-
1
-
-
0025943945
-
Transcriptional repression by YY1, a human GLI-Kruppel-related protein, and relief of repression by adenovirus E1A protein
-
Shi Y, Seto E, Chang LS, Shenk T. Transcriptional repression by YY1, a human GLI-Kruppel-related protein, and relief of repression by adenovirus E1A protein. Cell 1991;67:377-88.
-
(1991)
Cell
, vol.67
, pp. 377-388
-
-
Shi, Y.1
Seto, E.2
Chang, L.S.3
Shenk, T.4
-
2
-
-
0030941901
-
Everything you have ever wanted to know about Yin Yang 1
-
Shi Y, Lee JS, Galvin KM. Everything you have ever wanted to know about Yin Yang 1. Biochim Biophys Acta 1997;1332:F49-66.
-
(1997)
Biochim Biophys Acta
, vol.1332
-
-
Shi, Y.1
Lee, J.S.2
Galvin, K.M.3
-
3
-
-
0032880120
-
Targeted disruption of mouse Yin Yang 1 transcription factor results in periimplantation lethality
-
Donohoe ME, Zhang X, McGinnis L, Biggers J, Li E, Shi Y. Targeted disruption of mouse Yin Yang 1 transcription factor results in periimplantation lethality. Mol Cell Biol 1999;19:7237-44.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 7237-7244
-
-
Donohoe, M.E.1
Zhang, X.2
McGinnis, L.3
Biggers, J.4
Li, E.5
Shi, Y.6
-
4
-
-
79952274283
-
Yin Yang 1: A multifaceted protein beyond a transcription factor
-
Deng Z, Cao P, Wan MM, Sui G. Yin Yang 1: a multifaceted protein beyond a transcription factor. Transcription 2010;1:81-4.
-
(2010)
Transcription
, vol.1
, pp. 81-84
-
-
Deng, Z.1
Cao, P.2
Wan, M.M.3
Sui, G.4
-
5
-
-
33644507479
-
Transcription factor YY1: Structure, function, and therapeutic implications in cancer biology
-
Gordon S, Akopyan G, Garban H, Bonavida B. Transcription factor YY1: structure, function, and therapeutic implications in cancer biology. Oncogene 2006;25:1125-42.
-
(2006)
Oncogene
, vol.25
, pp. 1125-1142
-
-
Gordon, S.1
Akopyan, G.2
Garban, H.3
Bonavida, B.4
-
6
-
-
2942702012
-
Yin Yang 1 is a negative regulator of p53
-
Sui G, Affar el B, Shi Y, Brignone C, Wall NR, Yin P, et al. Yin Yang 1 is a negative regulator of p53. Cell 2004;117:859-72.
-
(2004)
Cell
, vol.117
, pp. 859-872
-
-
Sui, G.1
Affar, B.2
Shi, Y.3
Brignone, C.4
Wall, N.R.5
Yin, P.6
-
7
-
-
67649440546
-
Transcription factor YY1 expression in human gastrointestinal cancer cells
-
Chinnappan D, Xiao D, Ratnasari A, Andry C, King TC, Weber HC. Transcription factor YY1 expression in human gastrointestinal cancer cells. Int J Oncol 2009;34:1417-23.
-
(2009)
Int J Oncol
, vol.34
, pp. 1417-1423
-
-
Chinnappan, D.1
Xiao, D.2
Ratnasari, A.3
Andry, C.4
King, T.C.5
Weber, H.C.6
-
8
-
-
24644478534
-
Expression of transcription factor Yin Yang 1 in prostate cancer
-
Seligson D, Horvath S, Huerta-Yepez S, Hanna S, Garban H, Roberts A, et al. Expression of transcription factor Yin Yang 1 in prostate cancer. Int J Oncol 2005;27:131-41.
-
(2005)
Int J Oncol
, vol.27
, pp. 131-141
-
-
Seligson, D.1
Horvath, S.2
Huerta-Yepez, S.3
Hanna, S.4
Garban, H.5
Roberts, A.6
-
9
-
-
76349095132
-
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
-
Semenza GL. Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene 2010;29:625-34.
