-
1
-
-
8144228566
-
Why do cancers have high aerobic glycolysis?
-
Gatenby R.A., Gillies R.J. Why do cancers have high aerobic glycolysis?. Nat. Rev. Cancer 2004, 4:891-899.
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 891-899
-
-
Gatenby, R.A.1
Gillies, R.J.2
-
2
-
-
33749478922
-
Cancer's molecular sweet tooth and the Warburg effect
-
Kim J.W., Dang C.V. Cancer's molecular sweet tooth and the Warburg effect. Cancer Res. 2006, 66:8927-8930.
-
(2006)
Cancer Res.
, vol.66
, pp. 8927-8930
-
-
Kim, J.W.1
Dang, C.V.2
-
3
-
-
12444279265
-
On the origin of cancer cells
-
Warburg O. On the origin of cancer cells. Science 1956, 123:309-314.
-
(1956)
Science
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
4
-
-
79955398591
-
Otto Warburg's contributions to current concepts of cancer metabolism
-
Koppenol W.H., Bounds P.L., Dang C.V. Otto Warburg's contributions to current concepts of cancer metabolism. Nat. Rev. Cancer 2011, 11:325-337.
-
(2011)
Nat. Rev. Cancer
, vol.11
, pp. 325-337
-
-
Koppenol, W.H.1
Bounds, P.L.2
Dang, C.V.3
-
5
-
-
84858604270
-
Metabolic reprogramming: a cancer hallmark even warburg did not anticipate
-
Ward P.S., Thompson C.B. Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. Cancer Cell 2012, 21:297-308.
-
(2012)
Cancer Cell
, vol.21
, pp. 297-308
-
-
Ward, P.S.1
Thompson, C.B.2
-
6
-
-
79958103961
-
Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells
-
Mazurek S. Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells. Int. J. Biochem. Cell Biol. 2011, 43:969-980.
-
(2011)
Int. J. Biochem. Cell Biol.
, vol.43
, pp. 969-980
-
-
Mazurek, S.1
-
7
-
-
66249108601
-
Understanding the Warburg effect: the metabolic requirements of cell proliferation
-
Vander Heiden M.G., Cantley L.C., Thompson C.B. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009, 324:1029-1033.
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander Heiden, M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
8
-
-
7944226627
-
Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes
-
Altenberg B., Greulich K.O. Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes. Genomics 2004, 84:1014-1020.
-
(2004)
Genomics
, vol.84
, pp. 1014-1020
-
-
Altenberg, B.1
Greulich, K.O.2
-
9
-
-
2942724235
-
MTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
-
Majumder P.K., Febbo P.G., Bikoff R., Berger R., Xue Q., McMahon L.M., Manola J., Brugarolas J., McDonnell T.J., Golub T.R., Loda M., Lane H.A., Sellers W.R. MTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. Nat. Med. 2004, 10:594-601.
-
(2004)
Nat. Med.
, vol.10
, pp. 594-601
-
-
Majumder, P.K.1
Febbo, P.G.2
Bikoff, R.3
Berger, R.4
Xue, Q.5
McMahon, L.M.6
Manola, J.7
Brugarolas, J.8
McDonnell, T.J.9
Golub, T.R.10
Loda, M.11
Lane, H.A.12
Sellers, W.R.13
-
10
-
-
0022930036
-
The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing
-
Noguchi T., Inoue H., Tanaka T. The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing. J. Biol. Chem. 1986, 261:13807-13812.
-
(1986)
J. Biol. Chem.
, vol.261
, pp. 13807-13812
-
-
Noguchi, T.1
Inoue, H.2
Tanaka, T.3
-
11
-
-
75149150660
-
HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer
-
David C.J., Chen M., Assanah M., Canoll P., Manley J.L. HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer. Nature 2010, 463:364-368.
-
(2010)
Nature
, vol.463
, pp. 364-368
-
-
David, C.J.1
Chen, M.2
Assanah, M.3
Canoll, P.4
Manley, J.L.5
-
12
-
-
0017200419
-
Purification and properties of pyruvate kinase from human lung
-
Corcoran E., Phelan J.J., Fottrell P.F. Purification and properties of pyruvate kinase from human lung. Biochim. Biophys. Acta 1976, 446:96-104.
