RM, DePinho RA, Cavenee WK, and Furnari FB. PCAF modulates PTEN activity. J Biol Chem 281: 26562-26568, 2006.
-
(2006)
J Biol Chem
, vol.281
, pp. 26562-26568
-
-
Okumura, K.1
Mendoza, M.2
Bachoo, R.M.3
DePinho, R.A.4
Cavenee, W.K.5
Furnari, F.B.6
-
129
-
-
65649112534
-
Nitration of distinct tyrosine residues causes inactivation of histone deacetylase 2
-
Osoata GO, Yamamura S, Ito M, Vuppusetty C, Adcock IM, Barnes PJ, and Ito K. Nitration of distinct tyrosine residues causes inactivation of histone deacetylase 2. Biochem Biophys Res Commun 384: 366-371, 2009.
-
(2009)
Biochem Biophys Res Commun
, vol.384
, pp. 366-371
-
-
Osoata, G.O.1
Yamamura, S.2
Ito, M.3
Vuppusetty, C.4
Adcock, I.M.5
Barnes, P.J.6
Ito, K.7
-
130
-
-
84856071893
-
Protein aggregates are recruited to aggresome by histone deacetylase 6 via unanchored ubiquitin C termini
-
Ouyang H, Ali YO, Ravichandran M, Dong A, Qiu W, MacKenzie F, Dhe-Paganon S, Arrowsmith CH, and Zhai RG. Protein aggregates are recruited to aggresome by histone deacetylase 6 via unanchored ubiquitin C termini. J Biol Chem 287: 2317-2327, 2011.
-
(2011)
J Biol Chem
, vol.287
, pp. 2317-2327
-
-
Ouyang, H.1
Ali, Y.O.2
Ravichandran, M.3
Dong, A.4
Qiu, W.5
MacKenzie, F.6
Dhe-Paganon, S.7
Arrowsmith, C.H.8
Zhai, R.G.9
-
131
-
-
33846295218
-
FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis
-
Paik JH, Kollipara R, Chu G, Ji H, Xiao Y, Ding Z, Miao L, Tothova Z, Horner JW, Carrasco DR, Jiang S, Gilliland DG, Chin L, Wong WH, Castrillon DH, and DePinho RA. FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell 128: 309-323, 2007.
-
(2007)
Cell
, vol.128
, pp. 309-323
-
-
Paik, J.H.1
Kollipara, R.2
Chu, G.3
Ji, H.4
Xiao, Y.5
Ding, Z.6
Miao, L.7
Tothova, Z.8
Horner, J.W.9
Carrasco, D.R.10
Jiang, S.11
Gilliland, D.G.12
Chin, L.13
Wong, W.H.14
Castrillon, D.H.15
DePinho, R.A.16
-
132
-
-
34247107123
-
Histone deacetylase inhibitor trichostatin a potentiates doxorubicin-induced apoptosis by up-regulating PTEN expression
-
Pan L, Lu J, Wang X, Han L, Zhang Y, Han S, and Huang B. Histone deacetylase inhibitor trichostatin a potentiates doxorubicin-induced apoptosis by up-regulating PTEN expression. Cancer 109: 1676-1688, 2007.
-
(2007)
Cancer
, vol.109
, pp. 1676-1688
-
-
Pan, L.1
Lu, J.2
Wang, X.3
Han, L.4
Zhang, Y.5
Han, S.6
Huang, B.7
-
133
-
-
79952430906
-
Inactivating mutations of acetyltransferase genes in B-cell lymphoma
-
Pasqualucci L, Dominguez-Sola D, Chiarenza A, Fabbri G, Grunn A, Trifonov V, Kasper LH, Lerach S, Tang H, Ma J, Rossi D, Chadburn A, Murty VV, Mullighan CG, Gaidano G, Rabadan R, Brindle PK, and Dalla-Favera R. Inactivating mutations of acetyltransferase genes in B-cell lymphoma. Nature 471: 189-195, 2011.
-
(2011)
Nature
, vol.471
, pp. 189-195
-
-
Pasqualucci, L.1
Dominguez-Sola, D.2
Chiarenza, A.3
Fabbri, G.4
Grunn, A.5
Trifonov, V.6
Kasper, L.H.7
Lerach, S.8
Tang, H.9
Ma, J.10
Rossi, D.11
Chadburn, A.12
Murty, V.V.13
Mullighan, C.G.14
Gaidano, G.15
Rabadan, R.16
Brindle, P.K.17
Dalla-Favera, R.18
-
134
-
-
79960785531
-
Epigenetics: New questions on the response to hypoxia
-
Perez-Perri JI, Acevedo JM, and Wappner P. Epigenetics: new questions on the response to hypoxia. Int J Mol Sci 12: 4705-4721, 2011.
-
(2011)
Int J Mol Sci
, vol.12
, pp. 4705-4721
-
-
Perez-Perri, J.I.1
Acevedo, J.M.2
Wappner, P.3
-
135
-
-
33845631556
-
Pathway analysis of kidney cancer using proteomics and metabolic profiling
-
Perroud B, Lee J, Valkova N, Dhirapong A, Lin PY, Fiehn O, Kultz D, and Weiss RH. Pathway analysis of kidney cancer using proteomics and metabolic profiling. Mol Cancer 5: 64, 2006.
