An anaerobic-type α-ketoglutarate ferredoxin oxidoreductase completes the oxidative tricarboxylic acid cycle of Mycobacterium tuberculosis

PLoS Pathogens

Volumn 5, Issue 11, 2009, Pages

  Baughn, Anthony D ^a   Garforth, Scott J ^a   Vilchèze, Catherine ^a   Jacobs Jr , William R ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOGLUTARIC ACID; ALPHA KETOGLUTARATE FERREDOXIN OXIDOREDUCTASE; CARBON DIOXIDE; COENZYME A; FATTY ACID; GLYOXYLIC ACID; KETOGLUTARATE DECARBOXYLASE; OXOGLUTARATE DEHYDROGENASE; SUCCINIC SEMIALDEHYDE; UNCLASSIFIED DRUG; PYRUVATE SYNTHASE;

ANAEROBIC BACTERIUM; ARTICLE; BACTERIAL GROWTH; BACTERIAL METABOLISM; BACTERIAL STRAIN; CITRIC ACID CYCLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; FATTY ACID OXIDATION; GENE DELETION; GENETIC CODE; MUTANT; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATION; ANAEROBIC GROWTH; OXIDATION REDUCTION REACTION; PHYSIOLOGY;

MYCOBACTERIUM TUBERCULOSIS;

ANAEROBIOSIS; CITRIC ACID CYCLE; KETOGLUTARATE DEHYDROGENASE COMPLEX; MYCOBACTERIUM TUBERCULOSIS; OXIDATION-REDUCTION; PYRUVATE SYNTHASE;

EID: 73549105511     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1000662     Document Type: Article

References (45)

