메뉴 건너뛰기




Volumn 102, Issue 6, 2012, Pages 457-460

Approaches to target identification and validation for tuberculosis drug discovery: A University of Cape Town perspective

Author keywords

[No Author keywords available]

Indexed keywords

TUBERCULOSTATIC AGENT;

EID: 84865136016     PISSN: 02569574     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (4)

References (19)
  • 1
    • 66649090346 scopus 로고    scopus 로고
    • The diarylquinoline TMC207 for multidrug-resistant tuberculosis
    • Diacon AH, Pym A, Grobusch M, et al. The diarylquinoline TMC207 for multidrug-resistant tuberculosis. N Engl J Med 2009;360(23):2397-2405. [http://dx.doi.org/10.1056/NEJMoa0808427]
    • (2009) N Engl J Med , vol.360 , Issue.23 , pp. 2397-2405
    • Diacon, A.H.1    Pym, A.2    Grobusch, M.3
  • 2
    • 84871451232 scopus 로고    scopus 로고
    • (accessed February 2012)
    • http://www.dst.gov.za/publications-policies/strategies-reports/The%20Ten-Year%20Plan%20for%20Science%20and%20Technology.pdf (accessed February 2012).
  • 3
    • 33644991496 scopus 로고    scopus 로고
    • Global epidemiology of tuberculosis
    • Dye C. Global epidemiology of tuberculosis. Lancet 2006;367(9514):938-940. [http://dx.doi.org/10.1016/S0140-6736(06)68384-0]
    • (2006) Lancet , vol.367 , Issue.9514 , pp. 938-940
    • Dye, C.1
  • 5
    • 79251589638 scopus 로고    scopus 로고
    • The challenge of new drug discovery for tuberculosis
    • Koul A, Arnoult E, Lounis N, Guillemont J, Andries K. The challenge of new drug discovery for tuberculosis. Nature 2011;469(7331):483-490. [http://dx.doi.org/10.1038/nature09657]
    • (2011) Nature , vol.469 , Issue.7331 , pp. 483-490
    • Koul, A.1    Arnoult, E.2    Lounis, N.3    Guillemont, J.4    Andries, K.5
  • 6
    • 70449705831 scopus 로고    scopus 로고
    • The spectrum of latent tuberculosis: Rethinking the biology and intervention strategies
    • Barry CE 3rd, Boshoff HI, Dartois V, et al. The spectrum of latent tuberculosis: rethinking the biology and intervention strategies. Nat Rev Microbiol 2009;7(12):845-855. [http://dx.doi.org/10.1038/nrmicro2236]
    • (2009) Nat Rev Microbiol , vol.7 , Issue.12 , pp. 845-855
    • Barry III, C.E.1    Boshoff, H.I.2    Dartois, V.3
  • 7
    • 77952356637 scopus 로고    scopus 로고
    • Tuberculosis: What we don't know can, and does, hurt us
    • 852-826
    • Russell DG, Barry CE 3rd, Flynn JL. Tuberculosis: what we don't know can, and does, hurt us. Science 2010;328(5980):852-826. [http://dx.doi.org/10.1126/science.1184784]
    • (2010) Science , vol.328 , Issue.5980
    • Russell, D.G.1    Barry III, C.E.2    Flynn, J.L.3
  • 8
    • 33746493349 scopus 로고    scopus 로고
    • Tuberculosis chemotherapy: The influence of bacillary stress and damage response pathways on drug efficacy
    • Warner DF, Mizrahi V. Tuberculosis chemotherapy: the influence of bacillary stress and damage response pathways on drug efficacy. Clin Microbiol Rev 2006;19(3):558-570. [http://dx.doi.org/10.1128/CMR.00060-05]
    • (2006) Clin Microbiol Rev , vol.19 , Issue.3 , pp. 558-570
    • Warner, D.F.1    Mizrahi, V.2
  • 9
    • 79960700334 scopus 로고    scopus 로고
    • Palaeogenomics of Mycobacterium tuberculosis: Epidemic bursts with a degrading genome
    • Djelouadji Z, Raoult D, Drancourt M. Palaeogenomics of Mycobacterium tuberculosis: epidemic bursts with a degrading genome. Lancet Infect Dis 2011;11(8):641-650. [http://dx.doi.org/10.1016/S1473-3099(11)70093-7]
    • (2011) Lancet Infect Dis , vol.11 , Issue.8 , pp. 641-650
    • Djelouadji, Z.1    Raoult, D.2    Drancourt, M.3
  • 10
    • 79959913123 scopus 로고    scopus 로고
    • Central carbon metabolism in Mycobacterium tuberculosis: An unexpected frontier
    • Rhee KY, Carvalho LP, Bryk R, et al. Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier. Trends Microbiol 2011;19(7):307-314. [http://dx.doi.org/10.1016/j.tim.2011.03.008]