-
(2006)
Mol Cancer
, vol.5
, pp. 64
-
-
Perroud, B.1
Lee, J.2
Valkova, N.3
Dhirapong, A.4
Lin, P.Y.5
Fiehn, O.6
Kultz, D.7
Weiss, R.H.8
-
136
-
-
0038521295
-
The histone deacetylase 9 gene encodes multiple protein isoforms
-
Petrie K, Guidez F, Howell L, Healy L, Waxman S, Greaves M, and Zelent A. The histone deacetylase 9 gene encodes multiple protein isoforms. J Biol Chem 278: 16059-16072, 2003.
-
(2003)
J Biol Chem
, vol.278
, pp. 16059-16072
-
-
Petrie, K.1
Guidez, F.2
Howell, L.3
Healy, L.4
Waxman, S.5
Greaves, M.6
Zelent, A.7
-
137
-
-
84870658312
-
Dietary regulation of histone acetylases and deacetylases for the prevention of metabolic diseases
-
Pham TX and Lee J. Dietary regulation of histone acetylases and deacetylases for the prevention of metabolic diseases. Nutrients 4: 1868-1886, 2012.
-
(2012)
Nutrients
, vol.4
, pp. 1868-1886
-
-
Pham, T.X.1
Lee, J.2
-
138
-
-
84868220730
-
Tryptophan catabolism in cancer: Beyond IDO and tryptophan depletion
-
Platten M, Wick W, and Van den Eynde BJ. Tryptophan catabolism in cancer: beyond IDO and tryptophan depletion. Cancer Res 72: 5435-5440, 2012.
-
(2012)
Cancer Res
, vol.72
, pp. 5435-5440
-
-
Platten, M.1
Wick, W.2
Van Den Eynde, B.J.3
-
139
-
-
36849093080
-
Protein kinase CK2 is a key activator of histone deacetylase in hypoxia-associated tumors
-
Pluemsampant S, Safronova OS, Nakahama K, and Morita I. Protein kinase CK2 is a key activator of histone deacetylase in hypoxia-associated tumors. Int J Cancer 122: 333-341, 2008.
-
(2008)
Int J Cancer
, vol.122
, pp. 333-341
-
-
Pluemsampant, S.1
Safronova, O.S.2
Nakahama, K.3
Morita, I.4
-
140
-
-
78149426794
-
Sphingolipids and cancer: Ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance
-
Ponnusamy S, Meyers-Needham M, Senkal CE, Saddoughi SA, Sentelle D, Selvam SP, Salas A, and Ogretmen B. Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance. Future Oncol 6: 1603-1624, 2012.
-
(2012)
Future Oncol
, vol.6
, pp. 1603-1624
-
-
Ponnusamy, S.1
Meyers-Needham, M.2
Senkal, C.E.3
Saddoughi, S.A.4
Sentelle, D.5
Selvam, S.P.6
Salas, A.7
Ogretmen, B.8
-
141
-
-
37549064016
-
Cerebral metabolic adaptation and ketone metabolism after brain injury
-
Prins ML. Cerebral metabolic adaptation and ketone metabolism after brain injury. J Cereb Blood Flow Metab 28: 1-16, 2008.
-
(2008)
J Cereb Blood Flow Metab
, vol.28
, pp. 1-16
-
-
Prins, M.L.1
-
142
-
-
34250758641
-
HEF1-dependent Aurora A activation induces disassembly of the primary cilium
-
Pugacheva EN, Jablonski SA, Hartman TR, Henske EP, and Golemis EA. HEF1-dependent Aurora A activation induces disassembly of the primary cilium. Cell 129: 1351-1363, 2007.
-
(2007)
Cell
, vol.129
, pp. 1351-1363
-
-
Pugacheva, E.N.1
Jablonski, S.A.2
Hartman, T.R.3
Henske, E.P.4
Golemis, E.A.5
-
143
-
-
14544282413
-
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1
-
Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, and Puigserver P. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 434: 113-118, 2005.
-
(2005)
Nature
, vol.434
, pp. 113-118
-
-
Rodgers, J.T.1
Lerin, C.2
Haas, W.3
Gygi, S.P.4
Spiegelman, B.M.5
Puigserver, P.6
-
144
-
-
34248631385
-
The role of histone deacetylases (HDACs) in human cancer
-
Ropero S and Esteller M. The role of histone deacetylases (HDACs) in human cancer. Mol Oncol 1: 19-25, 2007.
-
(2007)
Mol Oncol
, vol.1
, pp. 19-25
-
-
Ropero, S.1
Esteller, M.2
-
145
-
-
33644946604
-
HATs and HDACs in neurodegeneration: A tale of disconcerted acetylation homeostasis
-
Saha RN and Pahan K. HATs and HDACs in neurodegeneration: a tale of disconcerted acetylation homeostasis. Cell Death Differ 13: 539-550, 2006.
-
(2006)
Cell Death Differ
, vol.13
, pp. 539-550
-
-
Saha, R.N.1
Pahan, K.2
-
146
-
-
0017042973
-
Lactate content and pH in muscle obtained after dynamic exercise
-
Sahlin K, Harris RC, Nylind B, and Hultman E. Lactate content and pH in muscle obtained after dynamic exercise. Pflugers Arch 367: 143-149, 1976.
