메뉴 건너뛰기




Volumn 52, Issue 3, 2012, Pages 312-321

Melatonin attenuates kainic acid-induced neurotoxicity in mouse hippocampus via inhibition of autophagy and α-synuclein aggregation

Author keywords

synuclein aggregation; autophagy; kainic acid; melatonin; mitochondria mass; ubiquitination

Indexed keywords

ALPHA SYNUCLEIN; CASPASE 12; CASPASE 3; CYTOCHROME C OXIDASE; DNA; KAINIC ACID; MELATONIN; MITOCHONDRIAL DNA; SMALL INTERFERING RNA;

EID: 84858748850     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/j.1600-079X.2011.00945.x     Document Type: Article
Times cited : (96)

References (59)
  • 1
    • 15844421283 scopus 로고    scopus 로고
    • Glutamate receptors modulate oxidative stress in neuronal cells
    • Boldyrev A, Bulygina E, Makhro A,. Glutamate receptors modulate oxidative stress in neuronal cells. Neurotox Res 2004; 6: 581-587.
    • (2004) Neurotox Res , vol.6 , pp. 581-587
    • Boldyrev, A.1    Bulygina, E.2    Makhro, A.3
  • 2
    • 57649178442 scopus 로고    scopus 로고
    • Oxidative stress and energy crises in neuronal dysfunction
    • Nicholls DG,. Oxidative stress and energy crises in neuronal dysfunction. Ann N Y Acad Sci 2008; 1147: 53-60.
    • (2008) Ann N y Acad Sci , vol.1147 , pp. 53-60
    • Nicholls, D.G.1
  • 3
    • 33847266285 scopus 로고    scopus 로고
    • Interactions between methamphetamine and environmental stress: Role of oxidative stress, glutamate and mitochondrial dysfunction
    • DOI 10.1111/j.1360-0443.2007.01770.x
    • Tata DA, Yamamoto BK,. Interactions between methamphetamine and environmental stress: role of oxidative stress, glutamate and mitochondrial dysfunction. Addiction 2007; 102 (Suppl 1): 49-60. (Pubitemid 46328208)
    • (2007) Addiction , vol.102 , Issue.SUPPL. 1 , pp. 49-60
    • Tata, D.A.1    Yamamoto, B.K.2
  • 4
    • 74149085909 scopus 로고    scopus 로고
    • Stabilization of mitochondrial function by tetramethylpyrazine protects against kainate-induced oxidative lesions in the rat hippocampus
    • Li SY, Jia YH, Sun WG, et al., Stabilization of mitochondrial function by tetramethylpyrazine protects against kainate-induced oxidative lesions in the rat hippocampus. Free Radic Biol Med 2010; 48: 597-608.
    • (2010) Free Radic Biol Med , vol.48 , pp. 597-608
    • Li, S.Y.1    Jia, Y.H.2    Sun, W.G.3
  • 5
    • 0035432155 scopus 로고    scopus 로고
    • Kainic acid induced selective mitochondrial oxidative phosphorylation enzyme dysfunction in cerebellar granule neurons: Protective effects of melatonin and GSH ethylester
    • Dabbeni-Sala F, Floreani M, Franceschini D, et al., Kainic acid induced selective mitochondrial oxidative phosphorylation enzyme dysfunction in cerebellar granule neurons: protective effects of melatonin and GSH ethylester. FASEB J 2001; 15: 1786-1788.
