Bisubstrate adenylation inhibitors of biotin protein ligase from mycobacterium tuberculosis

Chemistry and Biology

Volumn 18, Issue 11, 2011, Pages 1432-1441

  Duckworth, Benjamin P ^a   Geders, Todd W ^b   Tiwari, Divya ^c   Boshoff, Helena I ^d   Sibbald, Paul A ^a   Barry III, Clifton E ^d   Schnappinger, Dirk ^c   Finzel, Barry C ^b   Aldrich, Courtney C ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; ENZYME INHIBITOR; LIGASE; TUBERCULOSTATIC AGENT;

ANTIBIOTIC RESISTANCE; ARTICLE; BINDING SITE; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; DRUG EFFECT; ENZYME ACTIVATION; ENZYME SPECIFICITY; ENZYMOLOGY; KINETICS; METABOLISM; MICROBIOLOGICAL EXAMINATION; MYCOBACTERIUM TUBERCULOSIS; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION; SYNTHESIS; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY;

ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; BINDING SITES; CARBON-NITROGEN LIGASES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG RESISTANCE, BACTERIAL; ENZYME ACTIVATION; ENZYME INHIBITORS; KINETICS; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM TUBERCULOSIS; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

EID: 82255186665     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2011.08.013     Document Type: Article

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