-
1
-
-
0345107247
-
Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade
-
10.1186/1475-4924-2-28, 333410, 14511394
-
Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, Makela TP, Alessi DR, Hardie DG. Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade. J Biol 2003, 2:28. 10.1186/1475-4924-2-28, 333410, 14511394.
-
(2003)
J Biol
, vol.2
, pp. 28
-
-
Hawley, S.A.1
Boudeau, J.2
Reid, J.L.3
Mustard, K.J.4
Udd, L.5
Makela, T.P.6
Alessi, D.R.7
Hardie, D.G.8
-
2
-
-
10744230065
-
LKB1 is the upstream kinase in the AMP-activated protein kinase cascade
-
10.1016/j.cub.2003.10.031, 14614828
-
Woods A, Johnstone SR, Dickerson K, Leiper FC, Fryer LG, Neumann D, Schlattner U, Wallimann T, Carlson M, Carling D. LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr Biol 2003, 13:2004-2008. 10.1016/j.cub.2003.10.031, 14614828.
-
(2003)
Curr Biol
, vol.13
, pp. 2004-2008
-
-
Woods, A.1
Johnstone, S.R.2
Dickerson, K.3
Leiper, F.C.4
Fryer, L.G.5
Neumann, D.6
Schlattner, U.7
Wallimann, T.8
Carlson, M.9
Carling, D.10
-
3
-
-
1542618348
-
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
-
10.1073/pnas.0308061100, 373461, 14985505
-
Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci USA 2004, 101:3329-3335. 10.1073/pnas.0308061100, 373461, 14985505.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 3329-3335
-
-
Shaw, R.J.1
Kosmatka, M.2
Bardeesy, N.3
Hurley, R.L.4
Witters, L.A.5
DePinho, R.A.6
Cantley, L.C.7
-
5
-
-
66249108601
-
Understanding the Warburg effect: the metabolic requirements of cell proliferation
-
10.1126/science.1160809, 2849637, 19460998
-
Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009, 324:1029-1033. 10.1126/science.1160809, 2849637, 19460998.
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander Heiden, M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
6
-
-
0018963044
-
Regulation of rat liver acetyl-CoA carboxylase. Regulation of phosphorylation and inactivation of acetyl-CoA carboxylase by the adenylate energy charge
-
Yeh LA, Lee KH, Kim KH. Regulation of rat liver acetyl-CoA carboxylase. Regulation of phosphorylation and inactivation of acetyl-CoA carboxylase by the adenylate energy charge. J Biol Chem 1980, 255:2308-2314.
-
(1980)
J Biol Chem
, vol.255
, pp. 2308-2314
-
-
Yeh, L.A.1
Lee, K.H.2
Kim, K.H.3
-
7
-
-
0017847168
-
Reversible modulation of the activities of both liver microsomal hydroxymethylglutaryl Coenzyme A reductase and its inactivating enzyme. Evidence for regulation by phosphorylation-dephosphorylation
-
10.1016/0006-291X(78)91273-1, 666819
-
Ingebritsen TS, Lee H, Parker RA, Gibson DM. Reversible modulation of the activities of both liver microsomal hydroxymethylglutaryl Coenzyme A reductase and its inactivating enzyme. Evidence for regulation by phosphorylation-dephosphorylation. Biochem Biophys Res Comm 1978, 81:1268-1277. 10.1016/0006-291X(78)91273-1, 666819.
-
(1978)
Biochem Biophys Res Comm
, vol.81
, pp. 1268-1277
-
-
Ingebritsen, T.S.1
Lee, H.2
Parker, R.A.3
Gibson, D.M.4
-
8
-
-
0023642627
-
A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis
-
10.1016/0014-5793(87)80292-2, 2889619
-
Carling D, Zammit VA, Hardie DG. A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis. FEBS Lett 1987, 223:217-222. 10.1016/0014-5793(87)80292-2, 2889619.
-
(1987)
FEBS Lett
, vol.223
, pp. 217-222
-
-
Carling, D.1
Zammit, V.A.2
Hardie, D.G.3
-
9
-
-
0024546378
-
The AMP-activated protein kinase - a multisubstrate regulator of lipid metabolism
-
Hardie DG, Carling D, Sim ATR. The AMP-activated protein kinase - a multisubstrate regulator of lipid metabolism. Trends Biochem Sci 1989, 14:20-23.
-
(1989)
Trends Biochem Sci
, vol.14
, pp. 20-23
-
-
Hardie, D.G.1
Carling, D.2
Sim, A.T.R.3
-
10
-
-
0029978799
-
Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise
-
Winder WW, Hardie DG. Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise. Am J Physiol 1996, 270:E299-E304.
-
(1996)
Am J Physiol
, vol.270
-
-
Winder, W.W.1
Hardie, D.G.2
-
11
-
-
0031425839
-
AICAR decreases malonyl-CoA and increases fatty acid oxidation in skeletal muscle of the rat
-
Merrill GM, Kurth E, Hardie DG, Winder WW. AICAR decreases malonyl-CoA and increases fatty acid oxidation in skeletal muscle of the rat. Am J Physiol 1997, 273:E1107-E1112.
-
(1997)
Am J Physiol
, vol.273
-
-
Merrill, G.M.1
Kurth, E.2
Hardie, D.G.3
Winder, W.W.4
-
12
-
-
0032792665
-
The AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes
-
Winder WW, Hardie DG. The AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes. Am J Physiol 1999, 277:E1-E10.
-
(1999)
Am J Physiol
, vol.277
-
-
Winder, W.W.1
Hardie, D.G.2
-
13
-
-
0034773404
-
Role of AMP-activated protein kinase in mechanism of metformin action
-
209533, 11602624
-
Zhou G, Myers R, Li Y, Chen Y, Shen X, Fenyk-Melody J, Wu M, Ventre J, Doebber T, Fujii N, Musi N, Hirshman MF, Goodyear LJ, Moller DE. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 2001, 108:1167-1174. 209533, 11602624.
-
(2001)
J Clin Invest
, vol.108
, pp. 1167-1174
-
-
Zhou, G.1
Myers, R.2
Li, Y.3
Chen, Y.4
Shen, X.5
Fenyk-Melody, J.6
Wu, M.7
Ventre, J.8
Doebber, T.9
Fujii, N.10
Musi, N.11
Hirshman, M.F.12
Goodyear, L.J.13
Moller, D.E.14
-
14
-
-
77956410464
-
Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation
-
10.1016/j.cmet.2010.04.001, 2935965, 20519126
-
Hawley SA, Ross FA, Chevtzoff C, Green KA, Evans A, Fogarty S, Towler MC, Brown LJ, Ogunbayo OA, Evans AM, Hardie DG. Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation. Cell Metab 2010, 11:554-565. 10.1016/j.cmet.2010.04.001, 2935965, 20519126.
-
(2010)
Cell Metab
, vol.11
, pp. 554-565
-
-
Hawley, S.A.1
Ross, F.A.2
Chevtzoff, C.3
Green, K.A.4
Evans, A.5
Fogarty, S.6
Towler, M.C.7
Brown, L.J.8
Ogunbayo, O.A.9
Evans, A.M.10
Hardie, D.G.11
-
15
-
-
79954517977
-
Structure of mammalian AMPK and its regulation by ADP
-
10.1038/nature09932, 3078618, 21399626
-
Xiao B, Sanders MJ, Underwood E, Heath R, Mayer FV, Carmena D, Jing C, Walker PA, Eccleston JF, Haire LF, Saiu P, Howell SA, Aasland R, Martin SR, Carling D, Gamblin SJ. Structure of mammalian AMPK and its regulation by ADP. Nature 2011, 472:230-233. 10.1038/nature09932, 3078618, 21399626.