-
(1976)
Pflugers Arch
, vol.367
, pp. 143-149
-
-
Sahlin, K.1
Harris, R.C.2
Nylind, B.3
Hultman, E.4
-
147
-
-
33644868755
-
Induction of oxidative metabolism by mitochondrial frataxin inhibits cancer growth: Otto Warburg revisited
-
Schulz TJ, Thierbach R, Voigt A, Drewes G, Mietzner B, Steinberg P, Pfeiffer AF, and Ristow M. Induction of oxidative metabolism by mitochondrial frataxin inhibits cancer growth: Otto Warburg revisited. J Biol Chem 281: 977-981, 2006.
-
(2006)
J Biol Chem
, vol.281
, pp. 977-981
-
-
Schulz, T.J.1
Thierbach, R.2
Voigt, A.3
Drewes, G.4
Mietzner, B.5
Steinberg, P.6
Pfeiffer, A.F.7
Ristow, M.8
-
148
-
-
38649123072
-
Conserved metabolic regulatory functions of sirtuins
-
Schwer B and Verdin E. Conserved metabolic regulatory functions of sirtuins. Cell Metab 7: 104-112, 2008.
-
(2008)
Cell Metab
, vol.7
, pp. 104-112
-
-
Schwer, B.1
Verdin, E.2
-
149
-
-
50349095215
-
Caspase-8 cleaves histone deacetylase 7 and abolishes its transcription repressor function
-
Scott FL, Fuchs GJ, Boyd SE, Denault JB, Hawkins CJ, Dequiedt F, and Salvesen GS. Caspase-8 cleaves histone deacetylase 7 and abolishes its transcription repressor function. J Biol Chem 283: 19499-19510, 2008.
-
(2008)
J Biol Chem
, vol.283
, pp. 19499-19510
-
-
Scott, F.L.1
Fuchs, G.J.2
Boyd, S.E.3
Denault, J.B.4
Hawkins, C.J.5
Dequiedt, F.6
Salvesen, G.S.7
-
150
-
-
79251544228
-
Regulating the regulators: The post-translational code of class I HDAC1 and HDAC2
-
Segre CV and Chiocca S. Regulating the regulators: the post-translational code of class I HDAC1 and HDAC2. J Biomed Biotechnol 2011: 690848, 2011.
-
(2011)
J Biomed Biotechnol
, vol.2011
, pp. 690848
-
-
Segre, C.V.1
Chiocca, S.2
-
151
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3: 721-732, 2003.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
152
-
-
76349095132
-
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
-
Semenza GL. Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene 29: 625-634, 2010.
-
(2010)
Oncogene
, vol.29
, pp. 625-634
-
-
Semenza, G.L.1
-
153
-
-
84860494348
-
S-nitrosylation in the regulation of gene transcription
-
Sha Y and Marshall HE. S-nitrosylation in the regulation of gene transcription. Biochim Biophys Acta 1820: 701-711, 2012.
-
(2012)
Biochim Biophys Acta
, vol.1820
, pp. 701-711
-
-
Sha, Y.1
Marshall, H.E.2
-
154
-
-
84872166360
-
Suppression of oxidative stress by beta-hydroxybutyrate, an endogenous histone deacetylase inhibitor
-
Shimazu T, Hirschey MD, Newman J, He W, Shirakawa K, Le Moan N, Grueter CA, Lim H, Saunders LR, Stevens RD, Newgard CB, Farese RV, Jr., de Cabo R, Ulrich S, Akassoglou K, and Verdin E. Suppression of oxidative stress by beta-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science 339: 211-214, 2013.
-
(2013)
Science
, vol.339
, pp. 211-214
-
-
Shimazu, T.1
Hirschey, M.D.2
Newman, J.3
He, W.4
Shirakawa, K.5
Le Moan, N.6
Grueter, C.A.7
Lim, H.8
Saunders, L.R.9
Stevens, R.D.10
Newgard, C.B.11
Farese, R.V.12
De Cabo, R.13
Ulrich, S.14
Akassoglou, K.15
Verdin, E.16
-
155
-
-
84860217431
-
The functions and regulation of the PTEN tumour suppressor
-
Song MS, Salmena L, and Pandolfi PP. The functions and regulation of the PTEN tumour suppressor. Nat Rev Mol Cell Biol 13: 283-296, 2012.
-
(2012)
Nat Rev Mol Cell Biol
, vol.13
, pp. 283-296
-
-
Song, M.S.1
Salmena, L.2
Pandolfi, P.P.3
-
156
-
-
57349169361
-
YY1 protects cardiac myocytes from pathologic hypertrophy by interacting with HDAC5
-
Sucharov CC, Dockstader K, and McKinsey TA. YY1 protects cardiac myocytes from pathologic hypertrophy by interacting with HDAC5. Mol Biol Cell 19: 4141-4153, 2008.
