NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: Implications in Alzheimer's disease

Human Molecular Genetics

Volumn 24, Issue 11, 2014, Pages 3058-3081

  Corsetti, V ^a   Florenzano, F ^b   Atlante, A ^c   Bobba, A ^c   Ciotti, M T ^d   Natale, F ^d   Della Valle, F ^d   Borreca, A ^d   Manca, A ^b   Meli, G ^b   Ferraina, C ^b   Feligioni, M ^b   D'Aguanno, S ^d   Bussani, R ^e   Ammassari Teule, M ^d   Nicolin, V ^f   Calissano, P ^b   Amadoro, G ^a,b  

^a INSTITUTE OF TRANSLATIONAL PHARMACOLOGY   (Italy)

^b EUROPEAN BRAIN RESEARCH INSTITUTE   (Italy)

^c CNR   (Italy)

^d IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^e UNIVERSITY OF TRIESTE   (Italy)

^f UNIVERSITY OF TRIESTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; AMINO ACID; PARKIN; SHORT HAIRPIN RNA; TAU PROTEIN; UBIQUITIN CARBOXY TERMINAL ESTERASE 1; UBIQUITIN THIOLESTERASE; UNCLASSIFIED DRUG; MAPT PROTEIN, HUMAN; MITOCHONDRIAL PROTEIN; UBIQUITIN PROTEIN LIGASE; UCHL1 PROTEIN, HUMAN;

ALZHEIMER DISEASE; ANIMAL MODEL; ARTICLE; AUTOPHAGOSOME; AUTOPSY; BRAIN MAPPING; BRAIN MITOCHONDRION; BRAIN SYNAPTOSOME; CONTROLLED STUDY; FEMALE; GENE REPRESSION; GENE SILENCING; HIPPOCAMPUS; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MITOCHONDRIAL DYNAMICS; MITOPHAGY; NERVE CELL CULTURE; NERVE CELL NECROSIS; NEUROPATHOLOGY; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN HOMEOSTASIS; SYNAPSE; TURNOVER TIME; ANIMAL; C57BL MOUSE; GENETICS; HELA CELL LINE; METABOLISM; NERVE CELL; PATHOLOGY; PHYSIOLOGY; PROTEIN TRANSPORT; TRANSGENIC MOUSE; WISTAR RAT;

ANIMALIA;

ALZHEIMER DISEASE; ANIMALS; HELA CELLS; HUMANS; MICE, INBRED C57BL; MICE, TRANSGENIC; MITOCHONDRIAL DEGRADATION; MITOCHONDRIAL PROTEINS; NEURONS; PROTEIN TRANSPORT; RATS, WISTAR; TAU PROTEINS; UBIQUITIN THIOLESTERASE; UBIQUITIN-PROTEIN LIGASES;

EID: 84930729049     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddv059     Document Type: Article

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