Pathway profiling in Mycobacterium tuberculosis: Elucidation of cholesterol-derived catabolite and enzymes that catalyze its metabolism

Journal of Biological Chemistry

Volumn 286, Issue 51, 2011, Pages 43668-43678

  Thomas, Suzanne T ^a   VanderVen, Brian C ^b   Sherman, David R ^c   Russell, David G ^b   Sampson, Nicole S ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b Department of Obstetrics Gynecology   (United States)

^c SEATTLE BIOMEDICAL RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL-COA; HIGH RESOLUTION LC/MS; IN-VITRO; ISOTOPICALLY LABELED; KNOCK OUTS; LOW DENSITY LIPOPROTEINS; M. TUBERCULOSIS; METABOLOMES; MYCOBACTERIUM TUBERCULOSIS; PRIMARY FUNCTIONS; PROPANOATE; PROPANOIC ACID; SIDE-CHAINS; STRUCTURAL ELUCIDATION; WILD-TYPE STRAIN;

BIOINFORMATICS; BIOMOLECULES; ENZYME ACTIVITY; INTERNATIONAL TRADE; METABOLISM; METABOLITES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

CHOLESTEROL;

ACYL COENZYME A DEHYDROGENASE; CARBON 13; CARBON 14; CHOLESTEROL; INDANONE DERIVATIVE; PROPIONIC ACID; PROPIONYL COENZYME A;

ARTICLE; BACTERIAL GROWTH; BACTERIAL METABOLISM; BIOINFORMATICS; CARBON NUCLEAR MAGNETIC RESONANCE; CHOLESTEROL METABOLISM; CONTROLLED STUDY; DEHYDROGENATION; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME PURIFICATION; ENZYME STRUCTURE; HETEROLOGOUS EXPRESSION; ISOTOPE LABELING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLOME; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; OPERON; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STRAIN DIFFERENCE; WILD TYPE;

ACYL-COA DEHYDROGENASE; CATALYSIS; CHOLESTEROL; CHOLESTEROL, LDL; GENE EXPRESSION REGULATION, BACTERIAL; HEP G2 CELLS; HUMANS; ISOTOPES; LIPIDS; MUTATION; MYCOBACTERIUM TUBERCULOSIS; OPERON; PHENOTYPE; STEROIDS; TUBERCULOSIS;

EID: 83755168972     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.313643     Document Type: Article

References (46)