1. Dye C, Scheele S, Dolin P, Pathania V, Raviglione MC, et al. (1999) Global Burden of Tuberculosis: Estimated Incidence, Prevalence, and Mortality by Country. JAMA 282: 677-686.
2. Gandhi NR, Moll A, Sturm AW, Pawinski R, Govender T, et al. (2006) Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa. Lancet 368:1575-1580.
3. Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, et al. (1998) Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 393: 537-544.
4. Beste D, Hooper T, Stewart G, Bonde B, Avignone-Rossa C, et al. (2007) GSMN-TB: a web-based genome-scale network model of Mycobacterium tuberculosis metabolism. Genome Biology 8: R89.
5. Jamshidi N, Palsson B (2007) Investigating the metabolic capabilities of Mycobacterium tuberculosis H37Rv using the in silico strain iNJ661 and proposing alternative drug targets. BMC Systems Biology 1: 26.
6. Tian J, Bryk R, Shi S, Erdjument-Bromage H, Tempst P, et al. (2005) Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes. Mol Microbiol 57:859-868.
7. Argyrou A, Blanchard JS (2001) Mycobacterium tuberculosis Lipoamide Dehydrogenase Is Encoded by Rv0462 and Not by the lpdA or lpdB Genes. Biochemistry 40: 11353-11363.
8. Tian J, Bryk R, Itoh M, Suematsu M, Nathan C (2005) Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: Identification of alpha-ketoglutarate decarboxylase. Proc Natl Acad Sci USA 102: 10670-10675.
9. Muñ oz-Elias EJ, McKinney JD (2006) Carbon metabolism of intracellular bacteria. Cell Microbiol 8: 10-22.
10. O'Hare HM, Durán R, Cerveñansky C, Bellinzoni M, Wehenkel AM, et al. (2008) Regulation of glutamate metabolism by protein kinases in mycobacteria. Molecular Microbiology 70: 1408-1423.
11. Yun N-R, Arai H, Ishii M, Igarashi Y (2001) The genes for anabolic 2-oxoglutarate: ferredoxin oxidoreductase from Hydrogenobacter thermophilus TK-6. Biochem Biophys Res Comm 282: 589-594.
12. Gehring U, Arnon DI (1972) Purification and properties of alpha-ketoglutarate synthase from a photosynthetic bacterium. J Biol Chem 247: 6963-6969.
13. Mai X, Adams MWW (1996) Characterization of a fourth type of 2-keto acido-xidizing enzyme from a hyperthermophilic archaeon: 2-ketoglutarate ferredoxin oxidoreductase from Thermococcus litoralis. J Bacteriol 178: 5890-5896.
14. Pan N, Imlay JA (2001) How does oxygen inhibit central metabolism in the obligate anaerobe Bacteroides thetaiotaomicron? Mol Microbiol 39: 1562-1571.
15. Horner DS, Hirt RP, Embley TM (1999) A single eubacterial origin of eukaryotic pyruvate: ferredoxin oxidoreductase genes: implications for the evolution of anaerobic eukaryotes. Mol Biol Evol 16: 1280-1291.
16. Allison MJ, Robinson IM, Baetz AL (1979) Synthesis of a-ketoglutarate by reductive carboxylation of succinate in Veillonella, Selenomonas, and Bacteriodes species. J Bacteriol 140: 980-986.
17. Yoon K-S, Ishii M, Igarashi Y, Kodama T (1996) Purification and characterization of 2-oxoglutarate:ferredoxin oxidoreductase from a thermophilic obligately chemolithoautotrophic bacterium, Hydrogenobacter thermophilus TK-6. J Bacteriol 178: 3365-3368.
18. Pandey AK, Sassetti CM (2008) Mycobacterial persistence requires the utilization of host cholesterol. Proc Natl Acad Sci USA 105: 4376-4380.
19. Yam KC, D'Angelo I, Kalscheuer R, Zhu H, Wang J-X, et al. (2009) Studies of a Ring-Cleaving Dioxygenase Illuminate the Role of Cholesterol Metabolism in the Pathogenesis of Mycobacterium tuberculosis. PLoS Pathog 5: e1000344. doi:10.1371/journal.ppat.1000344.
20. McKinney JD, zu Bentrup KH, Munoz-Elias EJ, Miczak A, Chen B, et al. (2000) Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase. Nature 406: 735.
21. Munoz-Elias EJ, McKinney JD (2005) Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulence. Nat Med 11: 638.
22. Sassetti CM, Rubin EJ (2003) Genetic requirements for mycobacterial survival during infection. Proc Natl Acad Sci USA 100: 12989-12994.
23. Ragsdale SW (2003) Pyruvate Ferredoxin Oxidoreductase and Its Radical Intermediate. Chem Rev 103: 2333-2346.
24. Roback P, Beard J, Baumann D, Gille C, Henry K, et al. (2007) A predicted operon map for Mycobacterium tuberculosis. Nucl Acids Res 35: 5085-5095.
