An altered Mycobacterium tuberculosis metabolome induced by katG mutations resulting in isoniazid resistance

Antimicrobial Agents and Chemotherapy

Volumn 58, Issue 4, 2014, Pages 2144-2149

  Loots, Du Toit ^a  

^a NORTH WEST UNIVERSITY   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

ALKANE; ASCORBIC ACID; CARBON; CATALASE; FATTY ACID; ISONIAZID; KATG PROTEIN;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL STRAIN; CARBON SOURCE; DEGRADATION; ENERGY; GAS CHROMATOGRAPHY; METABOLITE; METABOLOME; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; OXIDATIVE STRESS; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; SYNTHESIS; TIME OF FLIGHT MASS SPECTROMETRY;

ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; ISONIAZID; METABOLOME; MUTATION; MYCOBACTERIUM TUBERCULOSIS; OXIDATIVE STRESS;

EID: 84896932200     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.02344-13     Document Type: Article

References (43)

1. Zhang Y. 2005. The magic bullets and tuberculosis drug targets. Annu. Rev. Pharmacol. 45:529-564. http://dx.doi.org/10.1146/annurev.pharmtox.45. 120403.100120. (Pubitemid 40261816)
2. Hazbón MH, Brimacombe M, Bobadilla del Valle M, Cavatore M, Guerrero MI, Varma-Basil M, Billman-Jacobe H, Lavender C, Fyfe J, García-Garciá L, León CI, Bose M, Chaves F, Murray M, Eisenach KD, Sifuentes-Osornio J, Cave MD, Ponce de León A, Alland D. 2006. Population genetics study of isoniazid resistance mutations and evolution of multidrug-resistant Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 50:2640-2649. http://dx.doi.org/10.1128/AAC.00112-06. (Pubitemid 44198682)
3. Olivier I, Loots DT. 2011. An overview of tuberculosis treatments and diagnostics. What role could metabolomics play? J. Cell Tissue Res. 11:2655-2671.
4. Janin YL. 2007. Antituberculosis drugs: ten years of research. Bioorg. Med. Chem. 15:2479-2513. http://dx.doi.org/10.1016/j.bmc.2007.01.030. (Pubitemid 46367698)
5. Dessen A, Quemard A, Blanchard JS, Jacobs WR, Jr, Sachettini JC. 1995. Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis. Science 267:1638-1641. http://dx.doi.org/10.1126/science.7886450.
6. Scior T, Morales IM, Eisele SJG, Domeyer D, Laufer S. 2002. Antitubercular isoniazid and drug resistance of Mycobacterium tuberculosis. Arch. Pharm. 335:511-525. http://dx.doi.org/10.1002/ardp.200290005. (Pubitemid 36314140)
7. Fox W, Sutherland I. 1995. The clinical significance of positive cultures and of isoniazid-resistant tubercle bacilli during the treatment of pulmonary tuberculosis. Thorax 10:85-98.
8. Bergval IL, Schuitema ARJ, Klatser PR, Anthony RM. 2009. Resistant mutants of Mycobacterium tuberculosis selected in vitro do not reflect the in vivo mechanism of isoniazid resistance. J. Antimicrob. Chemother. 64:515-523. http://dx.doi.org/10.1093/jac/dkp237.
9. Heym B, Zhang Y, Poulet S, Young D, Cole ST. 1993. Characterization of the katG gene encoding a catalase-peroxidase required for the isoniazid susceptibility of Mycobacterium tuberculosis. J. Bacteriol. 175:4255-4259. (Pubitemid 23206923)
10. Hassett DJ, Cohen MS. 1989. Bacterial adaptation to oxidative stress: implications for pathogenesis and interaction with phagocytic cells. FASEB J. 3:2574-2582. (Pubitemid 20013271)
11. Pym AS, Saint-Joanis B, Cole ST. 2002. Effect of katG mutations on the virulence of Mycobacterium tuberculosis and the implication for transmission in humans. Infect. Immun. 70:4955-4960. http://dx.doi.org/10.1128/IAI.70.9.4955- 4960.2002.