-
(2011)
Nature
, vol.472
, pp. 230-233
-
-
Xiao, B.1
Sanders, M.J.2
Underwood, E.3
Heath, R.4
Mayer, F.V.5
Carmena, D.6
Jing, C.7
Walker, P.A.8
Eccleston, J.F.9
Haire, L.F.10
Saiu, P.11
Howell, S.A.12
Aasland, R.13
Martin, S.R.14
Carling, D.15
Gamblin, S.J.16
-
16
-
-
34848840368
-
Structural basis for AMP binding to mammalian AMP-activated protein kinase
-
10.1038/nature06161, 17851531
-
Xiao B, Heath R, Saiu P, Leiper FC, Leone P, Jing C, Walker PA, Haire L, Eccleston JF, Davis CT, Martin SR, Carling D, Gamblin SJ. Structural basis for AMP binding to mammalian AMP-activated protein kinase. Nature 2007, 449:496-500. 10.1038/nature06161, 17851531.
-
(2007)
Nature
, vol.449
, pp. 496-500
-
-
Xiao, B.1
Heath, R.2
Saiu, P.3
Leiper, F.C.4
Leone, P.5
Jing, C.6
Walker, P.A.7
Haire, L.8
Eccleston, J.F.9
Davis, C.T.10
Martin, S.R.11
Carling, D.12
Gamblin, S.J.13
-
17
-
-
0029910018
-
Characterization of the AMP-activated protein kinase kinase from rat liver, and identification of threonine-172 as the major site at which it phosphorylates and activates AMP-activated protein kinase
-
10.1074/jbc.271.44.27879, 8910387
-
Hawley SA, Davison M, Woods A, Davies SP, Beri RK, Carling D, Hardie DG. Characterization of the AMP-activated protein kinase kinase from rat liver, and identification of threonine-172 as the major site at which it phosphorylates and activates AMP-activated protein kinase. J Biol Chem 1996, 271:27879-27887. 10.1074/jbc.271.44.27879, 8910387.
-
(1996)
J Biol Chem
, vol.271
, pp. 27879-27887
-
-
Hawley, S.A.1
Davison, M.2
Woods, A.3
Davies, S.P.4
Beri, R.K.5
Carling, D.6
Hardie, D.G.7
-
18
-
-
0028070457
-
Yeast SNF1 is functionally related to mammalian AMP-activated protein kinase and regulates acetyl-CoA carboxylase in vivo
-
Woods A, Munday MR, Scott J, Yang X, Carlson M, Carling D. Yeast SNF1 is functionally related to mammalian AMP-activated protein kinase and regulates acetyl-CoA carboxylase in vivo. J Biol Chem 1994, 269:19509-19515.
-
(1994)
J Biol Chem
, vol.269
, pp. 19509-19515
-
-
Woods, A.1
Munday, M.R.2
Scott, J.3
Yang, X.4
Carlson, M.5
Carling, D.6
-
19
-
-
0027932717
-
Mammalian AMP-activated protein kinase shares structural and functional homology with the catalytic domain of yeast Snf1 protein kinase
-
Mitchelhill KI, Stapleton D, Gao G, House C, Michell B, Katsis F, Witters LA, Kemp BE. Mammalian AMP-activated protein kinase shares structural and functional homology with the catalytic domain of yeast Snf1 protein kinase. J Biol Chem 1994, 269:2361-2364.
-
(1994)
J Biol Chem
, vol.269
, pp. 2361-2364
-
-
Mitchelhill, K.I.1
Stapleton, D.2
Gao, G.3
House, C.4
Michell, B.5
Katsis, F.6
Witters, L.A.7
Kemp, B.E.8
-
20
-
-
0038583957
-
Yeast Pak1 kinase associates with and activates Snf1
-
10.1128/MCB.23.11.3909-3917.2003, 155224, 12748292
-
Nath N, McCartney RR, Schmidt MC. Yeast Pak1 kinase associates with and activates Snf1. Mol Cell Biol 2003, 23:3909-3917. 10.1128/MCB.23.11.3909-3917.2003, 155224, 12748292.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 3909-3917
-
-
Nath, N.1
McCartney, R.R.2
Schmidt, M.C.3
-
21
-
-
0041700137
-
Elm1p is one of three upstream kinases for the Saccharomyces cerevisiae SNF1 complex
-
10.1016/S0960-9822(03)00459-7, 12906789
-
Sutherland CM, Hawley SA, McCartney RR, Leech A, Stark MJ, Schmidt MC, Hardie DG. Elm1p is one of three upstream kinases for the Saccharomyces cerevisiae SNF1 complex. Curr Biol 2003, 13:1299-1305. 10.1016/S0960-9822(03)00459-7, 12906789.
-
(2003)
Curr Biol
, vol.13
, pp. 1299-1305
-
-
Sutherland, C.M.1
Hawley, S.A.2
McCartney, R.R.3
Leech, A.4
Stark, M.J.5
Schmidt, M.C.6
Hardie, D.G.7
-
22
-
-
0041305909
-
Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases
-
10.1073/pnas.1533136100, 166400, 12847291
-
Hong SP, Leiper FC, Woods A, Carling D, Carlson M. Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases. Proc Natl Acad Sci USA 2003, 100:8839-8843. 10.1073/pnas.1533136100, 166400, 12847291.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 8839-8843
-
-
Hong, S.P.1
Leiper, F.C.2
Woods, A.3
Carling, D.4
Carlson, M.5
-
23
-
-
0032495530
-
A serine/threonine kinase gene defective in Peutz-Jeghers syndrome
-
10.1038/34432, 9428765
-
Hemminki A, Markie D, Tomlinson I, Avizienyte E, Roth S, Loukola A, Bignell G, Warren W, Aminoff M, Hoglund P, Jarvinen H, Kristo P, Pelin K, Ridanpaa M, Salovaara R, Toro T, Bodmer W, Olschwang S, Olsen AS, Stratton MR, de la Chapelle A, Aaltonen LA. A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. Nature 1998, 391:184-187. 10.1038/34432, 9428765.
-
(1998)
Nature
, vol.391
, pp. 184-187
-
-
Hemminki, A.1
Markie, D.2
Tomlinson, I.3
Avizienyte, E.4
Roth, S.5
Loukola, A.6
Bignell, G.7
Warren, W.8
Aminoff, M.9
Hoglund, P.10
Jarvinen, H.11
Kristo, P.12
Pelin, K.13
Ridanpaa, M.14
Salovaara, R.15
Toro, T.16
Bodmer, W.17
Olschwang, S.18
Olsen, A.S.19
Stratton, M.R.20
de la Chapelle, A.21
Aaltonen, L.A.22
more..
-
24
-
-
0031974516
-
Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase
-
10.1038/ng0198-38, 9425897
-
Jenne DE, Reimann H, Nezu J, Friedel W, Loff S, Jeschke R, Muller O, Back W, Zimmer M. Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. Nat Genet 1998, 18:38-43. 10.1038/ng0198-38, 9425897.
-
(1998)
Nat Genet
, vol.18
, pp. 38-43
-
-
Jenne, D.E.1
Reimann, H.2
Nezu, J.3
Friedel, W.4
Loff, S.5
Jeschke, R.6
Muller, O.7
Back, W.8
Zimmer, M.9
-
25
-
-
0038614742
-
Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD
-
10.1093/emboj/cdg292, 162144, 12805220
-
Baas AF, Boudeau J, Sapkota GP, Smit L, Medema R, Morrice NA, Alessi DR, Clevers HC. Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD. EMBO J 2003, 22:3062-3072. 10.1093/emboj/cdg292, 162144, 12805220.