-
(2008)
Mol Biol Cell
, vol.19
, pp. 4141-4153
-
-
Sucharov, C.C.1
Dockstader, K.2
McKinsey, T.A.3
-
157
-
-
84862025421
-
Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration
-
Sun Z, Miller RA, Patel RT, Chen J, Dhir R, Wang H, Zhang D, Graham MJ, Unterman TG, Shulman GI, Sztalryd C, Bennett MJ, Ahima RS, Birnbaum MJ, and Lazar MA. Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration. Nat Med 18: 934-942, 2012.
-
(2012)
Nat Med
, vol.18
, pp. 934-942
-
-
Sun, Z.1
Miller, R.A.2
Patel, R.T.3
Chen, J.4
Dhir, R.5
Wang, H.6
Zhang, D.7
Graham, M.J.8
Unterman, T.G.9
Shulman, G.I.10
Sztalryd, C.11
Bennett, M.J.12
Ahima, R.S.13
Birnbaum, M.J.14
Lazar, M.A.15
-
158
-
-
77952227625
-
Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species
-
Suzuki S, Tanaka T, Poyurovsky MV, Nagano H, Mayama T, Ohkubo S, Lokshin M, Hosokawa H, Nakayama T, Suzuki Y, Sugano S, Sato E, Nagao T, Yokote K, Tatsuno I, and Prives C. Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species. Proc Natl Acad Sci U S A 107: 7461-7466, 2010.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 7461-7466
-
-
Suzuki, S.1
Tanaka, T.2
Poyurovsky, M.V.3
Nagano, H.4
Mayama, T.5
Ohkubo, S.6
Lokshin, M.7
Hosokawa, H.8
Nakayama, T.9
Suzuki, Y.10
Sugano, S.11
Sato, E.12
Nagao, T.13
Yokote, K.14
Tatsuno, I.15
Prives, C.16
-
159
-
-
0034717022
-
N-terminal region, C-terminal region, nuclear export signal, and deacetylation activity of histone deacetylase-3 are essential for the viability of the DT40 chicken B cell line
-
Takami Y and Nakayama T. N-terminal region, C-terminal region, nuclear export signal, and deacetylation activity of histone deacetylase-3 are essential for the viability of the DT40 chicken B cell line. J Biol Chem 275: 16191-16201, 2000.
-
(2000)
J Biol Chem
, vol.275
, pp. 16191-16201
-
-
Takami, Y.1
Nakayama, T.2
-
160
-
-
62549166709
-
Inactivation of HDAC5 by SIK1 in AICAR-treated C2C12 myoblasts
-
Takemori H, Katoh Hashimoto Y, Nakae J, Olson EN, and Okamoto M. Inactivation of HDAC5 by SIK1 in AICAR-treated C2C12 myoblasts. Endocr J 56: 121-130, 2009.
-
(2009)
Endocr J
, vol.56
, pp. 121-130
-
-
Takemori, H.1
Katoh Hashimoto, Y.2
Nakae, J.3
Olson, E.N.4
Okamoto, M.5
-
161
-
-
84874066734
-
The import of the transcription factor STAT3 into mitochondria depends on GRIM-19, a component of the electron transport chain
-
Tammineni P, Anugula C, Mohammed F, Anjaneyulu M, Larner AC, and Sepuri NB. The import of the transcription factor STAT3 into mitochondria depends on GRIM-19, a component of the electron transport chain. J Biol Chem 288: 4723-4732, 2013.
-
(2013)
J Biol Chem
, vol.288
, pp. 4723-4732
-
-
Tammineni, P.1
Anugula, C.2
Mohammed, F.3
Anjaneyulu, M.4
Larner, A.C.5
Sepuri, N.B.6
-
162
-
-
79953164067
-
Liver regeneration after partial hepatectomy in rat is more impaired in a steatotic liver induced by dietary fructose compared to dietary fat
-
Tanoue S, Uto H, Kumamoto R, Arima S, Hashimoto S, Nasu Y, Takami Y, Moriuchi A, Sakiyama T, Oketani M, Ido A, and Tsubouchi H. Liver regeneration after partial hepatectomy in rat is more impaired in a steatotic liver induced by dietary fructose compared to dietary fat. Biochem Biophys Res Commun 407: 163-168, 2011.
-
(2011)
Biochem Biophys Res Commun
, vol.407
, pp. 163-168
-
-
Tanoue, S.1
Uto, H.2
Kumamoto, R.3
Arima, S.4
Hashimoto, S.5
Nasu, Y.6
Takami, Y.7
Moriuchi, A.8
Sakiyama, T.9
Oketani, M.10
Ido, A.11
Tsubouchi, H.12
-
163
-
-
84935033376
-
-
This reference has been deleted
-
This reference has been deleted.
-
-
-
-
164
-
-
0025330489
-
cAMP-dependent protein kinase: Framework for a diverse family of regulatory enzymes
-
Taylor SS, Buechler JA, and Yonemoto W. cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes. Annu Rev Biochem 59: 971-1005, 1990.
-
(1990)
Annu Rev Biochem
, vol.59
, pp. 971-1005
-
-
Taylor, S.S.1
Buechler, J.A.2
Yonemoto, W.3
-
165
-
-
58249089741
-
Colon cancer cells maintain low levels of pyruvate to avoid cell death caused by inhibition of HDAC1/HDAC3
-
Thangaraju M, Carswell KN, Prasad PD, and Ganapathy V. Colon cancer cells maintain low levels of pyruvate to avoid cell death caused by inhibition of HDAC1/HDAC3. Biochem J 417: 379-389, 2009.
