-
1
-
-
84864401215
-
Pathway-selective sensitization of mycobacterium tuberculosis for target-based whole-cell screening
-
Abrahams GL, Kumar A, Savvi S, Hung AW, Wen S, Abell C, Barry CE 3rd, Sherman DR, Boshoff HI, Mizrahi V. 2012. Pathway-selective sensitization of Mycobacterium tuberculosis for target-based whole-cell screening. Chem Biol 19: 844–854.
-
(2012)
Chem Biol
, vol.19
, pp. 844-854
-
-
Abrahams, G.L.1
Kumar, A.2
Savvi, S.3
Hung, A.W.4
Wen, S.5
Abell, C.6
Barry, C.E.7
Sherman, D.R.8
Boshoff, H.I.9
Mizrahi, V.10
-
2
-
-
67650074482
-
Cyclic amp intoxication of macrophages by a mycobacterium tuberculosis adenylate cyclase
-
Agarwal N, Lamichhane G, Gupta R, Nolan S, Bishai WR. 2009. Cyclic AMP intoxication of macrophages by a Mycobacterium tuberculosis adenylate cyclase. Nature 460: 98–102.
-
(2009)
Nature
, vol.460
, pp. 98-102
-
-
Agarwal, N.1
Lamichhane, G.2
Gupta, R.3
Nolan, S.4
Bishai, W.R.5
-
4
-
-
81755177792
-
Sequence-based analysis uncovers an abundance of non-coding rna in the total transcrip tome of mycobacterium tuberculosis
-
Arnvig KB, Comas I, Thomson NR, Houghton J, Boshoff HI, Croucher NJ, Rose G, Perkins TT, Parkhill J, Dougan G, et al. 2011. Sequence-based analysis uncovers an abundance of non-coding RNA in the total transcrip tome of Mycobacterium tuberculosis. PLoS Pathog 7: e1002342.
-
(2011)
Plos Pathog
, vol.7
-
-
Arnvig, K.B.1
Comas, I.2
Thomson, N.R.3
Houghton, J.4
Boshoff, H.I.5
Croucher, N.J.6
Rose, G.7
Perkins, T.T.8
Parkhill, J.9
Dougan, G.10
-
5
-
-
84895541126
-
Non-replicating mycobacterium tuberculosis elicits a reduced infectivity profile with corresponding modifications to the cell wall and extracellular matrix
-
Bacon J, Alderwick LJ, Allnutt JA, Gabasova E, Watson R, Hatch KA, Clark SO, Jeeves RE, Marriott A, Rayner E, et al. 2014. Non-replicating Mycobacterium tuberculosis elicits a reduced infectivity profile with corresponding modifications to the cell wall and extracellular matrix. PLoS ONE 9: e87329.
-
(2014)
Plos ONE
, vol.9
-
-
Bacon, J.1
Alderwick, L.J.2
Allnutt, J.A.3
Gabasova, E.4
Watson, R.5
Hatch, K.A.6
Clark, S.O.7
Jeeves, R.E.8
Marriott, A.9
Rayner, E.10
-
6
-
-
79958058975
-
Metabolic regulation of mycobacterial growth and antibiotic sensitivity
-
Baek SH, Li AH, Sassetti CM. 2011. Metabolic regulation of mycobacterial growth and antibiotic sensitivity. PLoS Biol 9: e1001065.
-
(2011)
Plos Biol
, vol.9
-
-
Baek, S.H.1
Li, A.H.2
Sassetti, C.M.3
-
7
-
-
84866929237
-
Extrapulmonary locations of mycobacterium tuberculosis dna during latent infection
-
Barrios-Payan J, Saqui-Salces M, Jeyanathan M, Alcantara Vazquez A, Castanon-Arreola M, Rook G, HernandezPando R. 2012. Extrapulmonary locations of Mycobacterium tuberculosis DNA during latent infection. J Infect Dis 206: 1194–1205.
-
(2012)
J Infect Dis
, vol.206
, pp. 1194-1205
-
-
Barrios-Payan, J.1
Saqui-Salces, M.2
Jeyanathan, M.3
Alcantara Vazquez, A.4
Castanon-Arreola, M.5
Rook, G.6
Hernandezpando, R.7
-
8
-
-
70449705831
-
The spectrum of latent tuberculosis: Rethinking the biology and intervention strategies
-
Barry CE 3rd, Boshoff HI, Dartois V, Dick T, Ehrt S, Flynn J, Schnappinger D, Wilkinson RJ, Young D. 2009. The spectrum of latent tuberculosis: Rethinking the biology and intervention strategies. Nat Rev Microbiol 7: 845–855.
-
(2009)
Nat Rev Microbiol
, vol.7
, pp. 845-855
-
-
Barry, C.E.1
Boshoff, H.I.2
Dartois, V.3
Dick, T.4
Ehrt, S.5
Flynn, J.6
Schnappinger, D.7
Wilkinson, R.J.8
Young, D.9
-
9
-
-
84892724315
-
An extracellular bacterial pathogen modulates host metabolism to regulate its own sensing and proliferation
-
Baruch M, Belotserkovsky I, Hertzog BB, Ravins M, Dov E, McIver KS, Le Breton YS, Zhou Y, Chen CY, Hanski E. 2014. An extracellular bacterial pathogen modulates host metabolism to regulate its own sensing and proliferation. Cell 156: 97–108.
-
(2014)
Cell
, vol.156
, pp. 97-108
-
-
Baruch, M.1
Belotserkovsky, I.2
Hertzog, B.B.3
Ravins, M.4
Dov, E.5
McIver, K.S.6
Le Breton, Y.S.7
Zhou, Y.8
Chen, C.Y.9
Hanski, E.10
-
10
-
-
73549105511
-
An anaerobic-type a-ketoglutarate ferredoxin oxidoreductase completes the oxidative tricarboxylic acid cycle of mycobacterium tuberculosis
-
Baughn AD, Garforth SJ, Vilcheze C, Jacobs WR Jr., 2009. An anaerobic-type a-ketoglutarate ferredoxin oxidoreductase completes the oxidative tricarboxylic acid cycle of Mycobacterium tuberculosis. PLoS Pathog 5: e1000662.
-
(2009)
Plos Pathog
, vol.5
-
-
Baughn, A.D.1
Garforth, S.J.2
Vilcheze, C.3
Jacobs, W.R.4
-
11
-
-
84873101916
-
Metabolic adaptations of pseudomonas aeruginosa during cystic fibrosis chronic lung infections
-
Behrends V, Ryall B, Zlosnik JE, Speert DP, Bundy JG, Williams HD. 2013. Metabolic adaptations of Pseudomonas aeruginosa during cystic fibrosis chronic lung infections. Environ Microbiol 15: 398–408.
-
(2013)
Environ Microbiol
, vol.15
, pp. 398-408
-
-
Behrends, V.1
Ryall, B.2
Zlosnik, J.E.3
Speert, D.P.4
Bundy, J.G.5
Williams, H.D.6
-
12
-
-
0037195388
-
Inhibition of acetate and propionate assimilation by itaconate via propionyl-coa carboxylase in isocitrate lyase-negative purple bacterium rhodospirillum rubrum
-
Berg IA, Filatova LV, Ivanovsky RN. 2002. Inhibition of acetate and propionate assimilation by itaconate via propionyl-CoA carboxylase in isocitrate lyase-negative purple bacterium Rhodospirillum rubrum. FEMS microbiology letters 216: 49–54.
-
(2002)
FEMS Microbiology Letters
, vol.216
, pp. 49-54
-
-
Berg, I.A.1
Filatova, L.V.2
Ivanovsky, R.N.3
-
13
-
-
78149422217
-
System-level strategies for studying the metabolism of mycobacterium tuberculosis
-
Beste DJ, McFadden J. 2010. System-level strategies for studying the metabolism of Mycobacterium tuberculosis. Mol Biosyst 6: 2363–2372.
-
(2010)
Mol Biosyst
, vol.6
, pp. 2363-2372
-
-
Beste, D.J.1
McFadden, J.2
-
14
-
-
14244250191
-
Compiling a molecular inventory for mycobacterium bovis bcg at two growth rates: Evidence for growth rate-mediated regulation of ribosome biosynthesis and lipid metabolism
-
Beste DJ, Peters J, Hooper T, Avignone-Rossa C, Bushell ME, McFadden J. 2005. Compiling a molecular inventory for Mycobacterium bovis BCG at two growth rates: Evidence for growth rate-mediated regulation of ribosome biosynthesis and lipid metabolism. J Bacteriol 187: 1677–1684.
-
(2005)
J Bacteriol
, vol.187
, pp. 1677-1684
-
-
Beste, D.J.1
Peters, J.2
Hooper, T.3
Avignone-Rossa, C.4
Bushell, M.E.5
McFadden, J.6
-
15
-
-
79960933284
-
13c metabolic flux analysis identifies an unusual route for pyruvate dissimilation in mycobacteria which requires isocitrate lyase and carbon dioxide fixation
-
13C metabolic flux analysis identifies an unusual route for pyruvate dissimilation in mycobacteria which requires isocitrate lyase and carbon dioxide fixation. PLoS Pathog 7: e1002091.
-
(2011)
Plos Pathog
, vol.7
-
-
Beste, D.J.1
Bonde, B.2
Hawkins, N.3
Ward, J.L.4
Beale, M.H.5
Noack, S.6
Noh, K.7
Kruger, N.J.8
Ratcliffe, R.G.9
McFadden, J.10
-
16
-
-
84883173541
-
13c-flux spectral analysis of host-pathogen metabolism reveals a mixed diet for intracellular mycobacterium tuberculosis
-
13C-flux spectral analysis of host-pathogen metabolism reveals a mixed diet for intracellular Mycobacterium tuberculosis. Chem Biol 20: 1012–1021.
-
(2013)
Chem Biol
, vol.20
, pp. 1012-1021
-
-
Beste, D.J.1
Noh, K.2
Niedenfuhr, S.3
Mendum, T.A.4
Hawkins, N.D.5
Ward, J.L.6
Beale, M.H.7
Wiechert, W.8
McFadden, J.9
-
17
-
-
84871057692
-
Upregulation of the phthiocerol dimycocerosate biosynthetic pathway by rifampin-resistant, rpob mutant mycobacterium tuberculosis
-
Bisson GP, Mehaffy C, Broeckling C, Prenni J, Rifat D, Lun DS, Burgos M, Weissman D, Karakousis PC, Dobos K. 2012. Upregulation of the phthiocerol dimycocerosate biosynthetic pathway by rifampin-resistant, rpoB mutant Mycobacterium tuberculosis. J Bacteriol 194: 6441–6452.
-
(2012)
J Bacteriol
, vol.194
, pp. 6441-6452
-
-
Bisson, G.P.1
Mehaffy, C.2
Broeckling, C.3
Prenni, J.4
Rifat, D.5
Lun, D.S.6
Burgos, M.7
Weissman, D.8
Karakousis, P.C.9
Dobos, K.10
-
18
-
-
78650982216
-
Simultaneous analysis of multiple mycobacterium tuberculosis knockdown mutants in vitro and in vivo
-
Blumenthal A, Trujillo C, Ehrt S, Schnappinger D. 2010. Simultaneous analysis of multiple Mycobacterium tuberculosis knockdown mutants in vitro and in vivo. PLoS ONE 5: e15667.
-
(2010)
Plos ONE
, vol.5
-
-
Blumenthal, A.1
Trujillo, C.2
Ehrt, S.3
Schnappinger, D.4
-
19
-
-
79959815566
-
Differential producibility analysis (dpa) of transcriptomic data with metabolic networks: Deconstructing the metabolic response of m. Tuberculosis
-
Bonde BK, Beste DJ, Laing E, Kierzek AM, McFadden J. 2011. Differential producibility analysis (DPA) of transcriptomic data with metabolic networks: Deconstructing the metabolic response of M. tuberculosis. PLoS Comput Biol 7: e1002060.
-
(2011)
Plos Comput Biol
, vol.7
-
-
Bonde, B.K.1
Beste, D.J.2
Laing, E.3
Kierzek, A.M.4
McFadden, J.5
-
20
-
-
11144250804
-
Tuberculosis—metabolism and respiration in the absence of growth
-
Boshoff HI, Barry CE 3rd. 2005. Tuberculosis—Metabolism and respiration in the absence of growth. Nat Rev Microbiol 3: 70–80.
-
(2005)
Nat Rev Microbiol
, vol.3
, pp. 70-80
-
-
Boshoff, H.I.1
Barry, C.E.2
-
21
-
-
78049306942
-
Systems biology approaches to understanding mycobacterial survival mechanisms
-
Boshoff HI, Lun DS. 2010. Systems biology approaches to understanding mycobacterial survival mechanisms. Drug Discov Today Dis Mech 7: e75–e82.
-
(2010)
Drug Discov Today Dis Mech
, vol.7
, pp. e75-e82
-
-
Boshoff, H.I.1
Lun, D.S.2
-
22
-
-
80053049896
-
Mycobacterial p1-type atpases mediate resistance to zinc poisoning in human macrophages
-
1-type ATPases mediate resistance to zinc poisoning in human macrophages. Cell Host Microbe 10: 248–259.
-
(2011)
Cell Host Microbe
, vol.10
, pp. 248-259
-
-
Botella, H.1
Peyron, P.2
Levillain, F.3
Poincloux, R.4
Poquet, Y.5
Brandli, I.6
Wang, C.7
Tailleux, L.8
Tilleul, S.9
Charriere, G.M.10
-
23
-
-
61949263942
-
Type ii fatty acid synthesis is not a suitable antibiotic target for gram-positive pathogens
-
Brinster S, Lamberet G, Staels B, Trieu-Cuot P, Gruss A, Poyart C. 2009. Type II fatty acid synthesis is not a suitable antibiotic target for Gram-positive pathogens. Nature 458: 83–86.
-
(2009)
Nature
, vol.458
, pp. 83-86
-
-
Brinster, S.1
Lamberet, G.2
Staels, B.3
Trieu-Cuot, P.4
Gruss, A.5
Poyart, C.6
-
24
-
-
78149304433
-
High content phenotypic cell-based visual screen identifies mycobacterium tuberculosis acyltrehalose-containing glycolipids involved in phagosome remodeling
-
Brodin P, Poquet Y, Levillain F, Peguillet I, Larrouy-Maumus G, Gilleron M, Ewann F, Christophe T, Fenistein D, Jang J, et al. 2010. High content phenotypic cell-based visual screen identifies Mycobacterium tuberculosis acyltrehalose-containing glycolipids involved in phagosome remodeling. PLoS Pathog 6: e1001100.