    • (2001) FASEB J , vol.15 , pp. 1786-1788
    • Dabbeni-Sala, F.1    Floreani, M.2    Franceschini, D.3
  • 7
    • 23644434967 scopus 로고    scopus 로고
    • Hypoxic preconditioning attenuated in kainic acid-induced neurotoxicity in rat hippocampus
    • DOI 10.1016/j.expneurol.2004.09.014, PII S0014488604003553
    • Chang AY, Wang CH, Chi JW, et al., Hypoxic preconditioning attenuated in kainic acid-induced neurotoxicity in rat hippocampus. Exp Neurol 2005; 195: 40-48. (Pubitemid 41116812)
    • (2005) Experimental Neurology , vol.195 , Issue.1 , pp. 40-48
    • Chang, A.Y.1    Wang, C.H.2    Chiu, T.H.3    Chi, J.W.4    Chen, C.F.5    Ho, L.T.6    Lin, A.M.Y.7
  • 8
  • 10
    • 0035979807 scopus 로고    scopus 로고
    • Alterations in cytochrome c oxidase activity and energy metabolites in response to kainic acid-induced status epilepticus
    • DOI 10.1016/S0006-8993(01)02657-9, PII S0006899301026579
    • Milatovic D, Zivin M, Gupta RC, et al., Alterations in cytochrome c oxidase activity and energy metabolites in response to kainic acid-induced status epilepticus. Brain Res 2001; 912: 67-78. (Pubitemid 32772793)
    • (2001) Brain Research , vol.912 , Issue.1 , pp. 67-78
    • Milatovic, D.1    Zivin, M.2    Gupta, R.C.3    Dettbarn, W.-D.4
  • 11
    • 38949112123 scopus 로고    scopus 로고
    • An autophagic mechanism is involved in apoptotic death of rat striatal neurons induced by the non-N-methyl-D-aspartate receptor agonist kainic acid
    • Wang Y, Han R, Liang ZQ, et al., An autophagic mechanism is involved in apoptotic death of rat striatal neurons induced by the non-N-methyl-D-aspartate receptor agonist kainic acid. Autophagy 2008; 4: 214-226. (Pubitemid 351231185)
    • (2008) Autophagy , vol.4 , Issue.2 , pp. 214-226
    • Wang, Y.1    Han, R.2    Liang, Z.-Q.3    Wu, J.-C.4    Zhang, X.-D.5    Gu, Z.-L.6    Qin, Z.-H.7
  • 14
    • 63449129338 scopus 로고    scopus 로고
    • Physiological and pathological role of alpha-synuclein in Parkinson's disease through iron mediated oxidative stress; The role of a putative iron-responsive element
    • Olivares D, Huang X, Branden L, et al., Physiological and pathological role of alpha-synuclein in Parkinson's disease through iron mediated oxidative stress; the role of a putative iron-responsive element. Int J Mol Sci 2009; 10: 1226-1260.
    • (2009) Int J Mol Sci , vol.10 , pp. 1226-1260
    • Olivares, D.1    Huang, X.2    Branden, L.3
  • 15
    • 78349268336 scopus 로고    scopus 로고
    • Anti-inflammatory effects of pioglitazone on iron-induced oxidative injury in the nigrostriatal dopaminergic system
    • Yu HC, Feng SF, Chao PL, et al., Anti-inflammatory effects of pioglitazone on iron-induced oxidative injury in the nigrostriatal dopaminergic system. Neuropathol Applied Neurobiol 2010; 36: 612-622.
    • (2010) Neuropathol Applied Neurobiol , vol.36 , pp. 612-622
    • Yu, H.C.1    Feng, S.F.2    Chao, P.L.3
  • 16
    • 0034602442 scopus 로고    scopus 로고
    • Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions
    • Giasson BI, Duda JE, Murray IV, et al., Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions. Science 2000; 290: 985-989.
    • (2000) Science , vol.290 , pp. 985-989
    • Giasson, B.I.1    Duda, J.E.2    Murray, I.V.3
  • 20
    • 0034529528 scopus 로고    scopus 로고
    • Ultrastructural characterization of the delimiting membranes of isolated autophagosomes and amphisomes by freeze-fracture electron microscopy
    • Fengsrud M, Erichsen ES, Berg TO, et al., Ultrastructural characterization of the delimiting membranes of isolated autophagosomes and amphisomes by freeze-fracture electron microscopy. Eur J Cell Biol 2000; 79: 871-882. (Pubitemid 32000721)
    • (2000) European Journal of Cell Biology , vol.79 , Issue.12 , pp. 871-882
    • Fengsrud, M.1    Erichsen, E.S.2    Berg, T.O.3    Raiborg, C.4    Seglen, P.O.5
  • 21
    • 41049087959 scopus 로고    scopus 로고
    • Autophagy-physiology and pathophysiology
    • Uchiyama Y, Shibata M, Koike M, et al., Autophagy-physiology and pathophysiology. Histochem Cell Biol 2008; 129: 407-420.
    • (2008) Histochem Cell Biol , vol.129 , pp. 407-420
    • Uchiyama, Y.1    Shibata, M.2    Koike, M.3
  • 22
    • 78650824020 scopus 로고    scopus 로고
    • Parkinson's disease involves autophagy and abnormal distribution of cathepsin L
    • Li L, Wang X, Fei X, et al., Parkinson's disease involves autophagy and abnormal distribution of cathepsin L. Neurosci Lett 2011; 489: 62-67.