-
(2009)
Biochem J
, vol.417
, pp. 379-389
-
-
Thangaraju, M.1
Carswell, K.N.2
Prasad, P.D.3
Ganapathy, V.4
-
166
-
-
13244287966
-
Regulation of FoxO activity by CBP/p300-mediated acetylation
-
van der Heide LP and Smidt MP. Regulation of FoxO activity by CBP/p300-mediated acetylation. Trends Biochem Sci 30: 81-86, 2005.
-
(2005)
Trends Biochem Sci
, vol.30
, pp. 81-86
-
-
Van Der Heide, L.P.1
Smidt, M.P.2
-
167
-
-
0038110044
-
Stimulation of c-MYC transcriptional activity and acetylation by recruitment of the cofactor CBP
-
Vervoorts J, Luscher-Firzlaff JM, Rottmann S, Lilischkis R, Walsemann G, Dohmann K, Austen M, and Luscher B. Stimulation of c-MYC transcriptional activity and acetylation by recruitment of the cofactor CBP. EMBO Rep 4: 484-490, 2003.
-
(2003)
EMBO Rep
, vol.4
, pp. 484-490
-
-
Vervoorts, J.1
Luscher-Firzlaff, J.M.2
Rottmann, S.3
Lilischkis, R.4
Walsemann, G.5
Dohmann, K.6
Austen, M.7
Luscher, B.8
-
168
-
-
57849096553
-
The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance
-
Villagra A, Cheng F, Wang HW, Suarez I, Glozak M, Maurin M, Nguyen D, Wright KL, Atadja PW, Bhalla K, Pinilla-Ibarz J, Seto E, and Sotomayor EM. The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance. Nat Immunol 10: 92-100, 2009.
-
(2009)
Nat Immunol
, vol.10
, pp. 92-100
-
-
Villagra, A.1
Cheng, F.2
Wang, H.W.3
Suarez, I.4
Glozak, M.5
Maurin, M.6
Nguyen, D.7
Wright, K.L.8
Atadja, P.W.9
Bhalla, K.10
Pinilla-Ibarz, J.11
Seto, E.12
Sotomayor, E.M.13
-
169
-
-
84866375559
-
Stimulation of histone deacetylase activity by metabolites of intermediary metabolism
-
Vogelauer M, Krall AS, McBrian MA, Li JY, and Kurdistani SK. Stimulation of histone deacetylase activity by metabolites of intermediary metabolism. J Biol Chem 287: 32006-32016, 2012.
-
(2012)
J Biol Chem
, vol.287
, pp. 32006-32016
-
-
Vogelauer, M.1
Krall, A.S.2
McBrian, M.A.3
Li, J.Y.4
Kurdistani, S.K.5
-
170
-
-
79952262759
-
Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy
-
Wagner JM, Hackanson B, Lubbert M, and Jung M. Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy. Clin Epigenetics 1: 117-136, 2010.
-
(2010)
Clin Epigenetics
, vol.1
, pp. 117-136
-
-
Wagner, J.M.1
Hackanson, B.2
Lubbert, M.3
Jung, M.4
-
171
-
-
0034652620
-
High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers
-
Walenta S, Wetterling M, Lehrke M, Schwickert G, Sundfor K, Rofstad EK, and Mueller-Klieser W. High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers. Cancer Res 60: 916-921, 2000.
-
(2000)
Cancer Res
, vol.60
, pp. 916-921
-
-
Walenta, S.1
Wetterling, M.2
Lehrke, M.3
Schwickert, G.4
Sundfor, K.5
Rofstad, E.K.6
Mueller-Klieser, W.7
-
172
-
-
3242793175
-
Expression of histone deacetylase 8, a class I histone deacetylase, is restricted to cells showing smooth muscle differentiation in normal human tissues
-
Waltregny D, De Leval L, Glenisson W, Ly Tran S, North BJ, Bellahcene A, Weidle U, Verdin E, and Castronovo V. Expression of histone deacetylase 8, a class I histone deacetylase, is restricted to cells showing smooth muscle differentiation in normal human tissues. Am J Pathol 165: 553-564, 2004.
-
(2004)
Am J Pathol
, vol.165
, pp. 553-564
-
-
Waltregny, D.1
De Leval, L.2
Glenisson, W.3
Ly Tran, S.4
North, B.J.5
Bellahcene, A.6
Weidle, U.7
Verdin, E.8
Castronovo, V.9
-
173
-
-
84858795617
-
Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation
-
Wang F, Chan CH, Chen K, Guan X, Lin HK, and Tong Q. Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation. Oncogene 31: 1546-1557, 2012.
-
(2012)
Oncogene
, vol.31
, pp. 1546-1557
-
-
Wang, F.1
Chan, C.H.2
Chen, K.3
Guan, X.4
Lin, H.K.5
Tong, Q.6
-
174
-
-
54449086844
-
HDAC1 cooperates with C/EBPalpha in the inhibition of liver proliferation in old mice
-
Wang GL, Salisbury E, Shi X, Timchenko L, Medrano EE, and Timchenko NA. HDAC1 cooperates with C/EBPalpha in the inhibition of liver proliferation in old mice. J Biol Chem 283: 26169-26178, 2008.
