Metabolic regulation of mycobacterial growth and antibiotic sensitivity

PLoS Biology

Volumn 9, Issue 5, 2011, Pages

  Baek, Seung Hun ^a   Li, Alice H ^a   Sassetti, Christopher M ^a,b  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON; CITRIC ACID; ETHAMBUTOL; ISONIAZID; PYRAZINAMIDE; TRIACYLGLYCEROL; ACETYL COENZYME A; BACTERIAL PROTEIN; TUBERCULOSTATIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GROWTH; BACTERIUM MUTANT; CELLULAR STRESS RESPONSE; CITRIC ACID CYCLE; CONTROLLED STUDY; GROWTH INHIBITION; GROWTH REGULATION; LIPOGENESIS; METABOLIC REGULATION; METABOLIC STRESS; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; SIGNAL TRANSDUCTION; TUBERCULOSIS; ANAEROBIC GROWTH; ANIMAL; ANTIBIOTIC RESISTANCE; BACTERIAL LOAD; BIOSYNTHESIS; C57BL MOUSE; DRUG EFFECT; GENETICS; LUNG; LUNG TUBERCULOSIS; METABOLISM; MICROBIOLOGY; MUTATION; PHYSIOLOGICAL STRESS; PHYSIOLOGY; SPLEEN;

BACTERIA (MICROORGANISMS); MYCOBACTERIUM TUBERCULOSIS;

ACETYL COENZYME A; ANAEROBIOSIS; ANIMALS; ANTITUBERCULAR AGENTS; BACTERIAL LOAD; BACTERIAL PROTEINS; BIOSYNTHETIC PATHWAYS; CITRIC ACID CYCLE; DRUG RESISTANCE, BACTERIAL; ETHAMBUTOL; ISONIAZID; LUNG; MICE; MICE, INBRED C57BL; MUTATION; MYCOBACTERIUM TUBERCULOSIS; PYRAZINAMIDE; SPLEEN; STRESS, PHYSIOLOGICAL; TRIGLYCERIDES; TUBERCULOSIS, PULMONARY;

EID: 79958058975     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.1001065     Document Type: Article

References (36)