    • (2011) Neurosci Lett , vol.489 , pp. 62-67
    • Li, L.1    Wang, X.2    Fei, X.3
  • 23
    • 0031036896 scopus 로고    scopus 로고
    • Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease
    • Anglade P, Vyas S, Javoy-Agid F, et al., Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease. Histol Histopathol 1997; 12: 25-31. (Pubitemid 27106916)
    • (1997) Histology and Histopathology , vol.12 , Issue.1 , pp. 25-31
    • Anglade, P.1
  • 24
    • 77956213267 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in Parkinson's disease
    • Zhu J, Chu CT,. Mitochondrial dysfunction in Parkinson's disease. J Alzheimers Dis 2010; 20 (Suppl 2): 325-334.
    • (2010) J Alzheimers Dis , vol.20 , Issue.SUPPL. 2 , pp. 325-334
    • Zhu, J.1    Chu, C.T.2
  • 25
    • 33750363298 scopus 로고    scopus 로고
    • The roles of intracellular protein-degradation pathways in neurodegeneration
    • DOI 10.1038/nature05291, PII NATURE05291
    • Rubinsztein DC,. The roles of intracellular protein-degradation pathways in neurodegeneration. Nature 2006; 443: 780-786. (Pubitemid 44622682)
    • (2006) Nature , vol.443 , Issue.7113 , pp. 780-786
    • Rubinsztein, D.C.1
  • 26
    • 70349481750 scopus 로고    scopus 로고
    • Enhanced alpha-synuclein expression in human neurodegenerative diseases: Pathogenetic and therapeutic implications
    • Mccormack AL, Di Monte DA,. Enhanced alpha-synuclein expression in human neurodegenerative diseases: pathogenetic and therapeutic implications. Curr Protein Pept Sci 2009; 10: 476-482.
    • (2009) Curr Protein Pept Sci , vol.10 , pp. 476-482
    • McCormack, A.L.1    Di Monte, D.A.2
  • 28
    • 33846915925 scopus 로고    scopus 로고
    • Kainic acid induces early and transient autophagic stress in mouse hippocampus
    • DOI 10.1016/j.neulet.2006.12.025, PII S0304394006013140
    • Shacka JJ, Lu J, Xie ZL, et al., Kainic acid induces early and transient autophagic stress in mouse hippocampus. Neurosci Lett 2007; 414: 57-60. (Pubitemid 46241649)
    • (2007) Neuroscience Letters , vol.414 , Issue.1 , pp. 57-60
    • Shacka, J.J.1    Lu, J.2    Xie, Z.-L.3    Uchiyama, Y.4    Roth, K.A.5    Zhang, J.6
  • 29
    • 77950663581 scopus 로고    scopus 로고
    • Melatonin, cardiolipin and mitochondrial bioenergetics in health and disease
    • Paradies G, Petrosillo G, Paradies V, et al., Melatonin, cardiolipin and mitochondrial bioenergetics in health and disease. J Pineal Res 2010; 48: 297-310.
    • (2010) J Pineal Res , vol.48 , pp. 297-310
    • Paradies, G.1    Petrosillo, G.2    Paradies, V.3
  • 30
    • 77954378907 scopus 로고    scopus 로고
    • Melatonin as a therapeutic tool in ophthalmology: Implications for glaucoma and uveitis
    • Rosenstein RE, Pandi-Perumal SR, Srinivasan V, et al., Melatonin as a therapeutic tool in ophthalmology: implications for glaucoma and uveitis. J Pineal Res 2010; 49: 1-13.
    • (2010) J Pineal Res , vol.49 , pp. 1-13
    • Rosenstein, R.E.1    Pandi-Perumal, S.R.2    Srinivasan, V.3
  • 31
    • 0028618440 scopus 로고
    • Melatonin - A highly potent endogenous radical scavenger and electron donor: New aspects of the oxidation chemistry of this indole accessed in vitro
    • Poeggeler B, Saarela S, Reiter RJ, et al., Melatonin - a highly potent endogenous radical scavenger and electron donor: new aspects of the oxidation chemistry of this indole accessed in vitro. Ann NY Acad Sci 1994; 738: 419-420.
    • (1994) Ann NY Acad Sci , vol.738 , pp. 419-420
    • Poeggeler, B.1    Saarela, S.2    Reiter, R.J.3
  • 32
    • 68249105603 scopus 로고    scopus 로고
    • Therapeutic potential of melatonin in traumatic central nervous system injury
    • Samantaray S, Das A, Thakore NP, et al., Therapeutic potential of melatonin in traumatic central nervous system injury. J Pineal Res 2009; 47: 134-142.