-
(2003)
EMBO J
, vol.22
, pp. 3062-3072
-
-
Baas, A.F.1
Boudeau, J.2
Sapkota, G.P.3
Smit, L.4
Medema, R.5
Morrice, N.A.6
Alessi, D.R.7
Clevers, H.C.8
-
26
-
-
0141753981
-
MO25a/b interact with STRADa/b enhancing their ability to bind, activate and localize LKB1 in the cytoplasm
-
10.1093/emboj/cdg490, 204473, 14517248
-
Boudeau J, Baas AF, Deak M, Morrice NA, Kieloch A, Schutkowski M, Prescott AR, Clevers HC, Alessi DR. MO25a/b interact with STRADa/b enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. EMBO J 2003, 22:5102-5114. 10.1093/emboj/cdg490, 204473, 14517248.
-
(2003)
EMBO J
, vol.22
, pp. 5102-5114
-
-
Boudeau, J.1
Baas, A.F.2
Deak, M.3
Morrice, N.A.4
Kieloch, A.5
Schutkowski, M.6
Prescott, A.R.7
Clevers, H.C.8
Alessi, D.R.9
-
27
-
-
0028845251
-
5'-AMP activates the AMP-activated protein kinase cascade, and Ca2+/calmodulin the calmodulin-dependent protein kinase I cascade, via three independent mechanisms
-
10.1074/jbc.270.45.27186, 7592975
-
Hawley SA, Selbert MA, Goldstein EG, Edelman AM, Carling D, Hardie DG. 5'-AMP activates the AMP-activated protein kinase cascade, and Ca2+/calmodulin the calmodulin-dependent protein kinase I cascade, via three independent mechanisms. J Biol Chem 1995, 270:27186-27191. 10.1074/jbc.270.45.27186, 7592975.
-
(1995)
J Biol Chem
, vol.270
, pp. 27186-27191
-
-
Hawley, S.A.1
Selbert, M.A.2
Goldstein, E.G.3
Edelman, A.M.4
Carling, D.5
Hardie, D.G.6
-
28
-
-
0029561919
-
5'-AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP-activated protein kinase. Studies using bacterially expressed human protein phosphatase-2Cα and native bovine protein phosphatase-2AC
-
10.1016/0014-5793(95)01368-7, 8549768
-
Davies SP, Helps NR, Cohen PTW, Hardie DG. 5'-AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP-activated protein kinase. Studies using bacterially expressed human protein phosphatase-2Cα and native bovine protein phosphatase-2AC. FEBS Lett 1995, 377:421-425. 10.1016/0014-5793(95)01368-7, 8549768.
-
(1995)
FEBS Lett
, vol.377
, pp. 421-425
-
-
Davies, S.P.1
Helps, N.R.2
Cohen, P.T.W.3
Hardie, D.G.4
-
29
-
-
79959338922
-
AMPK is a direct adenylate charge-regulated protein kinase
-
10.1126/science.1200094, 21680840
-
Oakhill JS, Steel R, Chen ZP, Scott JW, Ling N, Tam S, Kemp BE. AMPK is a direct adenylate charge-regulated protein kinase. Science 2011, 332:1433-1435. 10.1126/science.1200094, 21680840.
-
(2011)
Science
, vol.332
, pp. 1433-1435
-
-
Oakhill, J.S.1
Steel, R.2
Chen, Z.P.3
Scott, J.W.4
Ling, N.5
Tam, S.6
Kemp, B.E.7
-
30
-
-
0031127305
-
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha
-
Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, Reese CB, Cohen P. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Current Biol 1997, 7:261-269.
-
(1997)
Current Biol
, vol.7
, pp. 261-269
-
-
Alessi, D.R.1
James, S.R.2
Downes, C.P.3
Holmes, A.B.4
Gaffney, P.R.5
Reese, C.B.6
Cohen, P.7
-
31
-
-
1342342993
-
PDK1, the master regulator of AGC kinase signal transduction
-
10.1016/j.semcdb.2003.12.022, 15209375
-
Mora A, Komander D, van Aalten DM, Alessi DR. PDK1, the master regulator of AGC kinase signal transduction. Semin Cell Dev Biol 2004, 15:161-170. 10.1016/j.semcdb.2003.12.022, 15209375.
-
(2004)
Semin Cell Dev Biol
, vol.15
, pp. 161-170
-
-
Mora, A.1
Komander, D.2
van Aalten, D.M.3
Alessi, D.R.4
-
32
-
-
0037032835
-
The protein kinase complement of the human genome
-
10.1126/science.1075762, 12471243
-
Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S. The protein kinase complement of the human genome. Science 2002, 298:1912-1934. 10.1126/science.1075762, 12471243.
-
(2002)
Science
, vol.298
, pp. 1912-1934
-
-
Manning, G.1
Whyte, D.B.2
Martinez, R.3
Hunter, T.4
Sudarsanam, S.5
-
33
-
-
12144287284
-
LKB1 is a master kinase that activates 13 protein kinases of the AMPK subfamily, including the MARK/PAR-1 kinases
-
10.1038/sj.emboj.7600110, 381014, 14976552
-
Lizcano JM, Göransson O, Toth R, Deak M, Morrice NA, Boudeau J, Hawley SA, Udd L, Mäkelä TP, Hardie DG, Alessi DR. LKB1 is a master kinase that activates 13 protein kinases of the AMPK subfamily, including the MARK/PAR-1 kinases. EMBO J 2004, 23:833-843. 10.1038/sj.emboj.7600110, 381014, 14976552.
-
(2004)
EMBO J
, vol.23
, pp. 833-843
-
-
Lizcano, J.M.1
Göransson, O.2
Toth, R.3
Deak, M.4
Morrice, N.A.5
Boudeau, J.6
Hawley, S.A.7
Udd, L.8
Mäkelä, T.P.9
Hardie, D.G.10
Alessi, D.R.11
-
34
-
-
14244251499
-
Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate
-
10.1016/j.febslet.2005.01.042, 15733851
-
Jaleel M, McBride A, Lizcano JM, Deak M, Toth R, Morrice NA, Alessi DR. Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate. FEBS Lett 2005, 579:1417-1423. 10.1016/j.febslet.2005.01.042, 15733851.
-
(2005)
FEBS Lett
, vol.579
, pp. 1417-1423
-
-
Jaleel, M.1
McBride, A.2
Lizcano, J.M.3
Deak, M.4
Toth, R.5
Morrice, N.A.6
Alessi, D.R.7
-
35
-
-
30544437191
-
14-3-3 cooperates with LKB1 to regulate the activity and localisation of QSK and SIK
-
Al-Hakim AK, Goransson O, Deak M, Toth R, Campbell DG, Morrice NA, Prescott AR, Alessi DR. 14-3-3 cooperates with LKB1 to regulate the activity and localisation of QSK and SIK. J Cell Sci 2005, 118:5561-5573.
-
(2005)
J Cell Sci
, vol.118
, pp. 5561-5573
-
-
Al-Hakim, A.K.1
Goransson, O.2
Deak, M.3
Toth, R.4
Campbell, D.G.5
Morrice, N.A.6
Prescott, A.R.7
Alessi, D.R.8
-
36
-
-
23044432463
-
Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase
-
10.1016/j.cmet.2005.05.009, 16054095
-
Hawley SA, Pan DA, Mustard KJ, Ross L, Bain J, Edelman AM, Frenguelli BG, Hardie DG. Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab 2005, 2:9-19. 10.1016/j.cmet.2005.05.009, 16054095.