-
(1976)
Biochim. Biophys. Acta
, vol.446
, pp. 96-104
-
-
Corcoran, E.1
Phelan, J.J.2
Fottrell, P.F.3
-
13
-
-
0017172506
-
Pyruvate kinase isozymes in neurons, glia, neuroblastoma, and glioblastoma
-
Tolle S.W., Dyson R.D., Newburgh R.W., Cardenas J.M. Pyruvate kinase isozymes in neurons, glia, neuroblastoma, and glioblastoma. J. Neurochem. 1976, 27:1355-1360.
-
(1976)
J. Neurochem.
, vol.27
, pp. 1355-1360
-
-
Tolle, S.W.1
Dyson, R.D.2
Newburgh, R.W.3
Cardenas, J.M.4
-
14
-
-
0019487346
-
Immunohistological demonstration of the same type of pyruvate kinase isoenzyme (M2-Pk) in tumors of chicken and rat
-
Reinacher M., Eigenbrodt E. Immunohistological demonstration of the same type of pyruvate kinase isoenzyme (M2-Pk) in tumors of chicken and rat. Virchows Arch B Cell Pathol. Incl. Mol. Pathol. 1981, 37:79-88.
-
(1981)
Virchows Arch B Cell Pathol. Incl. Mol. Pathol.
, vol.37
, pp. 79-88
-
-
Reinacher, M.1
Eigenbrodt, E.2
-
15
-
-
0020476194
-
Purification and properties of pyruvate kinase type M2 from rat lung
-
Schering B., Eigenbrodt E., Linder D., Schoner W. Purification and properties of pyruvate kinase type M2 from rat lung. Biochim. Biophys. Acta 1982, 717:337-347.
-
(1982)
Biochim. Biophys. Acta
, vol.717
, pp. 337-347
-
-
Schering, B.1
Eigenbrodt, E.2
Linder, D.3
Schoner, W.4
-
16
-
-
0022245562
-
Pancreatic islets contain the M2 isoenzyme of pyruvate kinase. Its phosphorylation has no effect on enzyme activity
-
MacDonald M.J., Chang C.M. Pancreatic islets contain the M2 isoenzyme of pyruvate kinase. Its phosphorylation has no effect on enzyme activity. Mol. Cell. Biochem. 1985, 68:115-120.
-
(1985)
Mol. Cell. Biochem.
, vol.68
, pp. 115-120
-
-
MacDonald, M.J.1
Chang, C.M.2
-
17
-
-
0028175496
-
L- and M2-pyruvate kinase expression in renal cell carcinomas and their metastases
-
Brinck U., Eigenbrodt E., Oehmke M., Mazurek S., Fischer G. L- and M2-pyruvate kinase expression in renal cell carcinomas and their metastases. Virchows Arch. 1994, 424:177-185.
-
(1994)
Virchows Arch.
, vol.424
, pp. 177-185
-
-
Brinck, U.1
Eigenbrodt, E.2
Oehmke, M.3
Mazurek, S.4
Fischer, G.5
-
18
-
-
23044500915
-
Pyruvate kinase type M2 and its role in tumor growth and spreading
-
Mazurek S., Boschek C.B., Hugo F., Eigenbrodt E. Pyruvate kinase type M2 and its role in tumor growth and spreading. Semin. Cancer Biol. 2005, 15:300-308.
-
(2005)
Semin. Cancer Biol.
, vol.15
, pp. 300-308
-
-
Mazurek, S.1
Boschek, C.B.2
Hugo, F.3
Eigenbrodt, E.4
-
19
-
-
0023656468
-
The L- and R-type isozymes of rat pyruvate kinase are produced from a single gene by use of different promoters
-
Noguchi T., Yamada K., Inoue H., Matsuda T., Tanaka T. The L- and R-type isozymes of rat pyruvate kinase are produced from a single gene by use of different promoters. J. Biol. Chem. 1987, 262:14366-14371.
-
(1987)
J. Biol. Chem.
, vol.262
, pp. 14366-14371
-
-
Noguchi, T.1
Yamada, K.2
Inoue, H.3
Matsuda, T.4
Tanaka, T.5
-
20
-
-
0028295437
-
Transcriptional regulatory regions for expression of the rat pyruvate kinase M gene
-
Wang Z., Takenaka M., Imai E., Yamada K., Tanaka T., Noguchi T. Transcriptional regulatory regions for expression of the rat pyruvate kinase M gene. Eur. J. Biochem. 1994, 220:301-307.