-
(2010)
Plos Pathog
, vol.6
-
-
Brodin, P.1
Poquet, Y.2
Levillain, F.3
Peguillet, I.4
Larrouy-Maumus, G.5
Gilleron, M.6
Ewann, F.7
Christophe, T.8
Fenistein, D.9
Jang, J.10
-
25
-
-
40149083733
-
Selective killing of nonreplicating mycobacteria
-
Bryk R, Gold B, Venugopal A, Singh J, Samy R, Pupek K, Cao H, Popescu C, Gurney M, Hotha S, et al. 2008. Selective killing of nonreplicating mycobacteria. Cell Host Microbe 3: 137–145.
-
(2008)
Cell Host Microbe
, vol.3
, pp. 137-145
-
-
Bryk, R.1
Gold, B.2
Venugopal, A.3
Singh, J.4
Samy, R.5
Pupek, K.6
Cao, H.7
Popescu, C.8
Gurney, M.9
Hotha, S.10
-
26
-
-
84895778643
-
Lipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase
-
Bryk R, Arango N, Maksymiuk C, Balakrishnan A, Wu YT, Wong CH, Masquelin T, Hipskind P, Lima CD, Nathan C. 2013. Lipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase. Biochemistry 52: 9375–9384.
-
(2013)
Biochemistry
, vol.52
, pp. 9375-9384
-
-
Bryk, R.1
Arango, N.2
Maksymiuk, C.3
Balakrishnan, A.4
Wu, Y.T.5
Wong, C.H.6
Masquelin, T.7
Hipskind, P.8
Lima, C.D.9
Nathan, C.10
-
27
-
-
84895895475
-
Evolution and transmission of drug-resistant tuberculosis in a russian population
-
Casali N, Nikolayevskyy V, Balabanova Y, Harris SR, Ignatyeva O, Kontsevaya I, Corander J, Bryant J, Parkhill J, Nejentsev S, et al. 2014. Evolution and transmission of drug-resistant tuberculosis in a Russian population. Nat Genet 46: 279–286.
-
(2014)
Nat Genet
, vol.46
, pp. 279-286
-
-
Casali, N.1
Nikolayevskyy, V.2
Balabanova, Y.3
Harris, S.R.4
Ignatyeva, O.5
Kontsevaya, I.6
Corander, J.7
Bryant, J.8
Parkhill, J.9
Nejentsev, S.10
-
28
-
-
84871927537
-
Para-aminosalicylic acid acts as an alternative substrate of folate metabolism in mycobacterium tuberculosis
-
Chakraborty S, Gruber T, Barry CE 3rd, Boshoff HI, Rhee KY. 2013. Para-aminosalicylic acid acts as an alternative substrate of folate metabolism in Mycobacterium tuberculosis. Science 339: 88–91.
-
(2013)
Science
, vol.339
, pp. 88-91
-
-
Chakraborty, S.1
Gruber, T.2
Barry, C.E.3
Boshoff, H.I.4
Rhee, K.Y.5
-
29
-
-
0034442696
-
Identification of a mycobacterium bovis bcg auxotrophic mutant that protects guinea pigs against m. Bovis and hematogenous spread of mycobacterium tuberculosis without sensitization to tuberculin
-
Chambers MA, Williams A, Gavier-Widen D, Whelan A, Hall G, Marsh PD, Bloom BR, Jacobs WR, Hewinson RG. 2000. Identification of a Mycobacterium bovis BCG auxotrophic mutant that protects guinea pigs against M. bovis and hematogenous spread of Mycobacterium tuberculosis without sensitization to tuberculin. Infect Immun 68: 7094–7099.
-
(2000)
Infect Immun
, vol.68
, pp. 7094-7099
-
-
Chambers, M.A.1
Williams, A.2
Gavier-Widen, D.3
Whelan, A.4
Hall, G.5
Marsh, P.D.6
Bloom, B.R.7
Jacobs, W.R.8
Hewinson, R.G.9
-
30
-
-
34247143197
-
Low-oxygen-recovery assay for high-throughput screening of compounds against nonreplicating mycobacterium tuberculosis
-
Cho SH, Warit S, Wan B, Hwang CH, Pauli GF, Franzblau SG. 2007. Low-oxygen-recovery assay for high-throughput screening of compounds against nonreplicating Mycobacterium tuberculosis. Antimicrob Agents Chemother 51: 1380–1385.
-
(2007)
Antimicrob Agents Chemother
, vol.51
, pp. 1380-1385
-
-
Cho, S.H.1
Warit, S.2
Wan, B.3
Hwang, C.H.4
Pauli, G.F.5
Franzblau, S.G.6
-
31
-
-
73649143180
-
High content screening identifies decaprenyl-phosphoribose 20 epimerase as a target for intracellular antimycobacterial inhibitors
-
0 epimerase as a target for intracellular antimycobacterial inhibitors. PLoS Pathog 5: e1000645.
-
(2009)
Plos Pathog
, vol.5
-
-
Christophe, T.1
Jackson, M.2
Jeon, H.K.3
Fenistein, D.4
Contreras Dominguez, M.5
Kim, J.6
Genovesio, A.7
Carralot, J.P.8
Ewann, F.9
Kim, E.H.10
-
32
-
-
0032508046
-
Deciphering the biology of mycobacterium tuberculosis from the complete genome sequence
-
Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, et al. 1998. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 393: 537–544.
-
(1998)
Nature
, vol.393
, pp. 537-544
-
-
Cole, S.T.1
Brosch, R.2
Parkhill, J.3
Garnier, T.4
Churcher, C.5
Harris, D.6
Gordon, S.V.7
Eiglmeier, K.8
Gas, S.9
Barry, C.E.10
-
33
-
-
77952841173
-
Human t cell epitopes of mycobacterium tuberculosis are evolutionarily hyperconserved
-
Comas I, Chakravartti J, Small PM, Galagan J, Niemann S, Kremer K, Ernst JD, Gagneux S. 2010. Human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved. Nat Genet 42: 498–503.
-
(2010)
Nat Genet
, vol.42
, pp. 498-503
-
-
Comas, I.1
Chakravartti, J.2
Small, P.M.3
Galagan, J.4
Niemann, S.5
Kremer, K.6
Ernst, J.D.7
Gagneux, S.8
-
34
-
-
84884995578
-
Out-of-africa migration and neolithic coexpansion of mycobacterium tuberculosis with modern humans
-
Comas I, Coscolla M, Luo T, Borrell S, Holt KE, Kato-Maeda M, Parkhill J, Malla B, Berg S, Thwaites G, et al. 2013. Out-of-Africa migration and Neolithic coexpansion of Mycobacterium tuberculosis with modern humans. Nat Genet 45: 1176–1182.
-
(2013)
Nat Genet
, vol.45
, pp. 1176-1182
-
-
Comas, I.1
Coscolla, M.2
Luo, T.3
Borrell, S.4
Holt, K.E.5
Kato-Maeda, M.6
Parkhill, J.7
Malla, B.8
Berg, S.9
Thwaites, G.10
-
35
-
-
79959815079
-
Mycobacterium tuberculosis uses host triacylglycerol to accumulate lipid droplets and acquires a dormancylike phenotype in lipid-loaded macrophages
-
Daniel J, Maamar H, Deb C, Sirakova TD, Kolattukudy PE. 2011. Mycobacterium tuberculosis uses host triacylglycerol to accumulate lipid droplets and acquires a dormancylike phenotype in lipid-loaded macrophages. PLoS Pathog 7: e1002093.
-
(2011)
Plos Pathog
, vol.7
-
-
Daniel, J.1
Maamar, H.2
Deb, C.3
Sirakova, T.D.4
Kolattukudy, P.E.5
-
36
-
-
84894068321
-
The path of anti-tuberculosis drugs: From blood to lesions to mycobacterial cells
-
Dartois V. 2014. The path of anti-tuberculosis drugs: From blood to lesions to mycobacterial cells. Nat Rev Microbiol 12: 159–167.
-
(2014)
Nat Rev Microbiol
, vol.12
, pp. 159-167
-
-
Dartois, V.1
-
37
-
-
84881367368
-
A medicinal chemists’ guide to the unique difficulties of lead optimization for tuberculosis
-
Dartois V, Barry CE 3rd. 2013. A medicinal chemists’ guide to the unique difficulties of lead optimization for tuberculosis. Bioorg Med Chem Lett 23: 4741–4750.
-
(2013)
Bioorg Med Chem Lett
, vol.23
, pp. 4741-4750
-
-
Dartois, V.1
Barry, C.E.2
-
38
-
-
70349647606
-
Nitazoxanide kills replicating and nonreplicating mycobacterium tuberculosis and evades resistance
-
de Carvalho LP, Lin G, Jiang X, Nathan C. 2009. Nitazoxanide kills replicating and nonreplicating Mycobacterium tuberculosis and evades resistance. J Med Chem 52: 5789– 5792.
-
(2009)
J Med Chem
, vol.52
, pp. 5789-5792
-
-
De Carvalho, L.P.1
Lin, G.2
Jiang, X.3
Nathan, C.4
-
39
-
-
78049411009
-
Metabolomics of mycobacterium tuberculosis reveals compartmentalized co-catabolism of carbon substrates
-
de Carvalho LP, Fischer SM, Marrero J, Nathan C, Ehrt S, Rhee KY. 2010a. Metabolomics of Mycobacterium tuberculosis reveals compartmentalized co-catabolism of carbon substrates. Chem Biol 17: 1122–1131.
-
(2010)
Chem Biol
, vol.17
, pp. 1122-1131
-
-
De Carvalho, L.P.1
Fischer, S.M.2
Marrero, J.3
Nathan, C.4
Ehrt, S.5
Rhee, K.Y.6
-
40
-
-
77950961726
-
Activity-based metabolomic profiling of enzymatic function: Identification of rv1248c as a mycobacterial 2-hydroxy-3-oxoadipate synthase
-
de Carvalho LP, Zhao H, Dickinson CE, Arango NM, Lima CD, Fischer SM, Ouerfelli O, Nathan C, Rhee KY. 2010b. Activity-based metabolomic profiling of enzymatic function: Identification of Rv1248c as a mycobacterial 2-hydroxy-3-oxoadipate synthase. Chem Biol 17: 323–332.
-
(2010)
Chem Biol
, vol.17
, pp. 323-332
-
-
De Carvalho, L.P.1
Zhao, H.2
Dickinson, C.E.3
Arango, N.M.4
Lima, C.D.5
Fischer, S.M.6
Ouerfelli, O.7
Nathan, C.8
Rhee, K.Y.9
-
41
-
-
80955132757
-
Nitazoxanide disrupts membrane potential and intrabacterial ph homeostasis of mycobacterium tuberculosis
-
de Carvalho LP, Darby CM, Rhee K., Nathan C. 2011. Nitazoxanide disrupts membrane potential and intrabacterial pH homeostasis of Mycobacterium tuberculosis. ACS Med Chem Lett 2: 849–854.
-
(2011)
ACS Med Chem Lett
, vol.2
, pp. 849-854
-
-
De Carvalho, L.P.1
Darby, C.M.2
Rhee, K.3
Nathan, C.4
-
42
-
-
77956509403
-
Massive gene duplication event among clinical isolates of the mycobacterium tuberculosis w/beijing family
-
Domenech P, Kolly GS, Leon-Solis L, Fallow A, Reed MB. 2010. Massive gene duplication event among clinical isolates of the Mycobacterium tuberculosis W/Beijing family. J Bacteriol 192: 4562–4570.
-
(2010)
J Bacteriol
, vol.192
, pp. 4562-4570
-
-
Domenech, P.1
Kolly, G.S.2
Leon-Solis, L.3
Fallow, A.4
Reed, M.B.5
-
43
-
-
84868343034
-
Altered fatty acid metabolism due to rifampicin-resistance conferring mutations in the rpob gene of mycobacterium tuberculosis: Mapping the potential of pharmaco-metabolomics for global health and personalized medicine
-
du Preez I, Loots D. 2012. Altered fatty acid metabolism due to rifampicin-resistance conferring mutations in the rpoB gene of Mycobacterium tuberculosis: Mapping the potential of pharmaco-metabolomics for global health and personalized medicine. Omics 16: 596–603.
-
(2012)
Omics
, vol.16
, pp. 596-603
-
-
Du Preez, I.1
Loots, D.2
-
44
-
-
84875806423
-
New sputum metabolite markers implicating adaptations of the host to mycobacterium tuberculosis, and vice versa
-
du Preez I, Loots DT. 2013. New sputum metabolite markers implicating adaptations of the host to Mycobacterium tuberculosis, and vice versa. Tuberculosis (Edinb) 93: 330–337.
-
(2013)
Tuberculosis (Edinb)
, vol.93
, pp. 330-337
-
-
Du Preez, I.1
Loots, D.T.2
-
45
-
-
82255186665
-
Bisubstrate adenylation inhibitors of biotin protein ligase from mycobacterium tuberculosis
-
Duckworth BP, Geders TW, Tiwari D, Boshoff HI, Sibbald PA, Barry CE 3rd, Schnappinger D, Finzel BC, Aldrich CC. 2011. Bisubstrate adenylation inhibitors of biotin protein ligase from Mycobacterium tuberculosis. Chem Biol 18: 1432–1441.
-
(2011)
Chem Biol
, vol.18
, pp. 1432-1441
-
-
Duckworth, B.P.1
Geders, T.W.2
Tiwari, D.3
Boshoff, H.I.4
Sibbald, P.A.5
Barry, C.E.6
Schnappinger, D.7
Finzel, B.C.8
Aldrich, C.C.9
-
46
-
-
19744383611
-
Controlling gene expression in mycobacteria with anhydrotetracycline and tet repressor
-
Ehrt S, Guo XV, Hickey CM, Ryou M, Monteleone M, Riley LW, Schnappinger D. 2005. Controlling gene expression in mycobacteria with anhydrotetracycline and Tet repressor. Nucleic Acids Res 33: e21.
-
(2005)
Nucleic Acids Res
, vol.33
-
-
Ehrt, S.1
Guo, X.V.2
Hickey, C.M.3
Ryou, M.4
Monteleone, M.5
Riley, L.W.6
Schnappinger, D.7
-
47
-
-
84876253419
-
Multifunctional essentiality of succinate metabolism in adaptation to hypoxia in mycobacterium tuberculosis
-
Eoh H, Rhee KY. 2013. Multifunctional essentiality of succinate metabolism in adaptation to hypoxia in Mycobacterium tuberculosis. Proc Natl Acad Sci 110: 6554–6559.