12. Somoskovi A, Parsons LM, Salfinger M. 2001. The molecular basis of resistance to isoniazid, rifampin, and pyrazinamide in Mycobacterium tuberculosis. Respir. Res. 2:164-168. http://dx.doi.org/10.1186/rr54. (Pubitemid 34187923)
13. Slayden RA, Barry CE. 2000. The genetics and biochemistry of isoniazid resistance in Mycobacterium tuberculosis. Microbes Infect. 2:695-699. http://dx.doi.org/10.1016/S1286-4579(00)00359-2.
14. Gillespie SH. 2002. Evolution of drug resistance in Mycobacterium tuberculosis: clinical and molecular perspective. Antimicrob. Agents Chemother. 46:267-274. http://dx.doi.org/10.1128/AAC.46.2.267-274.2002. (Pubitemid 34087167)
15. Fu LM, Shinnick TM. 2007. Understanding the action of INH on a highly INH-resistant Mycobacterium tuberculosis strain using Genechips. Tuberculosis 87:63-70. http://dx.doi.org/10.1016/j.tube.2006.04.001. (Pubitemid 44960166)
16. Bertrand T, Eady NAJ, Jones JN, Jesmin Nagy JM, Jamart-Grégoire B, Raven EL, Brown KA. 2004. Crystal structure of Mycobacterium tuberculosis catalase-peroxidase. J. Biol. Chem. 279:38991-38999. http://dx.doi.org/10.1074/ jbc.M402382200. (Pubitemid 39296060)
17. Raman K, Chandra N. 2008. Mycobacterium tuberculosis interactome analysis unravels potential pathways to drug resistance. BMC Microbiol. 8:234. http://dx.doi.org/10.1186/1471-2180-8-234.
18. Dunn WB, Bailey NJC, Johnson HE. 2005. Measuring the metabolome: current analytical technologies. Analyst 130:606-625. http://dx.doi.org/10.1039/ b418288j. (Pubitemid 40685888)
19. Schoeman JC, Loots DT. 2011. Improved disease characterization and diagnostics using metabolomics: a review. J. Cell Tissue Res. 11:2673-2683.
20. Bergval I, Kwok B, Schuitema A, Kremer K, van Soolingen D, Klatser P, Anthony R. 2012. Preexisting isoniazid resistance, but not the genotype of Mycobacterium tuberculosis drives rifampicin resistance codon preference in vitro. PLoS One 7(1):e29108. http://dx.doi.org/10.1371/journal.pone.0029108.
21. Draisma HHM, Reijmers TH, Van der Kloet F, Bobeldijk-Pastotova I, Spies-Faber E, Vogels JTWE, Meulman JJ, Boomsma DI, Van der Greef J, Hankemeier T. 2010. Equating, or correction for between-block effects with application to body fluid LC-MS and NMR metabolomics data sets. Anal. Chem. 82:1039-1046. http://dx.doi.org/10.1021/ac902346a.
22. Schoeman JC, Du Preez I, Loots DT. 2012. A comparison of four sputum preextraction preparation methods for identifying and characterising Mycobacterium tuberculosis using GCxGC-TOFMS metabolomics. J. Microbiol. Methods 91:301-311. http://dx.doi.org/10.1016/j.mimet.2012.09.002.
23. Brereton RG. 2003. Chemometrics. Data analysis for the laboratory and chemical plant. J. Chemometrics 17:360-361.
24. Field AP. 2009. Discovering statistics using SPSS, 3rd ed, p 1-821. Sage Publications, London, United Kingdom.
25. Cabiscol E, Tamarit J, Ros J. 1999. Oxidative stress in bacteria and protein damage by reactive oxygen species. Internatl. Microbiol. 3:3-8.
26. Sherman DR, Sabo PJ, Hickey MJ, Arain TM, Mahairas GG, Yuan Y, Barry CE III, Stover K. 1995. Disparate responses to oxidative stress in saprophytic and pathogenic mycobacteria. Proc. Natl. Acad. Sci. U. S. A. 92:6625-6629. http://dx.doi.org/10.1073/pnas.92.14.6625.
27. Farr S, Kogoma T. 1991. Oxidative stress responses in Escherichia coli and Salmonella typhimurium. Microbiol. Rev. 55:561-585. (Pubitemid 21895167)