-
(1994)
Eur. J. Biochem.
, vol.220
, pp. 301-307
-
-
Wang, Z.1
Takenaka, M.2
Imai, E.3
Yamada, K.4
Tanaka, T.5
Noguchi, T.6
-
21
-
-
0032906762
-
Nutrient and hormonal regulation of pyruvate kinase gene expression
-
Yamada K., Noguchi T. Nutrient and hormonal regulation of pyruvate kinase gene expression. Biochem. J. 1999, 337(Pt 1):1-11.
-
(1999)
Biochem. J.
, vol.337
, Issue.PART 1
, pp. 1-11
-
-
Yamada, K.1
Noguchi, T.2
-
22
-
-
0030970080
-
Role of the stimulatory proteins Sp1 and Sp3 in the regulation of transcription of the rat pyruvate kinase M gene
-
Netzker R., Weigert C., Brand K. Role of the stimulatory proteins Sp1 and Sp3 in the regulation of transcription of the rat pyruvate kinase M gene. Eur. J. Biochem. 1997, 245:174-181.
-
(1997)
Eur. J. Biochem.
, vol.245
, pp. 174-181
-
-
Netzker, R.1
Weigert, C.2
Brand, K.3
-
23
-
-
0040480322
-
Glucose regulates the promoter activity of aldolase A and pyruvate kinase M2 via dephosphorylation of Sp1
-
Schafer D., Hamm-Kunzelmann B., Brand K. Glucose regulates the promoter activity of aldolase A and pyruvate kinase M2 via dephosphorylation of Sp1. FEBS Lett. 1997, 417:325-328.
-
(1997)
FEBS Lett.
, vol.417
, pp. 325-328
-
-
Schafer, D.1
Hamm-Kunzelmann, B.2
Brand, K.3
-
24
-
-
0032476059
-
Hypoxia regulates beta-enolase and pyruvate kinase-M promoters by modulating Sp1/Sp3 binding to a conserved GC element
-
Discher D.J., Bishopric N.H., Wu X., Peterson C.A., Webster K.A. Hypoxia regulates beta-enolase and pyruvate kinase-M promoters by modulating Sp1/Sp3 binding to a conserved GC element. J. Biol. Chem. 1998, 273:26087-26093.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 26087-26093
-
-
Discher, D.J.1
Bishopric, N.H.2
Wu, X.3
Peterson, C.A.4
Webster, K.A.5
-
25
-
-
0030570828
-
Differences in DNA-binding efficiency of Sp1 to aldolase and pyruvate kinase promoter correlate with altered redox states in resting and proliferating rat thymocytes
-
Schafer D., Hamm-Kunzelmann B., Hermfisse U., Brand K. Differences in DNA-binding efficiency of Sp1 to aldolase and pyruvate kinase promoter correlate with altered redox states in resting and proliferating rat thymocytes. FEBS Lett. 1996, 391:35-38.
-
(1996)
FEBS Lett.
, vol.391
, pp. 35-38
-
-
Schafer, D.1
Hamm-Kunzelmann, B.2
Hermfisse, U.3
Brand, K.4
-
26
-
-
0025855139
-
Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance
-
Marshall S., Bacote V., Traxinger R.R. Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance. J. Biol. Chem. 1991, 266:4706-4712.
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 4706-4712
-
-
Marshall, S.1
Bacote, V.2
Traxinger, R.R.3
-
27
-
-
84857694058
-
PPARgamma contributes to PKM2 and HK2 expression in fatty liver
-
Panasyuk G., Espeillac C., Chauvin C., Pradelli L.A., Horie Y., Suzuki A., Annicotte J.S., Fajas L., Foretz M., Verdeguer F., Pontoglio M., Ferre P., Scoazec J.Y., Birnbaum M.J., Ricci J.E., Pende M. PPARgamma contributes to PKM2 and HK2 expression in fatty liver. Nat. Commun. 2012, 3:672.
-
(2012)
Nat. Commun.
