MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation

EMBO Journal

Volumn 21, Issue 22, 2002, Pages 6236-6245

  Ito, Akihiro ^a   Kawaguchi, Yoshiharu ^a   Lai, Chun Hsiang ^a   Kovacs, Jeffrey J ^a   Higashimoto, Yuichiro ^b   Appella, Ettore ^b   Yao, Tso Pang ^a  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Acetylation; HDAC1; MDM2; p53; Ubiquitylation

Indexed keywords

HISTONE DEACETYLASE; LYSINE; PROTEIN MDM2; PROTEIN P53;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DEACETYLATION; DNA DAMAGE; FIBROBLAST; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN INDUCTION; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY;

3T3 CELLS; ACETYLATION; ACETYLTRANSFERASES; AMINO ACID SEQUENCE; ANIMALS; CELL CYCLE PROTEINS; CELLS, CULTURED; DNA; DNA DAMAGE; FIBROBLASTS; GENES, DOMINANT; HISTONE ACETYLTRANSFERASES; HISTONE DEACETYLASES; HUMANS; LYSINE; MACROMOLECULAR SUBSTANCES; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; RECOMBINANT FUSION PROTEINS; TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN;

EID: 0037112901     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdf616     Document Type: Article

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