Aβ1-42-mediated down-regulation of Uch-L1 is dependent on NF-κB activation and impaired BACE1 lysosomal degradation

Aging Cell

Volumn 11, Issue 5, 2012, Pages 834-844

  Guglielmotto, Michela ^a   Monteleone, Debora ^a   Boido, Marina ^a   Piras, Antonio ^a   Giliberto, Luca ^b   Borghi, Roberta ^c   Vercelli, Alessandro ^a   Fornaro, Michele ^d   Tabaton, Massimo ^c   Tamagno, Elena ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

^c UNIVERSITY OF GENOA   (Italy)

^d UNIVERSITY OF CATANIA   (Italy)

Author keywords

A 1 42; Azheimer's disease; BACE1; Lysosomes; NF B; Uch L1

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; BETA SECRETASE 1; CATHEPSIN D; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; UBIQUITIN C TERMINAL HYDROLASE L1; UBIQUITIN THIOLESTERASE; UNCLASSIFIED DRUG;

AGED; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; HUMAN; HUMAN TISSUE; LYSOSOME; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ACID ENDOPEPTIDASES; CASE-CONTROL STUDIES; CELL LINE, TUMOR; CEREBRAL CORTEX; DOWN-REGULATION; GENE EXPRESSION REGULATION; HUMANS; LYSOSOMES; NF-KAPPA B; PEPTIDE FRAGMENTS; SIGNAL TRANSDUCTION; TRANSFECTION; UBIQUITIN THIOLESTERASE;

EID: 84866450330     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/j.1474-9726.2012.00854.x     Document Type: Article

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