, vol.3
, pp. 672
-
-
Panasyuk, G.1
Espeillac, C.2
Chauvin, C.3
Pradelli, L.A.4
Horie, Y.5
Suzuki, A.6
Annicotte, J.S.7
Fajas, L.8
Foretz, M.9
Verdeguer, F.10
Pontoglio, M.11
Ferre, P.12
Scoazec, J.Y.13
Birnbaum, M.J.14
Ricci, J.E.15
Pende, M.16
-
28
-
-
44949142045
-
Identification of pyruvate kinase type M2 as potential oncoprotein in squamous cell carcinoma of tongue through microRNA profiling
-
Wong T.S., Liu X.B., Chung-Wai Ho A., Po-Wing Yuen A., Wai-Man Ng R., Ignace Wei W. Identification of pyruvate kinase type M2 as potential oncoprotein in squamous cell carcinoma of tongue through microRNA profiling. Int. J. Cancer 2008, 123:251-257.
-
(2008)
Int. J. Cancer
, vol.123
, pp. 251-257
-
-
Wong, T.S.1
Liu, X.B.2
Chung-Wai Ho, A.3
Po-Wing Yuen, A.4
Wai-Man Ng, R.5
Ignace Wei, W.6
-
29
-
-
79952749503
-
Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth
-
Sun Q., Chen X., Ma J., Peng H., Wang F., Zha X., Wang Y., Jing Y., Yang H., Chen R., Chang L., Zhang Y., Goto J., Onda H., Chen T., Wang M.R., Lu Y., You H., Kwiatkowski D., Zhang H. Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth. Proc. Natl. Acad. Sci. USA 2011, 108:4129-4134.
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 4129-4134
-
-
Sun, Q.1
Chen, X.2
Ma, J.3
Peng, H.4
Wang, F.5
Zha, X.6
Wang, Y.7
Jing, Y.8
Yang, H.9
Chen, R.10
Chang, L.11
Zhang, Y.12
Goto, J.13
Onda, H.14
Chen, T.15
Wang, M.R.16
Lu, Y.17
You, H.18
Kwiatkowski, D.19
Zhang, H.20
more..
-
30
-
-
79957567239
-
Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1
-
Luo W., Hu H., Chang R., Zhong J., Knabel M., O'Meally R., Cole R.N., Pandey A., Semenza G.L. Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Cell 2011, 145:732-744.
-
(2011)
Cell
, vol.145
, pp. 732-744
-
-
Luo, W.1
Hu, H.2
Chang, R.3
Zhong, J.4
Knabel, M.5
O'Meally, R.6
Cole, R.N.7
Pandey, A.8
Semenza, G.L.9
-
31
-
-
23944454868
-
Identification of a functional hypoxia-responsive element that regulates the expression of the egl nine homologue 3 (egln3/phd3) gene
-
Pescador N., Cuevas Y., Naranjo S., Alcaide M., Villar D., Landazuri M.O., Del Peso L. Identification of a functional hypoxia-responsive element that regulates the expression of the egl nine homologue 3 (egln3/phd3) gene. Biochem. J. 2005, 390:189-197.
-
(2005)
Biochem. J.
, vol.390
, pp. 189-197
-
-
Pescador, N.1
Cuevas, Y.2
Naranjo, S.3
Alcaide, M.4
Villar, D.5
Landazuri, M.O.6
Del Peso, L.7
-
32
-
-
84870885534
-
EGFR-Induced and PKCepsilon Monoubiquitylation-Dependent NF-kappaB Activation Upregulates PKM2 Expression and Promotes Tumorigenesis
-
Yang W., Xia Y., Cao Y., Zheng Y., Bu W., Zhang L., You M.J., Koh M.Y., Cote G., Aldape K., Li Y., Verma I.M., Chiao P.J., Lu Z. EGFR-Induced and PKCepsilon Monoubiquitylation-Dependent NF-kappaB Activation Upregulates PKM2 Expression and Promotes Tumorigenesis. Mol. Cell 2012, 48:771-784.
-
(2012)
Mol. Cell
, vol.48
, pp. 771-784
-
-
Yang, W.1
Xia, Y.2
Cao, Y.3
Zheng, Y.4
Bu, W.5
Zhang, L.6
You, M.J.7
Koh, M.Y.8
Cote, G.9
Aldape, K.10
Li, Y.11
Verma, I.M.12
Chiao, P.J.13
Lu, Z.14
-
33
-
-
84856189114
-
Nonmetabolic functions of pyruvate kinase isoform M2 in controlling cell cycle progression and tumorigenesis
-
Lu Z. Nonmetabolic functions of pyruvate kinase isoform M2 in controlling cell cycle progression and tumorigenesis. Chin. J. Cancer 2012, 31:5-7.