    • (2009) J Pineal Res , vol.47 , pp. 134-142
    • Samantaray, S.1    Das, A.2    Thakore, N.P.3
  • 33
    • 79960380554 scopus 로고    scopus 로고
    • Melatonin as a natural ally against oxidative stress: A physicochemical examination
    • Galano A, Tan DX, Reiter RJ,. Melatonin as a natural ally against oxidative stress: a physicochemical examination. J Pineal Res 2011; 51: 1-16.
    • (2011) J Pineal Res , vol.51 , pp. 1-16
    • Galano, A.1    Tan, D.X.2    Reiter, R.J.3
  • 34
    • 0034653993 scopus 로고    scopus 로고
    • Melatonin suppresses iron-induced neurodegeneration in rat brain
    • Lin AMY, Ho LT,. Melatonin suppresses iron-induced neurodegeneration in rat brain. Free Radic Biol Med 2000; 28: 904-911.
    • (2000) Free Radic Biol Med , vol.28 , pp. 904-911
    • Lin, A.M.Y.1    Ho, L.T.2
  • 35
    • 34447558382 scopus 로고    scopus 로고
    • Melatonin attenuates arsenite-induced apoptosis in rat brain: Involvement of mitochondrial and endoplasmic reticulum pathways and aggregation of α-synuclein
    • DOI 10.1111/j.1600-079X.2007.00456.x
    • Lin AMY, Fang SF, Chao PL, et al., Melatonin attenuates arsenite-induced apoptosis in rat brain: involvement of mitochondrial and ER pathways and aggregation of α-synuclein. J Pineal Res 2007; 43: 163-171. (Pubitemid 47078924)
    • (2007) Journal of Pineal Research , vol.43 , Issue.2 , pp. 163-171
    • Lin, A.M.Y.1    Fang, S.F.2    Chao, P.L.3    Yang, C.H.4
  • 36
    • 79951606158 scopus 로고    scopus 로고
    • Melatonin synergistically increases resveratrol-induced heme oxygenase-1 expression through the inhibition of ubiquitin-dependent proteasome pathway: A possible role in neuroprotection
    • Kwon KJ, Kim JN, Kim MK, et al., Melatonin synergistically increases resveratrol-induced heme oxygenase-1 expression through the inhibition of ubiquitin-dependent proteasome pathway: a possible role in neuroprotection. J Pineal Res 2011; 50: 110-123.
    • (2011) J Pineal Res , vol.50 , pp. 110-123
    • Kwon, K.J.1    Kim, J.N.2    Kim, M.K.3
  • 37
    • 70449339417 scopus 로고    scopus 로고
    • The antiapoptotic activity of melatonin in neurodegenerative diseases
    • Wang X,. The antiapoptotic activity of melatonin in neurodegenerative diseases. CNS Neurosci Ther 2009; 15: 345-357.
    • (2009) CNS Neurosci Ther , vol.15 , pp. 345-357
    • Wang, X.1
  • 38
    • 0033823057 scopus 로고    scopus 로고
    • Melatonin is protective in necrotic but not in caspase-dependent, free radical-independent apoptotic neuronal cell death in primary neuronal cultures
    • Harms C, Lautenschlager M, Bergk A, et al., Melatonin is protective in necrotic but not in caspase-dependent, free radical-independent apoptotic neuronal cell death in primary neuronal cultures. FASEB J 2000; 14: 1814-1824.
    • (2000) FASEB J , vol.14 , pp. 1814-1824
    • Harms, C.1    Lautenschlager, M.2    Bergk, A.3
  • 39
    • 77951477328 scopus 로고    scopus 로고
    • An overview of investigational antiapoptotic drugs with potential application for the treatment of neurodegenerative disorders
    • Camins A, Sureda FX, Junyent F, et al., An overview of investigational antiapoptotic drugs with potential application for the treatment of neurodegenerative disorders. Expert Opin Investig Drugs 2010; 19: 587-604.
    • (2010) Expert Opin Investig Drugs , vol.19 , pp. 587-604
    • Camins, A.1    Sureda, F.X.2    Junyent, F.3
  • 40
    • 77149160042 scopus 로고    scopus 로고
    • Melatonin protects N2a against ischemia/reperfusion injury through autophagy enhancement
    • Guo Y, Wang J, Wang Z, et al., Melatonin protects N2a against ischemia/reperfusion injury through autophagy enhancement. J Huazhong Univ Sci Technolog Med Sci 2010; 30: 1-7.
