Phosphatase and tensin homolog (PTEN)-induced Putative Kinase 1 (PINK1)-dependent ubiquitination of endogenous parkin attenuates mitophagy: Study in human primary fibroblasts and induced pluripotent stem cell-derived neurons

Journal of Biological Chemistry

Volumn 288, Issue 4, 2013, Pages 2223-2237

  Rakovic, Aleksandar ^a   Shurkewitsch, Katharina ^a   Seibler, Philip ^a   Grünewald, Anne ^a   Zanon, Alessandra ^a,b   Hagenah, Johann ^a   Krainc, Dimitri ^c   Klein, Christine ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

^b Center for Biomedicine   (Italy)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEINS; CELL LINES; CELL MODEL; CELLULAR MODEL; DOSE-DEPENDENT; ENDOGENOUS LEVEL; MITOCHONDRIAL FUNCTION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL PROTEIN; NEURONAL CELL; OUTER MITOCHONDRIAL MEMBRANES; OVER-EXPRESSION; PARKINSON DISEASE; PLURIPOTENT; POLYUBIQUITINATION; UBIQUITIN; UBIQUITIN LIGASES; UBIQUITIN-PROTEASOME SYSTEM; UBIQUITINATION;

CELL CULTURE; CELL MEMBRANES; ENZYMES; FIBROBLASTS; MAGNESIUM PRINTING PLATES; MITOCHONDRIA; NEURONS; STEM CELLS;

PROTEINS;

MITOCHONDRIAL PROTEIN; OUTER MEMBRANE PROTEIN; PARKIN; PHOSPHATASE AND TENSIN HOMOLOG INDUCED PUTATIVE KINASE 1; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEGRADATION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOPHAGY; PARKINSON DISEASE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; UBIQUITINATION;

CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROBLASTS; HOMOZYGOTE; HUMANS; INDUCED PLURIPOTENT STEM CELLS; LUNG; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA; MITOCHONDRIAL DEGRADATION; MODELS, BIOLOGICAL; MUTATION; MUTATION, MISSENSE; NEURONS; PARKINSON DISEASE; PROTEIN KINASES; STEM CELLS; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

EID: 84873843566     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.391680     Document Type: Article

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