-
(2012)
Chin. J. Cancer
, vol.31
, pp. 5-7
-
-
Lu, Z.1
-
34
-
-
84870598190
-
ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect
-
Yang W., Zheng Y., Xia Y., Ji H., Chen X., Guo F., Lyssiotis C.A., Aldape K., Cantley L.C., Lu Z. ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. Nat. Cell Biol. 2012, 14:1295-1304.
-
(2012)
Nat. Cell Biol.
, vol.14
, pp. 1295-1304
-
-
Yang, W.1
Zheng, Y.2
Xia, Y.3
Ji, H.4
Chen, X.5
Guo, F.6
Lyssiotis, C.A.7
Aldape, K.8
Cantley, L.C.9
Lu, Z.10
-
35
-
-
55949131783
-
Pyruvate kinase type M2: a key regulator within the tumour metabolome and a tool for metabolic profiling of tumours
-
Mazurek S. Pyruvate kinase type M2: a key regulator within the tumour metabolome and a tool for metabolic profiling of tumours. Ernst Schering Found Symp. Proc. 2007, 99-124.
-
(2007)
Ernst Schering Found Symp. Proc.
, pp. 99-124
-
-
Mazurek, S.1
-
36
-
-
0026467983
-
Double role for pyruvate kinase type M2 in the expansion of phosphometabolite pools found in tumor cells
-
Eigenbrodt E., Reinacher M., Scheefers-Borchel U., Scheefers H., Friis R. Double role for pyruvate kinase type M2 in the expansion of phosphometabolite pools found in tumor cells. Crit. Rev. Oncog. 1992, 3:91-115.
-
(1992)
Crit. Rev. Oncog.
, vol.3
, pp. 91-115
-
-
Eigenbrodt, E.1
Reinacher, M.2
Scheefers-Borchel, U.3
Scheefers, H.4
Friis, R.5
-
37
-
-
21844468220
-
Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis
-
Dombrauckas J.D., Santarsiero B.D., Mesecar A.D. Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis. Biochemistry 2005, 44:9417-9429.
-
(2005)
Biochemistry
, vol.44
, pp. 9417-9429
-
-
Dombrauckas, J.D.1
Santarsiero, B.D.2
Mesecar, A.D.3
-
38
-
-
40749099894
-
Pyruvate kinase M2 is a phosphotyrosine-binding protein
-
Christofk H.R., Vander Heiden M.G., Wu N., Asara J.M., Cantley L.C. Pyruvate kinase M2 is a phosphotyrosine-binding protein. Nature 2008, 452:181-186.
-
(2008)
Nature
, vol.452
, pp. 181-186
-
-
Christofk, H.R.1
Vander Heiden, M.G.2
Wu, N.3
Asara, J.M.4
Cantley, L.C.5
-
39
-
-
82555170271
-
Nuclear PKM2 regulates beta-catenin transactivation upon EGFR activation
-
Yang W., Xia Y., Ji H., Zheng Y., Liang J., Huang W., Gao X., Aldape K., Lu Z. Nuclear PKM2 regulates beta-catenin transactivation upon EGFR activation. Nature 2011, 480:118-122.
-
(2011)
Nature
, vol.480
, pp. 118-122
-
-
Yang, W.1
Xia, Y.2
Ji, H.3
Zheng, Y.4
Liang, J.5
Huang, W.6
Gao, X.7
Aldape, K.8
Lu, Z.9
-
40
-
-
0038075441
-
L-serine in disease and development
-
de Koning T.J., Snell K., Duran M., Berger R., Poll-The B.T., Surtees R. L-serine in disease and development. Biochem. J. 2003, 371:653-661.
-
(2003)
Biochem. J.
, vol.371
, pp. 653-661
-
-
de Koning, T.J.1
Snell, K.2
Duran, M.3
Berger, R.4
Poll-The, B.T.5
Surtees, R.6
-
41
-
-
84869082905
-
Serine is a natural ligand and allosteric activator of pyruvate kinase M2
-
Chaneton B., Hillmann P., Zheng L., Martin A.C., Maddocks O.D., Chokkathukalam A., Coyle J.E., Jankevics A., Holding F.P., Vousden K.H., Frezza C., O'Reilly M., Gottlieb E. Serine is a natural ligand and allosteric activator of pyruvate kinase M2. Nature 2012, 491:458-462.
