Roles of autophagy in MPP+-induced neurotoxicity in vivo: The involvement of mitochondria and α-synuclein aggregation

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Hung, Kai Chih ^a   Huang, Hui Ju ^b   Lin, Ming Wei ^a   Lei, Yen Ping ^a   Lin, Anya Maan Yuh ^a,b  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; ALPHA SYNUCLEIN; ATG7 PROTEIN; BIOLOGICAL MARKER; CHLORAL HYDRATE; CYTOCHROME C OXIDASE; HEME OXYGENASE 1; LC3 II PROTEIN; SMALL INTERFERING RNA; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG; 1,3-BIS(4-HYDROXYPHENYL)-4-METHYL-5-(4-(2-PIPERIDINYLETHOXY)PHENOL)-1H-PYRAZOLE; ATG7 PROTEIN, RAT; CASP9 PROTEIN, RAT; CASPASE 9; LC3 PROTEIN, RAT; MICROTUBULE ASSOCIATED PROTEIN; PIPERIDINE DERIVATIVE; PROTEIN AGGREGATE; PYRAZOLE DERIVATIVE; TYROSINE 3 MONOOXYGENASE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; IN VIVO STUDY; LIPID PEROXIDATION; MALE; MITOCHONDRION; NERVE DEGENERATION; NEUROTOXICITY; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PROTEIN AGGREGATION; RAT; SUBSTANTIA NIGRA; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; METABOLISM; NEUROTOXICITY SYNDROMES; PATHOLOGY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; TOXICITY;

ALPHA-SYNUCLEIN; ANIMALS; AUTOPHAGY; CASPASE 9; GENE EXPRESSION REGULATION; HEME OXYGENASE-1; INJECTIONS, INTRAVENTRICULAR; LIPID PEROXIDATION; MALE; MICROTUBULE-ASSOCIATED PROTEINS; MITOCHONDRIA; NEUROTOXICITY SYNDROMES; PIPERIDINES; PROTEIN AGGREGATES; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SUBSTANTIA NIGRA; TYROSINE 3-MONOOXYGENASE; UBIQUITIN-ACTIVATING ENZYMES;

EID: 84898622934     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0091074     Document Type: Article

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