Identification of novel inhibitors of nonreplicating mycobacterium tuberculosis using a carbon starvation model

ACS Chemical Biology

Volumn 8, Issue 10, 2013, Pages 2224-2234

  Grant, Sarah Schmidt ^a,b,c,d   Kawate, Tomohiko ^a,c,d   Nag, Partha P ^a   Silvis, Melanie R ^a   Gordon, Katherine ^a   Stanley, Sarah A ^a,c,d   Kazyanskaya, Edward ^a   Nietupski, Raymond ^a   Golas, Aaron ^a   Fitzgerald, Michael ^a   Cho, Sanghyun ^e   Franzblau, Scott G ^e   Hung, Deborah T ^a,c,d  

^a BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 ((2 (1,3 DIOXAN 2 YL)ETHYL)THIO) 5 PHENYL 1,3,4 OXADIAZOLE; 3 (3 TOLYL) 5 ((1 PIPERIDINYL)CARBONYLMETHYL)THIO 1,2,4 THIADIAZOLE; 6,7 DIHYDRO 2 NITRO 6 (4 TRIFLUOROMETHOXYBENZYLOXY) 5H IMIDAZO[2,1 B][1,3]OXAZINE; ANTIBIOTIC AGENT; BEDAQUILINE; CARBON; CLOFAZIMINE; ISONIAZID; MOXIFLOXACIN; N (3 METHYLPYRIDIN 2 YL) 4 (PYRIDIN 2 YL)THIAZOL 2 AMINE; N (4 CHLOROPHENYL) 5 (1 METHYL 5 (TRIFLUOROMETHYL) 1H PYRAZOL 3 YL)THIOPHENE 2 CARBOXAMIDE; OFLOXACIN; PYRAZINAMIDE; RIFAMPICIN; STREPTOMYCIN; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG; MOLECULAR LIBRARY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC SENSITIVITY; ANTIBIOTIC THERAPY; ARTICLE; BACTERIUM CULTURE; COLONY FORMING UNIT; CONTROLLED STUDY; CULTURE MEDIUM; DRUG MEGADOSE; DRUG TARGETING; HIGH THROUGHPUT SCREENING; HYPOXIA; LEPROSY; MINIMUM INHIBITORY CONCENTRATION; MODEL; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; NUTRIENT; PATHOPHYSIOLOGY; PRIORITY JOURNAL; STARVATION; TREATMENT DURATION; TUBERCULOSIS; BIOLOGICAL MODEL; CELL CYCLE; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; FOOD; METABOLISM; MICROBIAL SENSITIVITY TEST; MOLECULAR LIBRARY; PHARMACOLOGY;

BACTERIA (MICROORGANISMS); MYCOBACTERIUM TUBERCULOSIS;

ANTITUBERCULAR AGENTS; CARBON; CELL CYCLE; FOOD; MICROBIAL SENSITIVITY TESTS; MODELS, BIOLOGICAL; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; SMALL MOLECULE LIBRARIES;

EID: 84886571125     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb4004817     Document Type: Article

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