-
(2005)
Cell Metab
, vol.2
, pp. 9-19
-
-
Hawley, S.A.1
Pan, D.A.2
Mustard, K.J.3
Ross, L.4
Bain, J.5
Edelman, A.M.6
Frenguelli, B.G.7
Hardie, D.G.8
-
37
-
-
23044437445
-
Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells
-
10.1016/j.cmet.2005.06.005, 16054096
-
Woods A, Dickerson K, Heath R, Hong SP, Momcilovic M, Johnstone SR, Carlson M, Carling D. Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells. Cell Metab 2005, 2:21-33. 10.1016/j.cmet.2005.06.005, 16054096.
-
(2005)
Cell Metab
, vol.2
, pp. 21-33
-
-
Woods, A.1
Dickerson, K.2
Heath, R.3
Hong, S.P.4
Momcilovic, M.5
Johnstone, S.R.6
Carlson, M.7
Carling, D.8
-
38
-
-
23844471263
-
The Ca2+/calmoldulin-dependent protein kinase kinases are AMP-activated protein kinase kinases
-
10.1074/jbc.M503824200, 15980064
-
Hurley RL, Anderson KA, Franzone JM, Kemp BE, Means AR, Witters LA. The Ca2+/calmoldulin-dependent protein kinase kinases are AMP-activated protein kinase kinases. J Biol Chem 2005, 280:29060-29066. 10.1074/jbc.M503824200, 15980064.
-
(2005)
J Biol Chem
, vol.280
, pp. 29060-29066
-
-
Hurley, R.L.1
Anderson, K.A.2
Franzone, J.M.3
Kemp, B.E.4
Means, A.R.5
Witters, L.A.6
-
39
-
-
33745823168
-
Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes
-
10.1084/jem.20052469, 2118355, 16818670
-
Tamas P, Hawley SA, Clarke RG, Mustard KJ, Green K, Hardie DG, Cantrell DA. Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes. J Exp Med 2006, 203:1665-1670. 10.1084/jem.20052469, 2118355, 16818670.
-
(2006)
J Exp Med
, vol.203
, pp. 1665-1670
-
-
Tamas, P.1
Hawley, S.A.2
Clarke, R.G.3
Mustard, K.J.4
Green, K.5
Hardie, D.G.6
Cantrell, D.A.7
-
40
-
-
33746979242
-
Thrombin activates AMP-activated protein kinase in endothelial cells via a pathway involving Ca2+/calmodulin-dependent protein kinase kinase beta
-
10.1128/MCB.00383-06, 1592798, 16880506
-
Stahmann N, Woods A, Carling D, Heller R. Thrombin activates AMP-activated protein kinase in endothelial cells via a pathway involving Ca2+/calmodulin-dependent protein kinase kinase beta. Mol Cell Biol 2006, 26:5933-5945. 10.1128/MCB.00383-06, 1592798, 16880506.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 5933-5945
-
-
Stahmann, N.1
Woods, A.2
Carling, D.3
Heller, R.4
-
41
-
-
1842582870
-
AMP-activated protein kinase plays a role in the control of food intake
-
Andersson U, Filipsson K, Abbott CR, Woods A, Smith K, Bloom SR, Carling D, Small CJ. AMP-activated protein kinase plays a role in the control of food intake. J Biol Chem 2004, 279:12005-12008.
-
(2004)
J Biol Chem
, vol.279
, pp. 12005-12008
-
-
Andersson, U.1
Filipsson, K.2
Abbott, C.R.3
Woods, A.4
Smith, K.5
Bloom, S.R.6
Carling, D.7
Small, C.J.8
-
42
-
-
80052922112
-
Hunger states switch a flip-flop memory circuit via a synaptic AMPK-dependent positive feedback loop
-
10.1016/j.cell.2011.07.039, 3209501, 21925320
-
Yang Y, Atasoy D, Su HH, Sternson SM. Hunger states switch a flip-flop memory circuit via a synaptic AMPK-dependent positive feedback loop. Cell 2011, 146:992-1003. 10.1016/j.cell.2011.07.039, 3209501, 21925320.
-
(2011)
Cell
, vol.146
, pp. 992-1003
-
-
Yang, Y.1
Atasoy, D.2
Su, H.H.3
Sternson, S.M.4
-
43
-
-
76549089547
-
Calmodulin-dependent protein kinase kinase-beta activates AMPK without forming a stable complex - synergistic effects of Ca2+ and AMP
-
10.1042/BJ20091372, 2830670, 19958286
-
Fogarty S, Hawley SA, Green KA, Saner N, Mustard KJ, Hardie DG. Calmodulin-dependent protein kinase kinase-beta activates AMPK without forming a stable complex - synergistic effects of Ca2+ and AMP. Biochem J 2010, 426:109-118. 10.1042/BJ20091372, 2830670, 19958286.
-
(2010)
Biochem J
, vol.426
, pp. 109-118
-
-
Fogarty, S.1
Hawley, S.A.2
Green, K.A.3
Saner, N.4
Mustard, K.J.5
Hardie, D.G.6
-
44
-
-
20044370885
-
Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction
-
10.1038/sj.emboj.7600667, 1142598, 15889149
-
Sakamoto K, McCarthy A, Smith D, Green KA, Hardie DG, Ashworth A, Alessi DR. Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction. EMBO J 2005, 24:1810-1820. 10.1038/sj.emboj.7600667, 1142598, 15889149.
-
(2005)
EMBO J
, vol.24
, pp. 1810-1820
-
-
Sakamoto, K.1
McCarthy, A.2
Smith, D.3
Green, K.A.4
Hardie, D.G.5
Ashworth, A.6
Alessi, D.R.7
-
45
-
-
80053163909
-
AMP-activated protein kinase (AMPK) {beta}1{beta}2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise
-
10.1073/pnas.1105062108, 3179037, 21896769
-
O'Neill HM, Maarbjerg SJ, Crane JD, Jeppesen J, Jorgensen SB, Schertzer JD, Shyroka O, Kiens B, van Denderen BJ, Tarnopolsky MA, Kemp BE, Richter EA, Steinberg GR. AMP-activated protein kinase (AMPK) {beta}1{beta}2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise. Proc Natl Acad Sci USA 2011, 108:16092-16097. 10.1073/pnas.1105062108, 3179037, 21896769.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 16092-16097
-
-
O'Neill, H.M.1
Maarbjerg, S.J.2
Crane, J.D.3
Jeppesen, J.4
Jorgensen, S.B.5
Schertzer, J.D.6
Shyroka, O.7
Kiens, B.8
van Denderen, B.J.9
Tarnopolsky, M.A.10
Kemp, B.E.11
Richter, E.A.12
Steinberg, G.R.13
-
46
-
-
27144506185
-
The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism
-
10.1038/nature03967, 16148943
-
Koo SH, Flechner L, Qi L, Zhang X, Screaton RA, Jeffries S, Hedrick S, Xu W, Boussouar F, Brindle P, Takemori H, Montminy M. The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Nature 2005, 437:1109-1114. 10.1038/nature03967, 16148943.
-
(2005)
Nature
, vol.437
, pp. 1109-1114
-
-
Koo, S.H.1
Flechner, L.2
Qi, L.3
Zhang, X.4
Screaton, R.A.5
Jeffries, S.6
Hedrick, S.7
Xu, W.8
Boussouar, F.9
Brindle, P.10
Takemori, H.11
Montminy, M.12
-
47
-
-
0345714892
-
At the crossroads: AMP-activated kinase and the LKB1 tumor suppressor link cell proliferation to metabolic regulation
-
10.1186/1475-4924-2-26, 333408, 14575531
-
Kyriakis JM. At the crossroads: AMP-activated kinase and the LKB1 tumor suppressor link cell proliferation to metabolic regulation. J Biol 2003, 2:26. 10.1186/1475-4924-2-26, 333408, 14575531.