    • (2010) J Huazhong Univ Sci Technolog Med Sci , vol.30 , pp. 1-7
    • Guo, Y.1    Wang, J.2    Wang, Z.3
  • 41
    • 78349253806 scopus 로고    scopus 로고
    • The mechanism for the neuroprotective effect of melatonin against methamphetamine-induced autophagy
    • Nopparat C, Porter J, Ebadi M, et al., The mechanism for the neuroprotective effect of melatonin against methamphetamine-induced autophagy. J Pineal Res 2010; 49: 382-389.
    • (2010) J Pineal Res , vol.49 , pp. 382-389
    • Nopparat, C.1    Porter, J.2    Ebadi, M.3
  • 44
    • 59249083454 scopus 로고    scopus 로고
    • Monitoring starvation-induced reactive oxygen species formation
    • Scherz-Shouval R, Elazar Z,. Monitoring starvation-induced reactive oxygen species formation. Methods Enzymol 2009; 452: 119-130.
    • (2009) Methods Enzymol , vol.452 , pp. 119-130
    • Scherz-Shouval, R.1    Elazar, Z.2
  • 45
    • 34247186472 scopus 로고    scopus 로고
    • Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4
    • DOI 10.1038/sj.emboj.7601623, PII 7601623
    • Scherz-Shouval R, Shvets E, Fass E, et al., Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. EMBO J 2007; 26: 1749-1760. (Pubitemid 46624042)
    • (2007) EMBO Journal , vol.26 , Issue.7 , pp. 1749-1760
    • Scherz-Shouval, R.1    Shvets, E.2    Fass, E.3    Shorer, H.4    Gil, L.5    Elazar, Z.6
  • 46
    • 32844464580 scopus 로고    scopus 로고
    • Lysosomal enzyme cathepsin B is involved in kainic acid-induced excitotoxicity in rat striatum
    • DOI 10.1016/j.brainres.2005.10.074, PII S0006899305015337
    • Wang Y, Gu ZL, Cao Y, et al., Lysosomal enzyme cathepsin B is involved in kainic acid-induced excitotoxicity in rat striatum. Brain Res 2006; 1071: 245-249. (Pubitemid 43255494)
    • (2006) Brain Research , vol.1071 , Issue.1 , pp. 245-249
    • Wang, Y.1    Gu, Z.-L.2    Cao, Y.3    Liang, Z.-Q.4    Han, R.5    Bennett, M.C.6    Qin, Z.-H.7
  • 47
    • 33750354046 scopus 로고    scopus 로고
    • Parkin and defective ubiquitination in Parkinson's disease
    • Dawson TM,. Parkin and defective ubiquitination in Parkinson's disease. J Neural Transm Suppl 2006; 70: 209-213. (Pubitemid 44622201)
    • (2006) Journal of Neural Transmission, Supplement , Issue.70 , pp. 209-213
    • Dawson, T.M.1
  • 48
    • 67449123313 scopus 로고    scopus 로고
    • The role of ubiquitin linkages on alpha-synuclein induced-toxicity in a Drosophila model of Parkinson's disease
    • Lee FK, Wong AK, Lee YW, et al., The role of ubiquitin linkages on alpha-synuclein induced-toxicity in a Drosophila model of Parkinson's disease. J Neurochem 2009; 110: 208-219.
    • (2009) J Neurochem , vol.110 , pp. 208-219
    • Lee, F.K.1    Wong, A.K.2    Lee, Y.W.3
  • 49
    • 0041589248 scopus 로고    scopus 로고
    • Alpha-Synuclein is degraded by both autophagy and the proteasome
    • Webb JL, Ravikumar B, Atkins J, et al., Alpha-Synuclein is degraded by both autophagy and the proteasome. J Biol Chem 2003; 278: 25009-250013.
    • (2003) J Biol Chem , vol.278 , pp. 25009-250013
    • Webb, J.L.1    Ravikumar, B.2    Atkins, J.3
  • 50
    • 53049098471 scopus 로고    scopus 로고
    • Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells
    • Vogiatzi T, Xilouri M, Vekrellis K, et al., Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells. J Biol Chem 2008; 283: 23542-23556.