-
(2010)
Oncogene
, vol.29
, pp. 625-634
-
-
Semenza, G.L.1
-
10
-
-
78650373860
-
Hypoxia and hypoxia-inducible factors: Master regulators of metastasis
-
Lu X, Kang Y. Hypoxia and hypoxia-inducible factors: master regulators of metastasis. Clin Cancer Res 2010;16:5928-35.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 5928-5935
-
-
Lu, X.1
Kang, Y.2
-
11
-
-
79953870540
-
Targeting HIF1alpha eliminates cancer stem cells in hematological malignancies
-
Wang Y, Liu Y, Malek SN, Zheng P, Liu Y. Targeting HIF1alpha eliminates cancer stem cells in hematological malignancies. Cell Stem Cell 2011;8:399-411.
-
(2011)
Cell Stem Cell
, vol.8
, pp. 399-411
-
-
Wang, Y.1
Liu, Y.2
Malek, S.N.3
Zheng, P.4
Liu, Y.5
-
12
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003;3:721-32.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
13
-
-
2342661143
-
Intratumoral hypoxia, radiation resistance, and HIF-1
-
Semenza GL. Intratumoral hypoxia, radiation resistance, and HIF-1. Cancer Cell 2004;5:405-6.
-
(2004)
Cancer Cell
, vol.5
, pp. 405-406
-
-
Semenza, G.L.1
-
14
-
-
0029051439
-
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
-
Wang GL, Jiang BH, Rue EA, Semenza GL. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci U S A 1995;92:5510-4.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 5510-5514
-
-
Wang, G.L.1
Jiang, B.H.2
Rue, E.A.3
Semenza, G.L.4
-
15
-
-
0041465022
-
HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steadystate levels of HIF-1alpha in normoxia
-
Berra E,Benizri E, Ginouves A, Volmat V, Roux D, Pouyssegur J. HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steadystate levels of HIF-1alpha in normoxia. EMBO J 2003;22: 4082-90.
-
(2003)
EMBO J
, vol.22
, pp. 4082-4090
-
-
Berra, E.1
Benizri, E.2
Ginouves, A.3
Volmat, V.4
Roux, D.5
Pouyssegur, J.6
-
16
-
-
43649093915
-
Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway
-
Kaelin WG Jr, Ratcliffe PJ. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell 2008;30: 393-402.
-
(2008)
Mol Cell
, vol.30
, pp. 393-402
-
-
Kaelin Jr., W.G.1
Ratcliffe, P.J.2
-
17
-
-
45749145804
-
Enhancement of angiogenesis through stabilization of hypoxia-inducible factor-1 by silencing prolyl hydroxylase domain-2 gene
-
Wu S, Nishiyama N, Kano MR, Morishita Y, Miyazono K, Itaka K, et al. Enhancement of angiogenesis through stabilization of hypoxia-inducible factor-1 by silencing prolyl hydroxylase domain-2 gene. Mol Ther 2008;16:1227-34.
-
(2008)
Mol Ther
, vol.16
, pp. 1227-1234
-
-
Wu, S.1
Nishiyama, N.2
Kano, M.R.3
Morishita, Y.4
Miyazono, K.5
Itaka, K.6
-
18
-
-
0036245628
-
U6 promoter-driven siRNAs with four uridine 3′ overhangs efficiently suppress targeted gene expression in mammalian cells
-
Miyagishi M, Taira K. U6 promoter-driven siRNAs with four uridine 3′ overhangs efficiently suppress targeted gene expression in mammalian cells. Nat Biotechnol 2002;20:497-500.
-
(2002)
Nat Biotechnol
, vol.20
, pp. 497-500
-
-
Miyagishi, M.1
Taira, K.2
-
19
-
-
1342342857
-
Strategies for generation of an siRNA expression library directed against the human genome
-
Miyagishi M, Taira K. Strategies for generation of an siRNA expression library directed against the human genome. Oligonucleotides 2003;13:325-33.
