Mutant A53T α-Synuclein induces neuronal death by increasing mitochondrial autophagy

Journal of Biological Chemistry

Volumn 286, Issue 12, 2011, Pages 10814-10824

  Choubey, Vinay ^a   Safiulina, Dzhamilja ^a   Vaarmann, Annika ^a   Cagalinec, Michal ^a   Wareski, Przemyslaw ^a   Kuum, Malle ^a   Zharkovsky, Alexander ^a   Kaasik, Allen ^a  

^a UNIVERSITY OF TARTU   (Estonia)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOPHAGOSOMES; AUTOPHAGY; COMMON FEATURES; CONTRIBUTING FACTOR; CORTICAL NEURONS; DOMINANT NEGATIVE; DYNAMIN; INTRACELLULAR ACCUMULATION; LEWY BODIES; MITOCHONDRIAL DYSFUNCTION; NET LOSS; NEURONAL CELL; NEURONAL DEATH; P-D MODEL; PARKINSON DISEASE; SYNUCLEIN; UP-REGULATION; WILD TYPES;

CELL DEATH; DISEASES; GENES; PARKS;

MITOCHONDRIA;

ADENOSINE TRIPHOSPHATE; ALPHA SYNUCLEIN; ATG12 PROTEIN; BECLIN 1; CITRATE SYNTHASE; DYNAMIN I; MEMBRANE PROTEIN; MITOFUSIN 2; PARKIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; RAPAMYCIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTOPHAGY; BRAIN CELL; CELL MUTANT; CELL VIABILITY; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVITY; GENE OVEREXPRESSION; NERVE CELL DEGENERATION; NERVE CELL NECROSIS; NERVE TRANSECTION; NONHUMAN; PARKINSON DISEASE; PLASMID; PRIORITY JOURNAL; RAT; RENILLA; WESTERN BLOTTING;

ALPHA-SYNUCLEIN; AMINO ACID SUBSTITUTION; ANIMALS; AUTOPHAGY; DISEASE MODELS, ANIMAL; GENE SILENCING; MEMBRANE PROTEINS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MUTATION, MISSENSE; NEURONS; PARKINSON DISEASE; PC12 CELLS; RATS; RATS, WISTAR; UBIQUITIN-PROTEIN LIGASES;

EID: 79953202481     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.132514     Document Type: Article

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