25. Niebisch A, Kabus A, Schultz C, Weil B, Bott M (2006) Corynebacterial protein kinase G controls 2-oxoglutarate dehydrogenase activity via the phosphorylation status of the OdhI protein. J Biol Chem 281: 12300-12307.
26. Sambandamurthy VK, Derrick SC, Hsu T, Chen B, Larsen MH, et al. (2006) Mycobacterium tuberculosis deltaRD1 deltapanCD: A safe and limited replicating mutant strain that protects immunocompetent and immunocompromised mice against experimental tuberculosis. Vaccine 24: 6309-6320.
27. Bardarov S, Bardarov S Jr, Pavelka MS Jr, Sambandamurthy V, Larsen M, et al. (2002) Specialized transduction: an efficient method for generating marked and unmarked targeted gene disruptions in Mycobacterium tuberculosis, M. bovis BCG and M. smegmatis. Microbiology 148: 3007-3017.
28. Lamichhane G, Zignol M, Blades NJ, Geiman DE, Dougherty A, et al. (2003) A postgenomic method for predicting essential genes at subsaturation levels of mutagenesis: Application to Mycobacterium tuberculosis. Proc Natl Acad Sci USA 100: 7213-7218.
29. Sharma V, Sharma S, zu Bentrup KH, McKinney JD, Russell DG, et al. (2000) Structure of isocitrate lyase, a persistence factor of Mycobacterium tuberculosis. Nat Struct Mol Biol 7: 663-668.
30. Jakoby WB, Scott EM (1959) Aldehyde Oxidation. III. Succinic semialdehyde dehydrogenase. J Biol Chem 234: 937-940.
31. Sassetti CM, Boyd DH, Rubin EJ (2001) Comprehensive identification of conditionally essential genes in mycobacteria. Proc Natl Acad Sci USA 98:12712-12717.
32. Chabriere E, Charon M-H, Volbeda A, Pieulle L, Hatchikian EC, et al. (1999) Crystal structures of the key anaerobic enzyme pyruvate: ferredoxin oxidoreductase, free and in complex with pyruvate. Nat Struct Mol Biol 6: 182.
33. Dawes SS, Warner DF, Tsenova L, Timm J, McKinney JD, et al. (2003) Ribonucleotide Reduction in Mycobacterium tuberculosis: Function and Expression of Genes Encoding Class Ib and Class II Ribonucleotide Reductases. Infect Immun 71: 6124-6131.
34. Sohaskey CD, Wayne LG (2003) Role of narK2X and narGHJI in Hypoxic Upregulation of Nitrate Reduction by Mycobacterium tuberculosis. J Bacteriol 185:7247-7256.
35. Florczyk MA, McCue LA, Purkayastha A, Currenti E, Wolin MJ, et al. (2003) A Family of acr-Coregulated Mycobacterium tuberculosis Genes Shares a Common DNA Motif and Requires Rv3133c (dosR or devR) for Expression. Infect Immun 71: 5332-5343.
36. Aguilera J, Van Dijken JP, De Winde JH, Pronk JT (2005) Carbonic anhydrase (Nce103p): an essential biosynthetic enzyme for growth of Saccharomyces cerevisiae at atmospheric carbon dioxide pressure. Biochem J 391: 311-316.
37. Schulz H (1991) Beta oxidation of fatty acids. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1081: 109.
38. Yang X, Nesbitt NM, Dubnau E, Smith I, Sampson NS (2009) Cholesterol Metabolism Increases the Metabolic Pool of Propionate in Mycobacterium tuberculosis. Biochemistry 48: 3819-3821.
39. Snapper SB, Melton RE, Mustafa S, Kieser T, Jr WRJ (1990) Isolation and characterization of efficient plasmid transformation mutants of Mycobacterium smegmatis. Mol Microbiol 4: 1911-1919.
40. Thompson JS, Malamy MH (1990) Sequencing the gene for an imipenemcefoxitin-hydrolyzing enzyme (CfiA) from Bacteroides fragilis TAL2480 reveals strong similarity between CfiA and Bacillus cereus b-lactamase II. J Bacteriol 172:2584-2593.
41. Baughn AD, Malamy MH (2002) A mitochondrial-like aconitase in the bacterium Bacteroides fragilis: Implications for the evolution of the mitochondrial Krebs cycle. Proc Natl Acad Sci, USA 99: 4662-4667.
42. Wherry WB, Ervin DM (1918) The necessity of carbon dioxide for the growth of B. tuberculosis. J Infect Dis 22: 194-197.
43. Hatfull GF, Jacobs WR (2000) Molecular Genetics of Mycobacteria. Washington, D.C.: ASM Press.
44. Lee S, Kriakov J, Vilcheze C, Dai Z, Hatfull GF, et al. (2004) Bxz1, a new generalized transducing phage for mycobacteria. FEMS microbiology letters 241: 271-276.
45. Adams MW, Mortenson LE (1982) The effect of cyanide and ferricyanide on the activity of the dissimilatory nitrate reductase of Escherichia coli. J Biol Chem 257:1791-1799.