-
(2013)
Proc Natl Acad Sci
, vol.110
, pp. 6554-6559
-
-
Eoh, H.1
Rhee, K.Y.2
-
48
-
-
84864357703
-
The immunological life cycle of tuberculosis
-
Ernst JD. 2012. The immunological life cycle of tuberculosis. Nat Rev Immunol 12: 581–591.
-
(2012)
Nat Rev Immunol
, vol.12
, pp. 581-591
-
-
Ernst, J.D.1
-
49
-
-
84895823701
-
Dual role of transcription and transcript stability in the regulation of gene expression in escherichia coli cells cultured on glucose at different growth rates
-
Esquerre T, Laguerre S, Turlan C, Carpousis AJ, Girbal L, Cocaign-Bousquet M. 2013. Dual role of transcription and transcript stability in the regulation of gene expression in Escherichia coli cells cultured on glucose at different growth rates. Nucleic Acids Res 42: 2460–2472.
-
(2013)
Nucleic Acids Res
, vol.42
, pp. 2460-2472
-
-
Esquerre, T.1
Laguerre, S.2
Turlan, C.3
Carpousis, A.J.4
Girbal, L.5
Cocaign-Bousquet, M.6
-
50
-
-
74949135138
-
Neutrophils are the predominant infected phagocytic cells in the airways of patients with active pulmonary tb
-
Eum SY, Kong JH, Hong MS, Lee YJ, Kim JH, Hwang SH, Cho SN, Via LE, Barry CE 3rd. 2010. Neutrophils are the predominant infected phagocytic cells in the airways of patients with active pulmonary TB. Chest 137: 122–128.
-
(2010)
Chest
, vol.137
, pp. 122-128
-
-
Eum, S.Y.1
Kong, J.H.2
Hong, M.S.3
Lee, Y.J.4
Kim, J.H.5
Hwang, S.H.6
Cho, S.N.7
Via, L.E.8
Barry, C.E.9
-
51
-
-
84884992001
-
Genomic analysis identifies targets of convergent positive selection in drug resistant mycobacterium tuberculosis
-
Farhat MR, Shapiro BJ, Kieser K, Sultana R, Jacobson KR, Victor TC, Warren RM, Streicher EM, Calver A, Sloutsky A, et al. 2013. Genomic analysis identifies targets of convergent positive selection in drug resistant Mycobacterium tuberculosis. Nat Genet 45: 1183–1189.
-
(2013)
Nat Genet
, vol.45
, pp. 1183-1189
-
-
Farhat, M.R.1
Shapiro, B.J.2
Kieser, K.3
Sultana, R.4
Jacobson, K.R.5
Victor, T.C.6
Warren, R.M.7
Streicher, E.M.8
Calver, A.9
Sloutsky, A.10
-
52
-
-
79955460244
-
Use of whole genome sequencing to estimate the mutation rate of mycobacterium tuberculosis during latent infection
-
Ford CB, Lin PL, Chase MR, Shah RR, Iartchouk O, Galagan J, Mohaideen N, Ioerger TR, Sacchettini JC, Lipsitch M, et al. 2011. Use of whole genome sequencing to estimate the mutation rate of Mycobacterium tuberculosis during latent infection. Nat Genet 43: 482–486.
-
(2011)
Nat Genet
, vol.43
, pp. 482-486
-
-
Ford, C.B.1
Lin, P.L.2
Chase, M.R.3
Shah, R.R.4
Iartchouk, O.5
Galagan, J.6
Mohaideen, N.7
Ioerger, T.R.8
Sacchettini, J.C.9
Lipsitch, M.10
-
53
-
-
84859495671
-
Mycobacterium tuberculosis— heterogeneity revealed through whole genome sequencing
-
Ford C, Yusim K, Ioerger T, Feng S, Chase M, Greene M, Korber B, Fortune S. 2012. Mycobacterium tuberculosis— Heterogeneity revealed through whole genome sequencing. Tuberculosis (Edinb) 92: 194–201.
-
(2012)
Tuberculosis (Edinb)
, vol.92
, pp. 194-201
-
-
Ford, C.1
Yusim, K.2
Ioerger, T.3
Feng, S.4
Chase, M.5
Greene, M.6
Korber, B.7
Fortune, S.8
-
54
-
-
84867334162
-
Comprehensive analysis of methods used for the evaluation of compounds against mycobacterium tuberculosis
-
Franzblau SG, DeGroote MA, Cho SH, Andries K, Nuermberger E, Orme IM, Mdluli K, Angulo-Barturen I, Dick T, Dartois V, et al. 2012. Comprehensive analysis of methods used for the evaluation of compounds against Mycobacterium tuberculosis. Tuberculosis (Edinb) 92: 453–488.
-
(2012)
Tuberculosis (Edinb)
, vol.92
, pp. 453-488
-
-
Franzblau, S.G.1
Degroote, M.A.2
Cho, S.H.3
Andries, K.4
Nuermberger, E.5
Orme, I.M.6
Mdluli, K.7
Angulo-Barturen, I.8
Dick, T.9
Dartois, V.10
-
55
-
-
84880506145
-
The mycobacterium tuberculosis regulatory network and hypoxia
-
Galagan JE, Minch K, Peterson M, Lyubetskaya A, Azizi E, Sweet L, Gomes A, Rustad T, Dolganov G, Glotova I, et al. 2013. The Mycobacterium tuberculosis regulatory network and hypoxia. Nature 499: 178–183.
-
(2013)
Nature
, vol.499
, pp. 178-183
-
-
Galagan, J.E.1
Minch, K.2
Peterson, M.3
Lyubetskaya, A.4
Azizi, E.5
Sweet, L.6
Gomes, A.7
Rustad, T.8
Dolganov, G.9
Glotova, I.10
-
56
-
-
43249101747
-
Cytological and transcript analyses reveal fat and lazy persister-like bacilli in tuberculous sputum
-
Garton NJ, Waddell SJ, Sherratt AL, Lee SM, Smith RJ, Senner C, Hinds J, Rajakumar K, Adegbola RA, Besra GS, et al. 2008. Cytological and transcript analyses reveal fat and lazy persister-like bacilli in tuberculous sputum. PLoS Med 5: e75.
-
(2008)
Plos Med
, vol.5
-
-
Garton, N.J.1
Waddell, S.J.2
Sherratt, A.L.3
Lee, S.M.4
Smith, R.J.5
Senner, C.6
Hinds, J.7
Rajakumar, K.8
Adegbola, R.A.9
Besra, G.S.10
-
57
-
-
59649119960
-
A replication clock for mycobacterium tuberculosis
-
Gill WP, Harik NS, Whiddon MR, Liao RP, Mittler JE, Sherman DR. 2009. A replication clock for Mycobacterium tuberculosis. Nat Med 15: 211–214.
-
(2009)
Nat Med
, vol.15
, pp. 211-214
-
-
Gill, W.P.1
Harik, N.S.2
Whiddon, M.R.3
Liao, R.P.4
Mittler, J.E.5
Sherman, D.R.6
-
58
-
-
84885542771
-
Genome-level analyses of mycobacterium bovis lineages reveal the role of snps and antisense transcription in differential gene expression
-
Golby P, Nunez J, Witney A, Hinds J, Quail MA, Bentley S, Harris S, Smith N, Hewinson RG, Gordon SV. 2013. Genome-level analyses of Mycobacterium bovis lineages reveal the role of SNPs and antisense transcription in differential gene expression. BMC Genomics 14: 710.
-
(2013)
BMC Genomics
, vol.14
, pp. 710
-
-
Golby, P.1
Nunez, J.2
Witney, A.3
Hinds, J.4
Quail, M.A.5
Bentley, S.6
Harris, S.7
Smith, N.8
Hewinson, R.G.9
Gordon, S.V.10
-
59
-
-
84867061487
-
Nonsteroidal anti-inflammatory drug sensitizes mycobacterium tuberculosis to endogenous and exogenous antimicrobials
-
Gold B, Pingle M, Brickner SJ, Shah N, Roberts J, Rundell M, Bracken WC, Warrier T, Somersan S, Venugopal A, et al. 2012. Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials. Proc Natl Acad Sci 109: 16004– 16011.
-
(2012)
Proc Natl Acad Sci
, vol.109
, pp. 16004-16011
-
-
Gold, B.1
Pingle, M.2
Brickner, S.J.3
Shah, N.4
Roberts, J.5
Rundell, M.6
Bracken, W.C.7
Warrier, T.8
Somersan, S.9
Venugopal, A.10
-
60
-
-
84887406804
-
Why are membrane targets discovered by phenotypic screens and genome sequencing in mycobacterium tuberculosis?
-
Goldman RC. 2013. Why are membrane targets discovered by phenotypic screens and genome sequencing in Mycobacterium tuberculosis? Tuberculosis (Edinb) 93: 569–588.
-
(2013)
Tuberculosis (Edinb)
, vol.93
, pp. 569-588
-
-
Goldman, R.C.1
-
63
-
-
0036266673
-
Construction and phenotypic characterization of an auxotrophic mutant of mycobacterium tuberculosis defective in l-arginine biosynthesis
-
Gordhan BG, Smith DA, Alderton H, McAdam RA, Bancroft GJ, Mizrahi V. 2002. Construction and phenotypic characterization of an auxotrophic mutant of Mycobacterium tuberculosis defective in L-arginine biosynthesis. Infect Immun 70: 3080–3084.
-
(2002)
Infect Immun
, vol.70
, pp. 3080-3084
-
-
Gordhan, B.G.1
Smith, D.A.2
Alderton, H.3
McAdam, R.A.4
Bancroft, G.J.5
Mizrahi, V.6
-
64
-
-
84886600677
-
Mycobacterium tuberculosis nitrogen assimilation and host colonization require aspartate
-
Gouzy A, Larrouy-Maumus G, Wu TD, Peixoto A, Levillain F, Lugo-Villarino G, Gerquin-Kern JL, de Carvalho LP, Poquet Y, Neyrolles O. 2013. Mycobacterium tuberculosis nitrogen assimilation and host colonization require aspartate. Nat Chem Biol 9: 674–676.
-
(2013)
Nat Chem Biol
, vol.9
, pp. 674-676
-
-
Gouzy, A.1
Larrouy-Maumus, G.2
Wu, T.D.3
Peixoto, A.4
Levillain, F.5
Lugo-Villarino, G.6
Gerquin-Kern, J.L.7
De Carvalho, L.P.8
Poquet, Y.9
Neyrolles, O.10
-
65
-
-
84895761851
-
Mycobacterium tuberculosis exploits asparagine to assimilate nitrogen and resist acid stress during infection
-
Gouzy A, Larrouy-Maumus G, Bottai D, Levillain F, Dumas A, Wallach JB, Caire-Brandli I, de Chastellier C, Wu TD, Poincloux R, et al. 2014. Mycobacterium tuberculosis exploits asparagine to assimilate nitrogen and resist acid stress during Infection. PLoS Pathog 10: e1003928.
-
(2014)
Plos Pathog
, vol.10
-
-
Gouzy, A.1
Larrouy-Maumus, G.2
Bottai, D.3
Levillain, F.4
Dumas, A.5
Wallach, J.B.6
Caire-Brandli, I.7
De Chastellier, C.8
Wu, T.D.9
Poincloux, R.10
-
66
-
-
84886571125
-
Identification of novel inhibitors of nonreplicating mycobacterium tuberculosis using a carbon starvation model
-
Grant SS, Kawate T, Nag PP, Silvis MR, Gordon K, Stanley SA, Kazyanskaya E, Nietupski R, Golas A, Fitzgerald M, et al. 2013. Identification of novel inhibitors of nonreplicating Mycobacterium tuberculosis using a carbon starvation model. ACS Chem Biol 8: 2224–2234.
-
(2013)
ACS Chem Biol
, vol.8
, pp. 2224-2234
-
-
Grant, S.S.1
Kawate, T.2
Nag, P.P.3
Silvis, M.R.4
Gordon, K.5
Stanley, S.A.6
Kazyanskaya, E.7
Nietupski, R.8
Golas, A.9
Fitzgerald, M.10
-
67
-
-
80053459692
-
High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism
-
Griffin JE, Gawronski JD, Dejesus MA, Ioerger TR, Akerley BJ, Sassetti CM. 2011. High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism. PLoS Pathog 7: e1002251.
-
(2011)
Plos Pathog
, vol.7
-
-
Griffin, J.E.1
Gawronski, J.D.2
Dejesus, M.A.3
Ioerger, T.R.4
Akerley, B.J.5
Sassetti, C.M.6
-
68
-
-
84857619791
-
Cholesterol catabolism by mycobacterium tuberculosis requires transcriptional and metabolic adaptations
-
Griffin JE, Pandey AK, Gilmore SA, Mizrahi V, McKinney JD, Bertozzi CR, Sassetti CM. 2012. Cholesterol catabolism by Mycobacterium tuberculosis requires transcriptional and metabolic adaptations. Chem Biol 19: 218– 227.
-
(2012)
Chem Biol
, vol.19
, pp. 218-227
-
-
Griffin, J.E.1
Pandey, A.K.2
Gilmore, S.A.3
Mizrahi, V.4
McKinney, J.D.5
Bertozzi, C.R.6
Sassetti, C.M.7
-
69
-
-
84856162572
-
Predicting the in vivo mechanism of action for drug leads using nmr metabolomics
-
Halouska S, Fenton RJ, Barletta RG, Powers R. 2012. Predicting the in vivo mechanism of action for drug leads using NMR metabolomics. ACS Chem Biol 7: 166–171.
-
(2012)
ACS Chem Biol
, vol.7
, pp. 166-171
-
-
Halouska, S.1
Fenton, R.J.2
Barletta, R.G.3
Powers, R.4
-
70
-
-
84893872841
-
Metabolomics analysis identifies d-alanine-d-alanine ligase as the primary lethal target of d-cycloserine in mycobacteria
-
Halouska S, Fenton RJ, Zinniel DK, Marshall DD, Barletta RG, Powers R. 2013. Metabolomics analysis identifies D-alanine-D-alanine ligase as the primary lethal target of D-cycloserine in mycobacteria. J Proteome Res 13: 1065–1076.
-
(2013)
J Proteome Res
, vol.13
, pp. 1065-1076
-
-
Halouska, S.1
Fenton, R.J.2
Zinniel, D.K.3
Marshall, D.D.4
Barletta, R.G.5
Powers, R.6
-
72
-
-
0034502343
-
Persistence of dna from mycobacterium tuberculosis in superficially normal lung tissue during latent infection
-
Hernandez-Pando R, Jeyanathan M, Mengistu G, Aguilar D, Orozco H, Harboe M, Rook GA, Bjune G. 2000. Persistence of DNA from Mycobacterium tuberculosis in superficially normal lung tissue during latent infection. Lancet 356: 2133–2138.
