Soluble pathological tau in the entorhinal cortex leads to presynaptic deficits in an early Alzheimer's disease model

Acta Neuropathologica

Volumn 127, Issue 2, 2014, Pages 257-270

  Polydoro, Manuela ^a   Dzhala, Volodymyr I ^a   Pooler, Amy M ^a,b   Nicholls, Samantha B ^a   McKinney, A Patrick ^c   Sanchez, Laura ^a   Pitstick, Rose ^d   Carlson, George A ^d   Staley, Kevin J ^a   Spires Jones, Tara L ^a   Hyman, Bradley T ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c The Harvard Center for Neurodegeneration & Repair   (United States)

^d MCLAUGHLIN RESEARCH INSTITUTE   (United States)

Author keywords

Alzheimer's disease; Arc induction; Synaptic dysfunction; Tau

Indexed keywords

TAU PROTEIN;

ALZHEIMER DISEASE; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DENTATE GYRUS; ELECTROPHYSIOLOGY; ENTORHINAL CORTEX; HIPPOCAMPUS; HISTOPATHOLOGY; HUMAN; MOUSE; NERVE CELL PLASTICITY; NERVE DEGENERATION; NEUROTRANSMITTER RELEASE; NONHUMAN; PERFORANT NERVE TRACT; PRESYNAPTIC NERVE; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN PHOSPHORYLATION; TASK PERFORMANCE; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; ANIMALS; CYTOSKELETAL PROTEINS; DISEASE MODELS, ANIMAL; ELECTROPHYSIOLOGICAL PHENOMENA; ENTORHINAL CORTEX; HIPPOCAMPUS; HUMANS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NERVE TISSUE PROTEINS; NEURONAL PLASTICITY; PRESYNAPTIC TERMINALS; TAU PROTEINS;

EID: 84896719288     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-013-1215-5     Document Type: Article

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