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Volumn 71, Issue 24, 2011, Pages 7525-7536

Androgen receptor and nutrient signaling pathways coordinate the demand for increased amino acid transport during prostate cancer progression

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; AMINO ACID; AMINO ACID TRANSPORTER; ANDROGEN RECEPTOR; L TYPE AMINO ACID TRANSPORTER 1; L TYPE AMINO ACID TRANSPORTER 3; LEUCINE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; UNCLASSIFIED DRUG;

EID: 84255199561     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-11-1821     Document Type: Article
Times cited : (150)

References (46)
  • 1
    • 84928580276 scopus 로고
    • Studies on prostatic cancer: I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate
    • Huggins C, Hodges CV. Studies on prostatic cancer: I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate. Cancer Res 1941;1:293-7.
    • (1941) Cancer Res , vol.1 , pp. 293-297
    • Huggins, C.1    Hodges, C.V.2
  • 2
    • 2342558431 scopus 로고    scopus 로고
    • Androgen receptor in prostate cancer
    • DOI 10.1210/er.2002-0032
    • Heinlein CA, Chang C. Androgen receptor in prostate cancer. Endocr Rev 2004;25:276-308. (Pubitemid 38501396)
    • (2004) Endocrine Reviews , vol.25 , Issue.2 , pp. 276-308
    • Heinlein, C.A.1    Chang, C.2
  • 3
    • 65649118955 scopus 로고    scopus 로고
    • PTEN deficiency is fully penetrant for prostate adenocarcinoma in C57BL/6 mice via mTOR-dependent growth
    • Blando J, Portis M, Benavides F, Alexander A, Mills G, Dave B, et al. PTEN deficiency is fully penetrant for prostate adenocarcinoma in C57BL/6 mice via mTOR-dependent growth. Am J Pathol 2009;174:1869-79.
    • (2009) Am J Pathol , vol.174 , pp. 1869-1879
    • Blando, J.1    Portis, M.2    Benavides, F.3    Alexander, A.4    Mills, G.5    Dave, B.6
  • 5
    • 0032577699 scopus 로고    scopus 로고
    • The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
    • DOI 10.1074/jbc.273.22.13375
    • Maehama T, Dixon JE. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 1998;273:13375-8. (Pubitemid 28268370)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.22 , pp. 13375-13378
    • Maehama, T.1    Dixon, J.E.2
  • 6
    • 34347220473 scopus 로고    scopus 로고
    • Defining the Role of mTOR in Cancer
    • DOI 10.1016/j.ccr.2007.05.008, PII S1535610807001511
    • Guertin DA, Sabatini DM. Defining the role of mTOR in cancer. Cancer Cell 2007;12:9-22. (Pubitemid 47001784)
    • (2007) Cancer Cell , vol.12 , Issue.1 , pp. 9-22
    • Guertin, D.A.1    Sabatini, D.M.2
  • 7
    • 78649348967 scopus 로고    scopus 로고
    • Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress
    • Sengupta S, Peterson TR, Sabatini DM. Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Mol Cell 2010;40:310-22.
    • (2010) Mol Cell , vol.40 , pp. 310-322
    • Sengupta, S.1    Peterson, T.R.2    Sabatini, D.M.3
  • 8
    • 0033597129 scopus 로고    scopus 로고
    • Leucine regulates translation of specific mRNAs in L6 myoblasts through mTOR-mediated changes in availability of eIF4E and phosphorylation of ribosomal protein S6
    • Kimball SR, Shantz LM, Horetsky RL, Jefferson LS. Leucine regulates translation of specific mRNAs in L6 myoblasts through mTOR-mediated changes in availability of eIF4E and phosphorylation of ribosomal protein S6. J Biol Chem 1999;274:11647-52.
    • (1999) J Biol Chem , vol.274 , pp. 11647-11652
    • Kimball, S.R.1    Shantz, L.M.2    Horetsky, R.L.3    Jefferson, L.S.4
  • 9
    • 33644683295 scopus 로고    scopus 로고
    • Glutamatergic regulation of the p70S6 kinase in primary mouse neurons
    • DOI 10.1074/jbc.C500363200
    • Lenz G, Avruch J. Glutamatergic regulation of the p70S6 kinase in primary mouse neurons. J Biol Chem 2005;280:38121-4. (Pubitemid 43853706)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.46 , pp. 38121-38124
    • Lenz, G.1    Avruch, J.2
  • 10
    • 79551565620 scopus 로고    scopus 로고
    • Amino acid signaling to mTOR mediated by inositol polyphosphate multikinase
    • Kim S, Kim SF, Maag D, Maxwell MJ, Resnick AC, Juluri KR, et al. Amino acid signaling to mTOR mediated by inositol polyphosphate multikinase. Cell Metab 2011;13:215-21.