-
(2000)
Lancet
, vol.356
, pp. 2133-2138
-
-
Hernandez-Pando, R.1
Jeyanathan, M.2
Mengistu, G.3
Aguilar, D.4
Orozco, H.5
Harboe, M.6
Rook, G.A.7
Bjune, G.8
-
73
-
-
0142029069
-
Survival perspectives from the world’s most successful pathogen, mycobacterium tuberculosis
-
Hingley-Wilson SM, Sambandamurthy VK, Jacobs WR Jr., 2003. Survival perspectives from the world’s most successful pathogen, Mycobacterium tuberculosis. Nat Immunol 4: 949–955.
-
(2003)
Nat Immunol
, vol.4
, pp. 949-955
-
-
Hingley-Wilson, S.M.1
Sambandamurthy, V.K.2
Jacobs, W.R.3
-
74
-
-
0026674895
-
Cloning of mycobacterial histidine synthesis genes by complementation of a myco bacterium smegmatis auxotroph
-
Hinshelwood S, Stoker NG. 1992. Cloning of mycobacterial histidine synthesis genes by complementation of a Myco bacterium smegmatis auxotroph. Mol Microbiol 6: 2887– 2895.
-
(1992)
Mol Microbiol
, vol.6
, pp. 2887-2895
-
-
Hinshelwood, S.1
Stoker, N.G.2
-
75
-
-
31844449080
-
Deletion of the mycobacterium tuberculosis a-crystallin-like hspx gene causes increased bacterial growth in vivo
-
Hu Y, Movahedzadeh F, Stoker NG, Coates AR. 2006. Deletion of the Mycobacterium tuberculosis a-crystallin-like hspX gene causes increased bacterial growth in vivo. Infect Immun 74: 861–868.
-
(2006)
Infect Immun
, vol.74
, pp. 861-868
-
-
Hu, Y.1
Movahedzadeh, F.2
Stoker, N.G.3
Coates, A.R.4
-
76
-
-
34247612307
-
Multiple high-throughput analyses monitor the response of
-
Ishii N, Nakahigashi K, Baba T, Robert M, Soga T, Kanai A, Hirasawa T, Naba M, Hirai K, Hoque A, et al. 2007. Multiple high-throughput analyses monitor the response of E. coli to perturbations. Science 316: 593–597.
-
(2007)
E. Coli to Perturbations. Science
, vol.316
, pp. 593-597
-
-
Ishii, N.1
Nakahigashi, K.2
Baba, T.3
Robert, M.4
Soga, T.5
Kanai, A.6
Hirasawa, T.7
Naba, M.8
Hirai, K.9
Hoque, A.10
-
77
-
-
84923784982
-
The mycobacterial cell envelope—lipids
-
Jackson M. 2014. The mycobacterial cell envelope—Lipids. Cold Spring Harb Perspect Med 4: a021105.
-
(2014)
Cold Spring Harb Perspect Med
, vol.4
-
-
Jackson, M.1
-
78
-
-
33846807242
-
Long-chain multiple methyl-branched fatty acid-containing lipids of mycobacterium tuberculosis: Biosynthesis, transport, regulation and biological activities
-
Jackson M, Stadthagen G, Gicquel B. 2007. Long-chain multiple methyl-branched fatty acid-containing lipids of Mycobacterium tuberculosis: Biosynthesis, transport, regulation and biological activities. Tuberculosis (Edinb) 87: 78–86.
-
(2007)
Tuberculosis (Edinb)
, vol.87
, pp. 78-86
-
-
Jackson, M.1
Stadthagen, G.2
Gicquel, B.3
-
79
-
-
34247617733
-
Lipidomics reveals control of mycobacterium tuberculosis virulence lipids via metabolic coupling
-
Jain M, Petzold CJ, Schelle MW, Leavell MD, Mougous JD, Bertozzi CR, Leary JA, Cox JS. 2007. Lipidomics reveals control of Mycobacterium tuberculosis virulence lipids via metabolic coupling. Proc Natl Acad Sci 104: 5133– 5138.
-
(2007)
Proc Natl Acad Sci
, vol.104
, pp. 5133-5138
-
-
Jain, M.1
Petzold, C.J.2
Schelle, M.W.3
Leavell, M.D.4
Mougous, J.D.5
Bertozzi, C.R.6
Leary, J.A.7
Cox, J.S.8
-
80
-
-
77954039582
-
Identification of host-dependent survival factors for intracellular mycobacterium tuberculosis through an sirna screen
-
Jayaswal S, Kamal MA, Dua R, Gupta S, Majumdar T, Das G, Kumar D, Rao KV. 2010. Identification of host-dependent survival factors for intracellular Mycobacterium tuberculosis through an siRNA screen. PLoS Pathog 6: e1000839.
-
(2010)
Plos Pathog
, vol.6
-
-
Jayaswal, S.1
Kamal, M.A.2
Dua, R.3
Gupta, S.4
Majumdar, T.5
Das, G.6
Kumar, D.7
Rao, K.V.8
-
81
-
-
78650753476
-
Trehalose-recycling abc transporter lpqy-suga-sugb-sugc is essential for virulence of mycobacterium tuberculosis
-
Kalscheuer R, Weinrick B, Veeraraghavan U, Besra GS, Jacobs WR Jr., 2010. Trehalose-recycling ABC transporter LpqY-SugA-SugB-SugC is essential for virulence of Mycobacterium tuberculosis. Proc Natl Acad Sci 107: 21761– 21766.
-
(2010)
Proc Natl Acad Sci
, vol.107
, pp. 21761-21766
-
-
Kalscheuer, R.1
Weinrick, B.2
Veeraraghavan, U.3
Besra, G.S.4
Jacobs, W.R.5
-
82
-
-
10744233688
-
Mycobacterium tuberculosis growth at the cavity surface: A microenvironment with failed immunity
-
Kaplan G, Post FA, Moreira AL, Wainwright H, Kreiswirth BN, Tanverdi M, Mathema B, Ramaswamy SV, Walther G, Steyn LM, et al. 2003. Mycobacterium tuberculosis growth at the cavity surface: A microenvironment with failed immunity. Infect Immun 71: 7099–7108.
-
(2003)
Infect Immun
, vol.71
, pp. 7099-7108
-
-
Kaplan, G.1
Post, F.A.2
Moreira, A.L.3
Wainwright, H.4
Kreiswirth, B.N.5
Tanverdi, M.6
Mathema, B.7
Ramaswamy, S.V.8
Walther, G.9
Steyn, L.M.10
-
83
-
-
38349088326
-
Altered expression of isoniazid-regulated genes in drug-treated dormant mycobacterium tuberculosis
-
Karakousis PC, Williams EP, Bishai WR. 2008. Altered expression of isoniazid-regulated genes in drug-treated dormant Mycobacterium tuberculosis. J Antimicrob Chemother 61: 323–331.
-
(2008)
J Antimicrob Chemother
, vol.61
, pp. 323-331
-
-
Karakousis, P.C.1
Williams, E.P.2
Bishai, W.R.3
-
84
-
-
16244381720
-
The pyruvate requirement of some members of the mycobacterium tuberculosis complex is due to an inactive pyruvate kinase: Implications for in vivo growth
-
Keating LA, Wheeler PR, Mansoor H, Inwald JK, Dale J, Hewinson RG, Gordon SV. 2005. The pyruvate requirement of some members of the Mycobacterium tuberculosis complex is due to an inactive pyruvate kinase: Implications for in vivo growth. Mol Microbiol 56: 163–174.
-
(2005)
Mol Microbiol
, vol.56
, pp. 163-174
-
-
Keating, L.A.1
Wheeler, P.R.2
Mansoor, H.3
Inwald, J.K.4
Dale, J.5
Hewinson, R.G.6
Gordon, S.V.7
-
85
-
-
84872234951
-
High throughput phenotypic analysis of mycobacterium tuberculosis and mycobacterium bovis strains’ metabolism using biolog phenotype microarrays
-
Khatri B, Fielder M, Jones G, Newell W, Abu-Oun M, Wheeler PR. 2013. High throughput phenotypic analysis of Mycobacterium tuberculosis and Mycobacterium bovis strains’ metabolism using biolog phenotype microarrays. PLoS ONE 8: e52673.
-
(2013)
Plos ONE
, vol.8
-
-
Khatri, B.1
Fielder, M.2
Jones, G.3
Newell, W.4
Abu-Oun, M.5
Wheeler, P.R.6
-
86
-
-
77956930778
-
Caseation of human tuberculosis granulomas correlates with elevated host lipid metabolism
-
Kim MJ, Wainwright HC, Locketz M, Bekker LG, Walther GB, Dittrich C, Visser A, Wang W, Hsu FF, Wiehart U, et al. 2010. Caseation of human tuberculosis granulomas correlates with elevated host lipid metabolism. EMBO Mol Med 2: 258–274.
-
(2010)
EMBO Mol Med
, vol.2
, pp. 258-274
-
-
Kim, M.J.1
Wainwright, H.C.2
Locketz, M.3
Bekker, L.G.4
Walther, G.B.5
Dittrich, C.6
Visser, A.7
Wang, W.8
Hsu, F.F.9
Wiehart, U.10
-
87
-
-
84888113573
-
A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence
-
Kim JH, O’Brien KM, Sharma R, Boshoff HI, Rehren G, Chakraborty S, Wallach JB, Monteleone M, Wilson DJ, Aldrich CC, et al. 2013. A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence. Proc Natl Acad Sci 110: 19095–19100.
-
(2013)
Proc Natl Acad Sci
, vol.110
, pp. 19095-19100
-
-
Kim, J.H.1
O’Brien, K.M.2
Sharma, R.3
Boshoff, H.I.4
Rehren, G.5
Chakraborty, S.6
Wallach, J.B.7
Monteleone, M.8
Wilson, D.J.9
Aldrich, C.C.10
-
88
-
-
84870284140
-
Mr1 presents microbial vitamin b metabolites to mait cells
-
Kjer-Nielsen L, Patel O, Corbett AJ, Le Nours J, Meehan B, Liu L, Bhati M, Chen Z, Kostenko L, Reantragoon R, et al. 2012. MR1 presents microbial vitamin B metabolites to MAIT cells. Nature 491: 717–723.
-
(2012)
Nature
, vol.491
, pp. 717-723
-
-
Kjer-Nielsen, L.1
Patel, O.2
Corbett, A.J.3
Le Nours, J.4
Meehan, B.5
Liu, L.6
Bhati, M.7
Chen, Z.8
Kostenko, L.9
Reantragoon, R.10
-
89
-
-
84896281808
-
The impact of drug resistance on mycobacterium tuberculosis physiology: What can we learn from rifampicin?
-
Koch A, Mizrahi V, Warner DF. 2014. The impact of drug resistance on Mycobacterium tuberculosis physiology: What can we learn from rifampicin? Emerg Microb Infect 3: e17.
-
(2014)
Emerg Microb Infect
, vol.3
-
-
Koch, A.1
Mizrahi, V.2
Warner, D.F.3
-
90
-
-
84897115137
-
Assessing the essentiality of the decaprenyl-phospho-darabinofuranose pathway in mycobacterium tuberculosis using conditional mutants
-
Kolly GS, Boldrin F, Sala C, Dhar N, Hartkoorn RC, Ventura M, Serafini A, McKinney JD, Manganelli R, Cole ST. 2014. Assessing the essentiality of the decaprenyl-phospho-Darabinofuranose pathway in Mycobacterium tuberculosis using conditional mutants. Mol Microbiol 92: 194–211.
-
(2014)
Mol Microbiol
, vol.92
, pp. 194-211
-
-
Kolly, G.S.1
Boldrin, F.2
Sala, C.3
Dhar, N.4
Hartkoorn, R.C.5
Ventura, M.6
Serafini, A.7
McKinney, J.D.8
Manganelli, R.9
Cole, S.T.10
-
91
-
-
84904260030
-
Delayed bactericidal response of mycobacterium tuberculosis to bedaquiline involves remodelling of bacterial metabolism
-
Koul A, Vranckx L, Dhar N, Gohlmann HW, Ozdemir E, Neefs JM, Schulz M, Lu P, Mortz E, McKinney JD, et al. 2014. Delayed bactericidal response of Mycobacterium tuberculosis to bedaquiline involves remodelling of bacterial metabolism. Nat Commun 5: 3369.
-
(2014)
Nat Commun
, vol.5
, pp. 3369
-
-
Koul, A.1
Vranckx, L.2
Dhar, N.3
Gohlmann, H.W.4
Ozdemir, E.5
Neefs, J.M.6
Schulz, M.7
Lu, P.8
Mortz, E.9
McKinney, J.D.10
-
92
-
-
78651512996
-
Regulation between survival, persistence, and elimination of intracellular mycobacteria: A nested equilibrium of delicate balances
-
Kumar D, Rao KV. 2011. Regulation between survival, persistence, and elimination of intracellular mycobacteria: A nested equilibrium of delicate balances. Microbes Infect 13: 121–133.
-
(2011)
Microbes Infect
, vol.13
, pp. 121-133
-
-
Kumar, D.1
Rao, K.V.2
-
93
-
-
77649112187
-
Genome-wide analysis of the host intracellular network that regulates survival of mycobacterium tuberculosis
-
Kumar D, Nath L, Kamal MA, Varshney A, Jain A, Singh S, Rao KV. 2010. Genome-wide analysis of the host intracellular network that regulates survival of Mycobacterium tuberculosis. Cell 140: 731–743.
-
(2010)
Cell
, vol.140
, pp. 731-743
-
-
Kumar, D.1
Nath, L.2
Kamal, M.A.3
Varshney, A.4
Jain, A.5
Singh, S.6
Rao, K.V.7
-
94
-
-
84885079788
-
Proteomic analysis of mycobacterium tuberculosis isolates resistant to kanamycin and amikacin
-
Kumar B, Sharma D, Sharma P, Katoch VM, Venkatesan K, Bisht D. 2013. Proteomic analysis of Mycobacterium tuberculosis isolates resistant to kanamycin and amikacin. J Proteomics 94: 68–77.
-
(2013)
J Proteomics
, vol.94
, pp. 68-77
-
-
Kumar, B.1
Sharma, D.2
Sharma, P.3
Katoch, V.M.4
Venkatesan, K.5
Bisht, D.6
-
95
-
-
84879913785
-
Discovery of a glycerol 3-phosphate phosphatase reveals glycerophospholipid polar head recycling in mycobacterium tuberculosis
-
Larrouy-Maumus G, Biswas T, Hunt DM, Kelly G, Tsodikov OV, de Carvalho LP. 2013. Discovery of a glycerol 3-phosphate phosphatase reveals glycerophospholipid polar head recycling in Mycobacterium tuberculosis. Proc Natl Acad Sci 110: 11320–11325.