28. Springer B, Kidan YG, Prammananan T, Ellrott K, Böttger EC, Sander P. 2001. Mechanisms of streptomycin resistance: selection of mutations in the 16S rRNA gene conferring resistance. Antimicrob. Agents Chemother. 45:2877-2884. http://dx.doi.org/10.1128/AAC.45.10.2877-2884.2001. (Pubitemid 32906686)
29. Deretic V, Song J, Pagán-Ramos E. 1997. Loss of oxyR in Mycobacterium tuberculosis. Trends Microbiol. 5:367-372. http://dx.doi.org/10. 1016/S0966-842X(97)01112-8. (Pubitemid 27374943)
30. Gupta S, Chatterji D. 2005. Stress responses in mycobacteria. IUBMB Life 57:149-159. http://dx.doi.org/10.1080/15216540500090611. (Pubitemid 40695153)
31. Springer B, Master S, Sander P, Zahrt T, McFalone M, Song J, Papavinasundaram KG, Colston MJ, Boettger E, Deretic V. 2001. Silencing of oxidative stress response in Mycobacterium tuberculosis: expression patterns of ahpC in virulent and avirulent strains and effect of ahpC inactivation. Infect. Immun. 69:5967-5973. http://dx.doi.org/10.1128/IAI.69.10.5967-5973.2001. (Pubitemid 32885154)
32. Jaeger T, Budde H, Flohé L, Menge U, Singh M, Trujillo M, Radi R. 2004. Multiple thioredoxin-mediated routes to detoxify hydroperoxides in Mycobacterium tuberculosis. Arch. Biochem. Biophys. 423:182-191. http://dx.doi.org/10.1016/j.abb.2003.11.021. (Pubitemid 38198227)
33. Li Y, He Z. 2012. The mycobacterial LysR-type regulator OxyS responds to oxidative stress and negatively regulates expression of the catalaseperoxidase gene. PLoS One 7(1):e30186. http://dx.doi.org/10.1371/journal.pone.0030186.
34. Rojo F. 2009. Degradation of alkanes by bacteria. Environ. Microbiol. 11:2477-2490. http://dx.doi.org/10.1111/j.1462-2920.2009.01948.x.
35. Ron EZ, Rosenberg E. 2002. Biosurfactants and oil bioremediation. Curr. Opin. Biotechnol. 13:249-252. http://dx.doi.org/10.1016/S0958-1669(02)00316-6. (Pubitemid 35299545)
36. Schnappinger D, Ehrt S, Voskuil MI, Liu Y, Mangan JA, Monahan IM, Dolganov G, Efron B, Butcher PD, Nathan C, Schoolnik GK. 2003. Transcriptional adaptation of Mycobacterium tuberculosis within macrophages: insights into the phagosomal environment. J. Exp. Med. 198:693-704. http://dx.doi.org/10.1084/jem. 20030846. (Pubitemid 37087769)
37. Emtiazi G, Knapp JS. 1994. The biodegradation of piperazine and structurally-related linear and cyclic amines. Biodegradation 5:83-92. http://dx.doi.org/10.1007/BF00700633. (Pubitemid 2119462)
38. Whistance GR, Brown BS, Threlfall DR. 1970. Biosynthesis of ubiquinone in non-photosynthetic Gram-negative bacteria. Biochem. J. 117:119-128.
39. Søballe B, Poole RK. 2000. Ubiquinone limits oxidative stress in Escherichia coli. Microbiology 146:787-796. (Pubitemid 30201025)
40. Chattopadhyay MK, Tabor CW, Tabor H. 2003. Polyamines protect Escherichia coli cells from the toxic effect of oxygen. Proc. Natl. Acad. Sci. U. S. A. 100:2261-2265. http://dx.doi.org/10.1073/pnas.2627990100. (Pubitemid 36297487)
41. Tkachenko A, Nesterova L, Pshenichnov M. 2001. The role of the natural polyamine putrescine in defense against oxidative stress in Escherichia coli. Arch. Microbiol. 176:155-157. http://dx.doi.org/10.1007/s002030100301. (Pubitemid 32692657)
42. Hofmann J, Ashry AENE, Anwar S, Erban A, Kopka J, Grundler F. 2010. Metabolic profiling reveals local and systemic responses of host plants to nematode parasitism. Plant J. 62:1058-1071. http://dx.doi.org/10.1111/j.1365- 313X.2010.04217.x.
43. Woluck BA, Communi D. 2006. Mycobacterium tuberculosis possesses a functional enzyme for the synthesis of vitamin C, L-gulono-1,4-lactone dehydrogenase. FEBS J. 273:4435-4445. http://dx.doi.org/10.1111/j.1742-4658. 2006.05443.x. (Pubitemid 44401595)