    • (2011) Cell Metab , vol.13 , pp. 215-221
    • Kim, S.1    Kim, S.F.2    Maag, D.3    Maxwell, M.J.4    Resnick, A.C.5    Juluri, K.R.6
  • 13
    • 25444457577 scopus 로고    scopus 로고
    • hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase
    • DOI 10.1074/jbc.M507201200
    • Byfield MP, Murray JT, Backer JM. hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase. J Biol Chem 2005;280:33076-82. (Pubitemid 41368357)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.38 , pp. 33076-33082
    • Byfield, M.P.1    Murray, J.T.2    Backer, J.M.3
  • 14
    • 72049124015 scopus 로고    scopus 로고
    • ATF4-dependent transcription mediates signaling of amino acid limitation
    • Kilberg MS, Shan J, Su N. ATF4-dependent transcription mediates signaling of amino acid limitation. Trends Endocrinol Metab 2009;20:436-43.
    • (2009) Trends Endocrinol Metab , vol.20 , pp. 436-443
    • Kilberg, M.S.1    Shan, J.2    Su, N.3
  • 18
    • 58549111213 scopus 로고    scopus 로고
    • Prognostic significance of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in early stage squamous cell carcinoma of the lung
    • Kaira K, Oriuchi N, Imai H, Shimizu K, Yanagitani N, Sunaga N, et al. Prognostic significance of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in early stage squamous cell carcinoma of the lung. Cancer Sci 2009;100:248-54.
    • (2009) Cancer Sci , vol.100 , pp. 248-254
    • Kaira, K.1    Oriuchi, N.2    Imai, H.3    Shimizu, K.4    Yanagitani, N.5    Sunaga, N.6
  • 19
    • 57649185073 scopus 로고    scopus 로고
    • L-type amino-acid transporter 1 as a novel biomarker for high-grade malignancy in prostate cancer
    • Sakata T, Ferdous G, Tsuruta T, Satoh T, Baba S, Muto T, et al. L-type amino-acid transporter 1 as a novel biomarker for high-grade malignancy in prostate cancer. Pathol Int 2009;59:7-18.
    • (2009) Pathol Int , vol.59 , pp. 7-18
    • Sakata, T.1    Ferdous, G.2    Tsuruta, T.3    Satoh, T.4    Baba, S.5    Muto, T.6
  • 20
    • 0141592695 scopus 로고    scopus 로고
    • Enhanced androgen receptor signaling correlates with the androgen-refractory growth in a newly established MDA PCa 2b-hr human prostate cancer cell subline
    • Hara T, Nakamura K, Araki H, Kusaka M, Yamaoka M. Enhanced androgen receptor signaling correlates with the androgen-refractory growth in a newly established MDA PCa 2b-hr human prostate cancer cell subline. Cancer Res 2003;63:5622-8. (Pubitemid 37139887)
    • (2003) Cancer Research , vol.63 , Issue.17 , pp. 5622-5628
    • Hara, T.1    Nakamura, K.2    Araki, H.3    Kusaka, M.4    Yamaoka, M.5
  • 22
    • 78650827887 scopus 로고    scopus 로고
    • Luciferase expression and bioluminescence does not affect tumor cell growth in vitro or in vivo
    • Tiffen JC, Bailey CG, Ng C, Rasko JE, Holst J. Luciferase expression and bioluminescence does not affect tumor cell growth in vitro or in vivo. Mol Cancer 2010;9:299.
