Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux

Science

Volumn 327, Issue 5968, 2010, Pages 1004-1007

  Wang, Qijun ^a   Zhang, Yakun ^b   Yang, Chen ^c   Xiong, Hui ^a,b   Lin, Yan ^a   Yao, Jun ^a   Li, Hong ^c   Xie, Lu ^c   Zhao, Wei ^c   Yao, Yufeng ^d   Ning, Zhi Bin ^c   Zeng, Rong ^c   Xiong, Yue ^a,e   Guan, Kun Liang ^a,f   Zhao, Shimin ^a   Zhao, Guo Ping ^a,b,c,g  

^a FUDAN UNIVERSITY   (China)

^b CHINESE NATIONAL HUMAN GENOME CENTER AT SHANGHAI   (China)

^c INSTITUTE OF PLANT PHYSIOLOGY AND ECOLOGY   (China)

^d SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^e UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

GLYOXYLIC ACID; LYSINE;

BIOCHEMISTRY; CYTOLOGY; ENVIRONMENTAL CHANGE; ENZYME ACTIVITY; EUKARYOTE; METABOLISM; PHYSIOLOGY; PROTEIN; REACTION RATE;

ACETYLATION; ARTICLE; CARBON SOURCE; CELL ENERGY; CELL GROWTH; CHEMICAL REACTION; CITRIC ACID CYCLE; ENVIRONMENTAL CHANGE; ENZYME METABOLISM; GLUCONEOGENESIS; GLYCOLYSIS; MAMMAL; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; SALMONELLA ENTERICA;

ACETYLATION; ACETYLTRANSFERASES; AMINO ACID SEQUENCE; BACTERIAL PROTEINS; CITRIC ACID; ENERGY METABOLISM; ENZYMES; GENE EXPRESSION REGULATION, BACTERIAL; GLUCONEOGENESIS; GLUCOSE; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; GLYCOLYSIS; GROUP III HISTONE DEACETYLASES; ISOCITRATE LYASE; LYSINE; METABOLIC NETWORKS AND PATHWAYS; MULTIENZYME COMPLEXES; MUTATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT PROTEINS; SALMONELLA TYPHIMURIUM;

EUKARYOTA; MAMMALIA; PROKARYOTA; SALMONELLA;

EID: 77149120797     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1179687     Document Type: Article

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17. We thank members of Fudan Molecular Cell Biology laboratory for their inputs throughout this work. L. Wang of Nankai University, China, provided the S. Enterica G2466 for this study. This work is supported by state key development programs of basic research of China (2009CB918401 and 2006CB806700), national high technology research and development program of China (2006AA02A308), National Natural Science Foundation of China (30830002), and Shanghai key basic research project, China (08JC1400900).