    • (2008) J Biol Chem , vol.283 , pp. 23542-23556
    • Vogiatzi, T.1    Xilouri, M.2    Vekrellis, K.3
  • 51
    • 79955694568 scopus 로고    scopus 로고
    • Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity
    • Qiao L, Hamamichi S, Caldwell KA, et al., Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity. Mol Brain 2008; 1: 17.
    • (2008) Mol Brain , vol.1 , pp. 17
    • Qiao, L.1    Hamamichi, S.2    Caldwell, K.A.3
  • 53
    • 0031893232 scopus 로고    scopus 로고
    • Redox regulation of ubiquitin-conjugating enzymes: Mechanistic insights using the thiol-specific oxidant diamide
    • Obin M, Shang F, Gong X, et al., Redox regulation of ubiquitin- conjugating enzymes: mechanistic insights using the thiol-specific oxidant diamide. FASEB J 1998; 12: 561-569. (Pubitemid 28183515)
    • (1998) FASEB Journal , vol.12 , Issue.7 , pp. 561-569
    • Obin, M.1    Shang, F.2    Gong, X.3    Handelman, G.4    Blumberg, J.5    Taylor, A.6
  • 54
    • 1442275729 scopus 로고    scopus 로고
    • Clearance of α-Synuclein Oligomeric Intermediates via the Lysosomal Degradation Pathway
    • DOI 10.1523/JNEUROSCI.3809-03.2004
    • Lee HJ, Khoshaghideh F, Patel S, et al., Clearance of alpha-synuclein oligomeric ntermediates via the lysosomal degradation pathway. J Neurosci 2004; 4: 1888-1896. (Pubitemid 38292800)
    • (2004) Journal of Neuroscience , vol.24 , Issue.8 , pp. 1888-1896
    • Lee, H.-J.1    Khoshaghideh, F.2    Patel, S.3    Lee, S.-J.4
  • 55
    • 0038143287 scopus 로고    scopus 로고
    • Parkinsonian mimetics induce aspects of unfolded protein response in death of dopaminergic neurons
    • DOI 10.1074/jbc.M211821200
    • Holtz WA, O'malley KL,. Parkinsonian mimetics induce aspects of unfolded protein response in death of dopaminergic neurons. J Biol Chem 2003; 278: 19367-19377. (Pubitemid 36799332)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.21 , pp. 19367-19377
    • Holtz, W.A.1    O'Malley, K.L.2
  • 56
    • 79551647443 scopus 로고    scopus 로고
    • Induction of the unfolded protein response by α-synuclein in experimental models of Parkinson's disease
    • Bellucci A, Navarria L, Zaltieri M, et al., Induction of the unfolded protein response by α-synuclein in experimental models of Parkinson's disease. J Neurochem 2011; 116: 588-605.
    • (2011) J Neurochem , vol.116 , pp. 588-605
    • Bellucci, A.1    Navarria, L.2    Zaltieri, M.3
  • 57
    • 0034610743 scopus 로고    scopus 로고
    • Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β
    • DOI 10.1038/47513
    • Nakagawa T, Zhu H, Morishima N, et al., Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 2000; 403: 98-103. (Pubitemid 30038529)
    • (2000) Nature , vol.403 , Issue.6765 , pp. 98-103
    • Nakagawa, T.1    Zhu, H.2    Morishima, N.3    Li, E.4    Xu, J.5    Yankner, B.A.6    Yuan, J.7
  • 58
    • 82155162775 scopus 로고    scopus 로고
    • Autophagic activity in cortical neurons under acute oxidative stress directly contributes to cell death
    • Higgins GC, Devenish RJ, Beart PM, et al., Autophagic activity in cortical neurons under acute oxidative stress directly contributes to cell death. Cell Mol Life Sci 2011; 68: 3725-3740.
    • (2011) Cell Mol Life Sci , vol.68 , pp. 3725-3740
    • Higgins, G.C.1    Devenish, R.J.2    Beart, P.M.3
  • 59
    • 1842608814 scopus 로고    scopus 로고
    • Heme oxygenase-1: Transducer of pathological brain iron sequestration under oxidative stress
    • DOI 10.1196/annals.1306.007
    • Schipper HM,. Heme oxygenase-1: transducer of pathological brain iron sequestration under oxidative stress. Ann NY Acad Sci 2004; 1012: 84-93. (Pubitemid 38453517)
    • (2004) Annals of the New York Academy of Sciences , vol.1012 , pp. 84-93
    • Schipper, H.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.