HDAC6 Modulates Cell Motility by Altering the Acetylation Level of Cortactin

Molecular Cell

Volumn 27, Issue 2, 2007, Pages 197-213

  Zhang, Xiaohong ^a   Yuan, Zhigang ^a   Zhang, Yingtao ^b   Yong, Sarah ^a   Salas Burgos, Alexis ^c   Koomen, John ^a   Olashaw, Nancy ^a   Parsons, J Thomas ^d   Yang, Xiang Jiao ^e   Dent, Sharon R ^f   Yao, Tso Pang ^g   Lane, William S ^h   Seto, Edward ^a  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

^c UNIVERSITY OF CONCEPCIÓN   (Chile)

^d UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^e MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^f UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^g DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h HARVARD UNIVERSITY   (United States)

Author keywords

CELLBIO; PROTEINS

Indexed keywords

ACTIN BINDING PROTEIN; CORTACTIN; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE 6; HISTONE DEACETYLASE INHIBITOR; PROTEIN TYROSINE KINASE;

ACETYLATION; ARTICLE; CELL MOTILITY; HELA CELL; HUMAN; NONHUMAN; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN STRUCTURE;

ACETYLATION; ACTINS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; CELL CYCLE PROTEINS; CELL MOVEMENT; CORTACTIN; HELA CELLS; HISTONE ACETYLTRANSFERASES; HISTONE DEACETYLASES; HUMANS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NIH 3T3 CELLS; PROTEIN BINDING; RABBITS; RECOMBINANT PROTEINS; REPETITIVE SEQUENCES, AMINO ACID; SEQUENCE HOMOLOGY, AMINO ACID; TRANSCRIPTION FACTORS;

EID: 34447315270     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2007.05.033     Document Type: Article

References (22)

1. Bali P., Pranpat M., Bradner J., Balasis M., Fiskus W., Guo F., Rocha K., Kumaraswamy S., Boyapalle S., Atadja P., et al. Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors. J. Biol. Chem. 280 (2005) 26729-26734
2. Bowden E.T., Onikoyi E., Slack R., Myoui A., Yoneda T., Yamada K.M., and Mueller S.C. Co-localization of cortactin and phosphotyrosine identifies active invadopodia in human breast cancer cells. Exp. Cell Res. 312 (2006) 1240-1253
3. Boyault C., Gilquin B., Zhang Y., Rybin V., Garman E., Meyer-Klaucke W., Matthias P., Muller C.W., and Khochbin S. HDAC6-p97/VCP controlled polyubiquitin chain turnover. EMBO J. 25 (2006) 3357-3366
4. Bryce N.S., Clark E.S., Leysath J.L., Currie J.D., Webb D.J., and Weaver A.M. Cortactin promotes cell motility by enhancing lamellipodial persistence. Curr. Biol. 15 (2005) 1276-1285
5. Coligan J.E., Dunn B.M., Ploegh H.L., Speicher D.W., and Wingfield P.T. Current Protocols in Protein Science (1995), John Wiley & Sons, Inc., New York
6. Haggarty S.J., Koeller K.M., Wong J.C., Grozinger C.M., and Schreiber S.L. Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation. Proc. Natl. Acad. Sci. USA 100 (2003) 4389-4394
7. Head J.A., Jiang D., Li M., Zorn L.J., Schaefer E.M., Parsons J.T., and Weed S.A. Cortactin tyrosine phosphorylation requires Rac1 activity and association with the cortical actin cytoskeleton. Mol. Biol. Cell 14 (2003) 3216-3229
8. Hook S.S., Orian A., Cowley S.M., and Eisenman R.N. Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes. Proc. Natl. Acad. Sci. USA 99 (2002) 13425-13430
9. Hubbert C., Guardiola A., Shao R., Kawaguchi Y., Ito A., Nixon A., Yoshida M., Wang X.F., and Yao T.P. HDAC6 is a microtubule-associated deacetylase. Nature 417 (2002) 455-458
10. Kawaguchi Y., Kovacs J.J., McLaurin A., Vance J.M., Ito A., and Yao T.P. The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress. Cell 115 (2003) 727-738
11. Kovacs J.J., Murphy P.J., Gaillard S., Zhao X., Wu J.T., Nicchitta C.V., Yoshida M., Toft D.O., Pratt W.B., and Yao T.P. HDAC6 Regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor. Mol. Cell 18 (2005) 601-607
12. Matsuyama A., Shimazu T., Sumida Y., Saito A., Yoshimatsu Y., Seigneurin-Berny D., Osada H., Komatsu Y., Nishino N., Khochbin S., et al. In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation. EMBO J. 21 (2002) 6820-6831
13. Nobes C.D., and Hall A. Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 81 (1995) 53-62
14. North B.J., Marshall B.L., Borra M.T., Denu J.M., and Verdin E. The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. Mol. Cell 11 (2003) 437-444
15. Ogryzko V.V., Kotani T., Zhang X., Schiltz R.L., Howard T., Yang X.J., Howard B.H., Qin J., and Nakatani Y. Histone-like TAFs within the PCAF histone acetylase complex. Cell 94 (1998) 35-44
16. Pufall M.A., Lee G.M., Nelson M.L., Kang H.S., Velyvis A., Kay L.E., McIntosh L.P., and Graves B.J. Variable control of Ets-1 DNA binding by multiple phosphates in an unstructured region. Science 309 (2005) 142-145
17. Ren Q., and Gorovsky M.A. The nonessential H2A N-terminal tail can function as an essential charge patch on the H2A.Z variant N-terminal tail. Mol. Cell. Biol. 23 (2003) 2778-2789
18. Seigneurin-Berny D., Verdel A., Curtet S., Lemercier C., Garin J., Rousseaux S., and Khochbin S. Identification of components of the murine histone deacetylase 6 complex: link between acetylation and ubiquitination signaling pathways. Mol. Cell. Biol. 21 (2001) 8035-8044
19. Weed S.A., Du Y., and Parsons J.T. Translocation of cortactin to the cell periphery is mediated by the small GTPase Rac1. J. Cell Sci. 111 (1998) 2433-2443
20. Wong K., Zhang J., Awasthi S., Sharma A., Rogers L., Matlock E.F., Van Lint C., Karpova T., McNally J., and Harrod R. Nerve growth factor receptor signaling induces histone acetyltransferase domain-dependent nuclear translocation of p300/CREB-binding protein-associated factor and hGCN5 acetyltransferases. J. Biol. Chem. 279 (2004) 55667-55674
21. Wu H., and Parsons J.T. Cortactin, an 80/85-kilodalton pp60src substrate, is a filamentous actin-binding protein enriched in the cell cortex. J. Cell Biol. 120 (1993) 1417-1426
22. Zhang Y., Li N., Caron C., Matthias G., Hess D., Khochbin S., and Matthias P. HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo. EMBO J. 22 (2003) 1168-1179