-
(2013)
Proc Natl Acad Sci
, vol.110
, pp. 11320-11325
-
-
Larrouy-Maumus, G.1
Biswas, T.2
Hunt, D.M.3
Kelly, G.4
Tsodikov, O.V.5
De Carvalho, L.P.6
-
96
-
-
67649482280
-
Efficacy and safety of live attenuated persistent and rapidly cleared mycobacterium tuberculosis vaccine candidates in non-human primates
-
Larsen MH, Biermann K, Chen B, Hsu T, Sambandamurthy VK, Lackner AA, Aye PP, Didier P, Huang D, Shao L, et al. 2009. Efficacy and safety of live attenuated persistent and rapidly cleared Mycobacterium tuberculosis vaccine candidates in non-human primates. Vaccine 27: 4709–4717.
-
(2009)
Vaccine
, vol.27
, pp. 4709-4717
-
-
Larsen, M.H.1
Biermann, K.2
Chen, B.3
Hsu, T.4
Sambandamurthy, V.K.5
Lackner, A.A.6
Aye, P.P.7
Didier, P.8
Huang, D.9
Shao, L.10
-
98
-
-
84874859777
-
Intracellular mycobacterium tuberculosis exploits host-derived fatty acids to limit metabolic stress
-
Lee W, VanderVen BC, Fahey RJ, Russell DG. 2013. Intracellular Mycobacterium tuberculosis exploits host-derived fatty acids to limit metabolic stress. J Biol Chem 288: 6788–6800.
-
(2013)
J Biol Chem
, vol.288
, pp. 6788-6800
-
-
Lee, W.1
Vanderven, B.C.2
Fahey, R.J.3
Russell, D.G.4
-
99
-
-
84874523447
-
Database resources for the tuberculosis community
-
Lew JM, Mao C, Shukla M, Warren A, Will R, Kuznetsov D, Xenarios I, Robertson BD, Gordon SV, Schnappinger D, et al. 2013. Database resources for the tuberculosis community. Tuberculosis (Edinb) 93: 12–17.
-
(2013)
Tuberculosis (Edinb)
, vol.93
, pp. 12-17
-
-
Lew, J.M.1
Mao, C.2
Shukla, M.3
Warren, A.4
Will, R.5
Kuznetsov, D.6
Xenarios, I.7
Robertson, B.D.8
Gordon, S.V.9
Schnappinger, D.10
-
100
-
-
84871416651
-
Identification of small rnas in mycobacterium smegmatis using heterologous hfq
-
Li SK, Ng PK, Qin H, Lau JK, Lau JP, Tsui SK, Chan TF, Lau TC. 2013. Identification of small RNAs in Mycobacterium smegmatis using heterologous Hfq. RNA 19: 74–84.
-
(2013)
RNA
, vol.19
, pp. 74-84
-
-
Li, S.K.1
Ng, P.K.2
Qin, H.3
Lau, J.K.4
Lau, J.P.5
Tsui, S.K.6
Chan, T.F.7
Lau, T.C.8
-
101
-
-
70349427123
-
Quantitative comparison of active and latent tuberculosis in the cynomolgus macaque model
-
Lin PL, Rodgers M, Smith L, Bigbee M, Myers A, Bigbee C, Chiosea I, Capuano SV, Fuhrman C, Klein E, et al. 2009. Quantitative comparison of active and latent tuberculosis in the cynomolgus macaque model. Infect Immun 77: 4631–4642.
-
(2009)
Infect Immun
, vol.77
, pp. 4631-4642
-
-
Lin, P.L.1
Rodgers, M.2
Smith, L.3
Bigbee, M.4
Myers, A.5
Bigbee, C.6
Chiosea, I.7
Capuano, S.V.8
Fuhrman, C.9
Klein, E.10
-
102
-
-
84891853921
-
Sterilization of granulomas is common in active and latent tuberculosis despite within-host variability in bacterial killing
-
Lin PL, Ford CB, Coleman MT, Myers AJ, Gawande R, Ioerger T, Sacchettini J, Fortune S., Flynn JL. 2013. Sterilization of granulomas is common in active and latent tuberculosis despite within-host variability in bacterial killing. Nat Med 20: 75–79.
-
(2013)
Nat Med
, vol.20
, pp. 75-79
-
-
Lin, P.L.1
Ford, C.B.2
Coleman, M.T.3
Myers, A.J.4
Gawande, R.5
Ioerger, T.6
Sacchettini, J.7
Fortune, S.8
Flynn, J.L.9
-
103
-
-
84895458423
-
Systemsbased approaches to probing metabolic variation within the mycobacterium tuberculosis complex
-
Lofthouse EK, Wheeler PR, Beste DJ, Khatri BL, Wu H, Mendum TA, Kierzek AM, McFadden J. 2013. Systemsbased approaches to probing metabolic variation within the Mycobacterium tuberculosis complex. PLoS ONE 8: e75913.
-
(2013)
Plos ONE
, vol.8
-
-
Lofthouse, E.K.1
Wheeler, P.R.2
Beste, D.J.3
Khatri, B.L.4
Wu, H.5
Mendum, T.A.6
Kierzek, A.M.7
McFadden, J.8
-
104
-
-
84896932200
-
An altered mycobacterium tuberculosis metabolome induced by katg mutations resulting in isoniazid resistance
-
Loots DT. 2014. An altered Mycobacterium tuberculosis metabolome induced by katG mutations resulting in isoniazid resistance. Antimicrob Agents Chemother 58: 2144–2149.
-
(2014)
Antimicrob Agents Chemother
, vol.58
, pp. 2144-2149
-
-
Loots, D.T.1
-
105
-
-
84855333428
-
Neutrophils in tuberculosis: Friend or foe?
-
Lowe DM, Redford PS, Wilkinson RJ, O’Garra A, Martineau AR. 2012. Neutrophils in tuberculosis: Friend or foe? Trends Immunol 33: 14–25.
-
(2012)
Trends Immunol
, vol.33
, pp. 14-25
-
-
Lowe, D.M.1
Redford, P.S.2
Wilkinson, R.J.3
O’Garra, A.4
Martineau, A.R.5
-
106
-
-
84893184836
-
A metabolic biosignature of early response to anti-tuberculosis treatment
-
Mahapatra S, Hess AM, Johnson JL, Eisenach KD, DeGroote MA, Gitta P, Joloba ML, Kaplan G, Walzl G, Boom WH, et al. 2014. A metabolic biosignature of early response to anti-tuberculosis treatment. BMC Infect Dis 14: 53.
-
(2014)
BMC Infect Dis
, vol.14
, pp. 53
-
-
Mahapatra, S.1
Hess, A.M.2
Johnson, J.L.3
Eisenach, K.D.4
Degroote, M.A.5
Gitta, P.6
Joloba, M.L.7
Kaplan, G.8
Walzl, G.9
Boom, W.H.10
-
107
-
-
77953105101
-
Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for mycobacterium tuberculosis to establish and maintain infection
-
Marrero J, Rhee K., Schnappinger D, Pethe K, Ehrt S. 2010. Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection. Proc Natl Acad Sci 107: 9819–9824.
-
(2010)
Proc Natl Acad Sci
, vol.107
, pp. 9819-9824
-
-
Marrero, J.1
Rhee, K.2
Schnappinger, D.3
Pethe, K.4
Ehrt, S.5
-
108
-
-
84875071289
-
Glucose phosphorylation is required for mycobacterium tuberculosis persistence in mice
-
Marrero J, Trujillo C, Rhee K., Ehrt S. 2013. Glucose phosphorylation is required for Mycobacterium tuberculosis persistence in mice. PLoS Pathog 9: e1003116.
-
(2013)
Plos Pathog
, vol.9
-
-
Marrero, J.1
Trujillo, C.2
Rhee, K.3
Ehrt, S.4
-
109
-
-
84880126124
-
Microenvironments in tuberculous granulomas are delineated by distinct populations of macrophage subsets and expression of nitric oxide synthase and arginase isoforms
-
Mattila JT, Ojo OO, Kepka-Lenhart D, Marino S, Kim JH, Eum SY, Via LE, Barry CE 3rd, Klein E, Kirschner DE, et al. 2013. Microenvironments in tuberculous granulomas are delineated by distinct populations of macrophage subsets and expression of nitric oxide synthase and arginase isoforms. J Immunol 191: 773–784.
-
(2013)
J Immunol
, vol.191
, pp. 773-784
-
-
Mattila, J.T.1
Ojo, O.O.2
Kepka-Lenhart, D.3
Marino, S.4
Kim, J.H.5
Eum, S.Y.6
Via, L.E.7
Barry, C.E.8
Klein, E.9
Kirschner, D.E.10
-
110
-
-
0028923695
-
In vivo growth characteristics of leucine and methionine auxotrophic mutants of mycobacterium bovis bcg generated by transposon mutagenesis
-
McAdam RA, Weisbrod TR, Martin J, Scuderi JD, Brown AM, Cirillo JD, Bloom BR, Jacobs WR Jr., 1995. In vivo growth characteristics of leucine and methionine auxotrophic mutants of Mycobacterium bovis BCG generated by transposon mutagenesis. Infect Immun 63: 1004– 1012.
-
(1995)
Infect Immun
, vol.63
, pp. 1004-1012
-
-
McAdam, R.A.1
Weisbrod, T.R.2
Martin, J.3
Scuderi, J.D.4
Brown, A.M.5
Cirillo, J.D.6
Bloom, B.R.7
Jacobs, W.R.8
-
111
-
-
84858991130
-
Comparative analysis of mycobacterium and related actinomycetes yields insight into the evolution of mycobacterium tuberculosis pathogenesis
-
McGuire AM, Weiner B, Park ST, Wapinski I, Raman S, Dolganov G, Peterson M, Riley R, Zucker J, Abeel T, et al. 2012. Comparative analysis of mycobacterium and related actinomycetes yields insight into the evolution of Mycobacterium tuberculosis pathogenesis. BMC Genomics 13: 120.
-
(2012)
BMC Genomics
, vol.13
, pp. 120
-
-
McGuire, A.M.1
Weiner, B.2
Park, S.T.3
Wapinski, I.4
Raman, S.5
Dolganov, G.6
Peterson, M.7
Riley, R.8
Zucker, J.9
Abeel, T.10
-
112
-
-
0342794213
-
Persistence of mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase
-
McKinney JD, Honer zu Bentrup K, Munoz-Elias EJ, Miczak A, Chen B, Chan WT, Swenson D, Sacchettini JC, Jacobs WR Jr., Russell DG. 2000. Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase. Nature 406: 735–738.
-
(2000)
Nature
, vol.406
, pp. 735-738
-
-
McKinney, J.D.1
Honer Zu Bentrup, K.2
Munoz-Elias, E.J.3
Miczak, A.4
Chen, B.5
Chan, W.T.6
Swenson, D.7
Sacchettini, J.C.8
Jacobs, W.R.9
Russell, D.G.10
-
113
-
-
84877343356
-
Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production
-
Michelucci A, Cordes T, Ghelfi J, Pailot A, Reiling N, Goldmann O, Binz T, Wegner A, Tallam A, Rausell A, et al. 2013. Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production. Proc Natl Acad Sci 110: 7820–7825.
-
(2013)
Proc Natl Acad Sci
, vol.110
, pp. 7820-7825
-
-
Michelucci, A.1
Cordes, T.2
Ghelfi, J.3
Pailot, A.4
Reiling, N.5
Goldmann, O.6
Binz, T.7
Wegner, A.8
Tallam, A.9
Rausell, A.10
-
114
-
-
77349099314
-
Division and cell envelope regulation by ser/thr phosphorylation: Mycobacterium shows the way
-
Molle V, Kremer L. 2010. Division and cell envelope regulation by Ser/Thr phosphorylation: Mycobacterium shows the way. Mol Microbiol 75: 1064–1077.
-
(2010)
Mol Microbiol
, vol.75
, pp. 1064-1077
-
-
Molle, V.1
Kremer, L.2
-
115
-
-
20944450448
-
Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulence
-
Munoz-Elias EJ, McKinney JD. 2005. Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulence. Nat Med 11: 638–644.
-
(2005)
Nat Med
, vol.11
, pp. 638-644
-
-
Munoz-Elias, E.J.1
McKinney, J.D.2
-
116
-
-
33644819211
-
Carbon metabolism of intracellular bacteria
-
Munoz-Elias EJ, McKinney JD. 2006. Carbon metabolism of intracellular bacteria. Cell Microbiol 8: 10–22.
-
(2006)
Cell Microbiol
, vol.8
, pp. 10-22
-
-
Munoz-Elias, E.J.1
McKinney, J.D.2
-
117
-
-
33745235266
-
Role of the methylcitrate cycle in mycobacterium tuberculosis metabolism, intracellular growth, and virulence
-
Munoz-Elias EJ, Upton AM, Cherian J, McKinney JD. 2006. Role of the methylcitrate cycle in Mycobacterium tuberculosis metabolism, intracellular growth, and virulence. Mol Microbiol 60: 1109–1122.
-
(2006)
Mol Microbiol
, vol.60
, pp. 1109-1122
-
-
Munoz-Elias, E.J.1
Upton, A.M.2
Cherian, J.3
McKinney, J.D.4
-
118
-
-
84875498895
-
The immune response in tuberculosis
-
O’Garra A, Redford PS, McNab FW, Bloom CI, Wilkinson RJ, Berry MP. 2013. The immune response in tuberculosis. Annu Rev Immunol 31: 475–527.
-
(2013)
Annu Rev Immunol
, vol.31
, pp. 475-527
-
-
O’Garra, A.1
Redford, P.S.2
McNab, F.W.3
Bloom, C.I.4
Wilkinson, R.J.5
Berry, M.P.6
-
119
-
-
84857232529
-
A metabolomics approach to characterise and identify various mycobacterium species
-
Olivier I, Loots D. 2012. A metabolomics approach to characterise and identify various Mycobacterium species. J Microbiol Methods 88: 419–426.
-
(2012)
J Microbiol Methods
, vol.88
, pp. 419-426
-
-
Olivier, I.1
Loots, D.2
-
120
-
-
84881232776
-
The mycobacterium tuberculosis secreted protein rv0203 transfers heme to membrane proteins mmpl3 and mmpl11
-
Owens CP, Chim N, Graves AB, Harmston CA, Iniguez A, Contreras H, Liptak MD, Goulding CW. 2013. The Mycobacterium tuberculosis secreted protein Rv0203 transfers heme to membrane proteins MmpL3 and MmpL11. J Biol Chem 288: 21714–21728.