-
(2008)
J Biol Chem
, vol.283
, pp. 26169-26178
-
-
Wang, G.L.1
Salisbury, E.2
Shi, X.3
Timchenko, L.4
Medrano, E.E.5
Timchenko, N.A.6
-
175
-
-
84255199561
-
Androgen receptor and nutrient signaling pathways coordinate the demand for increased amino acid transport during prostate cancer progression
-
Wang Q, Bailey CG, Ng C, Tiffen J, Thoeng A, Minhas V, Lehman ML, Hendy SC, Buchanan G, Nelson CC, Rasko JE, and Holst J. Androgen receptor and nutrient signaling pathways coordinate the demand for increased amino acid transport during prostate cancer progression. Cancer Res 71: 7525-7536, 2011.
-
(2011)
Cancer Res
, vol.71
, pp. 7525-7536
-
-
Wang, Q.1
Bailey, C.G.2
Ng, C.3
Tiffen, J.4
Thoeng, A.5
Minhas, V.6
Lehman, M.L.7
Hendy, S.C.8
Buchanan, G.9
Nelson, C.C.10
Rasko, J.E.11
Holst, J.12
-
176
-
-
77149120797
-
Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux
-
Wang Q, Zhang Y, Yang C, Xiong H, Lin Y, Yao J, Li H, Xie L, Zhao W, Yao Y, Ning ZB, Zeng R, Xiong Y, Guan KL, Zhao S, and Zhao GP. Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux. Science 327: 1004-1007, 2010.
-
(2010)
Science
, vol.327
, pp. 1004-1007
-
-
Wang, Q.1
Zhang, Y.2
Yang, C.3
Xiong, H.4
Lin, Y.5
Yao, J.6
Li, H.7
Xie, L.8
Zhao, W.9
Yao, Y.10
Ning, Z.B.11
Zeng, R.12
Xiong, Y.13
Guan, K.L.14
Zhao, S.15
Zhao, G.P.16
-
177
-
-
61449093727
-
Glucose metabolism as a target of histone deacetylase inhibitors
-
Wardell SE, Ilkayeva OR, Wieman HL, Frigo DE, Rathmell JC, Newgard CB, and McDonnell DP. Glucose metabolism as a target of histone deacetylase inhibitors. Mol Endocrinol 23: 388-401, 2009.
-
(2009)
Mol Endocrinol
, vol.23
, pp. 388-401
-
-
Wardell, S.E.1
Ilkayeva, O.R.2
Wieman, H.L.3
Frigo, D.E.4
Rathmell, J.C.5
Newgard, C.B.6
McDonnell, D.P.7
-
179
-
-
59849101586
-
Function of mitochondrial Stat3 in cellular respiration
-
Wegrzyn J, Potla R, Chwae YJ, Sepuri NB, Zhang Q, Koeck T, Derecka M, Szczepanek K, Szelag M, Gornicka A, Moh A, Moghaddas S, Chen Q, Bobbili S, Cichy J, Dulak J, Baker DP, Wolfman A, Stuehr D, Hassan MO, Fu XY, Avadhani N, Drake JI, Fawcett P, Lesnefsky EJ, and Larner AC. Function of mitochondrial Stat3 in cellular respiration. Science 323: 793-797, 2009.
-
(2009)
Science
, vol.323
, pp. 793-797
-
-
Wegrzyn, J.1
Potla, R.2
Chwae, Y.J.3
Sepuri, N.B.4
Zhang, Q.5
Koeck, T.6
Derecka, M.7
Szczepanek, K.8
Szelag, M.9
Gornicka, A.10
Moh, A.11
Moghaddas, S.12
Chen, Q.13
Bobbili, S.14
Cichy, J.15
Dulak, J.16
Baker, D.P.17
Wolfman, A.18
Stuehr, D.19
Hassan, M.O.20
Fu, X.Y.21
Avadhani, N.22
Drake, J.I.23
Fawcett, P.24
Lesnefsky, E.J.25
Larner, A.C.26
more..
-
180
-
-
66249105703
-
ATP-citrate lyase links cellular metabolism to histone acetylation
-
Wellen KE, Hatzivassiliou G, Sachdeva UM, Bui TV, Cross JR, and Thompson CB. ATP-citrate lyase links cellular metabolism to histone acetylation. Science 324: 1076-1080, 2009.
-
(2009)
Science
, vol.324
, pp. 1076-1080
-
-
Wellen, K.E.1
Hatzivassiliou, G.2
Sachdeva, U.M.3
Bui, T.V.4
Cross, J.R.5
Thompson, C.B.6
-
181
-
-
57749088701
-
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
-
Wise DR, DeBerardinis RJ, Mancuso A, Sayed N, Zhang XY, Pfeiffer HK, Nissim I, Daikhin E, Yudkoff M, McMahon SB, and Thompson CB. Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction. Proc Natl Acad Sci U S A 105: 18782-18787, 2008.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 18782-18787
-
-
Wise, D.R.1
DeBerardinis, R.J.2
Mancuso, A.3
Sayed, N.4
Zhang, X.Y.5
Pfeiffer, H.K.6
Nissim, I.7
Daikhin, E.8
Yudkoff, M.9
McMahon, S.B.10
Thompson, C.B.11
-
182
-
-
77955281020
-
Glutamine addiction: A new therapeutic target in cancer
-
Wise DR and Thompson CB. Glutamine addiction: a new therapeutic target in cancer. Trends Biochem Sci 35: 427-433, 2010.
