Phosphorylation of Parkin by the cyclin-dependent kinase 5 at the linker region modulates its ubiquitin-ligase activity and aggregation

Journal of Biological Chemistry

Volumn 282, Issue 17, 2007, Pages 12842-12850

  Avraham, Eyal ^a   Rott, Ruth ^a   Liani, Esti ^a   Szargel, Raymonde ^a   Engelender, Simone ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

AGGLOMERATION; CELL DEATH; ENZYME ACTIVITY; IMMUNOLOGY; MEDICAL PROBLEMS; MUTAGENESIS; PHOSPHORYLATION;

DOPAMINERGIC CELLS; IMMUNOPRECIPITATION; MUTANTS; PARKINSON DISEASE;

PROTEINS;

ALPHA SYNUCLEIN; CYCLIN DEPENDENT KINASE 5; MITOGEN ACTIVATED PROTEIN KINASE P38; PARKIN; SERINE; UBIQUITIN PROTEIN LIGASE; CARRIER PROTEIN; CDK5 PROTEIN, HUMAN; NERVE PROTEIN; SNCAIP PROTEIN, HUMAN; UBIQUITIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; EMBRYO; ENZYME ACTIVITY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IN VITRO STUDY; IN VIVO STUDY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; UBIQUITINATION; WILD TYPE; AMINO ACID SUBSTITUTION; ANIMAL; BRAIN; CELL INCLUSION; CELL LINE; COMPARATIVE STUDY; GENETICS; METABOLISM; MISSENSE MUTATION; PARKINSON DISEASE; PHOSPHORYLATION; PROTEIN PROCESSING; RAT;

RATTUS;

ALPHA-SYNUCLEIN; AMINO ACID SUBSTITUTION; ANIMALS; BRAIN; CARRIER PROTEINS; CELL LINE; CYCLIN-DEPENDENT KINASE 5; HUMANS; INCLUSION BODIES; MUTATION, MISSENSE; NERVE TISSUE PROTEINS; PARKINSON DISEASE; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RATS; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

EID: 34250344611     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M608243200     Document Type: Article

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