-
(2013)
J Biol Chem
, vol.288
, pp. 21714-21728
-
-
Owens, C.P.1
Chim, N.2
Graves, A.B.3
Harmston, C.A.4
Iniguez, A.5
Contreras, H.6
Liptak, M.D.7
Goulding, C.W.8
-
121
-
-
41949119272
-
Mycobacterial persistence requires the utilization of host cholesterol
-
Pandey AK, Sassetti CM. 2008. Mycobacterial persistence requires the utilization of host cholesterol. Proc Natl Acad Sci 105: 4376–4380.
-
(2008)
Proc Natl Acad Sci
, vol.105
, pp. 4376-4380
-
-
Pandey, A.K.1
Sassetti, C.M.2
-
122
-
-
0242407462
-
Starvation survival response of mycobacterium tuberculosis
-
Parish T. 2003. Starvation survival response of Mycobacterium tuberculosis. J Bacteriol 185: 6702–6706.
-
(2003)
J Bacteriol
, vol.185
, pp. 6702-6706
-
-
Parish, T.1
-
123
-
-
0037371176
-
Deletion of two-component regulatory systems increases the virulence of mycobacterium tuberculosis
-
Parish T, Smith DA, Kendall S, Casali N, Bancroft GJ, Stoker NG. 2003. Deletion of two-component regulatory systems increases the virulence of Mycobacterium tuberculosis. Infect Immun 71: 1134–1140.
-
(2003)
Infect Immun
, vol.71
, pp. 1134-1140
-
-
Parish, T.1
Smith, D.A.2
Kendall, S.3
Casali, N.4
Bancroft, G.J.5
Stoker, N.G.6
-
124
-
-
0037634042
-
Vaccine efficacy of a lysine auxotroph of mycobacterium tuberculosis
-
Pavelka MS Jr., Chen B, Kelley CL, Collins FM, Jacobs WR Jr., 2003. Vaccine efficacy of a lysine auxotroph of Mycobacterium tuberculosis. Infect Immun 71: 4190–4192.
-
(2003)
Infect Immun
, vol.71
, pp. 4190-4192
-
-
Pavelka, M.S.1
Chen, B.2
Kelley, C.L.3
Collins, F.M.4
Jacobs, W.R.5
-
125
-
-
79251537963
-
A chemical genetic screen in mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy
-
Pethe K, Sequeira PC, Agarwalla S, Rhee K, Kuhen K, Phong WY, Patel V, Beer D, Walker JR, Duraiswamy J, et al. 2010. A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy. Nat Commun 1: 57.
-
(2010)
Nat Commun
, vol.1
, pp. 57
-
-
Pethe, K.1
Sequeira, P.C.2
Agarwalla, S.3
Rhee, K.4
Kuhen, K.5
Phong, W.Y.6
Patel, V.7
Beer, D.8
Walker, J.R.9
Duraiswamy, J.10
-
126
-
-
57149096869
-
Foamy macrophages from tuberculous patients’ granulomas constitute a nutrient-rich reservoir for m. Tuberculosis persistence
-
Peyron P, Vaubourgeix J, Poquet Y, Levillain F, Botanch C, Bardou F, Daffe M, Emile JF, Marchou B, Cardona PJ, et al. 2008. Foamy macrophages from tuberculous patients’ granulomas constitute a nutrient-rich reservoir for M. tuberculosis persistence. PLoS Pathog 4: e1000204.
-
(2008)
Plos Pathog
, vol.4
-
-
Peyron, P.1
Vaubourgeix, J.2
Poquet, Y.3
Levillain, F.4
Botanch, C.5
Bardou, F.6
Daffe, M.7
Emile, J.F.8
Marchou, B.9
Cardona, P.J.10
-
127
-
-
84890499902
-
Metabolomics reveal d-alanine: D-alanine ligase as the target of d-cycloserine in mycobacterium tuberculosis
-
Prosser GA, de Carvalho LP. 2013. Metabolomics reveal D-alanine: D-alanine ligase as the target of D-cycloserine in Mycobacterium tuberculosis. ACS Med Chem Lett 4: 1233–1237.
-
(2013)
ACS Med Chem Lett
, vol.4
, pp. 1233-1237
-
-
Prosser, G.A.1
De Carvalho, L.P.2
-
128
-
-
84866434542
-
Sustained generation of nitric oxide and control of mycobacterial infection requires argininosuccinate synthase 1
-
Qualls JE, Subramanian C, Rafi W, Smith AM, Balouzian L, DeFreitas AA, Shirey KA, Reutterer B, Kernbauer E, Stockinger S, et al. 2012. Sustained generation of nitric oxide and control of mycobacterial infection requires argininosuccinate synthase 1. Cell Host Microbe 12: 313–323.
-
(2012)
Cell Host Microbe
, vol.12
, pp. 313-323
-
-
Qualls, J.E.1
Subramanian, C.2
Rafi, W.3
Smith, A.M.4
Balouzian, L.5
Defreitas, A.A.6
Shirey, K.A.7
Reutterer, B.8
Kernbauer, E.9
Stockinger, S.10
-
129
-
-
20444419421
-
Genome-wide requirements for mycobacterium tuberculosis adaptation and survival in macrophages
-
Rengarajan J, Bloom BR, Rubin EJ. 2005. Genome-wide requirements for Mycobacterium tuberculosis adaptation and survival in macrophages. Proc Natl Acad Sci 102: 8327–8332.
-
(2005)
Proc Natl Acad Sci
, vol.102
, pp. 8327-8332
-
-
Rengarajan, J.1
Bloom, B.R.2
Rubin, E.J.3
-
130
-
-
84887074521
-
Minding the gaps: Metabolomics mends functional genomics
-
Rhee K. 2013. Minding the gaps: Metabolomics mends functional genomics. EMBO Rep 14: 949–950.
-
(2013)
EMBO Rep
, vol.14
, pp. 949-950
-
-
Rhee, K.1
-
131
-
-
79959913123
-
Central carbon metabolism in mycobacterium tuberculosis: An unexpected frontier
-
Rhee K., de Carvalho LP., Bryk R, Ehrt S, Marrero J, Park SW, Schnappinger D, Venugopal A, Nathan C. 2011. Central carbon metabolism in Mycobacterium tuberculosis: An unexpected frontier. Trends Microbiol 19: 307–314.
-
(2011)
Trends Microbiol
, vol.19
, pp. 307-314
-
-
Rhee, K.1
De Carvalho, L.P.2
Bryk, R.3
Ehrt, S.4
Marrero, J.5
Park, S.W.6
Schnappinger, D.7
Venugopal, A.8
Nathan, C.9
-
132
-
-
84864044868
-
Linking the transcriptional profiles and the physiological states of mycobacterium tuberculosis during an extended intracellular infection
-
Rohde KH, Veiga DF, Caldwell S, Balazsi G, Russell DG. 2012. Linking the transcriptional profiles and the physiological states of Mycobacterium tuberculosis during an extended intracellular infection. PLoS Pathog 8: e1002769.
-
(2012)
Plos Pathog
, vol.e1002769
, pp. 8
-
-
Rohde, K.H.1
Veiga, D.F.2
Caldwell, S.3
Balazsi, G.4
Russell, D.G.5
-
133
-
-
84888432770
-
Mapping of genotype-phenotype diversity among clinical isolates of mycobacterium tuberculosis by sequence-based transcriptional profiling
-
Rose G, Cortes T, Comas I, Coscolla M, Gagneux S, Young DB. 2013. Mapping of genotype-phenotype diversity among clinical isolates of Mycobacterium tuberculosis by sequence-based transcriptional profiling. Genome Biol Evol 5: 1849–1862.
-
(2013)
Genome Biol Evol
, vol.5
, pp. 1849-1862
-
-
Rose, G.1
Cortes, T.2
Comas, I.3
Coscolla, M.4
Gagneux, S.5
Young, D.B.6
-
134
-
-
79951902640
-
Mycobacterium tuberculosis and the intimate discourse of a chronic infection
-
Russell DG. 2011. Mycobacterium tuberculosis and the intimate discourse of a chronic infection. Immunol Rev 240: 252–268.
-
(2011)
Immunol Rev
, vol.240
, pp. 252-268
-
-
Russell, D.G.1
-
135
-
-
84871731081
-
Global analysis of mrna stability in mycobacterium tuberculosis
-
Rustad TR, Minch KJ, Brabant W, Winkler JK, Reiss DJ, Baliga NS, Sherman DR. 2013. Global analysis of mRNA stability in Mycobacterium tuberculosis. Nucleic Acids Res 41: 509–517.
-
(2013)
Nucleic Acids Res
, vol.41
, pp. 509-517
-
-
Rustad, T.R.1
Minch, K.J.2
Brabant, W.3
Winkler, J.K.4
Reiss, D.J.5
Baliga, N.S.6
Sherman, D.R.7
-
136
-
-
12844272269
-
Long-term protection against tuberculosis following vaccination with a severely attenuated double lysine and pantothenate auxotroph of mycobacterium tuberculosis
-
Sambandamurthy VK, Derrick SC, Jalapathy KV, Chen B, Russell RG, Morris SL, Jacobs WR Jr, 2005. Long-term protection against tuberculosis following vaccination with a severely attenuated double lysine and pantothenate auxotroph of Mycobacterium tuberculosis. Infect Immun 73: 1196–1203.
-
(2005)
Infect Immun
, vol.73
, pp. 1196-1203
-
-
Sambandamurthy, V.K.1
Derrick, S.C.2
Jalapathy, K.V.3
Chen, B.4
Russell, R.G.5
Morris, S.L.6
Jacobs, W.R.7
-
137
-
-
2142708662
-
Protection elicited by a double leucine and pantothenate auxotroph of mycobacterium tuberculosis in guinea pigs
-
Sampson SL, Dascher CC, Sambandamurthy VK, Russell RG, Jacobs WR Jr, Bloom BR, Hondalus MK. 2004. Protection elicited by a double leucine and pantothenate auxotroph of Mycobacterium tuberculosis in guinea pigs. Infect Immun 72: 3031–3037.
-
(2004)
Infect Immun
, vol.72
, pp. 3031-3037
-
-
Sampson, S.L.1
Dascher, C.C.2
Sambandamurthy, V.K.3
Russell, R.G.4
Jacobs, W.R.5
Bloom, B.R.6
Hondalus, M.K.7
-
138
-
-
79960649514
-
Extended safety and efficacy studies of a live attenuated double leucine and pantothenate auxotroph of mycobacterium tuberculosis as a vaccine candidate
-
Sampson SL, Mansfield KG, Carville A, Magee DM, Quitugua T, Howerth EW, Bloom BR, Hondalus MK. 2011. Extended safety and efficacy studies of a live attenuated double leucine and pantothenate auxotroph of Mycobacterium tuberculosis as a vaccine candidate. Vaccine 29: 4839–4847.
-
(2011)
Vaccine
, vol.29
, pp. 4839-4847
-
-
Sampson, S.L.1
Mansfield, K.G.2
Carville, A.3
Magee, D.M.4
Quitugua, T.5
Howerth, E.W.6
Bloom, B.R.7
Hondalus, M.K.8
-
139
-
-
0242268400
-
Genetic requirements for mycobacterial survival during infection
-
Sassetti CM, Rubin EJ. 2003. Genetic requirements for mycobacterial survival during infection. Proc Natl Acad Sci 100: 12989–12994.
-
(2003)
Proc Natl Acad Sci
, vol.100
, pp. 12989-12994
-
-
Sassetti, C.M.1
Rubin, E.J.2
-
140
-
-
0345701347
-
Genes required for mycobacterial growth defined by high density mutagenesis
-
Sassetti CM, Boyd DH, Rubin EJ. 2003. Genes required for mycobacterial growth defined by high density mutagenesis. Mol Microbiol 48: 77–84.
-
(2003)
Mol Microbiol
, vol.48
, pp. 77-84
-
-
Sassetti, C.M.1
Boyd, D.H.2
Rubin, E.J.3
-
141
-
-
44349163542
-
Functional characterization of a vitamin b12-dependent methylmalonyl pathway in mycobacterium tuberculosis: Implications for propionate metabolism during growth on fatty acids
-
12-dependent methylmalonyl pathway in Mycobacterium tuberculosis: Implications for propionate metabolism during growth on fatty acids. J Bacteriol 190: 3886–3895.
-
(2008)
J Bacteriol
, vol.190
, pp. 3886-3895
-
-
Savvi, S.1
Warner, D.F.2
Kana, B.D.3
McKinney, J.D.4
Mizrahi, V.5
Dawes, S.S.6
-
142
-
-
0043142536
-
Transcriptional adaptation of mycobacterium tuberculosis within macrophages: Insights into the phagosomal environment
-
Schnappinger D, Ehrt S, Voskuil MI, Liu Y, Mangan JA, Monahan IM, Dolganov G, Efron B, Butcher PD, Nathan C, et al. 2003. Transcriptional adaptation of Mycobacterium tuberculosis within macrophages: Insights into the phagosomal environment. J Exp Med 198: 693–704.
-
(2003)
J Exp Med
, vol.198
, pp. 693-704
-
-
Schnappinger, D.1
Ehrt, S.2
Voskuil, M.I.3
Liu, Y.4
Mangan, J.A.5
Monahan, I.M.6
Dolganov, G.7
Efron, B.8
Butcher, P.D.9
Nathan, C.10
-
143
-
-
48849094355
-
Host-directed drug targeting of factors hijacked by pathogens
-
Schwegmann A, Brombacher F. 2008. Host-directed drug targeting of factors hijacked by pathogens. Sci Signal 1: re8.
-
(2008)
Sci Signal
, vol.1
-
-
Schwegmann, A.1
Brombacher, F.2
-
145
-
-
29644437414
-
Dihydrolipoamide acyltransferase is critical for mycobacterium tuberculosis pathogenesis
-
Shi S, Ehrt S. 2006. Dihydrolipoamide acyltransferase is critical for Mycobacterium tuberculosis pathogenesis. Infect Immun 74: 56–63.
