Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 40, 2012, Pages 16004-16011

  Gold, Ben ^a   Pingle, Maneesh ^a   Brickner, Steven J ^b   Shah, Nilesh ^c   Roberts, Julia ^a   Rundell, Mark ^a   Bracken, W Clay ^a   Warrier, Thulasi ^a   Somersan, Selin ^a   Venugopal, Aditya ^a   Darby, Crystal ^a   Jiang, Xiuju ^a   Warren, J David ^a   Fernandez, Joseph ^e   Ouerfelli, Ouathek ^c   Nuermberger, Eric L ^d   Cunningham Bussel, Amy ^a   Rath, Poonam ^a   Chidawanyika, Tamutenda ^a   Deng, Haiteng ^e   Realubit, Ronald ^e   Fraser Glickman, J ^e   Nath, Carl F ^a   more..

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b SJ Brickner Consulting LLC   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d JOHNS HOPKINS HOSPITAL   (United States)

^e ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ACID; FATTY ACID; OXYPHENBUTAZONE; QUERCETIN; REACTIVE NITROGEN SPECIES;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERICIDAL ACTIVITY; CARBON SOURCE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EXPOSURE; DRUG MECHANISM; FEMALE; HIGH THROUGHPUT SCREENING; HYDROXYLATION; HYPOXIA; MINIMUM INHIBITORY CONCENTRATION; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; TUBERCULOSIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG RESISTANCE, MICROBIAL; FATTY ACIDS; FEMALE; HIGH-THROUGHPUT SCREENING ASSAYS; HYDROXYLATION; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM TUBERCULOSIS; OXYPHENBUTAZONE; REACTIVE NITROGEN SPECIES;

MYCOBACTERIUM TUBERCULOSIS;

EID: 84867061487     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1214188109     Document Type: Article

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