-
(2003)
Oligonucleotides
, vol.13
, pp. 325-333
-
-
Miyagishi, M.1
Taira, K.2
-
20
-
-
36048942316
-
Yin Yang 1 induces transcriptional activity of p73 through cooperation with E2F1
-
Wu S, Murai S, Kataoka K, Miyagishi M. Yin Yang 1 induces transcriptional activity of p73 through cooperation with E2F1. Biochem Biophys Res Commun 2008;365:75-81.
-
(2008)
Biochem Biophys Res Commun
, vol.365
, pp. 75-81
-
-
Wu, S.1
Murai, S.2
Kataoka, K.3
Miyagishi, M.4
-
21
-
-
0036359548
-
Hypoxia-a key regulatory factor in tumour growth
-
Harris AL. Hypoxia-a key regulatory factor in tumour growth. Nat Rev Cancer 2002;2:38-47.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 38-47
-
-
Harris, A.L.1
-
22
-
-
18844378923
-
Activation of hypoxia-induced transcription in normoxia
-
Hagg M, Wennstrom S. Activation of hypoxia-induced transcription in normoxia. Exp Cell Res 2005;306:180-91.
-
(2005)
Exp Cell Res
, vol.306
, pp. 180-191
-
-
Hagg, M.1
Wennstrom, S.2
-
23
-
-
78649364332
-
Hypoxia-inducible factors and the response to hypoxic stress
-
Majmundar AJ, Wong WJ, Simon MC. Hypoxia-inducible factors and the response to hypoxic stress. Mol Cell 2010;40:294-309.
-
(2010)
Mol Cell
, vol.40
, pp. 294-309
-
-
Majmundar, A.J.1
Wong, W.J.2
Simon, M.C.3
-
24
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;144:646-74.
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
25
-
-
79551542410
-
In vivo profiling of hypoxic gene expression in gliomas using the hypoxia marker EF5 and laser-capture microdissection
-
Marotta D, Karar J, Jenkins WT, Kumanova M, Jenkins KW, Tobias JW, et al. in vivo profiling of hypoxic gene expression in gliomas using the hypoxia marker EF5 and laser-capture microdissection. Cancer Res 2011;71:779-89.
-
(2011)
Cancer Res
, vol.71
, pp. 779-789
-
-
Marotta, D.1
Karar, J.2
Jenkins, W.T.3
Kumanova, M.4
Jenkins, K.W.5
Tobias, J.W.6
-
26
-
-
77952843621
-
In vivo dynamics and distinct functions of hypoxia in primary tumor growth and organotropic metastasis of breast cancer
-
Lu X, Yan CH, Yuan M, Wei Y, Hu G, Kang Y. in vivo dynamics and distinct functions of hypoxia in primary tumor growth and organotropic metastasis of breast cancer. Cancer Res 2010;70:3905-14.
-
(2010)
Cancer Res
, vol.70
, pp. 3905-3914
-
-
Lu, X.1
Yan, C.H.2
Yuan, M.3
Wei, Y.4
Hu, G.5
Kang, Y.6
-
27
-
-
33846652552
-
Hypoxia-inducible factor- 1alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression
-
Liao D, Corle C, Seagroves TN, Johnson RS. Hypoxia-inducible factor- 1alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression. Cancer Res 2007;67:563-72.
-
(2007)
Cancer Res
, vol.67
, pp. 563-572
-
-
Liao, D.1
Corle, C.2
Seagroves, T.N.3
Johnson, R.S.4
-
28
-
-
55549107180
-
Atypical CRM1-dependent nuclear export signal mediates regulation of hypoxia-inducible factor-1alpha by MAPK
-
Mylonis I, Chachami G, Paraskeva E, Simos G. Atypical CRM1-dependent nuclear export signal mediates regulation of hypoxia-inducible factor-1alpha by MAPK. J Biol Chem 2008;283:27620-7.