    • (2010) Mol Cancer , vol.9 , pp. 299
    • Tiffen, J.C.1    Bailey, C.G.2    Ng, C.3    Rasko, J.E.4    Holst, J.5
  • 23
    • 34247892541 scopus 로고    scopus 로고
    • +-independent system L amino acid transporter 3 in mice: A potential role in supply of branched-chain amino acids under nutrient starvation
    • DOI 10.2353/ajpath.2007.060428
    • Fukuhara D, Kanai Y, Chairoungdua A, Babu E, Bessho F, Kawano T, et al. Protein characterization of NA+-independent system L amino acid transporter 3 in mice: a potential role in supply of branched-chain amino acids under nutrient starvation. Am J Pathol 2007;170:888-98. (Pubitemid 47339358)
    • (2007) American Journal of Pathology , vol.170 , Issue.3 , pp. 888-898
    • Fukuhara, D.1    Kanai, Y.2    Chairoungdua, A.3    Babu, E.4    Bessho, F.5    Kawano, T.6    Akimoto, Y.7    Endou, H.8    Yan, K.9
  • 24
    • 78650675585 scopus 로고    scopus 로고
    • Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers
    • Fedele CG, Ooms LM, Ho M, Vieusseux J, O'Toole SA, Millar EK, et al. Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers. Proc Natl Acad SciUSA 2010;107:22231-6.
    • (2010) Proc Natl Acad SciUSA , vol.107 , pp. 22231-22236
    • Fedele, C.G.1    Ooms, L.M.2    Ho, M.3    Vieusseux, J.4    O'Toole, S.A.5    Millar, E.K.6
  • 25
    • 38349170961 scopus 로고    scopus 로고
    • Amino acid transport across mammalian intestinal and renal epithelia
    • Broer S. Amino acid transport across mammalian intestinal and renal epithelia. Physiol Rev 2008;88:249-86.
    • (2008) Physiol Rev , vol.88 , pp. 249-286
    • Broer, S.1
  • 26
    • 17144379653 scopus 로고    scopus 로고
    • Genome-wide characterization of gene expression variations and DNA copy number changes in prostate cancer cell lines
    • DOI 10.1002/pros.20158
    • Zhao H, Kim Y, Wang P, Lapointe J, Tibshirani R, Pollack JR, et al. Genome-wide characterization of gene expression variations and DNA copy number changes in prostate cancer cell lines. Prostate 2005;63:187-97. (Pubitemid 40525367)
    • (2005) Prostate , vol.63 , Issue.2 , pp. 187-197
    • Zhao, H.1    Kim, Y.2    Wang, P.3    Lapointe, J.4    Tibshirani, R.5    Pollack, J.R.6    Brooks, J.D.7
  • 27
    • 62449179630 scopus 로고    scopus 로고
    • Conserved gene expression programs integrate mammalian prostate development and tumorigenesis
    • Pritchard C, Mecham B, Dumpit R, Coleman I, Bhattacharjee M, Chen Q, et al. Conserved gene expression programs integrate mammalian prostate development and tumorigenesis. Cancer Res 2009;69:1739-47.
    • (2009) Cancer Res , vol.69 , pp. 1739-1747
    • Pritchard, C.1    Mecham, B.2    Dumpit, R.3    Coleman, I.4    Bhattacharjee, M.5    Chen, Q.6
  • 29
    • 67650758019 scopus 로고    scopus 로고
    • Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer
    • Wang Q, Li W, Zhang Y, Yuan X, Xu K, Yu J, et al. Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer. Cell 2009;138:245-56.
    • (2009) Cell , vol.138 , pp. 245-256
    • Wang, Q.1    Li, W.2    Zhang, Y.3    Yuan, X.4    Xu, K.5    Yu, J.6
  • 30
    • 77952103123 scopus 로고    scopus 로고
    • An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression
    • Yu J, Mani RS, Cao Q, Brenner CJ, Cao X, Wang X, et al. An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression. Cancer Cell 2010;17:443-54.
    • (2010) Cancer Cell , vol.17 , pp. 443-454
    • Yu, J.1    Mani, R.S.2    Cao, Q.3    Brenner, C.J.4    Cao, X.5    Wang, X.6
  • 31
    • 79960071366 scopus 로고    scopus 로고
    • The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis
    • Massie CE, Lynch A, Ramos-Montoya A, Boren J, Stark R, Fazli L, et al. The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis. EMBO J 2011;30:2719-33.