-
(2012)
Nature
, vol.491
, pp. 458-462
-
-
Chaneton, B.1
Hillmann, P.2
Zheng, L.3
Martin, A.C.4
Maddocks, O.D.5
Chokkathukalam, A.6
Coyle, J.E.7
Jankevics, A.8
Holding, F.P.9
Vousden, K.H.10
Frezza, C.11
O'Reilly, M.12
Gottlieb, E.13
-
42
-
-
84869888609
-
SAICAR stimulates pyruvate kinase isoform M2 and promotes cancer cell survival in glucose-limited conditions
-
Keller K.E., Tan I.S., Lee Y.S. SAICAR stimulates pyruvate kinase isoform M2 and promotes cancer cell survival in glucose-limited conditions. Science 2012, 338:1069-1072.
-
(2012)
Science
, vol.338
, pp. 1069-1072
-
-
Keller, K.E.1
Tan, I.S.2
Lee, Y.S.3
-
43
-
-
67650744588
-
Degradation of activated protein kinases by ubiquitination
-
Lu Z., Hunter T. Degradation of activated protein kinases by ubiquitination. Annu. Rev. Biochem. 2009, 78:435-475.
-
(2009)
Annu. Rev. Biochem.
, vol.78
, pp. 435-475
-
-
Lu, Z.1
Hunter, T.2
-
44
-
-
77449131347
-
Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth
-
Hitosugi T., Kang S., Vander Heiden M.G., Chung T.W., Elf S., Lythgoe K., Dong S., Lonial S., Wang X., Chen G.Z., Xie J., Gu T.L., Polakiewicz R.D., Roesel J.L., Boggon T.J., Khuri F.R., Gilliland D.G., Cantley L.C., Kaufman J., Chen J. Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth. Sci. Signal 2009, 2:ra73.
-
(2009)
Sci. Signal
, vol.2
-
-
Hitosugi, T.1
Kang, S.2
Vander Heiden, M.G.3
Chung, T.W.4
Elf, S.5
Lythgoe, K.6
Dong, S.7
Lonial, S.8
Wang, X.9
Chen, G.Z.10
Xie, J.11
Gu, T.L.12
Polakiewicz, R.D.13
Roesel, J.L.14
Boggon, T.J.15
Khuri, F.R.16
Gilliland, D.G.17
Cantley, L.C.18
Kaufman, J.19
Chen, J.20
more..
-
45
-
-
77149148756
-
Regulation of cellular metabolism by protein lysine acetylation
-
Zhao S., Xu W., Jiang W., Yu W., Lin Y., Zhang T., Yao J., Zhou L., Zeng Y., Li H., Li Y., Shi J., An W., Hancock S.M., He F., Qin L., Chin J., Yang P., Chen X., Lei Q., Xiong Y., Guan K.L. Regulation of cellular metabolism by protein lysine acetylation. Science 2010, 327:1000-1004.
-
(2010)
Science
, vol.327
, pp. 1000-1004
-
-
Zhao, S.1
Xu, W.2
Jiang, W.3
Yu, W.4
Lin, Y.5
Zhang, T.6
Yao, J.7
Zhou, L.8
Zeng, Y.9
Li, H.10
Li, Y.11
Shi, J.12
An, W.13
Hancock, S.M.14
He, F.15
Qin, L.16
Chin, J.17
Yang, P.18
Chen, X.19
Lei, Q.20
Xiong, Y.21
Guan, K.L.22
more..
-
46
-
-
79959371914
-
Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth
-
Lv L., Li D., Zhao D., Lin R., Chu Y., Zhang H., Zha Z., Liu Y., Li Z., Xu Y., Wang G., Huang Y., Xiong Y., Guan K.L., Lei Q.Y. Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth. Mol. Cell 2011, 42:719-730.