-
(2008)
J Biol Chem
, vol.283
, pp. 27620-27627
-
-
Mylonis, I.1
Chachami, G.2
Paraskeva, E.3
Simos, G.4
-
29
-
-
78649814934
-
Plk3 functions as an essential component of the hypoxia regulatory pathway by direct phosphorylation of HIF-1alpha
-
Xu D, Yao Y, Lu L, Costa M, Dai W. Plk3 functions as an essential component of the hypoxia regulatory pathway by direct phosphorylation of HIF-1alpha. J Biol Chem 2010;285:38944-50.
-
(2010)
J Biol Chem
, vol.285
, pp. 38944-38950
-
-
Xu, D.1
Yao, Y.2
Lu, L.3
Costa, M.4
Dai, W.5
-
30
-
-
35548935098
-
SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia
-
Cheng J, Kang X, Zhang S, Yeh ET. SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia. Cell 2007; 131:584-95.
-
(2007)
Cell
, vol.131
, pp. 584-595
-
-
Cheng, J.1
Kang, X.2
Zhang, S.3
Yeh, E.T.4
-
31
-
-
0036314978
-
Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein
-
Groulx I, Lee S. Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein. Mol Cell Biol 2002;22:5319-36.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 5319-5336
-
-
Groulx, I.1
Lee, S.2
-
32
-
-
79953147370
-
A perspective on cancer cell metastasis
-
Chaffer CL, Weinberg RA. A perspective on cancer cell metastasis. Science 2011;331:1559-64.
-
(2011)
Science
, vol.331
, pp. 1559-1564
-
-
Chaffer, C.L.1
Weinberg, R.A.2
-
33
-
-
77956282766
-
CXCR4/YY1 inhibition impairs VEGF network and angiogenesis during malignancy
-
de Nigris F, Crudele V, Giovane A, Casamassimi A, Giordano A, Garban HJ, et al. CXCR4/YY1 inhibition impairs VEGF network and angiogenesis during malignancy. Proc Natl Acad Sci U S A 2010;107:14484-9.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 14484-14489
-
-
De Nigris, F.1
Crudele, V.2
Giovane, A.3
Casamassimi, A.4
Giordano, A.5
Garban, H.J.6
-
34
-
-
33746123520
-
Direct transcriptional up-regulation of cyclooxygenase-2 by hypoxia-inducible factor (HIF)-1 promotes colorectal tumor cell survival and enhances HIF-1 transcriptional activity during hypoxia
-
Kaidi A, Qualtrough D, Williams AC, Paraskeva C. Direct transcriptional up-regulation of cyclooxygenase-2 by hypoxia-inducible factor (HIF)-1 promotes colorectal tumor cell survival and enhances HIF-1 transcriptional activity during hypoxia. Cancer Res 2006;66:6683-91.
-
(2006)
Cancer Res
, vol.66
, pp. 6683-6691
-
-
Kaidi, A.1
Qualtrough, D.2
Williams, A.C.3
Paraskeva, C.4
-
35
-
-
34548011229
-
Hypoxia enhances metastatic efficiency in HT1080 fibrosarcoma cells by increasing cell survival in lungs, not cell adhesion and invasion
-
Zhang L, Hill RP. Hypoxia enhances metastatic efficiency in HT1080 fibrosarcoma cells by increasing cell survival in lungs, not cell adhesion and invasion. Cancer Res 2007;67:7789-97.
-
(2007)
Cancer Res
, vol.67
, pp. 7789-7797
-
-
Zhang, L.1
Hill, R.P.2
-
36
-
-
0038481970
-
The pathogenesis of cancer metastasis: The 'seed and soil' hypothesis revisited
-
Fidler IJ. The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Nat Rev Cancer 2003;3:453-8.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 453-458
-
-
Fidler, I.J.1
-
37
-
-
63049104211
-
Microenvironmental regulation of metastasis
-
Joyce JA, Pollard JW. Microenvironmental regulation of metastasis. Nat Rev Cancer 2009;9:239-52.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 239-252
-
-
Joyce, J.A.1
Pollard, J.W.2
-
38
-
-
4344601100
-
YY1 inhibits the activation of the p53 tumor suppressor in response to genotoxic stress
-
Gronroos E, Terentiev AA, Punga T, Ericsson J. YY1 inhibits the activation of the p53 tumor suppressor in response to genotoxic stress. Proc Natl Acad Sci U S A 2004;101:12165-70.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 12165-12170
-
-
Gronroos, E.1
Terentiev, A.A.2
Punga, T.3
Ericsson, J.4
-
39
-
-
77950905821
-
P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis
-
Yamakuchi M, Lotterman CD, Bao C, Hruban RH, Karim B, Mendell JT, et al. P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis. Proc Natl Acad Sci U S A 2010;107: 6334-9.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 6334-6339
-
-
Yamakuchi, M.1
Lotterman, C.D.2
Bao, C.3
Hruban, R.H.4
Karim, B.5
Mendell, J.T.6
-
40
-
-
66249108601
-
Understanding the Warburg effect: The metabolic requirements of cell proliferation
-
Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009;324:1029-33.