    • (2011) EMBO J , vol.30 , pp. 2719-2733
    • Massie, C.E.1    Lynch, A.2    Ramos-Montoya, A.3    Boren, J.4    Stark, R.5    Fazli, L.6
  • 32
    • 0031017102 scopus 로고    scopus 로고
    • An androgen response element in a far upstream enhancer region is essential for high, androgen-regulated activity of the prostate-specific antigen promoter
    • DOI 10.1210/me.11.2.148
    • Cleutjens KB, van der Korput HA, van Eekelen CC, van Rooij HC, Faber PW, Trapman J. An androgen response element in a far upstream enhancer region is essential for high, androgen-regulated activity of the prostate-specific antigen promoter. Mol Endocrinol 1997;11:148-61. (Pubitemid 27057428)
    • (1997) Molecular Endocrinology , vol.11 , Issue.2 , pp. 148-161
    • Cleutjens, K.B.J.M.1    Van Der, K.H.A.G.M.2    Van Eekelen, C.C.E.M.3    Van Rooij, H.C.J.4    Faber, P.W.5    Trapman, J.6
  • 36
    • 34249709906 scopus 로고    scopus 로고
    • Gene expression profiles of prostate cancer reveal involvement of multiple molecular pathways in the metastatic process
    • Chandran UR, Ma C, Dhir R, Bisceglia M, Lyons-Weiler M, Liang W, et al. Gene expression profiles of prostate cancer reveal involvement of multiple molecular pathways in the metastatic process. BMC Cancer 2007;7:64.
    • (2007) BMC Cancer , vol.7 , pp. 64
    • Chandran, U.R.1    Ma, C.2    Dhir, R.3    Bisceglia, M.4    Lyons-Weiler, M.5    Liang, W.6
  • 38
    • 70349731660 scopus 로고    scopus 로고
    • Inhibition of tumor growth progression by antiandrogens and mTOR inhibitor in a Pten-deficient mouse model of prostate cancer
    • Zhang W, Zhu J, Efferson CL, Ware C, Tammam J, Angagaw M, et al. Inhibition of tumor growth progression by antiandrogens and mTOR inhibitor in a Pten-deficient mouse model of prostate cancer. Cancer Res 2009;69:7466-72.
    • (2009) Cancer Res , vol.69 , pp. 7466-7472
    • Zhang, W.1    Zhu, J.2    Efferson, C.L.3    Ware, C.4    Tammam, J.5    Angagaw, M.6
  • 39
    • 79955975429 scopus 로고    scopus 로고
    • Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer
    • Carver B, Chapinski C, Wongvipat J, Hieronymus H, Chen Y, Chandarlapaty S, et al. Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer. Cancer Cell 2011;19:575-86.
    • (2011) Cancer Cell , vol.19 , pp. 575-586
    • Carver, B.1    Chapinski, C.2    Wongvipat, J.3    Hieronymus, H.4    Chen, Y.5    Chandarlapaty, S.6
  • 40
    • 79958764107 scopus 로고    scopus 로고
    • Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth
    • Mulholland DJ, Tran LM, Li Y, Cai H, Morim A, Wang S, et al. Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth. Cancer Cell 2011;19:792-804.
    • (2011) Cancer Cell , vol.19 , pp. 792-804
    • Mulholland, D.J.1    Tran, L.M.2    Li, Y.3    Cai, H.4    Morim, A.5    Wang, S.6
  • 41
    • 23044474905 scopus 로고    scopus 로고
    • Amino acid transporters ASCT2 and LAT1 in cancer: Partners in crime?
    • DOI 10.1016/j.semcancer.2005.04.005, PII S1044579X05000222, Tumor Metabolome
    • Fuchs BC, Bode BP. Amino acid transporters ASCT2 and LAT1 in cancer: partners in crime? Semin Cancer Biol 2005;15:254-66. (Pubitemid 41065034)
    • (2005) Seminars in Cancer Biology , vol.15 , Issue.4 , pp. 254-266
    • Fuchs, B.C.1    Bode, B.P.2
  • 42
  • 44
    • 0037225723 scopus 로고    scopus 로고
    • Physical association and functional interaction between beta1 integrin and CD98 on human T lymphocytes
    • DOI 10.1016/S0161-5890(02)00255-9, PII S0161589002002559
    • Miyamoto YJ, Mitchell JS, McIntyre BW. Physical association and functional interaction between beta1 integrin and CD98 on human T lymphocytes. Mol Immunol 2003;39:739-51. (Pubitemid 36078367)
    • (2003) Molecular Immunology , vol.39 , Issue.12 , pp. 739-751
    • Miyamoto, Y.J.1    Mitchell, J.S.2    McIntyre, B.W.3


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