-
(2010)
Trends Biochem Sci
, vol.35
, pp. 427-433
-
-
Wise, D.R.1
Thompson, C.B.2
-
183
-
-
61849144810
-
HDAC family: What are the cancer relevant targets?
-
Witt O, Deubzer HE, Milde T, and Oehme I. HDAC family: what are the cancer relevant targets? Cancer Lett 277: 8-21, 2009.
-
(2009)
Cancer Lett
, vol.277
, pp. 8-21
-
-
Witt, O.1
Deubzer, H.E.2
Milde, T.3
Oehme, I.4
-
185
-
-
84875473756
-
Transcription factor YY1 contributes to tumor growth by stabilizing hypoxia factor HIF-1alpha in a p53-independent manner
-
Wu S, Kasim V, Kano MR, Tanaka S, Ohba S, Miura Y, Miyata K, Liu X, Matsuhashi A, Chung UI, Yang L, Kataoka K, Nishiyama N, and Miyagishi M. Transcription factor YY1 contributes to tumor growth by stabilizing hypoxia factor HIF-1alpha in a p53-independent manner. Cancer Res 73: 1787-1799, 2013.
-
(2013)
Cancer Res
, vol.73
, pp. 1787-1799
-
-
Wu, S.1
Kasim, V.2
Kano, M.R.3
Tanaka, S.4
Ohba, S.5
Miura, Y.6
Miyata, K.7
Liu, X.8
Matsuhashi, A.9
Chung, U.I.10
Yang, L.11
Kataoka, K.12
Nishiyama, N.13
Miyagishi, M.14
-
186
-
-
0035099686
-
The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases
-
Wu WS, Vallian S, Seto E, Yang WM, Edmondson D, Roth S, and Chang KS. The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases. Mol Cell Biol 21: 2259-2268, 2001.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 2259-2268
-
-
Wu, W.S.1
Vallian, S.2
Seto, E.3
Yang, W.M.4
Edmondson, D.5
Roth, S.6
Chang, K.S.7
-
187
-
-
80052450371
-
The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching
-
Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, and Bruce JE. The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching. J Proteome Res 10: 4134-4149, 2011.
-
(2011)
J Proteome Res
, vol.10
, pp. 4134-4149
-
-
Yang, L.1
Vaitheesvaran, B.2
Hartil, K.3
Robinson, A.J.4
Hoopmann, M.R.5
Eng, J.K.6
Kurland, I.J.7
Bruce, J.E.8
-
188
-
-
84870023777
-
Acetylation of histone deacetylase 1 regulates NuRD corepressor complex activity
-
Yang T, Jian W, Luo Y, Fu X, Noguchi C, Bungert J, Huang S, and Qiu Y. Acetylation of histone deacetylase 1 regulates NuRD corepressor complex activity. J Biol Chem 287: 40279-40291, 2012.
-
(2012)
J Biol Chem
, vol.287
, pp. 40279-40291
-
-
Yang, T.1
Jian, W.2
Luo, Y.3
Fu, X.4
Noguchi, C.5
Bungert, J.6
Huang, S.7
Qiu, Y.8
-
189
-
-
84883751792
-
Regulation and function of pyruvate kinase M2 in cancer
-
Yang W and Lu Z. Regulation and function of pyruvate kinase M2 in cancer. Cancer Lett 339: 153-158, 2013.
-
(2013)
Cancer Lett
, vol.339
, pp. 153-158
-
-
Yang, W.1
Lu, Z.2
-
190
-
-
0037088643
-
Functional domains of histone deacetylase-3
-
Yang WM, Tsai SC, Wen YD, Fejer G, and Seto E. Functional domains of histone deacetylase-3. J Biol Chem 277: 9447-9454, 2002.
-
(2002)
J Biol Chem
, vol.277
, pp. 9447-9454
-
-
Yang, W.M.1
Tsai, S.C.2
Wen, Y.D.3
Fejer, G.4
Seto, E.5
-
191
-
-
39749127166
-
The Rpd3/Hda1 family of lysine deacetylases: From bacteria and yeast to mice and men
-
Yang XJ and Seto E. The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men. Nat Rev Mol Cell Biol 9: 206-218, 2008.
