Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function

Biochemistry

Volumn 49, Issue 24, 2010, Pages 5048-5056

  Dowling, Daniel P ^a   Gattis, Samuel G ^b   Fierke, Carol A ^b   Christianson, David W ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABSORPTION EDGES; ACTIVE SITE; AMINO ACID SEQUENCE; BIOLOGICAL FUNCTIONS; COFACTORS; DIFFERENCE-FOURIER MAP; HISTONE DEACETYLASES; HYDROXAMATE; IN-VIVO; LIVING CELL; METAL BINDING SITES; METAL CONCENTRATIONS; METAL CONTENT; METAL COORDINATION; METAL SPECIFICITY; METAL SUBSTITUTION; MICHAELIS COMPLEX; PROTEIN FOLDS; PROTEIN SAMPLES; RAT LIVERS; SOLUTION STUDY; X RAY CRYSTAL STRUCTURES; X-RAY DIFFRACTION DATA;

AMINO ACIDS; BINDING ENERGY; BINDING SITES; BIOCHEMISTRY; CATALYSTS; COBALT; COORDINATION REACTIONS; ELECTROMAGNETIC INDUCTION; ENZYMES; INDUCTIVELY COUPLED PLASMA; INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY; MANGANESE; MANGANESE COMPOUNDS; METAL IONS; ORGANIC ACIDS; PROTEIN FOLDING; STOICHIOMETRY; X RAY DIFFRACTION; ZINC;

METALS;

CARBON DIOXIDE; COBALT; COPPER; HISTONE DEACETYLASE 8; IRON; MANGANESE; NICKEL; ZINC;

ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME MECHANISM; ENZYME STRUCTURE; MASS SPECTROMETRY; METAL BINDING; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY; X RAY DIFFRACTION;

CATALYSIS; CATALYTIC DOMAIN; CATIONS, DIVALENT; COBALT; CRYSTALLOGRAPHY, X-RAY; FOURIER ANALYSIS; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; IRON; MANGANESE; MODELS, MOLECULAR; PROTEIN CONFORMATION; REPRESSOR PROTEINS;

RATTUS;

EID: 77953664293     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi1005046     Document Type: Article

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