Protein aggregates are recruited to aggresome by histone deacetylase 6 via unanchored ubiquitin C termini

Journal of Biological Chemistry

Volumn 287, Issue 4, 2012, Pages 2317-2327

  Ouyang, Hui ^a   Ali, Yousuf O ^b   Ravichandran, Mani ^a   Dong, Aiping ^a   Qiu, Wei ^c   MacKenzie, Farrell ^a   Dhe Paganon, Sirano ^a   Arrowsmith, Cheryl H ^a   Zhai, R Grace ^b,d  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY HEALTH NETWORK   (Canada)

^d RMSB 6069 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATAXIN-3; CURRENT MODELS; DIGLYCINE; DYNEIN MOTOR COMPLEX; HISTONE DEACETYLASES; IN-SITU; MICROTUBULE NETWORKS; MISFOLDED PROTEINS; POLYUBIQUITIN; PROTEIN AGGREGATES; PROTEIN COMPLEXES; SIGNALING PATHWAYS; UBIQUITIN;

AGGREGATES;

PROTEINS;

ATAXIN 3; DIGLYCINE; HISTONE DEACETYLASE 6; POLYUBIQUITIN; UBIQUITIN;

AGGRESOME; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; IMMUNOPRECIPITATION; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CLEAVAGE; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; UBIQUITINATION; ZNF UBIQUITIN BINDING DOMAIN;

CELL LINE; HISTONE DEACETYLASES; HUMANS; MULTIPROTEIN COMPLEXES; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; UBIQUITIN; UBIQUITINATED PROTEINS;

EID: 84856071893     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.273730     Document Type: Article

References (36)

1. Goldberg, A. L. (2003) Nature 426, 895-899
2. Tai, H. C., and Schuman, E. M. (2008) Nat. Rev. Neurosci. 9, 826-838
3. Johnston, J. A., Ward, C. L., and Kopito, R. R. (1998) J. Cell Biol. 143, 1883-1898
4. Garcia-Mata, R., Gao, Y. S., and Sztul, E. (2002) Traffic 3, 388-396
5. Chin, L. S., Olzmann, J. A., and Li, L. (2010) Biochem. Soc. Trans 38, 144-149
6. Lee, J. Y., Koga, H., Kawaguchi, Y., Tang, W., Wong, E., Gao, Y. S., Pandey, U. B., Kaushik, S., Tresse, E., Lu, J., Taylor, J. P., Cuervo, A. M., and Yao, T. P. (2010) EMBO J. 29, 969-980
7. Pandey, U. B., Nie, Z., Batlevi, Y., McCray, B. A., Ritson, G. P., Nedelsky, N. B., Schwartz, S. L., DiProspero, N. A., Knight, M. A., Schuldiner, O., Padmanabhan, R., Hild, M., Berry, D. L., Garza, D., Hubbert, C. C., Yao, T. P., Baehrecke, E. H., and Taylor, J. P. (2007) Nature 447, 859-863
8. Matthias, P., Yoshida, M., and Khochbin, S. (2008) Cell Cycle 7, 7-10
9. Valenzuela-Fernández, A., Cabrero, J. R., Serrador, J. M., and Sánchez- Madrid, F. (2008) Trends Cell Biol. 18, 291-297
10. Dompierre, J. P., Godin, J. D., Charrin, B. C., Cordelières, F. P., King, S. J., Humbert, S., and Saudou, F. (2007) J. Neurosci 27, 3571-3583
11. Kawaguchi, Y., Kovacs, J. J., McLaurin, A., Vance, J. M., Ito, A., and Yao, T. P. (2003) Cell 115, 727-738
12. Pai, M. T., Tzeng, S. R., Kovacs, J. J., Keaton, M. A., Li, S. S., Yao, T. P., and Zhou, P. (2007) J. Mol. Biol. 370, 290-302
13. Reyes-Turcu, F. E., Horton, J. R., Mullally, J. E., Heroux, A., Cheng, X., and Wilkinson, K. D. (2006) Cell 124, 1197-1208
14. Finley, D., and Chau, V. (1991) Annu. Rev. Cell Biol. 7, 25-69
15. Hicke, L., Schubert, H. L., and Hill, C. P. (2005) Nat. Rev. Mol. Cell Biol. 6, 610-621
16. Raiborg, C., Slagsvold, T., and Stenmark, H. (2006) Trends Biochem. Sci. 31, 541-544
17. Emsley, P., and Cowtan, K. (2004) Acta Crystallogr. 60, 2126-2132
18. Bricogne, G. (1993) Acta Crystallogr. 49, 37-60
19. Bonnet, J., Romier, C., Tora, L., and Devys, D. (2008) Trends Biochem. Sci. 33, 369-375
20. Hochstrasser, M. (1996) Annu. Rev. Genet. 30, 405-439
21. Boyault, C., Gilquin, B., Zhang, Y., Rybin, V., Garman, E., Meyer-Klaucke, W., Matthias, P., Müller, C. W., and Khochbin, S. (2006) EMBO J. 25, 3357-3366
22. Boyault, C., Sadoul, K., Pabion, M., and Khochbin, S. (2007) Oncogene 26, 5468-5476
23. Burnett, B., Li, F., and Pittman, R. N. (2003) Hum. Mol. Genet. 12, 3195-3205
24. Burnett, B. G., and Pittman, R. N. (2005) Proc. Natl. Acad. Sci. U.S.A. 102, 4330-4335
25. Donaldson, K. M., Li, W., Ching, K. A., Batalov, S., Tsai, C. C., and Joazeiro, C. A. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 8892-8897
26. Menzies, F. M., Huebener, J., Renna, M., Bonin, M., Riess, O., and Rubinsztein, D. C. (2010) Brain 133, 93-104
27. Paulson, H. L., Perez, M. K., Trottier, Y., Trojanowski, J. Q., Subramony, S. H., Das, S. S., Vig, P., Mandel, J. L., Fischbeck, K. H., and Pittman, R. N. (1997) Neuron 19, 333-344
28. Trottier, Y., Cancel, G., An-Gourfinkel, I., Lutz, Y., Weber, C., Brice, A., Hirsch, E., and Mandel, J. L. (1998) Neurobiol. Dis. 5, 335-347
29. Pozzi, C., Valtorta, M., Tedeschi, G., Galbusera, E., Pastori, V., Bigi, A., Nonnis, S., Grassi, E., and Fusi, P. (2008) Neurobiol. Dis. 30, 190-200
30. Zhai, R. G., Zhang, F., Hiesinger, P. R., Cao, Y., Haueter, C. M., and Bellen, H. J. (2008) Nature 452, 887-891
31. Amerik, A., Swaminathan, S., Krantz, B. A., Wilkinson, K. D., and Hochstrasser, M. (1997) EMBO J. 16, 4826-4838
32. Komander, D., Clague, M. J., and Urbé, S. (2009) Nat. Rev. Mol. Cell Biol. 10, 550-563
33. Mimnaugh, E. G., Chen, H. Y., Davie, J. R., Celis, J. E., and Neckers, L. (1997) Biochemistry 36, 14418-14429
34. Mao, Y., Senic-Matuglia, F., Di Fiore, P. P., Polo, S., Hodsdon, M. E., and De Camilli, P. (2005) Proc. Natl. Acad. Sci. U.S.A. 102, 12700-12705
35. Olzmann, J. A., Li, L., and Chin, L. S. (2008) Curr. Med. Chem. 15, 47-60
36. Rodriguez-Gonzalez, A., Lin, T., Ikeda, A. K., Simms-Waldrip, T., Fu, C., and Sakamoto, K. M. (2008) Cancer Res. 68, 2557-2560