-
(2011)
Mol. Cell
, vol.42
, pp. 719-730
-
-
Lv, L.1
Li, D.2
Zhao, D.3
Lin, R.4
Chu, Y.5
Zhang, H.6
Zha, Z.7
Liu, Y.8
Li, Z.9
Xu, Y.10
Wang, G.11
Huang, Y.12
Xiong, Y.13
Guan, K.L.14
Lei, Q.Y.15
-
47
-
-
82755166890
-
Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses
-
Anastasiou D., Poulogiannis G., Asara J.M., Boxer M.B., Jiang J.K., Shen M., Bellinger G., Sasaki A.T., Locasale J.W., Auld D.S., Thomas C.J., Vander Heiden M.G., Cantley L.C. Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses. Science 2011, 334:1278-1283.
-
(2011)
Science
, vol.334
, pp. 1278-1283
-
-
Anastasiou, D.1
Poulogiannis, G.2
Asara, J.M.3
Boxer, M.B.4
Jiang, J.K.5
Shen, M.6
Bellinger, G.7
Sasaki, A.T.8
Locasale, J.W.9
Auld, D.S.10
Thomas, C.J.11
Vander Heiden, M.G.12
Cantley, L.C.13
-
48
-
-
78649391422
-
Cellular metabolic stress: considering how cells respond to nutrient excess
-
Wellen K.E., Thompson C.B. Cellular metabolic stress: considering how cells respond to nutrient excess. Mol. Cell 2010, 40:323-332.
-
(2010)
Mol. Cell
, vol.40
, pp. 323-332
-
-
Wellen, K.E.1
Thompson, C.B.2
-
49
-
-
84865266173
-
PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis
-
Yang W., Xia Y., Hawke D., Li X., Liang J., Xing D., Aldape K., Hunter T., Alfred Yung W.K., Lu Z. PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis. Cell 2012, 150:685-696.
-
(2012)
Cell
, vol.150
, pp. 685-696
-
-
Yang, W.1
Xia, Y.2
Hawke, D.3
Li, X.4
Liang, J.5
Xing, D.6
Aldape, K.7
Hunter, T.8
Alfred Yung, W.K.9
Lu, Z.10
-
50
-
-
84869454490
-
PKM2 functions as a histone kinase
-
Lu Z. PKM2 functions as a histone kinase. Cell Cycle 2012, 11:4101-4102.
-
(2012)
Cell Cycle
, vol.11
, pp. 4101-4102
-
-
Lu, Z.1
-
51
-
-
84862776933
-
Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase
-
Gao X., Wang H., Yang J.J., Liu X., Liu Z.R. Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase. Mol. Cell 2012, 45:598-609.
-
(2012)
Mol. Cell
, vol.45
, pp. 598-609
-
-
Gao, X.1
Wang, H.2
Yang, J.J.3
Liu, X.4
Liu, Z.R.5
-
52
-
-
34250878954
-
Mechanisms of specificity in protein phosphorylation
-
Ubersax J.A., Ferrell J.E. Mechanisms of specificity in protein phosphorylation. Nat. Rev. Mol. Cell Biol. 2007, 8:530-541.
-
(2007)
Nat. Rev. Mol. Cell Biol.
, vol.8
, pp. 530-541
-
-
Ubersax, J.A.1
Ferrell, J.E.2
-
53
-
-
33847699250
-
Nuclear translocation of the tumor marker pyruvate kinase M2 induces programmed cell death
-
Stetak A., Veress R., Ovadi J., Csermely P., Keri G., Ullrich A. Nuclear translocation of the tumor marker pyruvate kinase M2 induces programmed cell death. Cancer Res. 2007, 67:1602-1608.
-
(2007)
Cancer Res.
, vol.67
, pp. 1602-1608
-
-
Stetak, A.1
Veress, R.2
Ovadi, J.3
Csermely, P.4
Keri, G.5
Ullrich, A.6
-
54
-
-
34547130319
-
Regulation of cell proliferation by interleukin-3-induced nuclear translocation of pyruvate kinase
-
Hoshino A., Hirst J.A., Fujii H. Regulation of cell proliferation by interleukin-3-induced nuclear translocation of pyruvate kinase. J. Biol. Chem. 2007, 282:17706-17711.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 17706-17711
-
-
Hoshino, A.1
Hirst, J.A.2
Fujii, H.3
-
55
-
-
66149133551
-
The SUMO-E3 ligase PIAS3 targets pyruvate kinase M2
-
Spoden G.A., Morandell D., Ehehalt D., Fiedler M., Jansen-Durr P., Hermann M., Zwerschke W. The SUMO-E3 ligase PIAS3 targets pyruvate kinase M2. J. Cell. Biochem. 2009, 107:293-302.
