Foamy macrophages from tuberculous patients' granulomas constitute a nutrient-rich reservoir for M. tuberculosis persistence

PLoS Pathogens

Volumn 4, Issue 11, 2008, Pages

  Peyron, Pascale ^a,b   Vaubourgeix, Julien ^a,b   Poquet, Yannick ^a,b   Levillain, Florence ^a,b   Botanch, Catherine ^a,b   Bardou, Fabienne ^a,b   Daffé, Mamadou ^a,b   Emile, Jean François ^c   Marchou, Bruno ^d   Cardona, Pere Joan ^e   De Chastellier, Chantal ^f   Altare, Frédéric ^a,b,g  

^a INSTITUT DE PHARMACOLOGIE ET DE BIOLOGIE STRUCTURALE   (France)

^b UNIVERSITÉ DE TOULOUSE   (France)

^c HÔPITAL AMBROISE PARÉ   (France)

^d CHU PURPAN   (France)

^e UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^f CENTRE D IMMUNOLOGIE DE MARSEILLE LUMINY   (France)

^g Team 12   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; FAT DROPLET; LIPID; LONG CHAIN FATTY ACID; MYCOLIC ACID;

ANTIBIOTIC RESISTANCE; ARTICLE; CELL DIFFERENTIATION; CELL MIGRATION; CELL POPULATION; ELECTRON MICROSCOPY; ENDOCYTOSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LUNG GRANULOMA; LUNG TUBERCULOSIS; MACROPHAGE; MYCOBACTERIUM TUBERCULOSIS; NUTRIENT; OXYGENATION; PATHOPHYSIOLOGY; PHAGOSOME; SCREENING; FOAM CELL; GRANULOMA; IMMUNOLOGY; MICROBIOLOGY; MYCOBACTERIOSIS; PATHOLOGY; PHAGOCYTOSIS; PHYSIOLOGY; TUBERCULOSIS; ULTRASTRUCTURE;

BACILLI (CLASS); BACILLUS (BACTERIUM); BACTERIA (MICROORGANISMS); CORYNEBACTERINEAE; MYCOBACTERIUM TUBERCULOSIS;

CELL DIFFERENTIATION; FOAM CELLS; GRANULOMA; HUMANS; LIPIDS; MACROPHAGES; MYCOBACTERIUM INFECTIONS; MYCOBACTERIUM TUBERCULOSIS; MYCOLIC ACIDS; PHAGOCYTOSIS; TUBERCULOSIS;

EID: 57149096869     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1000204     Document Type: Article

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