-
(2006)
Infect Immun
, vol.74
, pp. 56-63
-
-
Shi, S.1
Ehrt, S.2
-
146
-
-
80755126602
-
Mechanism-based inactivation by aromatization of the transaminase bioa involved in biotin biosynthesis in mycobaterium tuberculosis
-
Shi C, Geders TW, Park SW, Wilson DJ, Boshoff HI, Abayomi O, Barry CE 3rd, Schnappinger D, Finzel BC, Aldrich CC. 2011. Mechanism-based inactivation by aromatization of the transaminase BioA involved in biotin biosynthesis in Mycobaterium tuberculosis. J Am Chem Soc 133: 18194–18201.
-
(2011)
J am Chem Soc
, vol.133
, pp. 18194-18201
-
-
Shi, C.1
Geders, T.W.2
Park, S.W.3
Wilson, D.J.4
Boshoff, H.I.5
Abayomi, O.6
Barry, C.E.7
Schnappinger, D.8
Finzel, B.C.9
Aldrich, C.C.10
-
147
-
-
0346734118
-
Hypervirulent mutant of mycobacterium tuberculosis resulting from disruption of the mce1 operon
-
Shimono N, Morici L, Casali N, Cantrell S, Sidders B, Ehrt S, Riley LW. 2003. Hypervirulent mutant of Mycobacterium tuberculosis resulting from disruption of the mce1 operon. Proc Natl Acad Sci 100: 15918–15923.
-
(2003)
Proc Natl Acad Sci
, vol.100
, pp. 15918-15923
-
-
Shimono, N.1
Morici, L.2
Casali, N.3
Cantrell, S.4
Sidders, B.5
Ehrt, S.6
Riley, L.W.7
-
148
-
-
79955801104
-
1h nmr-based metabolomic profiling in mice infected with mycobacterium tuberculosis
-
1H NMR-based metabolomic profiling in mice infected with Mycobacterium tuberculosis. J Proteome Res 10: 2238–2247.
-
(2011)
J Proteome Res
, vol.10
, pp. 2238-2247
-
-
Shin, J.H.1
Yang, J.Y.2
Jeon, B.Y.3
Yoon, Y.J.4
Cho, S.N.5
Kang, Y.H.6
Ryu Do, H.7
Hwang, G.S.8
-
149
-
-
84896301243
-
Unusual large-scale chromosomal rearrangements in mycobacterium tuberculosis beijing b0/w148 cluster isolates
-
Shitikov EA, Bespyatykh JA, Ischenko DS, Alexeev DG, Karpova IY, Kostryukova ES, Isaeva YD, Nosova EY, Mokrousov IV, Vyazovaya AA, et al. 2014. Unusual large-scale chromosomal rearrangements in Mycobacterium tuberculosis Beijing B0/W148 cluster isolates. PLoS ONE 9: e84971.
-
(2014)
Plos ONE
, vol.9
-
-
Shitikov, E.A.1
Bespyatykh, J.A.2
Ischenko, D.S.3
Alexeev, D.G.4
Karpova, I.Y.5
Kostryukova, E.S.6
Isaeva, Y.D.7
Nosova, E.Y.8
Mokrousov, I.V.9
Vyazovaya, A.A.10
-
150
-
-
84869176200
-
Mycobacterium tuberculosis-driven targeted recalibration of macrophage lipid homeostasis promotes the foamy phenotype
-
Singh V, Jamwal S, Jain R, Verma P, Gokhale R, Rao KV. 2012. Mycobacterium tuberculosis-driven targeted recalibration of macrophage lipid homeostasis promotes the foamy phenotype. Cell Host Microbe 12: 669–681.
-
(2012)
Cell Host Microbe
, vol.12
, pp. 669-681
-
-
Singh, V.1
Jamwal, S.2
Jain, R.3
Verma, P.4
Gokhale, R.5
Rao, K.V.6
-
151
-
-
84874530185
-
Updating and curating metabolic pathways of tb
-
Slayden RA, Jackson M, Zucker J, Ramirez MV, Dawson CC, Crew R, Sampson NS, Thomas ST, Jamshidi N, Sisk P, et al. 2013. Updating and curating metabolic pathways of TB. Tuberculosis (Edinb) 93: 47–59.
-
(2013)
Tuberculosis (Edinb)
, vol.93
, pp. 47-59
-
-
Slayden, R.A.1
Jackson, M.2
Zucker, J.3
Ramirez, M.V.4
Dawson, C.C.5
Crew, R.6
Sampson, N.S.7
Thomas, S.T.8
Jamshidi, N.9
Sisk, P.10
-
152
-
-
0035145539
-
Characterization of auxotrophic mutants of mycobacterium tuberculosis and their potential as vaccine candidates
-
Smith DA, Parish T, Stoker NG, Bancroft GJ. 2001. Characterization of auxotrophic mutants of Mycobacterium tuberculosis and their potential as vaccine candidates. Infect Immun 69: 1142–1150.
-
(2001)
Infect Immun
, vol.69
, pp. 1142-1150
-
-
Smith, D.A.1
Parish, T.2
Stoker, N.G.3
Bancroft, G.J.4
-
153
-
-
84881068658
-
The microbial metabolites, short-chain fatty acids, regulate colonic treg cell homeostasis
-
reg cell homeostasis. Science 341: 569–573.
-
(2013)
Science
, vol.341
, pp. 569-573
-
-
Smith, P.M.1
Howitt, M.R.2
Panikov, N.3
Michaud, M.4
Gallini, C.A.5
Bohlooly, Y.M.6
Glickman, J.N.7
Garrett, W.S.8
-
154
-
-
84867449305
-
Metabolomic signatures in guinea pigs infected with epidemicassociated w-beijing strains of mycobacterium tuberculosis
-
Somashekar BS, Amin AG, Tripathi P, MacKinnon N, Rithner CD, Shanley CA, Basaraba R, Henao-Tamayo M, Kato-Maeda M, Ramamoorthy A, et al. 2012. Metabolomic signatures in guinea pigs infected with epidemicassociated W-Beijing strains of Mycobacterium tuberculosis. J Proteome Res 11: 4873–4884.
-
(2012)
J Proteome Res
, vol.11
, pp. 4873-4884
-
-
Somashekar, B.S.1
Amin, A.G.2
Tripathi, P.3
Mackinnon, N.4
Rithner, C.D.5
Shanley, C.A.6
Basaraba, R.7
Henao-Tamayo, M.8
Kato-Maeda, M.9
Ramamoorthy, A.10
-
155
-
-
84895732971
-
Identification of host-targeted small molecules that restrict intracellular mycobacterium tuberculosis growth
-
Stanley SA, Barczak AK, Silvis MR, Luo SS, Sogi K, Vokes M, Bray MA, Carpenter AE, Moore CB, Siddiqi N, et al. 2014. Identification of host-targeted small molecules that restrict intracellular Mycobacterium tuberculosis growth. PLoS Pathog 10: e1003946.
-
(2014)
Plos Pathog
, vol.10
-
-
Stanley, S.A.1
Barczak, A.K.2
Silvis, M.R.3
Luo, S.S.4
Sogi, K.5
Vokes, M.6
Bray, M.A.7
Carpenter, A.E.8
Moore, C.B.9
Siddiqi, N.10
-
156
-
-
42149102918
-
Insights from the complete genome sequence of mycobacterium marinum on the evolution of mycobacterium tuberculosis
-
Stinear TP, Seemann T, Harrison PF, Jenkin GA, Davies JK, Johnson PD, Abdellah Z, Arrowsmith C, Chillingworth T, Churcher C, et al. 2008. Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis. Genome Res 18: 729–741.
-
(2008)
Genome Res
, vol.18
, pp. 729-741
-
-
Stinear, T.P.1
Seemann, T.2
Harrison, P.F.3
Jenkin, G.A.4
Davies, J.K.5
Johnson, P.D.6
Abdellah, Z.7
Arrowsmith, C.8
Chillingworth, T.9
Churcher, C.10
-
157
-
-
80054737427
-
Itaconic acid is a mammalian metabolite induced during macrophage activation
-
Strelko CL, Lu W, Dufort FJ, Seyfried TN, Chiles TC, Rabinowitz JD, Roberts MF. 2011. Itaconic acid is a mammalian metabolite induced during macrophage activation. J Am Chem Soc 133: 16386–16389.
-
(2011)
J am Chem Soc
, vol.133
, pp. 16386-16389
-
-
Strelko, C.L.1
Lu, W.2
Dufort, F.J.3
Seyfried, T.N.4
Chiles, T.C.5
Rabinowitz, J.D.6
Roberts, M.F.7
-
158
-
-
84873095223
-
Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of mycobacterium tuberculosis
-
Supply P, Marceau M, Mangenot S, Roche D, Rouanet C, Khanna V, Majlessi L, Criscuolo A, Tap J, Pawlik A, et al. 2013. Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis. Nat Genet 45: 172–179.
-
(2013)
Nat Genet
, vol.45
, pp. 172-179
-
-
Supply, P.1
Marceau, M.2
Mangenot, S.3
Roche, D.4
Rouanet, C.5
Khanna, V.6
Majlessi, L.7
Criscuolo, A.8
Tap, J.9
Pawlik, A.10
-
159
-
-
84876285741
-
Succinate is an inflammatory signal that induces il-1b through hif-1a
-
Tannahill GM, Curtis AM, Adamik J, Palsson-McDermott EM, McGettrick AF, Goel G, Frezza C, Bernard NJ, Kelly B, Foley NH, et al. 2013. Succinate is an inflammatory signal that induces IL-1b through HIF-1a. Nature 496: 238–242.
-
(2013)
Nature
, vol.496
, pp. 238-242
-
-
Tannahill, G.M.1
Curtis, A.M.2
Adamik, J.3
Palsson-McDermott, E.M.4
McGettrick, A.F.5
Goel, G.6
Frezza, C.7
Bernard, N.J.8
Kelly, B.9
Foley, N.H.10
-
160
-
-
83755168972
-
Pathway profiling in mycobacterium tuberculosis: Elucidation of cholesterol-derived catabolite and enzymes that catalyze its metabolism
-
Thomas ST, VanderVen BC, Sherman DR, Russell DG, Sampson NS. 2011. Pathway profiling in Mycobacterium tuberculosis: Elucidation of cholesterol-derived catabolite and enzymes that catalyze its metabolism. J Biol Chem 286: 43668–43678.
-
(2011)
J Biol Chem
, vol.286
, pp. 43668-43678
-
-
Thomas, S.T.1
Vanderven, B.C.2
Sherman, D.R.3
Russell, D.G.4
Sampson, N.S.5
-
161
-
-
22644447865
-
Variant tricarboxylic acid cycle in mycobacterium tuberculosis: Identification of a-ketoglutarate decarboxylase
-
Tian J, Bryk R, Itoh M, Suematsu M, Nathan C. 2005a. Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: Identification of a-ketoglutarate decarboxylase. Proc Natl Acad Sci 102: 10670–10675.
-
(2005)
Proc Natl Acad Sci
, vol.102
, pp. 10670-10675
-
-
Tian, J.1
Bryk, R.2
Itoh, M.3
Suematsu, M.4
Nathan, C.5
-
162
-
-
22644436537
-
Mycobacterium tuberculosis appears to lack a-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes
-
Tian J, Bryk R, Shi S, Erdjument-Bromage H, Tempst P, Nathan C. 2005b. Mycobacterium tuberculosis appears to lack a-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes. Mol Microbiol 57: 859–868.
-
(2005)
Mol Microbiol
, vol.57
, pp. 859-868
-
-
Tian, J.1
Bryk, R.2
Shi, S.3
Erdjument-Bromage, H.4
Tempst, P.5
Nathan, C.6
-
163
-
-
10744228285
-
Differential expression of iron-, carbon-, and oxygen-responsive mycobacterial genes in the lungs of chronically infected mice and tuberculosis patients
-
Timm J, Post FA, Bekker LG, Walther GB, Wainwright HC, Manganelli R, Chan WT, Tsenova L, Gold B, Smith I, et al. 2003. Differential expression of iron-, carbon-, and oxygen-responsive mycobacterial genes in the lungs of chronically infected mice and tuberculosis patients. Proc Natl Acad Sci 100: 14321–14326.
-
(2003)
Proc Natl Acad Sci
, vol.100
, pp. 14321-14326
-
-
Timm, J.1
Post, F.A.2
Bekker, L.G.3
Walther, G.B.4
Wainwright, H.C.5
Manganelli, R.6
Chan, W.T.7
Tsenova, L.8
Gold, B.9
Smith, I.10
-
164
-
-
11144356962
-
Functional and evolutionary genomics of mycobacterium tuberculosis: Insights from genomic deletions in 100 strains
-
Tsolaki AG, Hirsh AE, DeRiemer K, Enciso JA, Wong MZ, Hannan M, Goguet de la Salmoniere YO, Aman K, KatoMaeda M, Small PM. 2004. Functional and evolutionary genomics of Mycobacterium tuberculosis: Insights from genomic deletions in 100 strains. Proc Natl Acad Sci 101: 4865–4870.
-
(2004)
Proc Natl Acad Sci
, vol.101
, pp. 4865-4870
-
-
Tsolaki, A.G.1
Hirsh, A.E.2
Deriemer, K.3
Enciso, J.A.4
Wong, M.Z.5
Hannan, M.6
Goguet De La Salmoniere, Y.O.7
Aman, K.8
Katomaeda, M.9
Small, P.M.10
-
165
-
-
79953175298
-
Discovery and characterization of a unique mycobacterial heme acquisition system
-
Tullius MV, Harmston CA, Owens CP, Chim N, Morse RP, McMath LM, Iniguez A, Kimmey JM, Sawaya MR, Whitelegge JP, et al. 2011. Discovery and characterization of a unique mycobacterial heme acquisition system. Proc Natl Acad Sci 108: 5051–5056.
-
(2011)
Proc Natl Acad Sci
, vol.108
, pp. 5051-5056
-
-
Tullius, M.V.1
Harmston, C.A.2
Owens, C.P.3
Chim, N.4
Morse, R.P.5
McMath, L.M.6
Iniguez, A.7
Kimmey, J.M.8
Sawaya, M.R.9
Whitelegge, J.P.10
-
167
-
-
49149122930
-
A membrane protein preserves intrabacterial ph in intraphagosomal mycobacterium tuberculosis
-
Vandal O., Pierini LM, Schnappinger D, Nathan C., Ehrt S. 2008. A membrane protein preserves intrabacterial pH in intraphagosomal Mycobacterium tuberculosis. Nat Med 14: 849–854.
-
(2008)
Nat Med
, vol.14
, pp. 849-854
-
-
Vandal, O.1
Pierini, L.M.2
Schnappinger, D.3
Nathan, C.4
Ehrt, S.5
-
168
-
-
84885388067
-
Gara is an essential regulator of metabolism in mycobacterium tuberculosis
-
Ventura M, Rieck B, Boldrin F, Degiacomi G, Bellinzoni M, Barilone N, Alzaidi F, Alzari PM, Manganelli R, O’Hare HM. 2013. GarA is an essential regulator of metabolism in Mycobacterium tuberculosis. Mol Microbiol 90: 356– 366.