-
(2009)
J. Cell. Biochem.
, vol.107
, pp. 293-302
-
-
Spoden, G.A.1
Morandell, D.2
Ehehalt, D.3
Fiedler, M.4
Jansen-Durr, P.5
Hermann, M.6
Zwerschke, W.7
-
56
-
-
40749163248
-
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
-
Christofk H.R., Vander Heiden M.G., Harris M.H., Ramanathan A., Gerszten R.E., Wei R., Fleming M.D., Schreiber S.L., Cantley L.C. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature 2008, 452:230-233.
-
(2008)
Nature
, vol.452
, pp. 230-233
-
-
Christofk, H.R.1
Vander Heiden, M.G.2
Harris, M.H.3
Ramanathan, A.4
Gerszten, R.E.5
Wei, R.6
Fleming, M.D.7
Schreiber, S.L.8
Cantley, L.C.9
-
57
-
-
78650126775
-
Pyruvate kinase M2 is a target of the tumor-suppressive microRNA-326 and regulates the survival of glioma cells
-
Kefas B., Comeau L., Erdle N., Montgomery E., Amos S., Purow B. Pyruvate kinase M2 is a target of the tumor-suppressive microRNA-326 and regulates the survival of glioma cells. Neuro-oncology 2010, 12:1102-1112.
-
(2010)
Neuro-oncology
, vol.12
, pp. 1102-1112
-
-
Kefas, B.1
Comeau, L.2
Erdle, N.3
Montgomery, E.4
Amos, S.5
Purow, B.6
-
58
-
-
77249150369
-
Identification of small molecule inhibitors of pyruvate kinase M2
-
Vander Heiden M.G., Christofk H.R., Schuman E., Subtelny A.O., Sharfi H., Harlow E.E., Xian J., Cantley L.C. Identification of small molecule inhibitors of pyruvate kinase M2. Biochem. Pharmacol. 2010, 79:1118-1124.
-
(2010)
Biochem. Pharmacol.
, vol.79
, pp. 1118-1124
-
-
Vander Heiden, M.G.1
Christofk, H.R.2
Schuman, E.3
Subtelny, A.O.4
Sharfi, H.5
Harlow, E.E.6
Xian, J.7
Cantley, L.C.8
-
59
-
-
80054883247
-
Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2
-
Chen J., Xie J., Jiang Z., Wang B., Wang Y., Hu X. Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2. Oncogene 2011, 30:4297-4306.
-
(2011)
Oncogene
, vol.30
, pp. 4297-4306
-
-
Chen, J.1
Xie, J.2
Jiang, Z.3
Wang, B.4
Wang, Y.5
Hu, X.6
-
60
-
-
84865976786
-
Anticancer targets in the glycolytic metabolism of tumors: a comprehensive review
-
Porporato P.E., Dhup S., Dadhich R.K., Copetti T., Sonveaux P. Anticancer targets in the glycolytic metabolism of tumors: a comprehensive review. Front. Pharmacol. 2011, 2:49.
-
(2011)
Front. Pharmacol.
, vol.2
, pp. 49
-
-
Porporato, P.E.1
Dhup, S.2
Dadhich, R.K.3
Copetti, T.4
Sonveaux, P.5
-
61
-
-
84877579872
-
Discovery of 2-((1H-benzo[d]imidazol-1-yl)methyl)-4H-pyrido[1,2-a]pyrimidin-4-ones as novel PKM2 activators
-
Guo C., Linton A., Jalaie M., et al. Discovery of 2-((1H-benzo[d]imidazol-1-yl)methyl)-4H-pyrido[1,2-a]pyrimidin-4-ones as novel PKM2 activators. Bioor. Med. Chem. Lett. 2013, 23:3358-3363.
-
(2013)
Bioor. Med. Chem. Lett.
, vol.23
, pp. 3358-3363
-
-
Guo, C.1
Linton, A.2
Jalaie, M.3
-
62
-
-
84866842363
-
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
-
Anastasiou D., Yu Y., Israelsen W.J., et al. Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nature chemical biology 2012, 8:839-847.
-
(2012)
Nature chemical biology
, vol.8
, pp. 839-847
-
-
Anastasiou, D.1
Yu, Y.2
Israelsen, W.J.3
|