1. WHO (2011) Global Tuberculosis Control 2011, World Health Organization, WHO/HTM/TB/2011.16
2. Russell, D. G., Cardona, P. J., Kim, M. J., Allain, S., and Altare, F. (2009) Nat. Immunol. 10, 943-948
3. Bloch, H., and Segal, W. (1956) J. Bacteriol. 72, 132-141
4. Marrero, J., Rhee, K. Y., Schnappinger, D., Pethe, K., and Ehrt, S. (2010) Proc. Natl. Acad. Sci. U.S.A. 107, 9819-9824
5. McKinney, J. D., Höner zu Bentrup, K., Muñoz-Elías, E. J., Miczak, A., Chen, B., Chan, W. T., Swenson, D., Sacchettini, J. C., Jacobs, W. R., Jr., and Russell, D. G. (2000) Nature 406, 735-738
6. Muñoz-Elías, E. J., Upton, A. M., Cherian, J., and McKinney, J. D. (2006) Mol. Microbiol. 60, 1109-1122
7. Van der Geize, R., Yam, K., Heuser, T., Wilbrink, M. H., Hara, H., Anderton, M. C., Sim, E., Dijkhuizen, L., Davies, J. E., Mohn, W. W., and Eltis, L. D. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 1947-1952
8. Nesbitt, N. M., Yang, X., Fontán, P., Kolesnikova, I., Smith, I., Sampson, N. S., and Dubnau, E. (2010) Infect. Immun. 78, 275-282
9. Griffin, J. E., Gawronski, J. D., Dejesus, M. A., Ioerger, T. R., Akerley, B. J., and Sassetti, C. M. (2011) PLoS Pathog. 7, e1002251
10. Yam, K. C., D'Angelo, I., Kalscheuer, R., Zhu, H., Wang, J. X., Snieckus, V., Ly, L. H., Converse, P. J., Jacobs, W. R., Jr., Strynadka, N., and Eltis, L. D. (2009) PLoS Pathog. 5, e1000344
11. Pandey, A. K., and Sassetti, C. M. (2008) Proc. Natl. Acad. Sci. U.S.A. 105, 4376-4380
12. Chang, J. C., Miner, M. D., Pandey, A. K., Gill, W. P., Harik, N. S., Sassetti, C. M., and Sherman, D. R. (2009) J. Bacteriol. 191, 5232-5239
13. Lack, N. A., Yam, K. C., Lowe, E. D., Horsman, G. P., Owen, R. L., Sim, E., and Eltis, L. D. (2010) J. Biol. Chem. 285, 434-443
14. Dresen, C., Lin, L. Y., D'Angelo, I., Tocheva, E. I., Strynadka, N., and Eltis, L. D. (2010) J. Biol. Chem. 285, 22264-22275
15. Sim, E., Sandy, J., Evangelopoulos, D., Fullam, E., Bhakta, S., Westwood, I., Krylova, A., Lack, N., and Noble, M. (2008) Curr. Drug Metab. 9, 510-519
16. Knol, J., Bodewits, K., Hessels, G. I., Dijkhuizen, L., and van der Geize, R. (2008) Biochem. J. 410, 339-346
17. Capyk, J. K., D'Angelo, I., Strynadka, N. C., and Eltis, L. D. (2009) J. Biol. Chem. 284, 9937-9946
18. Capyk, J. K., Kalscheuer, R., Stewart, G. R., Liu, J., Kwon, H., Zhao, R., Okamoto, S., Jacobs, W. R., Jr., Eltis, L. D., and Mohn, W. W. (2009) J. Biol. Chem. 284, 35534-35542
19. Yang, X., Dubnau, E., Smith, I., and Sampson, N. S. (2007) Biochemistry 46, 9058-9067
20. Miclo, A., and Germain, P. (1992) Appl. Microbiol. Biotechnol. 36, 456-460
21. Sih, C. J., Tai, H. H., Tsong, Y. Y., Lee, S. S., and Coombe, R. G. (1968) Biochemistry 7, 808-818
22. Chang, J. C., Harik, N. S., Liao, R. P., and Sherman, D. R. (2007) J. Infect Dis. 196, 788-795
23. Ouellet, H., Guan, S., Johnston, J. B., Chow, E. D., Kells, P. M., Burlingame, A. L., Cox, J. S., Podust, L. M., and de Montellano, P. R. (2010) Mol. Microbiol. 77, 730-742
24. Johnston, J. B., Ouellet, H., and Ortiz de Montellano, P. R. (2010) J. Biol. Chem. 285, 36352-36360
25. Bligh, E. G., and Dyer, W. J. (1959) Can. J. Biochem. Physiol. 37, 911-917
26. Dobson, G., Minnikin, D. E., Minniken, S. M., Parlett, J. H., and Good-fellow, M. (1985) in Chemical Methods in Bacterial Systematics (Good-fellow, M., and Minnikin, D. E., eds.) pp. 237-265, Academic Press, Inc., London
27. Smith, C. A., Want, E. J., O'Maille, G., Abagyan, R., and Siuzdak, G. (2006) Anal. Chem. 78, 779-787
28. Inhoffen, H. H., Quinkert, G., Schutz, S., Friedrich, G., and Tober, E. (1958) Chem. Ber. 91, 781-791
29. Inhoffen, H. H., Bruckner, K., and Grundel, R. (1954) Chem. Ber. 87, 1-13
30. Mincione, E., Bovicelli, P., and Forcellese, M. L. (1989) Synth. Commun. 19, 723-735
31. Leppik, R. A. (1982) Biochem. J. 202, 747-751
32. Slomp, G., Jr., and Johnson, J. L. (1958) J. Am. Chem. Soc. 80, 915-921
33. Lehman, T. C., Hale, D. E., Bhala, A., and Thorpe, C. (1990) Anal. Biochem. 186, 280-284
34. Lehman, T. C., and Thorpe, C. (1990) Biochemistry 29, 10594-10602
35. Isler, O., Ruegg, R., Wursch, J., Gey, K. F., and Pletscher, A. (1957) Helv. Chim. Acta 40, 2369-2373
36. Bloch, K. (1965) Science 150, 19-28
37. Popják, G., and Cornforth, J. W. (1966) Biochem. J. 101, 553-568
38. Popják, G., Goodman, W. S. Cornforth, J. W., Cornforth, R. H., and Ryhage, R. (1961) J. Biol. Chem. 236, 1934-1947
39. Popják, G., Edmond, J., Anet, F. A., and Easton, N. R., Jr. (1977) J. Am. Chem. Soc. 99, 931-935
40. Horinouchi, M., Hayashi, T., Koshino, H., Kurita, T., and Kudo, T. (2005) Appl. Environ. Microbiol. 71, 5275-5281
41. Hayakawa, S., Kanematsu, Y., and Fujiwara, T. (1967) Nature 214, 520-521
42. Hashimoto, S., and Hayakawa, S. (1977) Biochem. J. 164, 715-726
43. Nakamatsu, T., Beppu, T., and Arima, K. (1980) Agric. Biol. Chem. 44, 1469-1474
44. Kieslich, K. (1985) J. Basic Microbiol. 25, 461-474
45. van der Geize, R., Grommen, A. W., Hessels, G. I., Jacobs, A. A., and Dijkhuizen, L. (2011) PLoS Pathog. 7, e1002181
46. Capyk, J. K., Casabon, I., Gruninger, R., Strynadka, N. C., and Eltis, L. D. (2011) J. Biol. Chem. 286, 40717-40724