Lipidomics reveals control of Mycobacterium tuberculosis virulence lipids via metabolic coupling

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 12, 2007, Pages 5133-5138

  Jain, Madhulika ^a   Petzold, Christopher J ^b,d   Schelle, Michael W ^c   Leavell, Michael D ^b   Mougous, Joseph D ^c,e   Bertozzi, Carolyn R ^c   Leary, Julie A ^b   Cox, Jeffery S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Lipid virulence factor; Metabolic flux; Pathogenesis; PDIM; Sulfolipid 1

Indexed keywords

FATTY ACID; LIPID; METHYLMALONYL COENZYME A CARBOXYLTRANSFERASE; PHTHIOCEROL DIMYCOCEROSATE; POLYKETIDE; SULFOLIPID 1; UNCLASSIFIED DRUG; ACYL COENZYME A; METHYLMALONYL-COENZYME A; METHYLMALONYLCOENZYME A; MYCOCEROSIC ACID; PROPIONIC ACID; PROPIONIC ACID DERIVATIVE; SULFOLIPIDS;

ANIMAL TISSUE; ARTICLE; BACTERIAL GROWTH; BACTERIAL METABOLISM; BACTERIAL VIRULENCE; HOST PATHOGEN INTERACTION; LIPID METABOLISM; LIPOGENESIS; MASS SPECTROMETRY; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; CHEMICALLY INDUCED DISORDER; CHEMISTRY; DRUG EFFECT; GENETICS; GROWTH, DEVELOPMENT AND AGING; MOLECULAR WEIGHT; MUTATION; PATHOGENICITY; TUBERCULOSIS; VIRULENCE;

BACTERIA (MICROORGANISMS); MUS; MYCOBACTERIUM TUBERCULOSIS;

ACYL COENZYME A; ANIMALS; FATTY ACIDS; LIPID METABOLISM; LIPIDS; MICE; MICE, INBRED BALB C; MOLECULAR WEIGHT; MUTATION; MYCOBACTERIUM TUBERCULOSIS; PROPIONIC ACIDS; TUBERCULOSIS; VIRULENCE;

EID: 34247617733     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0610634104     Document Type: Article

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