-
(2008)
Nat Rev Mol Cell Biol
, vol.9
, pp. 206-218
-
-
Yang, X.J.1
Seto, E.2
-
192
-
-
0034905085
-
Regulation of transcription factor YY1 by acetylation and deacetylation
-
Yao YL, Yang WM, and Seto E. Regulation of transcription factor YY1 by acetylation and deacetylation. Mol Cell Biol 21: 5979-5991, 2001.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 5979-5991
-
-
Yao, Y.L.1
Yang, W.M.2
Seto, E.3
-
193
-
-
84860793042
-
Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation
-
Ye J, Mancuso A, Tong X, Ward PS, Fan J, Rabinowitz JD, and Thompson CB. Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation. Proc Natl Acad Sci U S A 109: 6904-6909, 2012.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 6904-6909
-
-
Ye, J.1
Mancuso, A.2
Tong, X.3
Ward, P.S.4
Fan, J.5
Rabinowitz, J.D.6
Thompson, C.B.7
-
194
-
-
33645322383
-
Metastasis-associated protein 1 enhances stability of hypoxia-inducible factor-1alpha protein by recruiting histone deacetylase 1
-
Yoo YG, Kong G, and Lee MO. Metastasis-associated protein 1 enhances stability of hypoxia-inducible factor-1alpha protein by recruiting histone deacetylase 1. EMBO J 25: 1231-1241, 2006.
-
(2006)
EMBO J
, vol.25
, pp. 1231-1241
-
-
Yoo, Y.G.1
Kong, G.2
Lee, M.O.3
-
195
-
-
12244251445
-
Stat3 dimerization regulated by reversible acetylation of a single lysine residue
-
Yuan ZL, Guan YJ, Chatterjee D, and Chin YE. Stat3 dimerization regulated by reversible acetylation of a single lysine residue. Science 307: 269-273, 2005.
-
(2005)
Science
, vol.307
, pp. 269-273
-
-
Yuan, Z.L.1
Guan, Y.J.2
Chatterjee, D.3
Chin, Y.E.4
-
196
-
-
84875149194
-
Regulation of nucleosome dynamics by histone modifications
-
Zentner GE and Henikoff S. Regulation of nucleosome dynamics by histone modifications. Nat Struct Mol Biol 20: 259-266, 2013.
-
(2013)
Nat Struct Mol Biol
, vol.20
, pp. 259-266
-
-
Zentner, G.E.1
Henikoff, S.2
-
197
-
-
84155197395
-
Mule determines the apoptotic response to HDAC inhibitors by targeted ubiquitination and destruction of HDAC2
-
Zhang J, Kan S, Huang B, Hao Z, Mak TW, and Zhong Q. Mule determines the apoptotic response to HDAC inhibitors by targeted ubiquitination and destruction of HDAC2. Genes Dev 25: 2610-2618, 2011.
-
(2011)
Genes Dev
, vol.25
, pp. 2610-2618
-
-
Zhang, J.1
Kan, S.2
Huang, B.3
Hao, Z.4
Mak, T.W.5
Zhong, Q.6
-
198
-
-
17044370869
-
Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4
-
Zhang X, Ozawa Y, Lee H, Wen YD, Tan TH, Wadzinski BE, and Seto E. Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4. Genes Dev 19: 827-839, 2005.
-
(2005)
Genes Dev
, vol.19
, pp. 827-839
-
-
Zhang, X.1
Ozawa, Y.2
Lee, H.3
Wen, Y.D.4
Tan, T.H.5
Wadzinski, B.E.6
Seto, E.7
-
199
-
-
34447315270
-
HDAC6 modulates cell motility by altering the acetylation level of cortactin
-
Zhang X, Yuan Z, Zhang Y, Yong S, Salas-Burgos A, Koomen J, Olashaw N, Parsons JT, Yang XJ, Dent SR, Yao TP, Lane WS, and Seto E. HDAC6 modulates cell motility by altering the acetylation level of cortactin. Mol Cell 27: 197-213, 2007.
-
(2007)
Mol Cell
, vol.27
, pp. 197-213
-
-
Zhang, X.1
Yuan, Z.2
Zhang, Y.3
Yong, S.4
Salas-Burgos, A.5
Koomen, J.6
Olashaw, N.7
Parsons, J.T.8
Yang, X.J.9
Dent, S.R.10
Yao, T.P.11
Lane, W.S.12
Seto, E.13
-
200
-
-
40749161986
-
Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally
-
Zhang Y, Kwon S, Yamaguchi T, Cubizolles F, Rousseaux S, Kneissel M, Cao C, Li N, Cheng HL, Chua K, Lombard D, Mizeracki A, Matthias G, Alt FW, Khochbin S, and Matthias P. Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally. Mol Cell Biol 28: 1688-1701, 2008.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 1688-1701
-
-
Zhang, Y.1
Kwon, S.2
Yamaguchi, T.3
Cubizolles, F.4
Rousseaux, S.5
Kneissel, M.6
Cao, C.7
Li, N.8
Cheng, H.L.9
Chua, K.10
Lombard, D.11
Mizeracki, A.12
Matthias, G.13
Alt, F.W.14
Khochbin, S.15
Matthias, P.16
-
201
-
-
63849224233
-
AMPK activators - Potential therapeutics for metabolic and other diseases
-
Zhou G, Sebhat IK, and Zhang BB. AMPK activators - potential therapeutics for metabolic and other diseases. Acta Physiol (Oxf) 196: 175-190, 2009.
-
(2009)
Acta Physiol (Oxf)
, vol.196
, pp. 175-190
-
-
Zhou, G.1
Sebhat, I.K.2
Zhang, B.B.3
|