-
(2003)
J Biol
, vol.2
, pp. 26
-
-
Kyriakis, J.M.1
-
48
-
-
0037026608
-
Critical roles of AMP-activated protein kinase in constitutive tolerance of cancer cells to nutrient deprivation and tumor formation
-
10.1038/sj.onc.1205737, 12203120
-
Kato K, Ogura T, Kishimoto A, Minegishi Y, Nakajima N, Miyazaki M, Esumi H. Critical roles of AMP-activated protein kinase in constitutive tolerance of cancer cells to nutrient deprivation and tumor formation. Oncogene 2002, 21:6082-6090. 10.1038/sj.onc.1205737, 12203120.
-
(2002)
Oncogene
, vol.21
, pp. 6082-6090
-
-
Kato, K.1
Ogura, T.2
Kishimoto, A.3
Minegishi, Y.4
Nakajima, N.5
Miyazaki, M.6
Esumi, H.7
-
49
-
-
0035929359
-
Cell cycle regulation via p53 phosphorylation by a 5'-AMP activated protein kinase activator, 5-aminoimidazole- 4-carboxamide-1-beta-d- ribofuranoside, in a human hepatocellular carcinoma cell line
-
10.1006/bbrc.2001.5627, 11554766
-
Imamura K, Ogura T, Kishimoto A, Kaminishi M, Esumi H. Cell cycle regulation via p53 phosphorylation by a 5'-AMP activated protein kinase activator, 5-aminoimidazole- 4-carboxamide-1-beta-d- ribofuranoside, in a human hepatocellular carcinoma cell line. Biochem Biophys Res Commun 2001, 287:562-567. 10.1006/bbrc.2001.5627, 11554766.
-
(2001)
Biochem Biophys Res Commun
, vol.287
, pp. 562-567
-
-
Imamura, K.1
Ogura, T.2
Kishimoto, A.3
Kaminishi, M.4
Esumi, H.5
-
50
-
-
84872159532
-
AMPK is a negative regulator of the Warburg effect and suppresses tumor growth In vivo
-
Faubert B, Boily G, Izreig S, Griss T, Samborska B, Dong Z, Dupuy F, Chambers C, Fuerth BJ, Viollet B, Mamer OA, Avizonis D, Deberardinis RJ, Siegel PM, Jones RG. AMPK is a negative regulator of the Warburg effect and suppresses tumor growth In vivo. Cell Metab 2012, 17:113-124.
-
(2012)
Cell Metab
, vol.17
, pp. 113-124
-
-
Faubert, B.1
Boily, G.2
Izreig, S.3
Griss, T.4
Samborska, B.5
Dong, Z.6
Dupuy, F.7
Chambers, C.8
Fuerth, B.J.9
Viollet, B.10
Mamer, O.A.11
Avizonis, D.12
Deberardinis, R.J.13
Siegel, P.M.14
Jones, R.G.15
-
51
-
-
20844449238
-
AMP-activated protein kinase induces a p53-dependent metabolic checkpoint
-
10.1016/j.molcel.2005.03.027, 15866171
-
Jones RG, Plas DR, Kubek S, Buzzai M, Mu J, Xu Y, Birnbaum MJ, Thompson CB. AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol Cell 2005, 18:283-293. 10.1016/j.molcel.2005.03.027, 15866171.
-
(2005)
Mol Cell
, vol.18
, pp. 283-293
-
-
Jones, R.G.1
Plas, D.R.2
Kubek, S.3
Buzzai, M.4
Mu, J.5
Xu, Y.6
Birnbaum, M.J.7
Thompson, C.B.8
-
52
-
-
33947250696
-
The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis
-
10.1038/ncb1537, 17237771
-
Liang J, Shao SH, Xu ZX, Hennessy B, Ding Z, Larrea M, Kondo S, Dumont DJ, Gutterman JU, Walker CL, Slingerland JM, Mills GB. The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis. Nat Cell Biol 2007, 9:218-224. 10.1038/ncb1537, 17237771.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 218-224
-
-
Liang, J.1
Shao, S.H.2
Xu, Z.X.3
Hennessy, B.4
Ding, Z.5
Larrea, M.6
Kondo, S.7
Dumont, D.J.8
Gutterman, J.U.9
Walker, C.L.10
Slingerland, J.M.11
Mills, G.B.12
-
53
-
-
34648828532
-
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy
-
10.1038/nrm2249, 17712357
-
Hardie DG. AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nat Rev Mol Cell Biol 2007, 8:774-785. 10.1038/nrm2249, 17712357.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 774-785
-
-
Hardie, D.G.1
-
54
-
-
84858782079
-
AMPK: a nutrient and energy sensor that maintains energy homeostasis
-
10.1038/nrm3311, 22436748
-
Hardie DG, Ross FA, Hawley SA. AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol 2012, 13:251-262. 10.1038/nrm3311, 22436748.
-
(2012)
Nat Rev Mol Cell Biol
, vol.13
, pp. 251-262
-
-
Hardie, D.G.1
Ross, F.A.2
Hawley, S.A.3
-
55
-
-
0345167800
-
TSC2 mediates cellular energy response to control cell growth and survival
-
10.1016/S0092-8674(03)00929-2, 14651849
-
Inoki K, Zhu T, Guan KL. TSC2 mediates cellular energy response to control cell growth and survival. Cell 2003, 115:577-590. 10.1016/S0092-8674(03)00929-2, 14651849.
-
(2003)
Cell
, vol.115
, pp. 577-590
-
-
Inoki, K.1
Zhu, T.2
Guan, K.L.3
-
56
-
-
42949139481
-
AMPK phosphorylation of raptor mediates a metabolic checkpoint
-
10.1016/j.molcel.2008.03.003, 2674027, 18439900
-
Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, Mery A, Vasquez DS, Turk BE, Shaw RJ. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell 2008, 30:214-226. 10.1016/j.molcel.2008.03.003, 2674027, 18439900.
-
(2008)
Mol Cell
, vol.30
, pp. 214-226
-
-
Gwinn, D.M.1
Shackelford, D.B.2
Egan, D.F.3
Mihaylova, M.M.4
Mery, A.5
Vasquez, D.S.6
Turk, B.E.7
Shaw, R.J.8
-
57
-
-
0036591972
-
Activation of GLUT1 by metabolic and osmotic stress: potential involvement of AMP-activated protein kinase (AMPK)
-
Barnes K, Ingram JC, Porras OH, Barros LF, Hudson ER, Fryer LG, Foufelle F, Carling D, Hardie DG, Baldwin SA. Activation of GLUT1 by metabolic and osmotic stress: potential involvement of AMP-activated protein kinase (AMPK). J Cell Sci 2002, 115:2433-2442.
-
(2002)
J Cell Sci
, vol.115
, pp. 2433-2442
-
-
Barnes, K.1
Ingram, J.C.2
Porras, O.H.3
Barros, L.F.4
Hudson, E.R.5
Fryer, L.G.6
Foufelle, F.7
Carling, D.8
Hardie, D.G.9
Baldwin, S.A.10
-
58
-
-
0037163076
-
The stimulation of glycolysis by hypoxia in activated monocytes is mediated by AMP-activated protein kinase and inducible 6-phosphofructo-2-kinase
-
10.1074/jbc.M205213200, 12065600
-
Marsin AS, Bouzin C, Bertrand L, Hue L. The stimulation of glycolysis by hypoxia in activated monocytes is mediated by AMP-activated protein kinase and inducible 6-phosphofructo-2-kinase. J Biol Chem 2002, 277:30778-30783. 10.1074/jbc.M205213200, 12065600.