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander Heiden, M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
41
-
-
79952280229
-
P53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase
-
Jiang P, Du W, Wang X, Mancuso A, Gao X, Wu M, et al. p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase. Nat Cell Biol 2011;13:310-6.
-
(2011)
Nat Cell Biol
, vol.13
, pp. 310-316
-
-
Jiang, P.1
Du, W.2
Wang, X.3
Mancuso, A.4
Gao, X.5
Wu, M.6
-
42
-
-
70349442548
-
The first 30 years of p53: Growing ever more complex
-
Levine AJ, Oren M. The first 30 years of p53: growing ever more complex. Nat Rev Cancer 2009;9:749-58.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 749-758
-
-
Levine, A.J.1
Oren, M.2
-
43
-
-
78650946588
-
The p53 pathway as a target in cancer therapeutics: Obstacles and promise
-
Mandinova A, Lee SW. The p53 pathway as a target in cancer therapeutics: obstacles and promise. Sci Transl Med 2011;3:64rv1.
-
(2011)
Sci Transl Med
, vol.3
-
-
Mandinova, A.1
Lee, S.W.2
-
44
-
-
0027333341
-
Yinyang 1 activates the c-myc promoter
-
Riggs KJ, Saleque S, Wong KK, Merrell KT, Lee JS, Shi Y, et al. Yinyang 1 activates the c-myc promoter. Mol Cell Biol 1993;13:7487-95.
-
(1993)
Mol Cell Biol
, vol.13
, pp. 7487-7495
-
-
Riggs, K.J.1
Saleque, S.2
Wong, K.K.3
Merrell, K.T.4
Lee, J.S.5
Shi, Y.6
-
45
-
-
47549117378
-
Loss of p53 induces epidermal growth factor receptor promoter activity in normal human keratinocytes
-
Bheda A, Creek KE, Pirisi L. Loss of p53 induces epidermal growth factor receptor promoter activity in normal human keratinocytes. Oncogene 2008;27:4315-23.
-
(2008)
Oncogene
, vol.27
, pp. 4315-4323
-
-
Bheda, A.1
Creek, K.E.2
Pirisi, L.3
-
46
-
-
84860238252
-
Yin Yang 1 plays an essential role in breast cancer and negatively regulates p27
-
Wan M, Huang W, Kute TE, Miller LD, Zhang Q, Hatcher H, et al. Yin Yang 1 plays an essential role in breast cancer and negatively regulates p27. Am J Pathol 2012;180:2120-33.
-
(2012)
Am J Pathol
, vol.180
, pp. 2120-2133
-
-
Wan, M.1
Huang, W.2
Kute, T.E.3
Miller, L.D.4
Zhang, Q.5
Hatcher, H.6
-
48
-
-
33750136313
-
Current state, achievements, and future prospects of polymeric micelles as nanocarriers for drug and gene delivery
-
Nishiyama N, Kataoka K. Current state, achievements, and future prospects of polymeric micelles as nanocarriers for drug and gene delivery. Pharmacol Ther 2006;112:630-48.
-
(2006)
Pharmacol Ther
, vol.112
, pp. 630-648
-
-
Nishiyama, N.1
Kataoka, K.2
|