Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1

Cell Death and Disease

Volumn 5, Issue 4, 2014, Pages

  Burbulla, L F ^a,b   Fitzgerald, J C ^a,b   Stegen, K ^a,b,c   Westermeier, J ^a,b,c   Thost, A K ^c   Kato, H ^c   Mokranjac, D ^d   Sauerwald, J ^a,b   Martins, L M ^e   Woitalla, D ^f   Rapaport, D ^c   Riess, O ^c   Proikas Cezanne, T ^c   Rasse, T M ^b   Kruger R ^a,b,c  

^a GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c UNIVERSITY OF TÜBINGEN   (Germany)

^d UNIVERSITY OF MUNICH   (Germany)

^e MRC TOXICOLOGY UNIT   (United Kingdom)

^f ST JOSEF HOSPITAL   (Germany)

Author keywords

Mitochondrial; Mitophagy; Mortalin; Parkinson's disease; Proteolytic stress

Indexed keywords

CHAPERONE; MORTALIN; PARKIN; PROTEIN; PROTEIN VARIANT; PROTEINPINK1; RAPAMYCIN; UNCLASSIFIED DRUG; CASPASE 3; CHAPERONIN 60; HEAT SHOCK PROTEIN 70; PROTEIN KINASE; PTEN-INDUCED PUTATIVE KINASE; UBIQUITIN PROTEIN LIGASE;

APOPTOSIS; ARTICLE; AUTOPHAGY; CELL STRESS; CONTROLLED STUDY; EX VIVO STUDY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; LYSOSOME; MITOCHONDRIAL PROTEOLYTIC STRESS; MITOCHONDRION; NERVE DEGENERATION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN HOMEOSTASIS; UNFOLDED PROTEIN RESPONSE; ANIMAL; BIOLOGICAL MODEL; CELL SURVIVAL; DRUG EFFECTS; ENZYME ACTIVATION; GENE SILENCING; HEK293 CELL LINE; METABOLISM; MOUSE; PHYSIOLOGICAL STRESS; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; CASPASE 3; CELL LINE, TUMOR; CELL SURVIVAL; CHAPERONIN 60; ENZYME ACTIVATION; GENE KNOCKDOWN TECHNIQUES; HEK293 CELLS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; MICE; MITOCHONDRIA; MODELS, BIOLOGICAL; PHENOTYPE; PROTEIN KINASES; PROTEOLYSIS; SIROLIMUS; STRESS, PHYSIOLOGICAL; UBIQUITIN-PROTEIN LIGASES;

EID: 84901056259     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2014.103     Document Type: Article

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