1. World Health Organization (2005) Global tuberculosis control: surveillance, planning, financing. Geneva, Switzerland.
2. Salomon J. A, Lloyd-Smith J. O, Getz W. M, Resch S, Sanchez M. S, et al. (2006) Prospects for advancing tuberculosis control efforts through novel therapies. PLoS Med 3: e273 doi:10.1371/journal.pmed.0030273.
3. Gomez J. E, McKinney J. D, (2004) M. tuberculosis persistence, latency, and drug tolerance. Tuberculosis (Edinb) 84: 29-44.
4. De Voss J. J, Rutter K, Schroeder B. G, Su H, Zhu Y, et al. (2000) The salicylate-derived mycobactin siderophores of Mycobacterium tuberculosis are essential for growth in macrophages. Proc Natl Acad Sci U S A 97: 1252-1257.
5. Rohde K, Yates R. M, Purdy G. E, Russell D. G, (2007) Mycobacterium tuberculosis and the environment within the phagosome. Immunol Rev 219: 37-54.
6. Via L. E, Lin P. L, Ray S. M, Carrillo J, Allen S. S, et al. (2008) Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates. Infect Immun 76: 2333-2340.
7. Pandey A. K, Sassetti C. M, (2008) Mycobacterial persistence requires the utilization of host cholesterol. Proc Natl Acad Sci U S A 105: 4376-4380.
8. Hayes C. S, Low D. A, (2009) Signals of growth regulation in bacteria. Curr Opin Microbiol 12: 667-673.
9. Gill W. P, Harik N. S, Whiddon M. R, Liao R. P, Mittler J. E, et al. (2009) A replication clock for Mycobacterium tuberculosis. Nat Med 15: 211-214.
10. Munoz-Elias E. J, Timm J, Botha T, Chan W. T, Gomez J. E, et al. (2005) Replication dynamics of Mycobacterium tuberculosis in chronically infected mice. Infect Immun 73: 546-551.
11. Tomasz A, Albino A, Zanati E, (1970) Multiple antibiotic resistance in a bacterium with suppressed autolytic system. Nature 227: 138-140.
12. Mitchison D. A, Coates A. R, (2004) Predictive in vitro models of the sterilizing activity of anti-tuberculosis drugs. Curr Pharm Des 10: 3285-3295.
13. Rao S. P, Alonso S, Rand L, Dick T, Pethe K, (2008) The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis. Proc Natl Acad Sci U S A 105: 11945-11950.
14. Corper H. J, Cohn M. L, (1933) The viability and virulence of old cultures of tubercle bacilli: studies on twelve-year broth culture maintained at incubator temperature. Am Rev Tuberc 28: 856-874.
15. Wayne L. G, Hayes L. G, (1996) An in vitro model for sequential study of shiftdown of Mycobacterium tuberculosis through two stages of nonreplicating persistence. Infect Immun 64: 2062-2069.
16. Sassetti C. M, Boyd D. H, Rubin E. J, (2001) Comprehensive identification of conditionally essential genes in mycobacteria. Proc Natl Acad Sci U S A 98: 12712-12717.
17. Sirakova T. D, Dubey V. S, Deb C, Daniel J, Korotkova T. A, et al. (2006) Identification of a diacylglycerol acyltransferase gene involved in accumulation of triacylglycerol in Mycobacterium tuberculosis under stress. Microbiology 152: 2717-2725.
18. Daniel J, Deb C, Dubey V. S, Sirakova T. D, Abomoelak B, et al. (2004) Induction of a novel class of diacylglycerol acyltransferases and triacylglycerol accumulation in Mycobacterium tuberculosis as it goes into a dormancy-like state in culture. J Bacteriol 186: 5017-5030.
19. Park H. D, Guinn K. M, Harrell M. I, Liao R, Voskuil M. I, et al. (2003) Rv3133c/dosR is a transcription factor that mediates the hypoxic response of Mycobacterium tuberculosis. Mol Microbiol 48: 833-843.
20. Garton N. J, Waddell S. J, Sherratt A. L, Lee S. M, Smith R. J, et al. (2008) Cytological and transcript analyses reveal fat and lazy persister-like bacilli in tuberculous sputum. PLoS Med 5: e75 doi:10.1371/journal.pmed.0050075.
21. Bacon J, Dover L. G, Hatch K. A, Zhang Y, Gomes J. M, et al. (2007) Lipid composition and transcriptional response of Mycobacterium tuberculosis grown under iron-limitation in continuous culture: identification of a novel wax ester. Microbiology 153: 1435-1444.
22. Yuan Y, Crane D. D, Simpson R. M, Zhu Y. Q, Hickey M. J, et al. (1998) The 16-kDa alpha-crystallin (Acr) protein of Mycobacterium tuberculosis is required for growth in macrophages. Proc Natl Acad Sci U S A 95: 9578-9583.
23. Honaker R. W, Dhiman R. K, Narayanasamy P, Crick D. C, Voskuil M. I, DosS responds to a reduced electron transport system to induce the Mycobacterium tuberculosis DosR regulon. J Bacteriol 192: 6447-6455.
24. Waltermann M, Hinz A, Robenek H, Troyer D, Reichelt R, et al. (2005) Mechanism of lipid-body formation in prokaryotes: how bacteria fatten up. Mol Microbiol 55: 750-763.
25. Shi L, Sohaskey C. D, Pfeiffer C, Datta P, Parks M, et al. Carbon flux rerouting during Mycobacterium tuberculosis growth arrest. Mol Microbiol 78: 1199-1215.
26. Leistikow R. L, Morton R. A, Bartek I. L, Frimpong I, Wagner K, et al. The Mycobacterium tuberculosis DosR regulon assists in metabolic homeostasis and enables rapid recovery from nonrespiring dormancy. J Bacteriol 192: 1662-1670.
27. Kohanski M. A, Dwyer D. J, Hayete B, Lawrence C. A, Collins J. J, (2007) A common mechanism of cellular death induced by bactericidal antibiotics. Cell 130: 797-810.
28. Singh R, Manjunatha U, Boshoff H. I, Ha Y. H, Niyomrattanakit P, et al. (2008) PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release. Science 322: 1392-1395.
29. van Stelten J, Silva F, Belin D, Silhavy T. J, (2009) Effects of antibiotics and a proto-oncogene homolog on destruction of protein translocator SecY. Science 325: 753-756.
30. Elbein A. D, Mitchell M, (1973) Levels of glycogen and trehalose in Mycobacterium smegmatis and the purification and properties of the glycogen synthetase. J Bacteriol 113: 863-873.
31. Deb C, Lee C. M, Dubey V. S, Daniel J, Abomoelak B, et al. (2009) A novel in vitro multiple-stress dormancy model for Mycobacterium tuberculosis generates a lipid-loaded, drug-tolerant, dormant pathogen. PLoS One 4: e6077 doi:10.1371/journal.pone.0006077.
32. Bachrach G, Colston M. J, Bercovier H, Bar-Nir D, Anderson C, et al. (2000) A new single-copy mycobacterial plasmid, pMF1, from Mycobacterium fortuitum which is compatible with the pAL5000 replicon. Microbiology 146 (Pt 2): 297-303.
33. Chan K, Knaak T, Satkamp L, Humbert O, Falkow S, et al. (2002) Complex pattern of Mycobacterium marinum gene expression during long-term granulomatous infection. Proc Natl Acad Sci U S A 99: 3920-3925.
34. Murry J. P, Pandey A. K, Sassetti C. M, Rubin E. J, (2009) Phthiocerol dimycocerosate transport is required for resisting interferon-gamma-independent immunity. J Infect Dis 200: 774-782.
35. Sassetti C. M, Rubin E. J, (2003) Genetic requirements for mycobacterial survival during infection. Proc Natl Acad Sci U S A 100: 12989-12994.
36. Evans A. M, DeHaven C. D, Barrett T, Mitchell M, Milgram E, (2009) Integrated, nontargeted ultrahigh performance liquid chromatography/electrospray ionization tandem mass spectrometry platform for the identification and relative quantification of the small-molecule complement of biological systems. Anal Chem 81: 6656-6667.