-
(2002)
J Biol Chem
, vol.277
, pp. 30778-30783
-
-
Marsin, A.S.1
Bouzin, C.2
Bertrand, L.3
Hue, L.4
-
59
-
-
0034687210
-
Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia
-
Marsin AS, Bertrand L, Rider MH, Deprez J, Beauloye C, Vincent MF, Van den Berghe G, Carling D, Hue L. Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia. Current Biol 2000, 10:1247-1255.
-
(2000)
Current Biol
, vol.10
, pp. 1247-1255
-
-
Marsin, A.S.1
Bertrand, L.2
Rider, M.H.3
Deprez, J.4
Beauloye, C.5
Vincent, M.F.6
Van den Berghe, G.7
Carling, D.8
Hue, L.9
-
60
-
-
67349276169
-
AMPK regulates energy expenditure by modulating NAD(+) metabolism and SIRT1 activity
-
10.1038/nature07813, 3616311, 19262508
-
Canto C, Gerhart-Hines Z, Feige JN, Lagouge M, Noriega L, Milne JC, Elliott PJ, Puigserver P, Auwerx J. AMPK regulates energy expenditure by modulating NAD(+) metabolism and SIRT1 activity. Nature 2009, 458:1056-1060. 10.1038/nature07813, 3616311, 19262508.
-
(2009)
Nature
, vol.458
, pp. 1056-1060
-
-
Canto, C.1
Gerhart-Hines, Z.2
Feige, J.N.3
Lagouge, M.4
Noriega, L.5
Milne, J.C.6
Elliott, P.J.7
Puigserver, P.8
Auwerx, J.9
-
61
-
-
0033949848
-
Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle
-
Winder WW, Holmes BF, Rubink DS, Jensen EB, Chen M, Holloszy JO. Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle. J Appl Physiol 2000, 88:2219-2226.
-
(2000)
J Appl Physiol
, vol.88
, pp. 2219-2226
-
-
Winder, W.W.1
Holmes, B.F.2
Rubink, D.S.3
Jensen, E.B.4
Chen, M.5
Holloszy, J.O.6
-
62
-
-
30044432434
-
Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer
-
10.1038/nm1337, 16341243
-
Thomas GV, Tran C, Mellinghoff IK, Welsbie DS, Chan E, Fueger B, Czernin J, Sawyers CL. Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer. Nat Med 2006, 12:122-127. 10.1038/nm1337, 16341243.
-
(2006)
Nat Med
, vol.12
, pp. 122-127
-
-
Thomas, G.V.1
Tran, C.2
Mellinghoff, I.K.3
Welsbie, D.S.4
Chan, E.5
Fueger, B.6
Czernin, J.7
Sawyers, C.L.8
-
63
-
-
67650480092
-
MTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome
-
10.1073/pnas.0900465106, 2708689, 19541609
-
Shackelford DB, Vasquez DS, Corbeil J, Wu S, Leblanc M, Wu CL, Vera DR, Shaw RJ. mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome. Proc Natl Acad Sci USA 2009, 106:11137-11142. 10.1073/pnas.0900465106, 2708689, 19541609.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 11137-11142
-
-
Shackelford, D.B.1
Vasquez, D.S.2
Corbeil, J.3
Wu, S.4
Leblanc, M.5
Wu, C.L.6
Vera, D.R.7
Shaw, R.J.8
-
64
-
-
0036645286
-
Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung
-
Sanchez-Cespedes M, Parrella P, Esteller M, Nomoto S, Trink B, Engles JM, Westra WH, Herman JG, Sidransky D. Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung. Cancer Res 2002, 62:3659-3662.
-
(2002)
Cancer Res
, vol.62
, pp. 3659-3662
-
-
Sanchez-Cespedes, M.1
Parrella, P.2
Esteller, M.3
Nomoto, S.4
Trink, B.5
Engles, J.M.6
Westra, W.H.7
Herman, J.G.8
Sidransky, D.9
-
65
-
-
34547926839
-
LKB1 modulates lung cancer differentiation and metastasis
-
10.1038/nature06030, 17676035
-
Ji H, Ramsey MR, Hayes DN, Fan C, McNamara K, Kozlowski P, Torrice C, Wu MC, Shimamura T, Perera SA, Liang MC, Cai D, Naumov GN, Bao L, Contreras CM, Li D, Chen L, Krishnamurthy J, Koivunen J, Chirieac LR, Padera RF, Bronson RT, Lindeman NI, Christiani DC, Lin X, Shapiro GI, Janne PA, Johnson BE, Meyerson M, Kwiatkowski DJ, Castrillon DH, Bardeesy N, Sharpless NE, Wong KK. LKB1 modulates lung cancer differentiation and metastasis. Nature 2007, 448:807-810. 10.1038/nature06030, 17676035.
-
(2007)
Nature
, vol.448
, pp. 807-810
-
-
Ji, H.1
Ramsey, M.R.2
Hayes, D.N.3
Fan, C.4
McNamara, K.5
Kozlowski, P.6
Torrice, C.7
Wu, M.C.8
Shimamura, T.9
Perera, S.A.10
Liang, M.C.11
Cai, D.12
Naumov, G.N.13
Bao, L.14
Contreras, C.M.15
Li, D.16
Chen, L.17
Krishnamurthy, J.18
Koivunen, J.19
Chirieac, L.R.20
Padera, R.F.21
Bronson, R.T.22
Lindeman, N.I.23
Christiani, D.C.24
Lin, X.25
Shapiro, G.I.26
Janne, P.A.27
Johnson, B.E.28
Meyerson, M.29
Kwiatkowski, D.J.30
Castrillon, D.H.31
Bardeesy, N.32
Sharpless, N.E.33
Wong, K.K.34
more..
-
66
-
-
64549113040
-
Somatic LKB1 mutations promote cervical cancer progression
-
10.1371/journal.pone.0005137, 2660434, 19340305
-
Wingo SN, Gallardo TD, Akbay EA, Liang MC, Contreras CM, Boren T, Shimamura T, Miller DS, Sharpless NE, Bardeesy N, Kwiatkowski DJ, Schorge JO, Wong KK, Castrillon DH. Somatic LKB1 mutations promote cervical cancer progression. PLoS ONE 2009, 4:e5137. 10.1371/journal.pone.0005137, 2660434, 19340305.
-
(2009)
PLoS ONE
, vol.4
-
-
Wingo, S.N.1
Gallardo, T.D.2
Akbay, E.A.3
Liang, M.C.4
Contreras, C.M.5
Boren, T.6
Shimamura, T.7
Miller, D.S.8
Sharpless, N.E.9
Bardeesy, N.10
Kwiatkowski, D.J.11
Schorge, J.O.12
Wong, K.K.13
Castrillon, D.H.14
-
67
-
-
84862119127
-
LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma
-
10.1016/j.ccr.2012.03.048, 22698401
-
Liu W, Monahan KB, Pfefferle AD, Shimamura T, Sorrentino J, Chan KT, Roadcap DW, Ollila DW, Thomas NE, Castrillon DH, Miller CR, Perou CM, Wong KK, Bear JE, Sharpless NE. LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma. Cancer Cell 2012, 21:751-764. 10.1016/j.ccr.2012.03.048, 22698401.