-
(2013)
Mol Microbiol
, vol.90
, pp. 356-366
-
-
Ventura, M.1
Rieck, B.2
Boldrin, F.3
Degiacomi, G.4
Bellinzoni, M.5
Barilone, N.6
Alzaidi, F.7
Alzari, P.M.8
Manganelli, R.9
O’Hare, H.M.10
-
169
-
-
78751520936
-
Virulence of mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes
-
Venugopal A, Bryk R, Shi S, Rhee K, Rath P, Schnappinger D, Ehrt S, Nathan C. 2011. Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes. Cell Host Microbe 9: 21–31.
-
(2011)
Cell Host Microbe
, vol.9
, pp. 21-31
-
-
Venugopal, A.1
Bryk, R.2
Shi, S.3
Rhee, K.4
Rath, P.5
Schnappinger, D.6
Ehrt, S.7
Nathan, C.8
-
170
-
-
46249108568
-
Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates
-
Via LE, Lin PL, Ray SM, Carrillo J, Allen SS, Eum SY, Taylor K, Klein E, Manjunatha U, Gonzales J, et al. 2008. Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates. Infect Immun 76: 2333–2340.
-
(2008)
Infect Immun
, vol.76
, pp. 2333-2340
-
-
Via, L.E.1
Lin, P.L.2
Ray, S.M.3
Carrillo, J.4
Allen, S.S.5
Eum, S.Y.6
Taylor, K.7
Klein, E.8
Manjunatha, U.9
Gonzales, J.10
-
171
-
-
84880664059
-
Differential virulence and disease progression following mycobacterium tuberculosis complex infection of the common marmoset (callithrix jacchus)
-
Via LE, Weiner DM, Schimel D, Lin PL, Dayao E, Tankersley SL, Cai Y, Coleman MT, Tomko J, Paripati P, et al. 2013. Differential virulence and disease progression following Mycobacterium tuberculosis complex infection of the common marmoset (Callithrix jacchus). Infect Immun 81: 2909–2919.
-
(2013)
Infect Immun
, vol.81
, pp. 2909-2919
-
-
Via, L.E.1
Weiner, D.M.2
Schimel, D.3
Lin, P.L.4
Dayao, E.5
Tankersley, S.L.6
Cai, Y.7
Coleman, M.T.8
Tomko, J.9
Paripati, P.10
-
172
-
-
12444344631
-
Elemental analysis of mycobacterium avium-, mycobacterium tuberculosis-, and mycobacterium smegmatis-containing phag osomes indicates pathogen-induced microenvironments within the host cell’s endosomal system
-
Wagner D, Maser J, Lai B, Cai Z, Barry CE 3rd, Honer Zu Bentrup K, Russell DG, Bermudez LE. 2005. Elemental analysis of Mycobacterium avium-, Mycobacterium tuberculosis-, and Mycobacterium smegmatis-containing phag osomes indicates pathogen-induced microenvironments within the host cell’s endosomal system. J Immunol 174: 1491–1500.
-
(2005)
J Immunol
, vol.174
, pp. 1491-1500
-
-
Wagner, D.1
Maser, J.2
Lai, B.3
Cai, Z.4
Barry, C.E.5
Honer Zu Bentrup, K.6
Russell, D.G.7
Bermudez, L.E.8
-
173
-
-
80052174382
-
Functional plasticity and allosteric regulation of a-ketoglutarate decarboxylase in central mycobacterial metabolism
-
Wagner T, Bellinzoni M, Wehenkel A, O’Hare HM, Alzari PM. 2011. Functional plasticity and allosteric regulation of a-ketoglutarate decarboxylase in central mycobacterial metabolism. Chem Biol 18: 1011–1020.
-
(2011)
Chem Biol
, vol.18
, pp. 1011-1020
-
-
Wagner, T.1
Bellinzoni, M.2
Wehenkel, A.3
O’Hare, H.M.4
Alzari, P.M.5
-
174
-
-
84857237436
-
Physiology of mycobacterium tuberculosis
-
(ed. Rubin EJ, Kaufmann SHE), Wiley-VCH, Weinheim, Germany
-
Warner DF, Mizrahi V. 2008. Physiology of Mycobacterium tuberculosis. InTuberculosis handbook, Vol. 1 (ed. Rubin EJ, Kaufmann SHE), pp. 53–59. Wiley-VCH, Weinheim, Germany.
-
(2008)
Intuberculosis Handbook
, vol.1
, pp. 53-59
-
-
Warner, D.F.1
Mizrahi, V.2
-
175
-
-
84865136016
-
Approaches to target identification and validation for tuberculosis drug discovery: A uct perspective
-
Warner DF, Mizrahi V. 2012. Approaches to target identification and validation for tuberculosis drug discovery: A UCT perspective. S Afr Med J 102: 457–460.
-
(2012)
S Afr Med J
, vol.102
, pp. 457-460
-
-
Warner, D.F.1
Mizrahi, V.2
-
176
-
-
34247642773
-
A riboswitch regulates expression of the coenzyme b12-independent methionine synthase in mycobacterium tuberculosis: Implications for differential methionine synthase function in strains h37rv and cdc1551
-
12-independent methionine synthase in Mycobacterium tuberculosis: Implications for differential methionine synthase function in strains H37Rv and CDC1551. J Bacteriol 189: 3655– 3659.
-
(2007)
J Bacteriol
, vol.189
, pp. 3655-3659
-
-
Warner, D.F.1
Savvi, S.2
Mizrahi, V.3
Dawes, S.S.4
-
177
-
-
80055079575
-
Fumarate reductase activity maintains an energized membrane in anaerobic mycobacterium tuberculosis
-
Watanabe S, Zimmermann M, Goodwin MB, Sauer U, Barry CE 3rd, Boshoff HI. 2011. Fumarate reductase activity maintains an energized membrane in anaerobic Mycobacterium tuberculosis. PLoS Pathog 7: e1002287.
-
(2011)
Plos Pathog
, vol.7
-
-
Watanabe, S.1
Zimmermann, M.2
Goodwin, M.B.3
Sauer, U.4
Barry, C.E.5
Boshoff, H.I.6
-
178
-
-
79952760675
-
Depletion of antibiotic targets has widely varying effects on growth
-
Wei JR, Krishnamoorthy V, Murphy K, Kim JH, Schnappinger D, Alber T, Sassetti CM, Rhee K., Rubin EJ. 2011. Depletion of antibiotic targets has widely varying effects on growth. Proc Natl Acad Sci 108: 4176–4181.
-
(2011)
Proc Natl Acad Sci
, vol.108
, pp. 4176-4181
-
-
Wei, J.R.1
Krishnamoorthy, V.2
Murphy, K.3
Kim, J.H.4
Schnappinger, D.5
Alber, T.6
Sassetti, C.M.7
Rhee, K.8
Rubin, E.J.9
-
179
-
-
84863411118
-
Independent large scale duplications in multiple m. Tuberculosis lineages overlapping the same genomic region
-
Weiner B, Gomez J, Victor TC, Warren RM, Sloutsky A, Plikaytis BB, Posey JE, van Helden PD, Gey van Pittius NC, Koehrsen M, et al. 2012a. Independent large scale duplications in multiple M. tuberculosis lineages overlapping the same genomic region. PLoS ONE 7: e26038.
-
(2012)
Plos ONE
, vol.7
-
-
Weiner, B.1
Gomez, J.2
Victor, T.C.3
Warren, R.M.4
Sloutsky, A.5
Plikaytis, B.B.6
Posey, J.E.7
Van Helden, P.D.8
Gey Van Pittius, N.C.9
Koehrsen, M.10
-
180
-
-
84864612118
-
Biomarkers of inflammation, immunosuppression and stress with active disease are revealed by metabolomic profiling of tuberculosis patients
-
Weiner J 3rd, Parida SK, Maertzdorf J, Black GF, Repsilber D, Telaar A, Mohney RP, Arndt-Sullivan C, Ganoza CA, Fae KC, et al. 2012b. Biomarkers of inflammation, immunosuppression and stress with active disease are revealed by metabolomic profiling of tuberculosis patients. PLoS ONE 7: e40221.
-
(2012)
Plos ONE
, vol.7
-
-
Weiner, J.1
Parida, S.K.2
Maertzdorf, J.3
Black, G.F.4
Repsilber, D.5
Telaar, A.6
Mohney, R.P.7
Arndt-Sullivan, C.8
Ganoza, C.A.9
Fae, K.C.10
-
181
-
-
0001969131
-
Metabolism of mycobacterium tuberculosis
-
(ed. Bloom BR),, . American Society for Microbiology, Washington, DC
-
Wheeler PR, Ratledge C. 1994. Metabolism of Mycobacterium tuberculosis. InTuberculosis: Pathogenesis, protection, and control (ed. Bloom BR), pp. 353–385. American Society for Microbiology, Washington, DC.
-
(1994)
Intuberculosis: Pathogenesis, Protection, and Control
, pp. 353-385
-
-
Wheeler, P.R.1
Ratledge, C.2
-
182
-
-
84891130978
-
Molybdenum cofactor: A key component of mycobacterium tuberculosis pathogenesis?
-
Williams M, Mizrahi V, Kana BD. 2014. Molybdenum cofactor: A key component of Mycobacterium tuberculosis pathogenesis? Crit Rev Microbiol 40: 18–29.
-
(2014)
Crit Rev Microbiol
, vol.40
, pp. 18-29
-
-
Williams, M.1
Mizrahi, V.2
Kana, B.D.3
-
183
-
-
84878718755
-
A chemical proteomics approach to profiling the atpbinding proteome of mycobacterium tuberculosis
-
Wolfe LM, Veeraraghavan U, Idicula-Thomas S, Schurer S, Wennerberg K, Reynolds R, Besra GS, Dobos KM. 2013. A chemical proteomics approach to profiling the ATPbinding proteome of Mycobacterium tuberculosis. Mol Cell Proteomics 12: 1644–1660.
-
(2013)
Mol Cell Proteomics
, vol.12
, pp. 1644-1660
-
-
Wolfe, L.M.1
Veeraraghavan, U.2
Idicula-Thomas, S.3
Schurer, S.4
Wennerberg, K.5
Reynolds, R.6
Besra, G.S.7
Dobos, K.M.8
-
184
-
-
34248345917
-
In vivo adaptation of the wayne model of latent tuberculosis
-
Woolhiser L, Tamayo MH, Wang B, Gruppo V, Belisle JT, Lenaerts AJ, Basaraba RJ, Orme IM. 2007. In vivo adaptation of the Wayne model of latent tuberculosis. Infect Immun 75: 2621–2625.
-
(2007)
Infect Immun
, vol.75
, pp. 2621-2625
-
-
Woolhiser, L.1
Tamayo, M.H.2
Wang, B.3
Gruppo, V.4
Belisle, J.T.5
Lenaerts, A.J.6
Basaraba, R.J.7
Orme, I.M.8
-
185
-
-
84866887386
-
Global assessment of genomic regions required for growth in mycobacterium tuberculosis
-
Zhang YJ, Ioerger TR, Huttenhower C, Long JE, Sassetti CM, Sacchettini JC, Rubin EJ. 2012. Global assessment of genomic regions required for growth in Mycobacterium tuberculosis. PLoS Pathog 8: e1002946.
-
(2012)
Plos Pathog
, vol.8
-
-
Zhang, Y.J.1
Ioerger, T.R.2
Huttenhower, C.3
Long, J.E.4
Sassetti, C.M.5
Sacchettini, J.C.6
Rubin, E.J.7
-
186
-
-
84885009252
-
Genome sequencing of 161 mycobacterium tuberculosis isolates from china identifies genes and intergenic regions associated with drug resistance
-
Zhang H, Li D, Zhao L, Fleming J, Lin N, Wang T, Liu Z, Li C, Galwey N, Deng J, et al. 2013a. Genome sequencing of 161 Mycobacterium tuberculosis isolates from China identifies genes and intergenic regions associated with drug resistance. Nat Genet 45: 1255– 1260.
-
(2013)
Nat Genet
, vol.45
, pp. 1255-1260
-
-
Zhang, H.1
Li, D.2
Zhao, L.3
Fleming, J.4
Lin, N.5
Wang, T.6
Liu, Z.7
Li, C.8
Galwey, N.9
Deng, J.10
-
187
-
-
84890037649
-
Tryptophan biosynthesis protects mycobacteria from cd4 t-cell-mediated killing
-
Zhang YJ, Reddy MC, Ioerger TR, Rothchild AC, Dartois V, Schuster BM, Trauner A, Wallis D, Galaviz S, Huttenhower C, et al. 2013b. Tryptophan biosynthesis protects mycobacteria from CD4 T-cell-mediated killing. Cell 155: 1296–1308.
-
(2013)
Cell
, vol.155
, pp. 1296-1308
-
-
Zhang, Y.J.1
Reddy, M.C.2
Ioerger, T.R.3
Rothchild, A.C.4
Dartois, V.5
Schuster, B.M.6
Trauner, A.7
Wallis, D.8
Galaviz, S.9
Huttenhower, C.10
-
188
-
-
84881409003
-
Walker jr, et al. 2013. Para-aminosalicylic acid is a prodrug targeting dihydrofolate reductase in mycobacterium tuberculosis
-
Zheng J, Rubin EJ, Bifani P, Mathys V, Lim V, Au M, Jang J, Nam J, Dick T, Walker JR, et al. 2013. para-Aminosalicylic acid is a prodrug targeting dihydrofolate reductase in Mycobacterium tuberculosis. J Biol Chem 288: 23447– 23456.
-
J Biol Chem
, vol.288
, pp. 23447-23456
-
-
Zheng, J.1
Rubin, E.J.2
Bifani, P.3
Mathys, V.4
Lim, V.5
Au, M.6
Jang, J.7
Nam, J.8
Dick, T.9
-
189
-
-
84885206980
-
Application of 1h nmr spectroscopy-based metabolomics to sera of tuberculosis patients
-
1H NMR spectroscopy-based metabolomics to sera of tuberculosis patients. J Proteome Res 12: 4642–4649.
-
(2013)
J Proteome Res
, vol.12
, pp. 4642-4649
-
-
Zhou, A.1
Ni, J.2
Xu, Z.3
Wang, Y.4
Lu, S.5
Sha, W.6
Karakousis, P.C.7
Yao, Y.F.8
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