    • (2011) Trends Microbiol , vol.19 , Issue.7 , pp. 307-314
    • Rhee, K.Y.1    Carvalho, L.P.2    Bryk, R.3
  • 12
    • 0035940515 scopus 로고    scopus 로고
    • Comprehensive identification of conditionally essential genes in mycobacteria
    • Sassetti CM, Boyd DH, Rubin EJ. Comprehensive identification of conditionally essential genes in mycobacteria. Proc Natl Acad Sci USA 2011;98(22):12712-12717. [http://dx.doi.org/10.1073/pnas.231275498]
    • (2011) Proc Natl Acad Sci USA , vol.98 , Issue.22 , pp. 12712-12717
    • Sassetti, C.M.1    Boyd, D.H.2    Rubin, E.J.3
  • 13
    • 80053459692 scopus 로고    scopus 로고
    • High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism
    • Griffin JE, Gawronski JD, Dejesus MA, Ioerger TR, Akerley BJ, Sassetti CM. High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism. PLoS Pathog 2011;7(9):e1002251. [http://dx.doi.org/10.1371/journal.ppat.1002251]
    • (2011) PLoS Pathog , vol.7 , Issue.9
    • Griffin, J.E.1    Gawronski, J.D.2    Dejesus, M.A.3    Ioerger, T.R.4    Akerley, B.J.5    Sassetti, C.M.6
  • 14
    • 78049411009 scopus 로고    scopus 로고
    • Metabolomics of Mycobacterium tuberculosis reveals compartmentalized co-catabolism of carbon substrates
    • De Carvalho LP, Fischer SM, Marrero J, Nathan C, Ehrt S, Rhee KY. Metabolomics of Mycobacterium tuberculosis reveals compartmentalized co-catabolism of carbon substrates. Chem Biol 2010;17(10):1122-1131. [http://dx.doi.org/10.1016/j.chembiol.2010.08.009]
    • (2010) Chem Biol , vol.17 , Issue.10 , pp. 1122-1131
    • de Carvalho, L.P.1    Fischer, S.M.2    Marrero, J.3    Nathan, C.4    Ehrt, S.5    Rhee, K.Y.6
  • 15
    • 33846896666 scopus 로고    scopus 로고
    • Systems biology and its impact on anti-infective drug development
    • Stumpf MP, Robertson BD, Duncan K, Young DB. Systems biology and its impact on anti-infective drug development. Prog Drug Res 2007;64(1):3-20. [http://dx.doi.org/10.1007/978-3-7643-7567-6_1]
    • (2007) Prog Drug Res , vol.64 , Issue.1 , pp. 3-20
    • Stumpf, M.P.1    Robertson, B.D.2    Duncan, K.3    Young, D.B.4
  • 16
    • 78149422217 scopus 로고    scopus 로고
    • System-level strategies for studying the metabolism of Mycobacterium tuberculosis
    • Beste DJ, McFadden J. System-level strategies for studying the metabolism of Mycobacterium tuberculosis. Mol Biosyst 2010;6(12):2363-2372. [http://dx.doi.org/10.1039/c003757p]
    • (2010) Mol Biosyst , vol.6 , Issue.12 , pp. 2363-2372
    • Beste, D.J.1    McFadden, J.2
  • 17
    • 78650982216 scopus 로고    scopus 로고
    • Simultaneous analysis of multiple Mycobacterium tuberculosis knockdown mutants in vitro and in vivo
    • Blumenthal A, Trujillo C, Ehrt S, Schnappinger D. Simultaneous analysis of multiple Mycobacterium tuberculosis knockdown mutants in vitro and in vivo. PLoS One 2010;5(12):e15667. [http://dx.doi.org/10.1371/journal.pone.0015667]
    • (2010) PLoS One , vol.5 , Issue.12
    • Blumenthal, A.1    Trujillo, C.2    Ehrt, S.3    Schnappinger, D.4
  • 18
    • 79952760675 scopus 로고    scopus 로고
    • Depletion of antibiotic targets has widely varying effects on growth
    • Wei JR, Krishnamoorthy V, Murphy K, et al. Depletion of antibiotic targets has widely varying effects on growth. Proc Natl Acad Sci USA 2011;108(10):4176-4181. [http://dx.doi.org/10.1073/pnas.1018301108]
    • (2011) Proc Natl Acad Sci USA , vol.108 , Issue.10 , pp. 4176-4181
    • Wei, J.R.1    Krishnamoorthy, V.2    Murphy, K.3
  • 19
    • 79959448080 scopus 로고    scopus 로고
    • Antibiotics as probes of biological complexity
    • Falconer SB, Czarny TL, Brown ED. Antibiotics as probes of biological complexity. Nat Chem Biol 2011;17:415-423. [http://dx.doi.org/10.1038/nchembio.590]
    • (2011) Nat Chem Biol , vol.17 , pp. 415-423
    • Falconer, S.B.1    Czarny, T.L.2    Brown, E.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.