-
(2012)
Cancer Cell
, vol.21
, pp. 751-764
-
-
Liu, W.1
Monahan, K.B.2
Pfefferle, A.D.3
Shimamura, T.4
Sorrentino, J.5
Chan, K.T.6
Roadcap, D.W.7
Ollila, D.W.8
Thomas, N.E.9
Castrillon, D.H.10
Miller, C.R.11
Perou, C.M.12
Wong, K.K.13
Bear, J.E.14
Sharpless, N.E.15
-
68
-
-
84865793242
-
AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells
-
10.1158/0008-5472.CAN-12-0429, 3433393, 22728651
-
Lee CW, Wong LL, Tse EY, Liu HF, Leong VY, Lee JM, Hardie DG, Ng IO, Ching YP. AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells. Cancer Res 2012, 72:4394-4404. 10.1158/0008-5472.CAN-12-0429, 3433393, 22728651.
-
(2012)
Cancer Res
, vol.72
, pp. 4394-4404
-
-
Lee, C.W.1
Wong, L.L.2
Tse, E.Y.3
Liu, H.F.4
Leong, V.Y.5
Lee, J.M.6
Hardie, D.G.7
Ng, I.O.8
Ching, Y.P.9
-
69
-
-
58649110598
-
Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation
-
10.1016/j.molcel.2008.12.026, 2715556, 19187764
-
Zheng B, Jeong JH, Asara JM, Yuan YY, Granter SR, Chin L, Cantley LC. Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation. Mol Cell 2009, 33:237-247. 10.1016/j.molcel.2008.12.026, 2715556, 19187764.
-
(2009)
Mol Cell
, vol.33
, pp. 237-247
-
-
Zheng, B.1
Jeong, J.H.2
Asara, J.M.3
Yuan, Y.Y.4
Granter, S.R.5
Chin, L.6
Cantley, L.C.7
-
70
-
-
33646828975
-
Insulin antagonizes ischemia-induced Thr172 phosphorylation of AMP-activated protein kinase alpha-subunits in heart via hierarchical phosphorylation of Ser485/491
-
Horman S, Vertommen D, Heath R, Neumann D, Mouton V, Woods A, Schlattner U, Wallimann T, Carling D, Hue L, Rider MH. Insulin antagonizes ischemia-induced Thr172 phosphorylation of AMP-activated protein kinase alpha-subunits in heart via hierarchical phosphorylation of Ser485/491. J Biol Chem 2006, 281:5335-5340.
-
(2006)
J Biol Chem
, vol.281
, pp. 5335-5340
-
-
Horman, S.1
Vertommen, D.2
Heath, R.3
Neumann, D.4
Mouton, V.5
Woods, A.6
Schlattner, U.7
Wallimann, T.8
Carling, D.9
Hue, L.10
Rider, M.H.11
-
71
-
-
51849111556
-
PI3K pathway alterations in cancer: variations on a theme
-
10.1038/onc.2008.245, 3398461, 18794884
-
Yuan TL, Cantley LC. PI3K pathway alterations in cancer: variations on a theme. Oncogene 2008, 27:5497-5510. 10.1038/onc.2008.245, 3398461, 18794884.
-
(2008)
Oncogene
, vol.27
, pp. 5497-5510
-
-
Yuan, T.L.1
Cantley, L.C.2
-
72
-
-
1842478144
-
The hepatitis C virus NS5A protein activates a phosphoinositide 3-kinase-dependent survival signaling cascade
-
Street A, Macdonald A, Crowder K, Harris M. The hepatitis C virus NS5A protein activates a phosphoinositide 3-kinase-dependent survival signaling cascade. J Biol Chem 2004, 279:12232-12241.
-
(2004)
J Biol Chem
, vol.279
, pp. 12232-12241
-
-
Street, A.1
Macdonald, A.2
Crowder, K.3
Harris, M.4
-
73
-
-
77954902957
-
Enhanced hepatitis C virus genome replication and lipid accumulation mediated by inhibition of AMP-activated protein kinase
-
10.1073/pnas.0912426107, 2895084, 20534540
-
Mankouri J, Tedbury PR, Gretton S, Hughes ME, Griffin SD, Dallas ML, Green KA, Hardie DG, Peers C, Harris M. Enhanced hepatitis C virus genome replication and lipid accumulation mediated by inhibition of AMP-activated protein kinase. Proc Natl Acad Sci USA 2010, 107:11549-11554. 10.1073/pnas.0912426107, 2895084, 20534540.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 11549-11554
-
-
Mankouri, J.1
Tedbury, P.R.2
Gretton, S.3
Hughes, M.E.4
Griffin, S.D.5
Dallas, M.L.6
Green, K.A.7
Hardie, D.G.8
Peers, C.9
Harris, M.10
-
74
-
-
20444461067
-
Metformin and reduced risk of cancer in diabetic patients
-
10.1136/bmj.38415.708634.F7, 558205, 15849206
-
Evans JM, Donnelly LA, Emslie-Smith AM, Alessi DR, Morris AD. Metformin and reduced risk of cancer in diabetic patients. BMJ 2005, 330:1304-1305. 10.1136/bmj.38415.708634.F7, 558205, 15849206.
-
(2005)
BMJ
, vol.330
, pp. 1304-1305
-
-
Evans, J.M.1
Donnelly, L.A.2
Emslie-Smith, A.M.3
Alessi, D.R.4
Morris, A.D.5
-
75
-
-
78649302320
-
Metformin and cancer risk in diabetic patients: a systematic review and meta-analysis
-
Decensi A, Puntoni M, Goodwin P, Cazzaniga M, Gennari A, Bonanni B, Gandini S. Metformin and cancer risk in diabetic patients: a systematic review and meta-analysis. Cancer Prev Res (Phila) 2010, 3:1451-1461.
-
(2010)
Cancer Prev Res (Phila)
, vol.3
, pp. 1451-1461
-
-
Decensi, A.1
Puntoni, M.2
Goodwin, P.3
Cazzaniga, M.4
Gennari, A.5
Bonanni, B.6
Gandini, S.7
-
76
-
-
84869788946
-
Metformin and the risk of cancer: time-related biases in observational studies
-
10.2337/dc12-0788, 23173135
-
Suissa S, Azoulay L. Metformin and the risk of cancer: time-related biases in observational studies. Diabetes Care 2012, 35:2665-2673. 10.2337/dc12-0788, 23173135.
-
(2012)
Diabetes Care
, vol.35
, pp. 2665-2673
-
-
Suissa, S.1
Azoulay, L.2
-
77
-
-
84857640868
-
The insulin and insulin-like growth factor receptor family in neoplasia: an update
-
Pollak M. The insulin and insulin-like growth factor receptor family in neoplasia: an update. Nat Rev Cancer 2012, 12:159-169.
-
(2012)
Nat Rev Cancer
, vol.12
, pp. 159-169
-
-
Pollak, M.1
-
78
-
-
79952538201
-
Diet and tumor LKB1 expression interact to determine sensitivity to anti-neoplastic effects of metformin in vivo
-
10.1038/onc.2010.483, 21102522
-
Algire C, Amrein L, Bazile M, David S, Zakikhani M, Pollak M. Diet and tumor LKB1 expression interact to determine sensitivity to anti-neoplastic effects of metformin in vivo. Oncogene 2011, 30:1174-1182. 10.1038/onc.2010.483, 21102522.
-
(2011)
Oncogene
, vol.30
, pp. 1174-1182
-
-
Algire, C.1
Amrein, L.2
Bazile, M.3
David, S.4
Zakikhani, M.5
Pollak, M.6
-
79
-
-
44449103256
-
Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice
-
10.1042/BJ20080557, 18387000
-
Huang X, Wullschleger S, Shpiro N, McGuire VA, Sakamoto K, Woods YL, McBurnie W, Fleming S, Alessi DR. Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice. Biochem J 2008, 412:211-221. 10.1042/BJ20080557, 18387000.
-
(2008)
Biochem J
, vol.412
, pp. 211-221
-
-
Huang, X.1
Wullschleger, S.2
Shpiro, N.3
McGuire, V.A.4
Sakamoto, K.5
Woods, Y.L.6
McBurnie, W.7
Fleming, S.8
Alessi, D.R.9
-
80
-
-
0034659785
-
Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain
-
10.1042/0264-6021:3480607, 1221104, 10839993
-
Owen MR, Doran E, Halestrap AP. Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Biochem J 2000, 348:607-614. 10.1042/0264-6021:3480607, 1221104, 10839993.
-
(2000)
Biochem J
, vol.348
, pp. 607-614
-
-
Owen, M.R.1
Doran, E.2
Halestrap, A.P.3
-
81
-
-
78149279712
-
AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury
-
503766, 15314686
-
Russell RR, Li J, Coven DL, Pypaert M, Zechner C, Palmeri M, Giordano FJ, Mu J, Birnbaum MJ, Young LH. AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury. J Clin Invest 2004, 114:495-503. 503766, 15314686.
-
(2004)
J Clin Invest
, vol.114
, pp. 495-503
-
-
Russell, R.R.1
Li, J.2
Coven, D.L.3
Pypaert, M.4
Zechner, C.5
Palmeri, M.6
Giordano, F.J.7
Mu, J.8
Birnbaum, M.J.9
Young, L.H.10
-
82
-
-
77954933558
-
Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
-
10.1172/JCI40671, 2898585, 20577053
-
Foretz M, Hebrard S, Leclerc J, Zarrinpashneh E, Soty M, Mithieux G, Sakamoto K, Andreelli F, Viollet B. Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state. J Clin Invest 2010, 120:2355-2369. 10.1172/JCI40671, 2898585, 20577053.
-
(2010)
J Clin Invest
, vol.120
, pp. 2355-2369
-
-
Foretz, M.1
Hebrard, S.2
Leclerc, J.3
Zarrinpashneh, E.4
Soty, M.5
Mithieux, G.6
Sakamoto, K.7
Andreelli, F.8
Viollet, B.9
-
83
-
-
84873584845
-
LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin
-
10.1016/j.ccr.2012.12.008, 23352126
-
Shackelford DB, Abt E, Gerken L, Vasquez DS, Seki A, Leblanc M, Wei L, Fishbein MC, Czernin J, Mischel PS, Shaw RJ. LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin. Cancer Cell 2013, 23:143-158. 10.1016/j.ccr.2012.12.008, 23352126.
-
(2013)
Cancer Cell
, vol.23
, pp. 143-158
-
-
Shackelford, D.B.1
Abt, E.2
Gerken, L.3
Vasquez, D.S.4
Seki, A.5
Leblanc, M.6
Wei, L.7
Fishbein, M.C.8
Czernin, J.9
Mischel, P.S.10
Shaw, R.J.11
-
84
-
-
70350236538
-
Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission
-
10.1158/0008-5472.CAN-09-2994, 2756324, 19752085
-
Hirsch HA, Iliopoulos D, Tsichlis PN, Struhl K. Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission. Cancer Res 2009, 69:7507-7511. 10.1158/0008-5472.CAN-09-2994, 2756324, 19752085.
-
(2009)
Cancer Res
, vol.69
, pp. 7507-7511
-
-
Hirsch, H.A.1
Iliopoulos, D.2
Tsichlis, P.N.3
Struhl, K.4
-
85
-
-
84860196738
-
Metformin kills and radiosensitizes cancer cells and preferentially kills cancer stem cells
-
3324825, 22500211
-
Song CW, Lee H, Dings RP, Williams B, Powers J, Santos TD, Choi BH, Park HJ. Metformin kills and radiosensitizes cancer cells and preferentially kills cancer stem cells. Sci Rep 2012, 2:362. 3324825, 22500211.
-
(2012)
Sci Rep
, vol.2
, pp. 362
-
-
Song, C.W.1
Lee, H.2
Dings, R.P.3
Williams, B.4
Powers, J.5
Santos, T.D.6
Choi, B.H.7
Park, H.J.8
-
86
-
-
84866538325
-
Metformin in early breast cancer: a prospective window of opportunity neoadjuvant study
-
10.1007/s10549-012-2223-1, 22933030
-
Niraula S, Dowling RJ, Ennis M, Chang MC, Done SJ, Hood N, Escallon J, Leong WL, McCready DR, Reedijk M, Stambolic V, Goodwin PJ. Metformin in early breast cancer: a prospective window of opportunity neoadjuvant study. Breast Cancer Res Treat 2012, 135:821-830. 10.1007/s10549-012-2223-1, 22933030.
-
(2012)
Breast Cancer Res Treat
, vol.135
, pp. 821-830
-
-
Niraula, S.1
Dowling, R.J.2
Ennis, M.3
Chang, M.C.4
Done, S.J.5
Hood, N.6
Escallon, J.7
Leong, W.L.8
McCready, D.R.9
Reedijk, M.10
Stambolic, V.11
Goodwin, P.J.12
-
87
-
-
79960845901
-
Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial
-
10.1007/s10549-011-1612-1, 21655990
-
Hadad S, Iwamoto T, Jordan L, Purdie C, Bray S, Baker L, Jellema G, Deharo S, Hardie DG, Pusztai L, Moulder-Thompson S, Dewar JA, Thompson AM. Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial. Breast Cancer Res Treat 2011, 128:783-794. 10.1007/s10549-011-1612-1, 21655990.
-
(2011)
Breast Cancer Res Treat
, vol.128
, pp. 783-794
-
-
Hadad, S.1
Iwamoto, T.2
Jordan, L.3
Purdie, C.4
Bray, S.5
Baker, L.6
Jellema, G.7
Deharo, S.8
Hardie, D.G.9
Pusztai, L.10
Moulder-Thompson, S.11
Dewar, J.A.12
Thompson, A.M.13
-
88
-
-
84863763440
-
AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress
-
10.1038/nature11066, 3607316, 22660331
-
Jeon SM, Chandel NS, Hay N. AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress. Nature 2012, 485:661-665. 10.1038/nature11066, 3607316, 22660331.
-
(2012)
Nature
, vol.485
, pp. 661-665
-
-
Jeon, S.M.1
Chandel, N.S.2
Hay, N.3
-
89
-
-
84859167179
-
Deregulated MYC expression induces dependence upon AMPK-related kinase 5
-
10.1038/nature10927, 22460906
-
Liu L, Ulbrich J, Muller J, Wustefeld T, Aeberhard L, Kress TR, Muthalagu N, Rycak L, Rudalska R, Moll R, Kempa S, Zender L, Eilers M, Murphy DJ. Deregulated MYC expression induces dependence upon AMPK-related kinase 5. Nature 2012, 483:608-612. 10.1038/nature10927, 22460906.
-
(2012)
Nature
, vol.483
, pp. 608-612
-
-
Liu, L.1
Ulbrich, J.2
Muller, J.3
Wustefeld, T.4
Aeberhard, L.5
Kress, T.R.6
Muthalagu, N.7
Rycak, L.8
Rudalska, R.9
Moll, R.10
Kempa, S.11
Zender, L.12
Eilers, M.13
Murphy, D.J.14
|